Articles tagged with Collagen
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Researchers at Helmholtz-Zentrum Berlin discovered that high-energy X-rays can cause damage to bone collagen, even at low irradiation doses. The study used powerful X-ray sources and sensitive detectors to examine the effects on fish and mammalian bone samples.
Researchers compared zebrafish and medaka bones, finding medaka lacks bone cells but retains water-absorbing Proteoglycans. The study suggests a new explanation for why some bones respond better to stress than others.
Researchers have developed an edible plant-based ink derived from food waste to create cost-effective scaffolds for culturing meat. This innovation could significantly reduce the cost of large-scale cultured meat production, making it more affordable and environmentally friendly.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Researchers at MUSC found that extracting and isolating Treg cells and transplanting them back into the same system successfully treats osteogenesis imperfecta for a year. The treatment results in stronger bones, increased osteoblast numbers, and decreased osteoclast numbers.
Researchers discovered that high levels of collagen type XII can trigger breast cancer cells to spread from the tumour to other parts of the body. The study suggests that measuring collagen XII levels in a patient's tumour biopsy could be used as an additional screening tool to identify aggressive breast cancers.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
Researchers discovered cancer cells produce a unique collagen that alters the tumor microbiome and promotes cancer progression. Loss of this collagen reduces cancer cell proliferation and boosts anti-tumor immune response, offering a potential therapeutic strategy.
A new biohybrid composite material demonstrates improved elasticity and fracture energy compared to existing zwitterionic materials, making it suitable for regenerative medicine applications. The material's biocompatibility allows it to recruit cells and support tissue regeneration.
A study by Michigan Medicine researchers has identified oncostreams, highly active cells connected to brain tumor growth and invasion. The team found that eliminating Collagen 1 production from tumor cells reduces tumor aggressive behavior. This discovery could lead to novel therapeutic targets for treating lethal brain tumors.
A new study from Oregon State University suggests that the gelatin in Pacific whiting skin has anti-aging properties, preventing wrinkles caused by ultraviolet radiation. The researchers found a positive response in a human cell model system, providing evidence for further research.
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
Researchers developed a live imaging system to observe collagen synthesis in fibroblasts, revealing the intracellular processing and transportation of collagen fibers. The study found that this step controls the speed of collagen synthesis, providing a new understanding of collagen production.
A study in eLife found that fine air pollution particles can increase the risk of lung cancer by altering lung tissue structure and reducing immune cell infiltration. The researchers identified peroxidasin as a key enzyme responsible for this effect, which could lead to new approaches for preventing or treating lung disease.
Researchers found that pancreatic cancer cells trigger the breakdown of collagen proteins, which increases arginine levels and signals stellate cells to build fibrotic meshes around tumors. This process, known as desmoplasia, creates a dense environment that promotes aggressive growth and blocks access to therapies.
Researchers at Osaka City University found that globin family members can suppress liver inflammation and fibrosis in mice. The proteins' antioxidant capacity was greater than glutathione and vitamin C, suggesting a potential therapy for liver fibrosis.
Researchers at Massachusetts General Hospital identified genetic variants in fibrillar collagen genes that increase the risk of spontaneous coronary artery dissection (SCAD), a common cause of fatal heart attacks in young women. The study's findings provide a potential new target for therapies to prevent SCAD.
A study published at Tokyo Medical and Dental University found that Mkx regulates cellular heterogeneity and gene expression in the PDL, revealing its importance in homeostasis. The results showed that a deficiency of Mkx promotes ossification in the PDL and suggests a compensatory mechanism via Scx to maintain homeostasis.
GeniPhys Inc. has received a two-year, $974,349 Small Business Innovation Research (SBIR) grant from the National Science Foundation to advance the commercialization of its initial product, Collymer Self Assembling Scaffold (Collymer SAS). The grant will be used to scale up manufacturing capabilities and file key regulatory submissions...
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Researchers use matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to track injected collagen in the heart. The technique allows for precise detection of therapeutic peptides and their distribution in the myocardial infarct.
Researchers at MUSC identified a potent antifibrotic peptide that reverses scarring in human and mouse tissues by activating an antifibrotic pathway. The E4 peptide has the potential to treat various diseases, including heart disease, lung fibrosis, liver cirrhosis, and chronic kidney disease.
