Research on enzymes and the reactions they drive. Covers enzyme evolution, plastic-degrading enzymes, brain immune cells, and molecular imaging.
Research published in the journal Genetics shows that fruit flies and humans regulate their circadian rhythms through similar cellular machinery. This discovery provides a viable animal model for circadian research and sheds light on the potential treatment of seasonal affective disorder, insomnia, and possibly some cancers.
Researchers have synthesized RNA enzymes that can replicate themselves without proteins, a breakthrough in understanding the origins of life. The system, which involves two enzymes that assemble each other, has been shown to sustain molecular information and give rise to variations through Darwinian evolution.
Dr. Debashis Ghosh's groundbreaking work has determined the three-dimensional structure of aromatase, a key enzyme in estrogen production. This breakthrough opens doors to customized, comprehensive medical treatment for breast cancer patients.
Researchers have discovered two enzymes involved in DNA demethylation, which could lead to targeted therapies aimed at slowing or preventing cancer. The enzymes control an 'on-and-off switch' for critical genes that trigger cancer and other diseases.
Researchers have developed a genetic modification that modifies the connections in lignin, making it easier to break down and access cellulose for ethanol production. The modified plants show increased sugar yields without compromising plant strength or lignin content.
Researchers find AID causes genetic malfunctions leading to Burkitt's lymphoma and potentially other cancers. The enzyme, responsible for immune system adaptation, also targets a cancer-promoting gene.
A team of researchers at the University of Oklahoma Health Sciences Center discovered a new enzyme that plays a primary role in how cancer tumors expand and spread. The enzyme, called sFAP, helps create scaffolding for cancer cells to attach, divide, and migrate.
Researchers at Johns Hopkins Medicine discovered how a lowly fungus regulates its version of cholesterol, gaining new insight into the target and action of cholesterol-lowering drugs. In humans, Insig limits cholesterol production by inactivating the enzyme HMG-CoA reductase through phosphorylation.
Researchers from Thomas Jefferson University reported that IDO2 enzyme is overexpressed in pancreatic cancer cells, potentially leading to targeted immunotherapy. Genetic analysis revealed that about 75% of patients have an active IDO2 enzyme, suggesting a novel therapeutic strategy.
An experimental TB drug called PA-824 has been found to work by producing nitric oxide gas, which kills the bacteria. The discovery could lead to the development of new drugs against other disease-causing bacteria, as humans lack the bacterial enzyme needed for the drug's effect.
A Queen's University study has shed new light on the control of a cell enzyme implicated in tissue damage after heart attacks and strokes. The research team discovered a way to block the enzyme's activity, which could lead to new drug treatments for stroke and heart disease.
Scientists have discovered an enzyme that can convert sugars into a precursor of acrylic glass, a plastic used in various applications. This breakthrough could make the production of acrylic glass more environmentally friendly and potentially increase its demand in the coming years.
Scientists have discovered a biological transformation that occurs in the absence of an enzyme, taking 2.3 billion years to complete. This finding highlights the importance of enzymes as catalysts in life processes and has implications for drug design and molecular studies.
A new study from the University of Iowa found that lung airway cells can activate vitamin D, leading to the expression of genes involved in immune defense. The active form of vitamin D helps fight bacterial infections and reduces inflammation.
Scientists at Gladstone Institute of Neurological Disease have identified a new approach to destroy amyloid-beta proteins, which are linked to Alzheimer's disease. By reducing the natural inhibitor cystatin C, they can unleash potent enzyme cathepsin B to clear AB proteins from the brain.
Hydrogen sulfide is produced in the endothelial lining of blood vessels and regulates blood pressure by relaxing blood vessels. The discovery has potential applications for designing drug therapies to enhance its formation as an alternative to current hypertension treatments.
A team led by UC San Diego professor Joseph Wang will create an automated sense-and-treat system that monitors biomarkers and administers treatment in real-time, aiming to improve soldier survival rates.
A study mapped the clan of mobile selfish genes Alu retrotransposons in the human genome, revealing that around 10,000 elements are still capable of jumping around and posing a major threat to human genetics. The research provides valuable insights into the behavior of these elements and their potential impact on personalized genomics.
Researchers have created a new therapy for preventing heart failure by developing a highly selective drug that blocks the production of aldosterone. The compounds were synthesized and tested in cell cultures and rat models, showing promising results.
