Articles tagged with Drug Interactions
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The European Bioinformatics Institute (EMBL-EBI) will gain free access to large collections of information on drug properties and small molecules after receiving £4.7 million from the Wellcome Trust. This will enable academia to participate in early-stage drug discovery, potentially improving prediction of side effects.
Scientists have developed a new technique to study neurons in three dimensions, allowing for faster analysis of neuronal activity and interactions. This breakthrough uses a fast-moving laser beam and multi-photon microscopy to provide a more detailed understanding of neuron function.
Researchers discovered that atypical antipsychotic drugs like olanzapine can disrupt energy metabolism in male rats, leading to increased blood sugar levels and abdominal fat storage. The study suggests that these changes may occur earlier than previously thought and could have implications for human health.
Researchers at the University at Buffalo found that taking ibuprofen while taking aspirin for stroke prevention reduces its effectiveness. In a study of 28 patients, all took ibuprofen and had no anti-platelet effect from their daily aspirin.
A new study from Brandeis University reveals that 1 in 10 elderly adults on Medicare consume more alcohol than recommended, with 9% engaging in unhealthy drinking habits. The study highlights the need for healthcare providers to be aware of this often-missed issue and consider individual factors when assessing risk.
Researchers at the Wellcome Trust Sanger Institute have developed a novel method to identify weak and transient protein interactions. By analyzing over 6000 experiments in mammalian cells, they discovered 17 new pairs of interactions that could lead to novel therapeutic opportunities for diseases such as cancer, diabetes, and growth.
Researchers have discovered a new ALS drug target by identifying an unexpected protein-protein interaction between SOD1 and Rac1. This interaction, which is impaired in familial ALS, leads to excessive ROS production and oxidative stress, contributing to the disease's progression.
A recent Argonne National Laboratory study found that proteins can move in more configurations than previously thought, especially in dilute solutions. The researchers discovered that environmental conditions influence which state a protein prefers to enter, and this knowledge may help understand how proteins interact with drugs.
The article explores the results of the ‘Oats at 10 Years’ study, which tracked the correlation between oat consumption and a healthier lifestyle. The study found that foods containing whole-oat sources of soluble fiber, such as oats, oat bran, and oat flour, could reduce the risk of coronary heart disease.
Researchers identified 273 human proteins required for HIV propagation using RNA interference, a technique that was previously untested on this scale. The study provides new insights into the HIV life cycle and offers potential new therapeutics.
Researchers at UAB have provided physical proof that two proteins involved in Cystic Fibrosis (CF) interact closely enough to cause a biochemical imbalance. This discovery may aid in understanding the biological underpinnings of CF and speeding up the development of new drugs to treat or cure the disease.
A literature review found that well-designed seminars, role-playing, and focused curricula can influence medical students' and residents' attitudes towards pharmaceutical companies. Medical schools can reduce the impact of industry influence by implementing policies to limit contact with company representatives.
Researchers found that nicotine can initially reverse alcohol-induced cognitive deficits, but tolerance develops with continued administration. Chronic nicotine exposure produces cross-tolerance to the effects of low-dose alcohol on learning, potentially exacerbating addiction.
A preliminary laboratory study suggests that consuming large amounts of caffeine with acetaminophen can lead to toxic interactions and liver damage. The researchers recommend limiting caffeine intake while taking acetaminophen, particularly for vulnerable groups such as those taking certain medications or excessive alcohol.
Researchers identified single nucleotide polymorphisms (SNPs) in the adducin 2 gene that influence blood pressure regulation among people with hypertension. The study found associations between SNPs and differential responses to different antihypertensive drugs, highlighting potential for tailored treatment regimens.
Acute lymphoblastic leukemia patients with Philadelphia chromosome (Ph+) experience poor response to imatinib due to emerging drug-resistant clones. Research reveals signals from the bone marrow microenvironment can sustain viability of Ph+ ALL cells, enabling rapid resistance development.
The University of Pittsburgh School of Medicine has been awarded a $16 million grant to establish the Pittsburgh Center for HIV Protein Interactions, which will investigate the life cycle of HIV. Researchers at the center will use advanced technologies to identify key virus-host interactions and develop new drug targets.
The new guidelines aim to reduce ambiguity and capture necessary information from experiments to provide a deeper level of understanding. They have been implemented in public repositories such as ArrayExpress, IntAct, and PRIDE, enabling easier identification and use of relevant data.
Scientists at Einstein College of Medicine have discovered the secret behind people living to 100 or more: favorable “longevity” genes that protect against disease-causing genes. The novel method used by researchers could lead to new drugs to protect against age-related diseases, including cardiovascular disease and diabetes.
