Research on enzymes and the reactions they drive. Covers enzyme evolution, plastic-degrading enzymes, brain immune cells, and molecular imaging.
Researchers at Rice University have developed a synthetic enzyme that can selectively bind with proteins and attach tags for identification. The method has shown promise in identifying signaling proteins involved in health and disease, including those related to cancer.
Researchers have uncovered a new pathway of microRNA generation, revealing why Argonaute2 proteins are necessary in mammals. This alternative route bypasses the Dicer enzyme, allowing Ago2 to directly mature and regulate genes.
Researchers have identified the enzyme that produces phytate, a naturally-occurring phosphate deposit found in seeds, beans, and tubers of many crops. This breakthrough has significant implications for reducing phytate-related pollution and improving animal feed efficiency.
Scientists have created an enzyme called CocE that can rapidly break down cocaine and its toxic metabolites. This breakthrough could lead to a new therapy for treating cocaine overdose, which causes over half a million emergency room visits annually.
Researchers have identified a potential drug target in the parasite life cycle, which could block its ability to infect humans. Cryptosporidium oocysts are stable outside a host and resistant to conventional water treatment methods.
Researchers determined the structure of an intermediate enzyme form participating in fundamental biology reactions. The discovery sheds light on life's origins and potential applications in producing renewable fuels and fighting pollution.
Researchers at Johns Hopkins found that resveratrol increases levels of an enzyme shielding nerve cells in the brain from damage, protecting against ischemic stroke. The study suggests that moderate wine consumption may have a lower incidence of cardiovascular disease.
Researchers have discovered that an enzyme found in white blood cells can break down carbon nanotubes into harmless components. This breakthrough finding has significant implications for the future use of carbon nanotubes in medicine, potentially rendering them harmless and reducing toxicity.
A study by University of Washington researchers suggests that dangerous plaques in blood vessels can rupture due to an overproduction of protein-digesting enzymes. This process is associated with plaque hemorrhage, artery-blocking clots, and a higher risk of heart attacks and strokes.
Researchers at the University of Gothenburg have discovered two closely related enzymes, FT and GGT, as promising targets for treating lung cancer. By blocking these enzymes in transgenic mice, they found that cell growth was inhibited, tumour formation decreased, and survival rates improved.
Scientists have discovered a more economical way to convert wood and other non-food biomass into ethanol fuel, reducing enzyme costs by up to 90%.
A Johns Hopkins team identified a class of chemical compounds that selectively slow down a tuberculosis protein's activity and block TB growth. The MetAP inhibitors have the potential to enhance existing therapy by targeting an essential enzyme in the bacteria's survival.
Research by LSU Health Sciences Center scientists has found that drug metabolism is influenced by the interaction between enzymes, which can affect a drug's elimination from the body or conversion into toxic byproducts. The study suggests that testing individual enzymes alone may not be sufficient to predict drug effectiveness and safety.
Researchers have identified a key enzyme, myeloperoxidase, as a significant predictor of mortality in Coronary Artery Disease (CAD) patients. High levels of the enzyme increase the risk of death by more than double over a 13-year period.
A team of researchers at the University of Colorado Boulder has discovered a previously unknown cellular switch that can be used to trigger programmed cell death. This process, known as apoptosis, is essential for preventing human diseases like cancer and autoimmune disorders. The study found that caspase, a well-known enzyme involved ...
Researchers discovered gribble's digestive system contains enzymes that break down wood polymers, offering clues for industrial conversion. This could lead to the production of biofuels produced with gribble enzymes, reducing dependence on fossil fuels.
Researchers confirm NEIL3 as a functional DNA glycosylase in both vitro and in vivo studies. The protein effectively removes damaged bases from DNA, particularly the FapyGua lesion, which may cause dangerous mutations.
Researchers at the Gladstone Institutes discovered that SIRT3 plays a crucial role in regulating fatty acid oxidation and identified it as a potential therapeutic target. Mice lacking SIRT3 exhibited impaired fat burning and increased levels of fat and triglycerides, highlighting the enzyme's importance in energy metabolism.
A University of Alberta researcher has identified a way to lower the amount of fat in the blood and improve glucose metabolism. The study found that decreasing the activity of an enzyme called triacylglycerol hydrolase (TGH) can also protect against diabetes and increase physical activity.
Research reveals that mice without an enzyme breaking down triglycerides exhibit improved metabolism with no negative effects, suggesting TGH as a promising therapeutic target. The liver compensates by synthesizing less fat and triglycerides are directed for oxidation.
