A mutated gene in more than 20% of breast cancer recurrences promotes metastasis and resistance to hormone therapy. Researchers identify potential vulnerabilities, leading to the development of personalized treatment approaches.
The study found an increase in mass shootings and proportion of women and children shot, highlighting worsening structural inequalities. The researchers emphasize the need for investment in public education, employment, and social services to address gun violence.
Researchers developed a model to identify vulnerable geographic areas for Wolbachia-carrying mosquito release, maximizing protection against dengue. The approach prioritizes areas with the greatest vulnerability, allowing targeted interventions.
Researchers subject Oreos to various tests, finding that the cream almost always separates onto one wafer, regardless of flavor or amount of filling. The team's study provides insights into the properties of yield stress fluids and offers a new approach to understanding non-Newtonian materials.
A new online program has been shown to improve health-related quality of life among adult stroke survivors. The study found that participants who received access to the program had higher scores on health-related quality of life and reported fewer problems with personal care and daily activities.
A study demonstrated that red blood cell vesicles can effectively carry immunotherapeutic RNA molecules to target breast cancer cells. This technology shows promise for delivering therapeutic RNA molecules to disease sites without degradation.
A cross-racial study of 1.87 million US veterans found significant differences in dementia incidence across five racial groups, with Hispanic and Black veterans at highest risk. Rates were significantly higher for Hispanics (99%) and Blacks (55%), while Asian veterans showed a 24% increase compared to whites.
A University of Helsinki research team used holographic duality to model early universe phase transitions and their potential impact on gravitational wave signals. The study, published in Physical Review Letters, suggests that such collisions could create powerful ripples in spacetime detectable by satellite missions like LISA.
Researchers discovered that checkpoint inhibitors can activate regulatory T cells, which can counteract the immune response. Blocking PD-L1 enhanced effector Treg activity, reducing ability to control parasite infections. This finding highlights complexity of immune system's balance between controlling pathogens and protecting healthy ...
Researchers from MIT found that Oreo creme tends to stick consistently to one side of the cookie, regardless of twisting speed or milk exposure. The study used a custom-made 'Oreometer' instrument to investigate cookie mechanics and encourage further research on rheology.
A randomized controlled trial found that an online program improved health-related quality of life among adult stroke survivors by promoting healthy lifestyle behaviors and reducing disability. The study showed significant benefits in personal care and daily activities for those who received access to the online program.
A new study finds that public praise energizes essential workers, while those who don't receive it experience negative emotions and poor coping mechanisms. Essential workers in less visible fields like corrections officers face significant challenges due to lack of appreciation.
A new study led by NYU researchers found that cannabis edibles mimicking popular snack foods have high THC content and may be easily confused for them, increasing the risk of accidental ingestion by children. The products often exceeded maximum limits set by state regulations, raising concerns about public health.
Wildfires in the Pacific Northwest are altering seasonal air pollution patterns and causing a spike in unhealthy pollutants in August. The research found that carbon monoxide levels have increased sharply, indicating the extent of smoke's impacts on clean air gains.
A new study by Yale University researchers found that medication treatment services are often not located in the most vulnerable communities, leaving them at risk of disrupted access to treatment during disasters. The study suggests that preparedness for natural disasters should prioritize those placed at highest risk.
A new study from the University of Georgia found that only about one-third of infants enrolled in WIC meet the daily recommendation for vitamin D by 13 months. Experts recommend increased education and supplementation to address this issue, which can lead to diseases like rickets and Type 1 diabetes.
Researchers find evidence of water pockets beneath the icy surface of Europa, which could facilitate exchange between the subsurface ocean and nutrients from neighboring celestial bodies. The discovery suggests a dynamic ice shell that supports habitability on the Jupiter moon.
Rutgers scientists found that inhaled nanoparticles can migrate from the lungs to the placenta and possibly fetal tissues after maternal exposure throughout pregnancy. This discovery raises concerns about the potential health effects of nanoparticle exposure on human fetuses.
Researchers propose that well-designed computerized clinical decision support can facilitate team approaches to healthcare, enhancing communication and coordinating group effort. The tool provides evidence-based information and guidance, enabling primary care physicians to oversee a diverse healthcare team more efficiently.