Researchers at the University of Minnesota Medical School have developed a noninvasive diagnostic tool for complex brain diseases by recording tiny magnetic fields in the brain. The technique, which uses magnetoencephalography (MEG), can predict Alzheimer's and other brain diseases with high accuracy.
A study published in the Journal of Clinical Pharmacology found that pomegranate juice does not impair the clearance of oral or intravenous midazolam, a test drug used to assess CYP3A activity. This suggests that pomegranate juice is safe for patients taking medications.
The Lancet Editorial warns that hypertension's increasing burden will largely stem from poor lifestyles, with a staggering 90% risk of developing the condition in developed countries. Effective treatments exist, yet many patients misbelieve they can 'cure' hypertension and stop medication when their blood pressure falls.
A study of 40,171 patients found a 4-6 fold increase in gastrointestinal bleeding when warfarin was used with antiplatelet agents. Physicians should be aware of these risks to better assess their patients' therapeutic risk-benefit profiles.
A study by the University of Alberta finds that adverse reactions to natural health products are being under-reported, with only 1.5% of pharmacists reporting suspected events to Health Canada. The lack of data on interactions makes it difficult to provide useful advice for managing adverse reactions.
The Lancet Series explores inappropriate prescribing in elderly people, with evidence suggesting overprescription of drugs and inadequate patient involvement. Drug-drug interactions are also a significant concern, with 46% of elderly outpatients at risk of potentially significant interactions.
Scientists at Wake Forest University School of Medicine have discovered that an obesity drug, orlistat, can be repurposed to target and kill cancer cells. The breakthrough, published in Nature Structural and Molecular Biology, provides a promising new avenue for the development of more potent cancer treatments.
Research reveals nearly half of people with diabetes use alternative therapies, which can interact with conventional medications and affect blood sugar levels. Healthcare professionals must be included in discussions about these therapies to document their use and identify potential problems.
A study of Medicare Part D plans in California and Hawaii found that while there is significant variation in drug formularies, most classes of drugs have at least one widely-covered option. The researchers identified specific drugs with high coverage rates, including generic drugs and some brand-name medications.
A study found that daily use of ginseng or ginkgo biloba supplements, or their combination, do not significantly alter the pharmacokinetics of most prescription drugs. Researchers tested 72 healthy adults with a cocktail of five drugs and found no differences in absorption or metabolism regardless of supplement use.
A new study by University of Arizona College of Pharmacy researchers found that pharmacists' workloads increase the potential for medication errors. The study analyzed data from 672 pharmacies and found that each additional prescription filled per hour increased the risk of dispensing potentially harmful combinations of medications.
A study found that nearly a third of cancer patients take at least one medication that can cause serious harm or interact with other medications, including anticancer treatments. The most common interactions involve warfarin and anticonvulsants, posing significant risks to patients with brain tumors.
In Beijing, patients use 'shang huo' to describe oral health issues like tooth pain and swelling. This concept illustrates how multiple medical traditions interact within a single oral health culture.
Medication errors are common and difficult to detect among outpatient transplant patients, with adverse events associated with 32% of errors. The root causes were identified as patient error (68%), financial issues (5%), and healthcare provider error (27%), highlighting the need for improved processes to prevent such errors.
Operations researchers introduced unbiased analytical tools to study criminal justice, shedding new light on crime patterns and the effectiveness of imprisonment. Prof. Blumstein's work reveals that crime rates fell during the crack cocaine epidemic as people turned away from the drug, while imprisonment did not prevent crime.
Researchers at MCG have made a groundbreaking discovery about G proteins, which could lead to better understanding of drug action. The study found that certain G proteins don't dissociate, affecting the response of cells to epinephrine.
A new UCLA study found that physicians rarely discuss medication costs with patients, which can lead to non-adherence and increased out-of-pocket expenses. The study, published in The American Journal of Managed Care, suggests that higher-income patients are more likely to initiate discussions about costs.
The Mount Sinai Medical Center will receive a $400,000 grant to develop and disseminate a curriculum educating health professionals about rational prescribing. The grant aims to promote critical thinking and healthy skepticism among healthcare providers, enabling them to make evidence-based prescribing decisions.
A new study found that patients with irritable bowel syndrome (IBS) reported greater global improvements in symptoms and less bloating after taking rifaximin, an antibiotic. The randomized, double-blind study demonstrated a sustained benefit of an antibiotic for IBS symptoms even after treatment was stopped.
A recent study published in Alcoholism: Clinical & Experimental Research found that nicotine decreases blood alcohol concentrations in adult rats. The second key finding is that the capability of nicotine to decrease BAC can only be observed if alcohol is given through the oral route of administration.