Researchers at Michigan State University used a new cooling method to study the reaction of iron and oxygen atoms in enzyme TauD, discovering never seen before steps that overturn conventional thought. This breakthrough has implications for understanding how enzymes function and designing inhibitors to prevent diseases.
A team of scientists from the University of Colorado has created a tiny RNA molecule that can catalyze protein synthesis, a crucial reaction for the building blocks of life. This breakthrough supports the 'RNA World' hypothesis, proposing that life on Earth evolved from early forms of RNA.
Researchers have created a method to convert non-food biomass into sugar, which is then fermented into ethanol. This approach produces significantly lower greenhouse gas emissions than traditional corn-based ethanol, offering a promising alternative for cleaner fuel production.
Chemists at Max Planck Institute develop enzyme that converts diverse molecules enantioselectively, producing desired biological activity. By modifying amino acids distant from the reaction site, they create an optimized catalyst with improved efficiency and selectivity.
A study has identified three genes associated with stuttering in volunteers from Pakistan, the US, and England. Mutations in these genes have been linked to other metabolic disorders, suggesting a possible inherited component to stuttering.
Researchers at LA BioMed found that patients with mild gallstone pancreatitis can safely undergo surgery within 48 hours of admission, reducing hospital stay lengths by a day. This new approach aims to shorten hospital stays and improve outcomes for these patients.
Researchers at the Agricultural Research Service's malting barley laboratory are studying the enzymes produced by barley grains as they germinate. They have found that the balance of these enzymes can impact the malt's flavor and other qualities, leading to improved malting barleys for the future.
A multinational team of researchers has identified a plan to develop new treatments for malaria by targeting the parasites' digestive enzymes. By blocking these enzymes, the parasites can no longer survive within human red blood cells, offering new hope for millions affected by global spread of drug-resistant parasites.
A study reveals that the absence of SIRT6 triggers a switch from cellular respiration to glycolysis, leading to increased glucose uptake and reduced mitochondrial energy production. This switch may contribute to tumor growth and provide new insights into treating type 2 diabetes.
A research team at Uppsala University discovered that point mutation can introduce new functions into an enzyme without major structural alterations. This finding may explain the emergence of resistance to toxins in various organisms, including insects, viruses, bacteria, and tumors.
Researchers have discovered a compound that can obstruct the enzyme protecting a deadly parasite causing sleeping sickness, Chagas disease, and leishmaniasis. The findings provide new hope for developing effective treatments against these incurable diseases.
Research suggests UbcH10 overexpression promotes aneuploidy and chromosome missegregation in tumors. High levels of UbcH10 in mice resulted in tumor formation across multiple tissues.
A team of researchers from Indiana University and Stanford University has determined how a 'chemical chaperone' activates the ALDH2 enzyme, which plays a crucial role in metabolizing toxins after a heart attack. The discovery could lead to new treatments by restoring enzyme function, reducing muscle damage caused by heart attacks.
Researchers discovered a molecule called Alda-1 that activates the defective enzyme, restoring its ability to metabolize acetaldehyde. The findings suggest a possible treatment for individuals with the enzyme defect, which affects approximately 40% of East Asian populations.
Researchers at Emory University School of Medicine have determined the structures of two enzymes that customize histones, revealing insights into how DNA's packaging is crucial for gene regulation. The discovery may help doctors better understand or prevent inherited mental retardation.
Researchers from Brown University have discovered that inhibiting Sirt1 activity in the brain's hypothalamic region can help control food intake and lead to a smaller weight gain. The study suggests a potential mechanism for new obesity treatments.
Biologists have discovered plant enzymes that enable plants to respond more efficiently to elevated carbon dioxide levels. This discovery could lead to the development of drought-resistant crops with improved water efficiency. The research found that specific proteins called carbonic anhydrases play a crucial role in this process.
A Brandeis study directly visualizes protein structures crucial for enzyme catalysis at high-energy states, suggesting new molecular sites for potential drug targets. The research reveals the importance of protein dynamics in enzyme function, offering insights into protein function and potential avenues for targeted drug design.
A five-year study shows enzyme replacement therapy reduces left ventricular mass index by around 10% and improves midwall fractional shortening in patients with baseline cardiac hypertrophy. The treatment also significantly improves average pain and quality of life scores.
Researchers developed microscopic polymer beads that can deliver an antioxidant enzyme into the heart, reducing dying cells and improving heart function after a simulated heart attack. The enzyme, superoxide dismutase (SOD), soaks up toxic free radicals produced during a heart attack.