Cancer cells secrete type III collagen to stay dormant, and when levels decrease, they wake up and create metastatic cancer. Researchers found that enriching the environment with collagen can force cells to remain in a dormant state and prevent tumor recurrence.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
Scientists have shown that applying an electric field to the skin affects collagen pathways, temporarily reducing production and increasing degradation. This opens new therapeutic perspectives for the topical treatment of skin fibrosis characterized by excessive collagen deposition.
A study published in the Journal of Cell Biology found that skin stem cell motility is crucial for wound healing and skin regeneration. The researchers discovered that a specific molecule, EGFR, drives skin stem cell movement and coordinates the production of collagen COL17A1.
Researchers at UNSW Sydney have found the specific protein responsible for keeping cells attached to collagen, a key finding for cancer research. The discovery could lead to new directions for cancer treatment by targeting the protein tropomyosin, which is involved in forming the anchor's chain.
A new study reanalyzes the Sorby vitamin C experiment, a landmark trial that determined the minimum vitamin C requirements for preventing scurvy. The analysis suggests that the recommended daily intake of 45mg may be too low to prevent weak scar strength.
A team of engineers discovered that the unique design of fish fins, with layered structures made up of stiff and soft materials, enables them to achieve remarkable dexterity and flexibility. This finding could lead to new materials and technologies for robotic applications and aircraft design.
Researchers at ETH Zurich have developed a multi-component molecule that interacts with collagen, allowing for the visualization of new tissue growth in the body. This breakthrough could have applications in oncology and wound healing, enabling surgeons to more accurately remove tumors and investigate tissue formation.
Researchers at Bar-Ilan University have developed a novel method for rapid repair of peripheral nerve injuries using nerve guidance conduits filled with engineered aligned collagen gels and NGF-coated magnetic particles. This technique has shown improved axon growth and functional motor restoration in rats with peripheral nerve injury,...
Researchers found that alphaCT1 molecule improves scar appearance by influencing fibroblast behavior, causing them to stretch and change direction. This can lead to more pliable tissue, reducing scarring in surgical procedures. The findings have potential to revolutionize plastic surgery and advance wound healing treatments.
A preclinical study identifies a small molecule inhibitor, KCN1, that dampens tumor drivers and limits disease progression. The study showed KCN1 to be well-tolerated and effective at reducing metastasis, suggesting potential as a treatment for metastatic uveal melanoma.
Researchers at TUM used organoids to investigate mechanical influences on organ growth, finding that collective cell movements deform collagen matrix, controlling further growth. This discovery provides a new model for simulating and investigating organ development.
Researchers at Tel-Aviv University developed a new biological material that generates electric currents and voltage through mechanical force, enabling the creation of implantable devices without batteries. The material, similar to collagen, is non-toxic and piezoelectric, with potential applications in medicine and energy harvesting.
Researchers used 4D printing to create a biomimetic microchannel scaffold made of collagen and hydroxyapatite, inducing blood vessel growth in a mouse model. The scaffold's unique structure allows for enhanced water absorption and cell infiltration.
A new study using bone collagen analysis shows that Japanese flounder exhibit behavioral groups with different migration patterns and feeding habits. The researchers analyzed vertebral-bone collagen isotope ratios to reconstruct individual migration and feeding history, revealing distinct differences among fish.
Researchers found that tumors with a softer matrix are more resistant to treatment, activating signaling pathways that promote cell survival. Targeting this pathway could enhance the effectiveness of chemo- and radiotherapy.
Researchers at the University of Texas MD Anderson Cancer Center discovered that collagen produced by cancer-associated fibroblasts slows tumor progression in pancreatic cancer. Collagen helps block immune signals that lead to suppression of anti-tumor immune response.
Purdue researchers developed a regenerative tissue filler that restored breast shape and consistency, supported new breast tissue formation, and prevented wound contraction and scar formation. The filler represents the first planned medical product using innovative collagen polymer technology.