A study has identified a new protein, Creb-binding protein (CBP), as a prognostic marker for above-average patient survival in HPV-positive head and neck carcinoma. CBP inhibitors are being developed as targeted therapies that can improve quality of life by reducing side effects associated with conventional chemotherapy or radiotherapy.
A study published in Nature Communications found that BMP9 treatment restored capillary density and improved alveolarization in mice with ACDMPV. The treatment showed promise for improving care for BPD and CDH, two conditions that also affect lung development.
A genome-wide screening using CRISPR-Cas9 identified KEAP1 and Nrf2 as key molecules in sorafenib resistance. The study found that ML385 can enhance the killing effect of sorafenib, while FGF21 positively regulates Nrf2 expression.
Researchers found plasma neurofilament light levels were elevated in all types of frontotemporal dementia, and in people who had mutations but hadn't shown symptoms yet. Higher levels of the protein were associated with greater disease severity and increased just before symptom onset.
A novel mesh plug treatment, Woven EndoBridge (WEB), has been shown to be equally effective in treating sidewall brain aneurysms compared to bifurcation aneurysms. The study found a complication rate similar between the two approaches and demonstrated the safety and efficacy of WEB for sidewall aneurysms.
A study examined the frequency of FDA's extrapolation of pivotal trial data to approved indications, finding it occurred in 45% of cases. This practice may lead to different clinical results in real-world use compared to trials.
Dr. Lauren Southerland will receive the award for her pioneering multidisciplinary geriatric models of care for older adults with emergency healthcare needs. Her research focuses on quality improvement, implementation science, and incorporating geriatric care into ED care.
A new portable COVID-19 test can detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples. The test uses a genetic phenomenon called S-gene target failure to identify the alpha variant, and can be used at home or other settings.
A recent study led by the University of Bonn found no evidence of iron fertilization stimulating algae growth and sequestering CO2 in the Antarctic Ocean during ice ages. Instead, other processes such as sea ice cover and ocean stratification prevented CO2 from escaping into the atmosphere.
A new study by CUNY SPH researchers found that nearly 40% of NYC parents are hesitant to vaccinate their young children against COVID-19, with many citing safety concerns. The study suggests that mandates may be key in increasing vaccine coverage among children.
The SLAS Technology April issue delves into the potential of single-cell transcriptomics for producing transcriptomes from heterogeneous samples. Kind et al. present a new process that reduces sequencing library preparation time by over 75% using the 10X Genomics Single Cell 3' kit.
New PSU research predicts the disappearance of Olympic Peninsula glaciers by 2070, with some remaining as tiny shells. The study highlights the impact of global warming on glacier mass and ecology in the region.
A new study from the University of Kansas found that effective change agents and realistic timelines are crucial for successful change implementation. The study identified six key organizational change management practices to achieve high adoption of change initiatives in the AEC industry.
Patients hospitalized with COVID-19 pneumonia are at a higher risk of developing new-onset dementia compared to those with other types of pneumonia, according to a recent study. The median time interval between infection and dementia diagnosis was 182 days for COVID-19 patients.
A national study found that differential response programs, which provide voluntary services to families at risk of child maltreatment, were associated with a 19% reduction in substantiated reports of child maltreatment and a 25% decrease in neglect reports. These programs also led to a 17% reduction in foster care placements.
Researchers at HKU have identified a new protein, SBK1, that regulates lipid metabolism in the liver and alleviates health problems caused by fatty liver disease. The study found that SBK1 activity reduces lipid accumulation, inflammation, hyperlipidemia, and hyperglycemia in mice with fructose-induced fatty liver disease.
Researchers found a clear link between elevated amyloid beta levels and the development of anxiety and apathy in Alzheimer's patients. These symptoms occur mainly due to underlying brain changes, not psychological reactions. The study suggests that psychiatric symptoms could be used as alternative outcome measures in treatment trials.
A study on the Three Gorges Dam reveals that it has caused significant reductions in annual average CO2, CH4, and N2O emissions in the Yangtze River. The dam's impact extends thousands of kilometers downstream, challenging previous assumptions about large dams' effects on greenhouse gas emissions.
The study analyzed drug-drug interactions associated with adverse clinical outcomes and/or adverse drug reactions in patients with COVID-19. Drug interaction checkers were found to be helpful in identifying such events, suggesting their potential utility in real-world settings.
