Articles tagged with Drug Interactions
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Researchers discovered a complex network of cell proteins that work together, suggesting medicines should target groups rather than individual proteins. This study, published in Science, has the potential to develop more effective treatments for illnesses.
Three new oral blood-thinning drugs may offer significant advantages over Coumadin, but their lack of clinical experience raises concerns about potential interactions. Many adults take multiple prescription drugs, increasing the risk of adverse interactions.
Researchers at UC Berkeley have discovered a new action mechanism for topoisomerases, enzymes that uncoil DNA, which could lead to the development of more effective antibiotics and anticancer drugs. The discovery, led by James Berger, provides a better understanding of how these enzymes interact with DNA and drugs.
Researchers have developed a new type of drug that targets the BCL6 protein, which is essential for lymphoma cell survival and multiplication. The breakthrough could lead to improved treatment options with fewer side effects, increasing cure rates for diffuse large B cell lymphomas.
Researchers find that combining certain antibiotics can halt bacterial evolution and favor non-resistant strains, potentially reversing the trend of antibiotic resistance. This approach could lead to identifying novel drug combinations that hinder resistance development without compromising effectiveness.
Researchers use powerful computers to identify molecular structures that have high potential as new medications by simultaneously targeting multiple hot spots on protein surfaces. This method has the potential to complement and increase efficiency of existing time-consuming methods.
A new graphical tool called RXplore allows physicians to instantly track down the cause of drug side effects by retrieving adverse reaction data for multiple medications simultaneously. The study found that physicians can retrieve accurate information 65% faster using Rxplore than traditional resources.
Researchers have discovered 65,000 unique relationships between proteins and plant-cell membranes in Arabidopsis, a relative of the mustard plant. This breakthrough using high-throughput screening technology will aid in understanding protein interactions to develop better crops and medicines.
Research by LSU Health Sciences Center scientists has found that drug metabolism is influenced by the interaction between enzymes, which can affect a drug's elimination from the body or conversion into toxic byproducts. The study suggests that testing individual enzymes alone may not be sufficient to predict drug effectiveness and safety.
A University of Michigan study found that nearly 16.8% of eligible emergency visits from 2000-2006 involved potentially inappropriate medications for patients aged 65 and older. The top five most common PIMs were promethazine, ketorolac, propoxyphene, meperidine, and diphenhydramine.
A study published in Intensive Care Medicine found that the AiDKlinik drug information system significantly reduces serious events resulting from drug interactions in ICU patients. The system, which includes over 64,000 drugs, helps physicians minimize adverse reactions by 43% and critical events like arrhythmia by up to 80%.
The event aims to enrich knowledge and understanding of life in St. Ann's by sharing personal experiences and exploring key local issues such as drug use, poverty, and social division. Interactive workshops and talks will be held on topics including immigration, the war on terror, and sex trafficking.
A University of Adelaide pathologist has sounded a warning about the dangers of herbal medicines, which can cause serious illnesses, exacerbate pre-existing health problems, or result in death if taken in excess or combined with prescription drugs. The study analyzed 251 Asian herbal products and found high levels of toxic substances.
A review article highlights the risks of herbal supplements interacting with heart medications, posing a significant threat to elderly patients. The authors emphasize the need for greater awareness and scientific scrutiny to ensure safe use and reduce harm among patients with heart disease.
Researchers from EMBL have discovered the molecular structure of a key protein involved in cellular communication systems that are affected in neurodegeneration, cancer and cardiovascular disease. The study provides insights into how this protein functions and how it can be targeted with drugs to develop new treatments.
Lymphatic filariasis, onchocerciasis, and other neglected tropical diseases (NTDs) cause significant morbidity and mortality globally. NTDs have been hindered by limited funding and coordination, but successful control initiatives like onchocerciasis elimination demonstrate the potential for progress.
Researchers found that antibiotic drugs can alter bacterial cell gene expression levels, leading to increased survival. The study suggests that antagonistic drug pairings can slow down the evolution of antibiotic resistance by restoring cellular equilibrium.
Scientists at UNC and UCSF developed a computational method to compare drug structures with naturally occurring ligands, predicting potential new uses and unexpected side effects of approved drugs. The approach has been validated in wet laboratory experiments.
A workshop conducted by the National Cancer Institute and FDA identified critical decision points in cancer biomarker and drug development. The points emphasize the importance of understanding the biology of the target and its interaction with drugs, as well as rigorous sample collection and quality control.
