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Science News for April 18, 2022


Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies

Researchers have shed light on how immune checkpoint protein LAG3 modulates T cell activity, providing crucial information for the development of new LAG3-blocking therapies. The study found that LAG3 suppresses T cell activation by disrupting coreceptor-Lck association, even in the absence of MHC Class II molecules.

SourceUniversity of Pittsburgh·JournalNature Immunology·TypeExperimental study·DateApr 18, 2022

Story tips: Supply chain crunch, safer batteries on impact and lithium light bright

A new report from Oak Ridge National Laboratory identifies supply chain must-haves for maintaining the pivotal role of hydropower in decarbonizing the nation's grid. The report also highlights advances in safer battery technologies and innovative electron microscopy techniques for imaging lithium in energy storage materials.

SourceDOE/Oak Ridge National Laboratory·JournalACS Nano·TypeExperimental study·DateApr 18, 2022

Clinicians grapple with decisions in crisis-care simulation

A simulated crisis-care event revealed the moral distress experienced by triage team members who had to prioritize patients for scarce resources. The study aimed to operationalize a process for making life-and-death patient decisions, but triage-team members struggled with balancing individual patient needs with fair resource allocation.

SourceUniversity of Washington School of Medicine/UW Medicine·JournalJAMA Network Open·TypeSurvey·DateApr 18, 2022

Perception matters: How fear about crime impacts presidential approval

A recent study published in Public Opinion Quarterly found that anxiety about crime is a key predictor of presidential approval, with individuals who believe crime has worsened being more likely to punish presidents for it. The researchers also discovered that racial differences play a significant role in how Americans hold presidents ...

SourceWashington University in St. Louis·JournalPublic Opinion Quarterly·TypeData/statistical analysis·DateApr 18, 2022

Automated CAST-R system helps to identify best antimicrobials to fight acute blood infections

Researchers developed an automated system called Clinical Antimicrobials Susceptibility Test Ramanometry (CAST-R) to identify the best antibiotics for treating acute blood infections. The system uses Raman microspectroscopy and machine learning to achieve rapid and accurate results, outperforming conventional methods in just three hours.

Microplastics in the food chain

Researchers from Flinders University have discovered microplastics in blue mussels and intertidal water at popular beaches in South Australia. The study found that single-use plastic was the main source of pollution, with concentrations four times higher near larger towns and cities.

SourceFlinders University·JournalScience of The Total Environment·TypeImaging analysis·DateApr 18, 2022

COVID-19 vaccine protects kids and teens from severe illness

The study found that vaccination with the Pfizer-BioNTech mRNA COVID-19 vaccine reduced the risk of COVID-19-associated hospitalizations in children ages 5–11 years and adolescents ages 12–18 years by two-thirds during the Omicron period. Protection against critical COVID-19 requiring life-supporting interventions remained high in vacc...

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalNew England Journal of Medicine·DateApr 18, 2022

Rice lab improves recipe for valuable chemical

The Rice University lab has improved the recipe for synthesizing molybdenum disulfide (MoS2), a highly sought-after material for its semiconducting properties. By using iodized salt, the team was able to speed up the synthesis process while reducing growth temperatures.

SourceRice University·JournalJournal of the American Chemical Society·TypeComputational simulation/modeling·DateApr 18, 2022

Extract from a common kitchen spice could be key to greener, more efficient fuel cells

Researchers at Clemson University and SSSIHL discovered a novel way to combine curcumin and gold nanoparticles to create an electrode that efficiently converts ethanol into electricity. The discovery brings replacing hydrogen as a fuel cell feedstock one step closer, with potential applications in sensors and supercapacitors.

SourceClemson University·JournalNano Energy·TypeExperimental study·DateApr 18, 2022

Can nanotechnology help fight viruses?

Recent advances in nanomaterial-based antiviral strategies have generated promising results, including antiviral nanodrugs, drug nanocarriers, and nanovaccines. These nano-sized particles can be useful for targeted delivery of antiviral treatments, leading to improved efficacy and reduced systemic toxicity.

SourceWiley·JournalSmall Structures·DateApr 18, 2022

Comprehensive care program helped reduce some racial disparities after hip and knee replacement

A bundled care Medicare program has led to reductions in some outcome disparities for Black patients compared to White patients undergoing hip and knee replacement surgery. The Comprehensive Care for Joint Replacement (CJR) Model has improved key outcomes such as hospital readmission rates, length of stay, and Medicare payments.

SourceWolters Kluwer Health·JournalJournal of Bone and Joint Surgery·DateApr 18, 2022

Climate change induced refugee crisis and chronic war in ancient Peru

Researchers found that favorable local climate change led to chronic warfare in ancient Peru, as neighboring regions experienced droughts and migrants put pressure on the agricultural economy. The study suggests that climate change can harm all populations, either directly or indirectly, through destabilization and refugee crises.