Scientists discover GM1-ganglioside builds up in brain cells of patients with GM1-gangliosidosis, disrupting calcium balance and leading to programmed cell death. The study suggests a two-step process and identifies key proteins involved in the disease.
Researchers have successfully transplanted genetically modified hematopoietic stem cells into mice, allowing their developing red blood cells to produce a critical lysosomal enzyme and preventing or reducing organ and central nervous system damage from Hurler's syndrome. This approach has the potential to improve treatment options for ...
A new system for delivering a scar-degrading enzyme has been developed, allowing for sustained delivery and improved degradation of dense scar tissue. This enables recovery from serious central nervous system injuries by facilitating nerve growth and regeneration.
A new method for harvesting purified protein molecules has been discovered, utilizing an enzymatic 'on-switch' to separate desired proteins from impurities. The technique, developed by a multi-institutional research team, shows promise for obtaining high-purity proteins with greater than 95% efficiency.
The Fraunhofer-Gesellschaft is launching a collaborative research program to identify new enzymes and metabolites in domestic insects for medical, pest control, and industrial applications. The program aims to develop new antibiotics and sustainable solutions for food production and quality control.
Researchers at Brookhaven National Laboratory identified an enzyme responsible for suberin production, which can help control water and nutrient transportation in plants. This discovery may lead to easier agricultural production of crops used for biofuels, enabling them to thrive in specific or harsh environments.
Scientists have discovered the atomic structure of an enzyme responsible for DNA replication in human mitochondria, which can cause harmful drug side effects. By targeting a different region of the enzyme, researchers aim to design more selective and less toxic anti-HIV drugs.
Researchers at the University of York have identified an enzyme called XplA that can break down royal demolition explosive (RDX) in the soil. The discovery provides significant insights into biological function and could lead to more efficient cleanup methods for RDX pollution.
A study found that genetic variation of the CYP2D6 enzyme is associated with clinical outcomes for women treated with tamoxifen. Women with reduced or absent CYP2D6 function had higher breast cancer event rates and poorer survival rates compared to those with extensive metabolism.
Researchers found a strong correlation between a genetic mutation of anti-oxidant enzymes and age-related hearing loss, with patients exhibiting the mutation being three times more likely to develop ARHL. The study also revealed no association between the NAT2 gene and ARHL.
Researchers discovered how bacteria convert methylmercury into a less-toxic form, a trait that lets them survive in mercury-rich environments. Understanding this mechanism may be a viable way to combat methylmercury pollution.
A Scripps Research team has identified histone deacetylase 3 as the key enzyme target for a potential Friedreich's ataxia drug. The findings could lead to treatments for related conditions like Huntington's disease and improve understanding of the disease.
Researchers at UNC are working on developing new methods to measure cellular signaling and tackle chronic pain. Dr. Joseph DeSimone is using a Pioneer Award to create new delivery methods for biological therapeutics, while Dr. Mark Zylka aims to treat pain with enzyme-based treatments. These projects have the potential to profoundly im...
Researchers at the University of Iowa discovered a way to deliver therapeutic molecules directly into brain cells using the blood-brain barrier. They found that unique alterations in the blood vessels surrounding brain cells can target specific diseases, allowing for non-invasive treatment of lysosomal storage diseases.
Kyoto University Professor Sakayu Shimizu received the 2009 Enzyme Engineering Award for his pioneering contributions to biotechnological tools and novel microbial reactions. His research has led to the commercialization of many biotechnological processes on a large scale.
A new mass spectrometry-based tool has been developed by University of Cincinnati experts, providing more precise and cost-effective data collection for drug discovery efforts. The novel application eliminates false-positive results and reduces reagent costs, saving substantial time and money.
Researchers found that a specific glutathione S-transferase in the insect gut converts plant hormone cis-OPDA into iso-OPDA, which is then used by caterpillars to survive on host plants. This adaptation allows generalist caterpillars to thrive on diverse plant species.
A study finds substantial improvement in a mouse model of a rare neurodegenerative disease after transplantation of normal human neural stem cells. The transplanted cells provided a critical enzyme missing in the brains of experimental mice, showing promise for a potential therapeutic approach.
Researchers mapped genetic mutations in Trichoderma reesei to boost cellulase production, increasing biofuel efficiency and reducing environmental impact. The study provides a blueprint for future studies on the fungus's genetic makeup.
Researchers at Sanford Burnham Prebys have identified a key enzyme in bacteria that can be targeted to kill dangerous pathogens. Chemical compounds have been discovered to inhibit this enzyme, showing promise for developing new antibacterial agents.