Researchers have created an algorithm called SCEPTTr that predicts the stability of collagen triple helices, a critical structure in skin, bones, muscles, tendons, and ligaments. The program expands on previous work to understand natural amino acids and provides detailed melting temperatures for each possible combination of sequences.
Researchers at Emory University developed a shape-shifting nanomaterial made of synthetic collagen that can be triggered to change its form from flat sheets to tubes and back again. The material has biomedical applications such as controlled-release drug delivery and tissue engineering.
A research team led by Michael Fox has identified the type of interneuron that produces collagen 19, a protein essential for healthy synapse formation and inhibitory circuit development in the brain. This discovery provides new insights into the molecular mechanisms underlying healthy brain development.
Researchers found that fibrous proteins form a solid layer on water's surface, interfering with fluid property measurements. This finding has the potential to improve bioprinting results by identifying optimal protein solution concentrations and operating parameters.
Researchers Marco Fielder and Arun Nair found that water and mineral content variations significantly impact collagen fibril behavior, leading to bio-composites with improved mechanical stability. Composites with 40% mineralization were twice as strong as those without minerals, regardless of water content.
Researchers found that cytotoxic T lymphocytes (CTLs) dig slow-moving channels through the extracellular matrix to facilitate fast movement of other CTLs. The study suggests modulating ECM properties could enhance immune response efficiency and lead to new therapeutic strategies in cancer treatment.
Researchers created an artificial skin equivalent that reproduces traction-force balance in the lateral direction, a property controlling skin structure and function. This human-skin equivalent enhances physiological skin function analysis, disease research, and reduces animal testing.
Researchers discovered that immobilizing extremities alters the way stem cells interact with their extracellular environment, switching their fate from becoming debilitating bone to benign fat. This finding could help doctors optimize healing in patients with extremity injuries.
Researchers at Radboud University Medical Center have redefined bone formation, finding that it does not require complex biomolecules in collagen. This breakthrough simplifies the production of bone substitutes and biomaterials.
Researchers are exploring how patterns of collagens serve as biomarkers for breast cancer risk and progression, with a focus on addressing health disparities. A $3 million grant is supporting the study, led by Dr. Peggi Angel at the Medical University of South Carolina.
A study by Cima and Clinica Universidad de Navarra has identified reparative cardiac fibroblasts that play a crucial role in repairing the heart after an infarction. These cells are activated when a patient suffers a heart attack, producing a collagen scar to prevent rupture of the ventricular wall.
Researchers at North Carolina State University developed a prototype vascular graft that combines synthetic fibers and collagen filaments to aid in regeneration of the coronary artery lining. The design showed improved strength, flexibility, and biological response compared to previous models.
Researchers found that donors without fractures had more flexible collagen and mineral nanostructure than those with fractures. The study suggests that flexibility at the nanoscale could be an important predictor of future bone fractures, highlighting the need for new treatments targeting nanoscale bone health.
A team of researchers from Washington University in St. Louis has determined for the first time how the process of wound healing begins, shedding light on fibrosis and cancer metastasis. They discovered a recursive process between fibroblasts and their environment, which can be controlled by manipulating cellular responses to drugs.
Researchers at Terasaki Institute for Biomedical Innovation have identified collagen V as a key factor regulating cardiac scar tissue size after a heart attack. The study found that fibroblasts without collagen V produce larger, more irregularly-structured scars, leading to reduced shrinkage and increased risk of complications.
Researchers found that a protein called type 5 collagen plays a critical role in regulating the size of scar tissue in the heart. Without it, scarring can lead to increased strain on the remaining heart muscle and higher risks of heart rhythm problems and sudden cardiac death.
Researchers studied how Toxoplasma parasites move rapidly through tissues using high-resolution imaging and force microscopy. They found that the parasites form specific attachments with collagen fibers, resulting in contractile forces that propel them forward.
Defective ACLP protein causes cellular stress and induces fibrosis in multiple organs, including lungs, livers, and adipose tissues. The study identifies a novel variant of EDS-causing mutations and reveals the protein's role in maintaining connective tissue integrity.
A study published in PNAS reveals that collagen maturation controls the availability of PEDF, a secreted protein involved in multiple biological functions. Researchers found that PEDF selectively destroys developing vessels by binding to newly synthesized collagen.