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Antisense oligonucleotide treatment shows promise in treating Parkinson's disease progression

Researchers from Tokyo Medical and Dental University demonstrate a proof of concept for antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies. The treatment, involving antisense oligonucleotides, effectively reduces Lewy pathology-like neuronal inclusion by over 90%.

SourceTokyo Medical and Dental University·JournalActa Neuropathologica Communications·DateJul 25, 2024