A Chinese man's use of Longdan Xieganwan led to the development of bladder tumors and eventual kidney failure. The herb contains aristolochic acid, which has been linked to an increased risk of bladder cancer. Doctors highlight the dangers of unregulated herbal therapy and emphasize the need for regulation.
Majority of healthcare opinion leaders support the Medicare Part D program, but favor changes to reduce complexity and improve coverage for vulnerable populations. Opinion leaders recommend policy changes such as filling the donut hole and eliminating the asset test to benefit low-income beneficiaries.
A study by the University of Alberta found that older farmers who stop taking prescribed pain medications are at higher risk of injury. The research identified several reasons for this, including distraction caused by pain, withdrawal symptoms, and incontinence-related discomfort.
The Smart Petri Dish uses porous silicon crystals filled with polystyrene to detect subtle changes in cell sizes and shapes, allowing for early detection of liver toxicity. The device can perform multiple assays simultaneously and is non-invasive, making it a potential tool for predicting human liver responses.
A study led by Dr. Paul Watkins found that grapefruit juice contains furanocoumarins, which inhibit an intestinal enzyme and cause interactions with certain medications. Removing these compounds from grapefruit juice eliminates the interaction, suggesting a new approach to managing medication side effects.
A Stanford scientist's study reveals that 21% of prescriptions dispensed in 2001 were for conditions with little or no FDA-approved evidence, and 73% had no scientific backing. This practice, known as off-label prescribing, carries unknown risks and lacks rigorous scrutiny.
A national study found that 85% of prescriptions for commonly prescribed drugs were for FDA-approved indications or off-label uses with strong scientific support. However, 21% of prescriptions lacked evidence to support their use.
Researchers found that hospitalized patients with schizophrenia are more likely to experience serious infections, respiratory failure, and sepsis compared to those without the condition. The study suggests that improved quality of care could help mitigate this increased risk.
The study uses a Fourier transform ICR mass spectrometer to analyze protein molecules and measure changes in receptor dynamics upon binding. This technique enables highly accurate pictures of tiny amounts of protein molecules, offering a powerful way to probe drug-protein interactions.
A study analyzing electronic health records found that 2,354 outpatients (0.7%) received prescription violations of black box warnings. Patients at risk included those over 75, female, or taking multiple medications. The researchers suggest improving FDA warnings to prevent such violations.
The Yale guidelines ban faculty from receiving gifts, meals, and free drug samples from industry, setting standards for financial conflict of interest disclosure in educational programs. The guidelines aim to promote an effective and ethical partnership between medical schools and pharmaceutical companies.
Research suggests that chronic drinking and smoking both lead to significant brain structural abnormalities, including reduced gray matter and neuronal injury. Chronic smoking may also hinder recovery during abstinence from alcohol, leading to impaired cognitive function.
A study found that 45% of heart patients use complementary or alternative medicines, but only 39% believe their doctors should know. Physicians must educate patients on risks and provide safe alternatives to prevent life-threatening interactions with prescribed cardiac medications.
E-MAP technique enables researchers to analyze epistatic interactions between genes in a systematic way, revealing new insights into protein functions and evolutionary processes. By quantifying the effects of interacting mutant genes, E-MAPs help optimize drug treatments and improve our understanding of biological systems.
Researchers developed a new method to identify novel drug targets for fighting malaria by comparing protein interactions in Plasmodium falciparum with other organisms. This approach could lead to the development of antimalarial drugs that exploit unique differences in protein wiring.
A study found that medical students are frequently exposed to pharmaceutical company gifts and activities, with 93.2% of respondents required to attend at least one sponsored lunch. Many students also believe they are entitled to gifts and think sponsored grand rounds can be educational but biased.
Standard clinical practice guidelines often focus on one disease and exclude coexisting conditions, leaving clinicians without guidance for caring for older patients with multiple chronic diseases. This can lead to polypharmacy, medication errors, and an unsustainable treatment burden.
The study highlights that current clinical practice guidelines (CPGs) often fail to address the complexities of caring for older adults with multiple chronic diseases. The authors recommend that CPGs be revised to include information on comorbidity, patient preferences, and life expectancy to provide more tailored guidance for clinicians.
The Lancet emphasizes the need for open discussion to understand the true extent of drug use, its risks, and effective management strategies. Doctors are lacking essential knowledge due to a lack of transparency and open debate.
Researchers believe gut microbes influence how medicines affect the body, leading to individualized treatments and drug discovery. Changes in gut microbiome composition may impact medication effectiveness between individuals.
A Vanderbilt University Medical Center study has identified a crucial early step in the HIV assembly process, revealing how the Gag protein is directed to the multivesicular body. The discovery could lead to the development of new drugs targeting this step, potentially blocking viral replication.