International experts will discuss the benefits of pet ownership on physical and mental health, including lower blood pressure and increased exercise. The conference aims to build upon existing research and generate more answers about the positive impact pets have on people's lives.
The University of North Carolina has been awarded a $8.6 million NIH grant to investigate the complex factors contributing to psychiatric disorders such as autism, depression, and anxiety. By using laboratory mice to screen genetic possibilities, researchers aim to understand how genes and environment interact to shape these traits.
Researchers conclude that controlled-release pills and capsules prone to dose dumping due to alcohol consumption require human testing. Formulations may pose significant overdose risks even after lab tests indicate faster release rates.
Marine biomedicine researchers have deciphered the structure of a naturally produced ocean-based compound hoiamide A, which offers a novel template for drug development. The findings suggest that hoiamide A may interact with neurons in different ways, potentially leading to therapeutic effects for diseases such as epilepsy and neurodeg...
A Barrow researcher has received a $275,000 grant from the NIH to develop an artificial system to produce a6 nicotinic receptors, which may be a new target for smoking cessation therapies. The project aims to study drug interactions with this key receptor and develop more effective treatments with fewer side effects.
A collaborative doctor-pharmacist partnership reduces hospitalizations for heart failure patients by cutting medication misuse and improving adherence. The Australian model, which includes home visits and follow-up appointments, results in a significant reduction in hospitalization rates.
A study found that patients satisfied with their GERD treatment had better health-related quality of life and were more likely to be taken seriously by their physicians. The quality of patient-physician communication was also a key factor in patient satisfaction.
A K-State researcher is studying protein interactions in the lens of the eye to understand how they trigger cataracts. The goal is to screen drugs that can inhibit or reverse abnormal processes causing cataracts, potentially leading to a nonsurgical method for restoring sight.
Research by University of Arizona College of Pharmacy found that prescribers identify only 42.7% of drug interactions correctly. This highlights the need for better education and awareness about potential drug-drug interactions among health professionals.
Researchers identified gaps in medication and opioid dependence documentation among MMT patients, leading to potential medication interactions and adverse events. Incomplete documentation occurs in up to 30% of cases, highlighting opportunities for improved communication and care coordination to enhance patient safety.
The International Society for Heart and Lung Transplantation recommends increased surveillance following generic immunosuppression medication changes to avoid adverse effects. This advisory aims to inform transplant practitioners about the challenges of prescribing generic medications in thoracic transplantation patients.
A study found that complex antithrombotic therapy is associated with a high risk of upper gastrointestinal events among vulnerable elders. The researchers also discovered that proton pump inhibitors may increase the risk of hip fractures in patients taking acid suppressors.
A study by University of California, San Diego researchers found that polypharmacology can explain the failure of cholesterol-controlling drugs like Torcetrapib. By analyzing protein-drug interaction networks, they identified potential off-target effects and proposed a novel computational strategy to design safer pharmaceuticals.
Patients and physicians found virtual visits similar to face-to-face visits on most measures, including time spent with the physician and overall satisfaction. The study suggests that virtual visits could be a viable option for chronic conditions and acute issues.
A study by Ottawa researchers found that an interactive voice response system can effectively monitor patients taking anticoagulants like warfarin, reducing the workload of clinical staff. The system improved patient outcomes and efficiency in managing anticoagulation therapy.
Researchers at USC and Rhenovia Pharma will use large-scale computer modeling to predict synergistic interactions within glutamate systems that might be targets for new drugs. The goal is to find a way to home in on specific neural cells without disturbing others, addressing malfunctions in diseases like schizophrenia.
A study of over 2,000 seniors found that quitting smoking can slow down gait and improve overall health. Changing bad habits such as poor food choices and lack of exercise can also have a significant impact on senior health.
The proportion of Medicare patients experiencing continuity of care between outpatient and inpatient settings decreased substantially between 1996 and 2006. Patients with co-existing illnesses and the oldest patients were more likely to have continuity with their outpatient physicians and PCP during hospitalization.
Research finds that licorice can block absorption of cyclosporine, a vital immunosuppressant for transplant patients. Laboratory rats showed significant drop in cyclosporine levels after consuming licorice extract.
Researchers at Caltech have discovered a tiny genetic mutation that prevents nicotine from binding to muscle cells' acetylcholine receptors. This subtle difference explains why nicotine is virtually powerless in muscle cells despite being highly addictive in the brain.
A Scripps Research team discovered peptides that inhibit viral production by 68-63% and reduce viral RNA levels by sevenfold. The findings offer a promising target for the development of anti-hepatitis C virus drugs.