SourceUniversity of Utah·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis·DateApr 18, 2022

About 30% of COVID patients develop “Long COVID,” UCLA research finds

A study of 309 people with long COVID found that fatigue, shortness of breath, and loss of sense of smell were the most persistent symptoms. The research also revealed that factors such as history of hospitalization, diabetes, and body mass index increased the risk of developing Long COVID.

SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of General Internal Medicine·TypeObservational study·DateApr 18, 2022

Lithium’s narrow paths limit batteries

Researchers found uneven charge distribution within lithium iron phosphate cathodes due to misaligned particles, leading to reduced battery performance. Introducing porosity or aligning particles could potentially improve uniform lithium insertion, enhancing energy density and charge/discharge rates.

SourceRice University·JournalACS Energy Letters·TypeExperimental study·DateApr 18, 2022

Bacterial soundtracks revealed by graphene membrane

A team of researchers from Delft University of Technology has captured the sound of a single bacterium using a graphene membrane. The graphene drum detected tiny oscillations caused by the bacteria's flagella, which can be converted into a 'soundtrack' and listened to. This technology has enormous implications for detecting antibiotic ...

SourceDelft University of Technology·JournalNature Nanotechnology·DateApr 18, 2022

Guiding a superconducting future with graphene quantum magic

Scientists have identified magic-angle twisted bilayer graphene as a promising material for high-temperature superconductivity. Researchers found that nematic order in MATBG originates from the interference between fluctuations of a novel degree-of-freedom combining valley and spin degrees.

SourceNagoya University·JournalPhysical Review Letters·TypeComputational simulation/modeling·DateApr 18, 2022

Study explores what food sector needs to know about how to reduce sodium

A comprehensive review of scientific literature on sodium reduction strategies in food production identifies five main approaches: salt reduction, salt replacers, flavor modification, physical modification, and functional modification. These methods can help food companies reduce sodium content while maintaining palatability.

SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalComprehensive Reviews in Food Science and Food Safety·TypeSystematic review·DateApr 18, 2022

Variable schedules harm workers and businesses

A new study by Cornell University found that variable work schedules lead to higher turnover rates due to economic security concerns, health issues, and work-life balance problems. This increased turnover negatively impacts business performance during crises like the COVID-19 pandemic.

SourceCornell University·JournalJournal of Applied Psychology·DateApr 18, 2022

Excess weight almost doubles risk of womb cancer

A recent study funded by Cancer Research UK has found that excess weight almost doubles a woman's risk of developing womb cancer. The study analyzed genetic samples from over 120,000 women and found that markers such as fasting insulin and testosterone increase the risk of womb cancer.

SourceCancer Research UK·JournalBMC Medicine·TypeData/statistical analysis·DateApr 18, 2022

Extreme genetic drift in the Maniq hunter-gatherers of southern Thailand

A recent study on the Maniq population found they exhibit high levels of genetic differentiation, similar to other isolated populations. The researchers also discovered that the Maniq retain a unique hunter-gatherer lifestyle and Hòabìnhian-related ancestry, setting them apart from other Southeast Asian groups.

SourceSMBE Journals (Molecular Biology and Evolution and Genome Biology and Evolution)·JournalGenome Biology and Evolution·TypeObservational study·DateApr 18, 2022

Regenerative potential of solid bone marrow aspirate concentrate

Researchers have discovered that a new type of solid bone marrow aspirate concentrate exhibits enhanced migratory potential and promotes greater cell growth compared to traditional platelet-rich fibrin. This breakthrough may lead to the development of novel therapeutics for promoting wound healing and bone regeneration.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalTissue Engineering Part A·TypeCase study·DateApr 18, 2022

Genetics affects functions of gut microbiome

A recent study by Cornell scientists explores the relationship between human genetics and gut microbiome functions, identifying correlations between genetic variations and microbiome-associated traits. The research, led by Ilana Brito, uses a novel computational approach to model the distribution of functions and species within the hum...

SourceCornell University·JournalScientific Reports·DateApr 18, 2022

Study: Black kidney transplant patients exhibit faster clearance rates of key immunosuppressive medicine tacrolimus

A new study found that Black kidney transplant recipients exhibit a faster clearance rate of tacrolimus, an immunosuppressive drug. The study suggests that considering both sex and race when dosing tacrolimus may reduce adverse effects and enhance transplant outcomes.

SourceUniversity at Buffalo·JournalPharmacotherapy The Journal of Human Pharmacology and Drug Therapy·DateApr 18, 2022

It’s all in the hiPS

A team of researchers from Osaka University and Kyoto University developed a stem cell-based biomaterial, hiPS-Cart, to treat IVD degeneration and prevent further deterioration. The biomaterial was able to survive and maintain its functionality in lab rats with NP removal, reversing IVF and vertebral bone degeneration.

SourceOsaka University·JournalBiomaterials·TypeExperimental study·DateApr 18, 2022