A systematic review and meta-analysis of 108 studies found that people with severe mental illness, including schizophrenia, have twice the cardiovascular-related mortality rate as the general population. The association has grown stronger over recent decades, with a possible link to changes in antipsychotic use and smoking prevalence.
A Canadian study of over 12,000 hospital admissions found that updated product label changes did not reduce rates of accidental acetaminophen overdose. The study suggests additional measures are needed to prevent these episodes beyond just labeling changes.
A new study found that microglia regulate neuronal subtypes differently in response to bacteria, affecting intrinsic excitability. Pyramidal cells exhibited lower excitability, while Purkinje cells showed higher excitability when modulated by microglia.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
Researchers from HKUST have identified secondary RNA elements that control DICER's cleavage activity, improving miRNA expression and shRNA design for effective gene silencing. The study provides a foundation for designing accurate and efficient short-hairpin RNAs.
Scientists tracked Cryptosporidium in real-time, revealing a simplified lifecycle that completes in three days with only three stages: asexual cells, male cells, and female cells. This understanding paves the way for potential vaccines or therapies to combat the disease.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A recent commentary in the Journal of the National Cancer Institute highlights the disproportionate cancer burden facing Asian Americans, largely attributed to historical prejudices and language barriers. The authors emphasize the need for increased funding and representation in clinical trials to address these disparities.
Scientists have found a new way dunes can form on Io's surface, which is icy and roiling. The researchers used mathematical equations to simulate the forces on a single grain of basalt or frost and calculate its path.
A study by Osaka University researchers reveals patients waited years for diagnosis of rare diseases like hereditary angioedema. Long diagnostic delays can be fatal, and raising awareness is key to improving treatment.
The 29th annual CNS meeting will feature scientific talks, posters, and receptions, with a focus on the latest advances in cognitive neuroscience. Registered press members will have access to these sessions, as well as a quiet Press Room, while COVID safety protocols are in place.
Researchers at Dartmouth have built the world's first superfluid circuit using pairs of ultracold electron-like atoms, allowing for controlled exploration of exotic materials like superconductors. The circuit enables analysis of electron movement in highly controllable settings.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
A Baylor College of Medicine study finds that type I interferon is a major driver of memory and cognitive loss in a mouse model of Alzheimer's disease. Blocking IFN reversed these memory and cognitive deficits in the animal model, suggesting that inflammation plays a key role in AD progression.
Researchers compared mechanical aeration and biofiltration systems to minimize odorous compounds in sewage treatment plants. Biofilters with pruning waste and sludge compost showed efficacy, but lasting effects were variable depending on compound type.
A new evidence-based matching program aims to improve treatment outcomes by pairing patients with therapists based on their previously established effectiveness strengths. The program, funded by PCORI, has shown promising results in reducing symptoms and improving patient care.
Researchers detected aphantasia through pupillary response to imagining dark and light objects. Participants without aphantasia showed a larger pupillary response when asked to imagine vividly, indicating the absence of visual imagery in those with aphantasia.
A new study by Scripps Research analyzed sensor data from wearable devices to track physiological responses to the COVID-19 vaccination. The findings show that resting heart rate increased significantly after vaccination, with stronger effects in younger individuals and those who had prior COVID-19 infection.
Scientists at the University of Freiburg have developed a novel process for 3D printing small and complex components made of transparent glass. Using Glassomer materials and Computed Axial Lithography, they can create structures with thicknesses as low as 50 micrometers in just a few minutes.
Research reveals that the compound eye tile pattern is controlled by geometrical patterns based on concentric circle growth, not just physical stability. The study found that individual eyes show a hexagonal pattern when evenly distributed, but change to square-type when the compound eye extends in the vertical direction.
A study found that small genetic variations impact an organism's ability to utilize energy from various nutrients. Researchers identified several genes contributing to sugar tolerance in fruit flies, which are also present in humans and linked to obesity and type 2 diabetes.
Researchers at Queen Mary University of London identified a way to overcome resistance to cancer drugs in leukemia cells by manipulating cellular pathways. By using a sequential treatment approach, the team was able to kill about 50% of leukemia samples and potentially develop a new treatment strategy for this devastating disease.
The April issue of SLAS Discovery highlights innovative approaches to accelerating lead identification for pancreatic cancer therapies. Authors explore the potential of completely scaffold-free 3D models and automated organoid assays to improve disease modeling and drug discovery.