A study by UCSF researchers identifies critical barriers hindering the adoption of electronic personal health records, including cost, privacy concerns, and design shortcomings. The authors propose solutions such as improving interoperability and using mobile phones as an entry point for consumers to access their records.
A study published in JAMA found that patients who receive a medication to reduce gastrointestinal bleeding alongside clopidogrel and aspirin after a heart attack have an increased risk of hospitalization for acute coronary syndrome or death. The study suggests that proton pump inhibitors may reduce the effectiveness of clopidogrel, but...
Researchers at WashU Medicine found that methadone is processed differently than previously thought, leading to under- or overdosing. The study suggests better dosing guidelines could improve treatment outcomes and reduce fatalities related to methadone use.
Researchers at MU College of Veterinary Medicine found that blocking specific proteins, AP-1 and SAF-1, may prevent cartilage breakdown in arthritis patients by inhibiting inflammation. This could lead to new therapeutic targets for treating the disease.
A new study found that clinicians override over 90% of drug interaction and allergy alerts, highlighting the need for improved decision support systems to enhance patient safety. The researchers recommend reclassifying alert severity, providing an option to suppress alerts, and customizing them for a clinician's specialty.
A new study found that proton pump inhibitors significantly increase the risk of heart attacks in patients taking clopidogrel after a heart attack. The risk was higher for certain proton pump inhibitors, including omeprazole and lansoprazole.
Researchers discovered that just four genetic variants in three yeast genes account for nearly 90% of the genetic contribution to sporulation efficiency. The findings suggest that transcription factors may harbor significant variations and point to the need for better statistical models and tools to understand genetic interactions.
The University of Texas Health Science Center at Houston has received a $2.5 million award to train investigators in gene-environment interaction, a pioneering area of genetic study. The program aims to discover why some people with known risk factors for disease get sick and others don't.
Researchers have discovered that deuterated pyridine adopts a different crystalline form than its normal counterpart, only achievable under high pressure. This finding has implications for the development of more specific and effective pharmaceutical agents.
Researchers discover novel compound F15845 that targets persistent sodium current, causing permanent excess sodium influx in heart cells. The drug has shown promising results in animal studies, with acceptable bioavailability when given orally.
A study found that 2.2 million older US adults take multiple medications, with half involving nonprescription medications, increasing the risk of harmful drug-drug interactions. The most common interaction was bleeding problems, often caused by combining prescription and over-the-counter medications.
A study found that nearly half of older adults in the US use prescription and over-the-counter medications concurrently, posing a significant risk of adverse drug interactions. The prevalence of concurrent medication use increased with age, with 68% of older adults using at least two types of medications.
Researchers have created a new therapy for preventing heart failure by developing a highly selective drug that blocks the production of aldosterone. The compounds were synthesized and tested in cell cultures and rat models, showing promising results.
A $4 million NIH-funded project led by OHSU aims to discover biologically active molecules from bacteria associated with marine mollusks in the Philippines. The project will catalog and preserve over 10,000 mollusk species, targeting potential central nervous system, cancer, and antimicrobial drugs.
Researchers at University of Missouri are studying the interactions between black cohosh and tamoxifen in a unique rat model to understand its safety and effectiveness. The goal is to provide reliable information on how women can use herbal supplements to enhance their breast cancer treatment and improve quality of life.
Researchers created a new model of behavior for the nicotinic acetylcholine receptor, showing that cholesterol is essential for its structure and function. The findings have broad implications for pharmacology and may shed light on recent data indicating low cholesterol's harmful effects on brain cells.
Researchers at Stanford University have discovered a vulnerable step in the hepatitis C virus' reproduction process that can be effectively targeted with an obsolete antihistamine. The novel technique used microfluidic chips to screen over 1,200 drug candidates and identified clemizole as a promising lead.
Duke University researchers found that antipsychotic drugs may not work as previously assumed, and that the biochemical pathways linked to the D2 receptor may function differently than expected. The study suggests that targeting the beta-arrestin pathway could lead to more effective treatments with fewer side effects.
Grapefruit juice and other common fruit juices, such as orange and apple, can decrease the absorption of certain drugs, including those used for heart disease, cancer, and organ transplantation. This interaction may lead to a loss of beneficial effects and potentially toxic overdoses.
A sociologist's analysis reveals that new prescription drugs are twice as likely to harm patients as to provide benefits superior to existing drugs. The study identifies institutional flaws in the FDA's review process, including under-funding and industry influence.