Articles tagged with Extracellular Proteins
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
Researchers developed an RNA-based therapeutic strategy targeting mutant KRAS genes, stimulating the immune system to attack tumours. The treatment, combining antisense oligonucleotides and immunomodulatory RNA, effectively killed cancer cells in laboratory studies, reducing tumour burden and extending survival.
Researchers from Pusan National University have developed engineered bacterial vesicles that use a novel surface-displaying protein to selectively target and eliminate E. coli and S. aureus bacteria. These vesicles, derived from lactic acid bacteria, offer a promising alternative to conventional antibiotics.
A study reveals that Galectin-1 protein, located in fibroblast nuclei, promotes tumor growth and resistance to treatment. The protein regulates gene expression at a specific level, activating KRAS, a key driver of uncontrolled growth and tumor aggressiveness.
Researchers at Rutgers University have discovered a way to identify and track material carried by extracellular vesicles, which play a key role in the development of renal diseases like polycystic kidney disease. This breakthrough could lead to new therapies for patients with PKD, a common genetic disorder.
A team of Chinese researchers identified a novel intercellular signaling mechanism between adipocytes and hepatocytes in endoplasmic reticulum stress response. The study reveals that ceramide, a fat molecule, plays a key role in activating the unfolded protein response pathway in hepatocytes.
Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
UMass Amherst researchers have identified the 'quality control' regulator for protein folding, a crucial process that ensures essential cellular functions. The discovery of this regulator, Sep15, could lead to new treatments targeting misfolded proteins associated with diseases like Alzheimer's and cystic fibrosis.
A study by Florida Atlantic University researchers has identified novel players in dopamine signaling using Caenorhabditis elegans. They found that mutations in the BBSome protein complex, which regulates transport and signaling in cells, can lead to rare genetic disorders like Bardet-Biedl Syndrome.
A recent study uses machine learning to analyze 950 microbial genomes, identifying 2,194 potential toxins that could be used as new antimicrobials or biotechnological tools. The researchers also discovered four new toxins with enzymatic activities against different molecules.
A new DNA-powered signal amplification technology called ACE significantly enhances the sensitivity of mass cytometry, enabling the detection of multiple proteins in single cells. This breakthrough allows researchers to investigate complex biological processes and study immune cell functions with unprecedented depth.
Researchers at Northwestern University developed a method to load therapeutic cargo into extracellular vesicles, effectively delivering engineered proteins to specific diseased cells. This approach could enable more effective and affordable biological medicines for diseases like immunotherapy and regenerative medicine.
Researchers from Jilin University provide a comprehensive overview of brain injury biomarkers, including neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, and neurofilament proteins. These biomarkers can help identify brain injuries and predict disease progression.
Researchers explore Extracellular signal-regulated kinase 5 (Erk5) and its unique structures regulating autophosphorylation and transcription. Erk5 is involved in angiogenesis, neurogenesis, energy metabolism, tumor growth, and metastasis, making it a potential target for cancer treatment.
Researchers reveal key findings on the ADAM17/iRhom2 complex, shedding light on its role in controlling signaling molecules. The study's structures show that iRhom2 acts as a gatekeeper to ADAM17 lifecycle, interacting with key regions of the protease.
Scientists discovered that tiny brain bubbles called small extracellular vesicles carry more complete instructions for altering cellular function than previously thought. Researchers found nearly 80% of identified mRNAs were full-length, allowing them to be transcribed by recipient cells into viable proteins.
Researchers have developed a cost-effective method to create waterproof and grease-resistant paper coatings using extracellular polymeric substances (EPS) from anaerobic granular sludge. The study found that EPS derived from waste sludge can improve paper coating properties, including water/grease-proofing behaviour.
Purdue researchers have successfully isolated and detected drug-metabolizing enzymes from extracellular vesicles, which could enable personalized medicine by monitoring individual responses to prescription drugs. The method may also aid in detecting signs of Parkinson's disease and analyzing liver metabolism.
Researchers found that dysregulation of RNA transfer between cells in different tissues shortens lifespan in roundworms. They demonstrated that this phenomenon, termed Intercellular/Extracellular Systemic RNA imbalance (InExS), can be caused by an increase in RNA uptake from the environment, leading to a reduction in organism's lifespan.
Plant scientists have discovered a sophisticated RNA defense system that plants use to attack gray mold cells, sending mRNA molecules that disrupt fungal cellular processes. This innovative approach could lead to the development of eco-friendly fungicides with minimal environmental impact and no harm to humans or animals.
A new study reveals a link between the removal of the FGFR1 protein's extracellular domain and a significant decrease in tumour volume. This finding offers a potential new avenue of treatment for patients with squamous cell carcinoma of the lungs, who have shown limited success with current therapies.
Researchers have discovered a novel enzyme family related to bacterial pathogenicity in Gram-negative bacteria. The study revealed that enzymes involved in OPG synthesis and regulation play crucial roles in bacterial infection capability.
Researchers discovered a new role for extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that leads to cancer cell death. Hyperactivation of ERK causes stress in cells, triggering cell death through specific proteins DR5 and NOXA.
A recent study published in Neuron reveals that Noelin proteins play a crucial role in learning and memory formation in the mammalian brain. The study found that these proteins act as 'universal anchors' controlling the distribution and dynamics of AMPA receptors, which are essential for synaptic plasticity.