Researchers developed an algorithm to analyze wearable heart rate data, discovering new signals indicating COVID-19 infection and disease progression. The study's findings could enable the use of wearables in tracking disease at home or during pandemics.
Researchers created two scales to measure factors related to time spent in nature, finding correlations between TSN and self-efficacy, intentions, and age. The study aims to inform future interventions to increase outdoor activities among adults.
A new model predicts how oil and gas wells heat up the surrounding permafrost, causing it to thaw and release methane. The study shows that operating a single well for 30 years can melt the surrounding permafrost in a 10-meter radius, releasing up to 500,000 cubic meters of methane.
Researchers at ACS Sustainable Chemistry & Engineering have identified a less toxic dye called pigment red 254 (PR254) as a greener alternative to current anthraquinone dyes used in signal smokes. PR254 forms a red-colored smoke cloud more effectively and is thermally stable, making it suitable for use in heat-generating systems.
Researchers at UCLA have discovered that amyloid fibrils in the brains of patients with frontotemporal degeneration are composed of the protein TMEM106B, not TDP-43 as expected. This finding may lead to new focus on TMEM106B in FTLD and similar brain diseases.
Five medical societies release recommendations for preventing central line-associated bloodstream infections (CLABSIs) in hospitals. The new guidance highlights the need to strengthen infection prevention programs amid worsening rates of these infections during the COVID-19 pandemic.
A study of 118 PPA autopsies found five diseases causing language impairments, each impacting a distinct part of the language network. The findings can inform targeted interventions and treatment approaches for patients with PPA.
The 9th World Congress on Targeting Microbiota 2022 will focus on recent advances in the microbiota field and therapeutic strategies. Key findings include research on probiotic strains, natural mineral waters, and extracellular vesicles.
A study published in Brain reveals a dedicated neural circuit responsible for post-sepsis anxiety and depression. The researchers identified a potential pharmacological treatment by silencing the amygdala circuit during sepsis, reducing the risk of developing anxiety disorders.
Deforestation in Indigenous lands, particularly in Apyterewa Territory, poses a significant threat to Brazil's ability to meet its international climate change mitigation targets. The Brazilian government must take effective action to enforce environmental laws and protect the Amazon region.
Girls perform better in English than boys from ages three to seven, leading to a possible explanation for the STEM gender gap in adults. Parents who invest more time teaching math to their children show weaker association with later-life math skills.
A new study has identified a strong predictor for the development of clinically important liver problems in people with Hemochromatosis. Researchers found that 84% of those with advanced liver fibrosis also had arthritis, highlighting the importance of early detection and monitoring.
A study in eLife found that fine air pollution particles can increase the risk of lung cancer by altering lung tissue structure and reducing immune cell infiltration. The researchers identified peroxidasin as a key enzyme responsible for this effect, which could lead to new approaches for preventing or treating lung disease.
Researchers have developed a new optical microscopy platform that allows them to visually track the timing and location of fat storage within intact cells of fruit flies. The tool is being used to untangle links between diet and phenomena like obesity, diabetes, and aging.
A survey study found increased risk factors and worse outcomes among transgender and gender-questioning high school students compared to their cisgender peers. The study highlights the need for targeted support and interventions to address these health disparities.
Researchers at UC Berkeley have developed a new way to 3D-print glass microstructures using computed axial lithography (CAL), which produces objects with higher optical quality and design flexibility. The CAL process enables smooth surfaces and complex geometries, making it ideal for manufacturing microscopic glass objects.
Researchers at Karolinska Institutet study how the immune system protects against malaria, finding that people who have contracted the disease before develop a tolerance that prevents severe disease. This knowledge can aid in the development of more effective vaccines.
Researchers are taking stock of advancements in ultrawide bandgap (UWBG) photodetectors with deep UV capabilities, highlighting their efficiency and potential for solar-blind applications. Further work is needed to optimize device performance, particularly in assembling materials over large area substrates.
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
Scientists have created a 3D model of two rare neuromuscular diseases using a tissue chip platform. The model mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, allowing researchers to study how a drug could potentially treat these devastating conditions.
The University of the Basque Country is taking steps to cut its environmental and social footprint by analyzing its impact through life-cycle assessment and modeling. By identifying areas for improvement, such as reducing transportation emissions and extending computer lifespan, the university aims to reduce its impact by up to 30%.