Researchers at University of Southern California reveal the atomic structure of APOBEC-3G, an enzyme that stops HIV replication. The discovery suggests new directions for developing anti-HIV drugs by targeting a viral protein that blocks the enzyme.
Researchers at the University of Illinois College of Medicine discovered a novel enzyme linked to anencephaly, a rare fatal birth defect. The study suggests that a genetic test may be developed to diagnose the condition early in pregnancy.
Researchers at University of Missouri-Columbia used paramagnetic resonance relaxation enhancement to directly visualize HIV-1 protease maturation into an active infection. The 'tail' amino acid residues form a temporary tunnel where the virus becomes infective, enabling researchers to better understand and target novel therapeutics.
The Conaway Lab identifies a new way in which the proteasome helps regulate gene expression through its interaction with the chromatin remodeling complex INO80. This mechanism involves the deubiquitinating enzyme Uch37, which can remove protein tags from other proteins.
Researchers identified acylated steryl-beta-glucosides as the active compounds behind germinated rice's health benefits, including improved cognitive function and anti-diabetic properties. These unique sterol-like molecules are concentrated in the rice bran and may be specific to rice.
Researchers have identified a coral gene called STPCA that responds to light cycles and produces bicarbonate to buffer against acidity. This adaptation allows corals to survive in shallow waters with limited food resources.
Researchers at Indiana University have discovered a molecule that could lead to new treatments for heart attacks and protect hearts during open heart surgery. The compound, Alda-1, was found to activate an enzyme that reduces cell death caused by lack of blood flow to the heart.
Researchers identify aldehyde dehydrogenase 2 (ALDH2) as a crucial enzyme in reducing cellular damage from free radicals. Activation of ALDH2 increases its activity during heart attacks, leading to a significant drop in associated damage and potential applications for treating various diseases.
A study at UT Southwestern Medical Center found that a bacterial molecule must be inactivated, not just killed, for an animal to regain full health after infection. The 'signal' molecule, lipopolysaccharide (LPS), triggers the immune response and causes inflammation, but also suppresses it temporarily.
A Florida State University researcher has discovered a molecular mechanism that gives scientists a better understanding of how evolution occurs at the molecular level. The study reveals an enzyme with two pathways dedicated to the same task, one of which is an evolutionary vestige left over from an ancient enzyme.
Brookhaven researchers modified a desaturase enzyme to produce three new products, including two variations of an allylic alcohol and a fatty acid with two double bonds. The discovery expands the potential for engineering designer plant oils as biofuels and raw materials.
Scientists at Emory University School of Medicine have identified a crucial protein called UHRF1 that acts like a bookmark to maintain the correct pattern of DNA methylation. This process is essential for normal development and preventing cancer, as alterations in methylation patterns can lead to gene silencing at the wrong times.
Bacteria use multifunctional enzymes to save energy and produce cell wall components, making them resistant to fluoroquinolone antibiotics. This 'moonlighting' activity protects the enzyme DNA gyrase from attack by antibiotics.
Researchers have discovered a key to cold tolerance in corn, allowing it to thrive in colder regions. By increasing PPDK enzyme production during cold weather, corn yields can be extended and growth seasons lengthened.
Researchers at Queen's University have found a new approach to regulating enzymes involved in blood clotting, potentially leading to novel treatments for heart attacks and strokes. The study targets the enzyme PDE5, which is also used in Viagra, and shows its selective inhibition could prevent platelet activation.
Researchers at Caltech developed a novel way to produce large quantities of drugs, including antiplaque toothpaste additives and antibiotics, using genetically modified yeast. The yeast produces reticuline, a precursor for benzylisoquinoline alkaloid molecules with various pharmacological activities.
The Scripps Research Institute team has identified a protein called Nrm1 that plays a crucial role in regulating the cell cycle. When DNA replication stalls, Nrm1's repression of certain genes is blocked, allowing those genes to be expressed again, which enables the production of proteins needed to correct the problem.
Researchers found that SOD1 protein stability and aggregation propensity are key factors in predicting patient survival. Mutations that increase stickiness and decrease stability of the protein correlate with reduced survival times.
Researchers found a compound in germinated brown rice that helps normalize blood sugar and enzymes out-of-whack with diabetes. This growth factor, ASG, increases levels of good enzymes and helps protect nerve membranes and homocysteine levels.
Researchers have found that cigarette smoke significantly worsens the consequences of viral infections in mice, leading to increased immune responses and airway damage. This study provides new insights into the mechanisms underlying the negative impact of cigarette smoke on lung health and may have implications for human disease preven...