Gray mold is a fungus that causes billions of dollars in crop losses each year, but researchers have discovered a way to control it without using toxic chemicals. The discovery reveals that gray mold uses lipid 'bubbles' to deliver RNA molecules that silence plant immune systems.
Researchers aim to treat pancreatic ductal adenocarcinoma by targeting amino acid transporter SLC6A14 and compensatory nutrient scavenging mechanisms autophagy and macropinocytosis. Using alpha-methyl-L-tryptophan and hydroxychlorquine, the study seeks to improve therapeutic outcomes in patients with pancreatic cancer.
Researchers at Nagoya University have discovered three new biomarkers for high-grade serous ovarian carcinoma using membrane proteins and polyketone-coated nanowires. The study reveals that small extracellular vesicles containing these proteins can be used to detect ovarian cancer, potentially leading to personalized medicine.
Researchers discovered that extracellular cytochrome nanowires are widespread in prokaryotic microbes, including both bacteria and archaea. The findings suggest that these nanowires, composed of a long chain of cytochrome proteins, play a crucial role in microbial metabolism by facilitating efficient electron transfer.
A team of researchers has created a new map of candidate extracellular RNA binding proteins and their associated RNAs in various bodily fluids. This resource was developed using computational analyses and validated experimentally, providing a foundation for understanding exRNA biology and its potential use in liquid biopsies.
Research by Whitehead et al. reveals that cellular senescence triggers amyloidosis through changes in small extracellular vesicles and extracellular matrix composition. The study provides novel insights into the formation of aortic medial amyloid and offers potential therapeutic targets for mitigating its effects.
Scientists have elucidated the regulatory functions of Pan1p, a key player in late-stage clathrin-mediated endocytosis. The protein drives actin assembly and disassembly, facilitating vesicle internalization.
Research reveals extracellular vesicles facilitate coordinated responses among pathogenic fungal cells, enabling them to overcome host defenses. The discovery could lead to the development of more effective therapies to combat fungal infections.
A novel screening platform has successfully detected over 95% of stage 1 pancreatic cancers using artificial intelligence-enabled protein marker analysis, outperforming current liquid biopsy tests in accuracy. This technology holds promise for early cancer detection and reducing mortality from this deadly disease.
Researchers at Vanderbilt University Medical Center have identified a new antibacterial mechanism where immune cells cooperate to capture and 'eat' bacteria. This cooperation enhances the killing power of macrophages, increasing phagocytosis of bacterial pathogens, including antibiotic-resistant staph
Researchers analyzed extracellular vesicles in human prostate cancer cells to understand how cancer spreads. The findings suggest a new approach to diagnose malignancies without invasive biopsies.
Researchers have discovered a new quality control system that allows cells to clear misfolded proteins from their surroundings. The Clusterin protein and heparan sulfate proteoglycans work together to bring misfolded proteins into cells for degradation, potentially leading to new therapeutic targets for neurodegenerative disorders like...
Scientists at Chiba University discovered that human cells have a system to capture and degrade aberrant extracellular proteins. The research found that Clusterin, an extracellular molecular chaperone, selectively binds to amyloid β and forms a complex that is taken up by cells via the heparan sulfate receptor.
Researchers developed a peptide-infused dressing that promotes dermal cell adhesion and proliferation, accelerating wound closure and tissue regeneration in diabetic mice. The dressing showed significant benefits compared to control treatments.
A team of researchers discovered that a single extracellular protein, ECMP-67, drives the formation of calcite in soft corals. This finding allows for understanding how these organisms thrive in environments where other species cannot survive.
Research found that extracellular proteins require less energy to produce than their cellular counterparts, even though they are lost to the environment. Microbes like E. coli and Pseudomonas syringae have optimized their protein synthesis to reduce energy costs, with over 100 proteins being more economical in nature.
Researchers at the University of Michigan found that bacteria spend more on internal proteins than external ones, conserving resources and improving their competitiveness. This thrifty behavior is linked to protein location and cost, with cheaper amino acids used in internal proteins.
A recent study published in the Journal of Clinical Investigation reveals a critical role for RAGE protein in glomerular fibrosis, a major driver of chronic kidney disease. The research sheds light on potential therapeutic targets to mitigate this devastating condition.
Listeria monocytogenes has discovered a mechanism for managing infection by living comfortably inside cells until ready to break out and spread the infection. The bacteria use a pore-forming toxin, listeriolysin O, that is modified with a PEST sequence tag, allowing it to evade the host's immune system.
Researchers identified a molecule that triggers the formation of deadly protein snarls in Alzheimer's disease. High levels of a shortened, malfunctioning version of the protein p35 in brains lead to hyperphosphorylation of tau protein, causing neurofibrillary tangles.
Researchers identify nephrin's role in the kidney's filtration barrier, finding a 'zipper-like' structure that allows blood to pass but not plasma proteins. Increasing nephrin production or restoring its function is thought to improve kidney function and restore proteinuria.
Researchers have determined the first structure of a functional protein unit involved in neurofibromatosis, which regulates Ras and contributes to tumor growth. The study confirms mechanistic ideas about neurofibromin's function and links NF1 to cancerogenesis.
Transforming growth factor beta (TGFb) uses a simple signaling pathway to convey distinct functions in different tissues, despite its multifaceted role. Researchers have identified the key steps involved in translating TGFb signals into individual patterns of gene expression.