Researchers found that adding pressure early in their protocol dramatically speeds up proteomic analysis, reducing the time-consuming first step from four hours to just one minute. This breakthrough increases the number of samples that can be analyzed, with the pressure method generating about 10% more unique peptides.
Scientists have made significant progress in understanding the replication of bluetongue virus, a major economic threat to farming. The 'heart' of the virus lies in its enzymes, which are crucial for initiating and sustaining infection.
Srivastava aims to examine the link between aldose reductase and lung inflammation in asthma. His research group has previously demonstrated the enzyme's role in other inflammatory diseases.
Researchers at St. Jude Children's Research Hospital found that the loss of NEU1 triggers a catastrophic fall in biochemical dominos leading to disrupted hematopoietic stem cell formation and enlarged spleens. The study sheds new light on the cause of sialidosis and its link to bone marrow transplantation failure.
A new approach to biofuel production uses plants to make enzymes, reducing costs and increasing efficiency. The technology, developed by Texas A&M University researchers, can produce multiple products from a single crop, making it a more economically viable option.
Researchers have identified a new target for TB treatment, solving a long-standing puzzle about bacterial cell wall production. The discovery reveals molecules that could be developed into drugs to treat tuberculosis, particularly for multi-drug resistant strains.
The DOE JGI has announced 44 DNA sequencing projects to explore the genetic potential of various organisms, including pine trees, duckweed, and microalgae. These projects will generate over 60 billion nucleotides of data, roughly equivalent to 20 human genomes.
Chemists at Ohio State University have successfully created synthetic molecules that can change shape to suit a particular chemical reaction, similar to natural enzymes. This breakthrough could lead to the development of new catalysts for the pharmaceutical and chemical industries.
The DOT1B enzyme helps epigenetically regulate VSG genes, allowing parasites to switch between coat variants. In its absence, silent genes become active, slowing down the switching process.
Researchers found that autophagy promotes premature activation of trypsinogen, a digestive enzyme that can damage pancreatic cells. In rodents with pancreatitis, high levels of autophagy were observed, and blocking the process reduced symptoms. The study reveals autophagy as a potential trigger for pancreatitis in mice.
Researchers at UC Davis have isolated and expressed a pheromone-degrading enzyme in the Japanese beetle, which could lead to more effective pest control methods. By degrading pheromones, males may be unable to detect females and reproduce.
EhROM1 enzyme plays a crucial role in E. histolytica's immune evasion and surface protein shedding. The discovery paves the way for developing rhomboid inhibitors as a novel anti-parasitic strategy.
Researchers found a new enzyme, EhROM1, that helps the dysentery-causing amoeba evade the immune system. The enzyme is part of an ancient group of enzymes used by malaria parasites to enter host cells.
Researchers found that genetic flaws affecting enzyme efficiency can be restored with supplements, offering a personalized approach to health. The study, supported by DARPA, aims to identify variants of enzymes that can be enhanced with vitamin supplementation.
Researchers have found a way to prevent malaria parasites from becoming sexually mature, a crucial step in transmission. This breakthrough could lead to the development of new drugs targeting this stage of the life cycle, helping to control the spread of drug resistance.
Bacteria with large metabolic networks and those living in diverse environments tend to be more modular. This makes sense as they adapt to changing environments by developing separate processes for different environments.
A chromatin modifying enzyme helps compensate for the fact that males have only one copy of the sex chromosome X by binding differently to male and female sex chromosomes. This process, called dosage compensation, ensures that males produce the same amount of proteins as females despite their single X chromosome.
Researchers have elucidated the structure and function of an enzyme decorating antibiotics with sugar molecules, which can help overcome antibiotic resistance. By understanding how these sugars are made, they aim to develop unnatural sugars with different properties.
A team of researchers from Iowa State University and the University of Hawai'i have developed a fungus that can remove organic material and solids from thin stillage, allowing for greater water recycling and reducing energy costs. This process could save ethanol producers up to $800 million a year in energy costs.
Researchers discovered a special digestive enzyme in silkworms that allows them to digest sucrose despite the presence of toxic alkaloids in mulberry leaves. The enzyme, beta-fructofuranosidase, is concentrated in the worm's gut and silk gland.
Researchers have made significant progress in diagnosing and preventing celiac disease, a condition where gluten triggers an autoimmune response. A new therapy, AT-1001, has shown promising results in improving intestinal permeability and reducing symptoms.