A new, high-yielding variety of camelina has been engineered with a gene that increases oil production by 21.4%. The modified seeds have lower levels of flavonoid compounds and mucilage, but higher levels of genes involved in oil synthesis.
SourceDOE/Brookhaven National Laboratory·JournalPlant Biotechnology Journal·DateJun 11, 2024
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Researchers have discovered the detailed mechanism of sugar signaling in plants, which involves a protein called KIN10 that acts as a 'sensor kinase' controlling biochemical pathways. The study reveals how sugar levels affect plant growth and oil production, providing insights into potential engineering of proteins to increase oil prod...
SourceDOE/Brookhaven National Laboratory·JournalScience Advances·DateMay 17, 2024
A new research project, PHOTOZYME, aims to develop photobiocatalytic tools to convert basic chemicals into chiral molecules. The project combines biocatalysis, photochemistry, and directed evolution to create sustainable molecular synthesis.
A new microscopy technique has been developed to investigate neutral lipids within lipid droplets of living cells. This method allows researchers to monitor the synthesis of neutral lipids directly and observe their behavior over a long period.
SourceInstitute for Basic Science·JournalChemical Science·DateJan 23, 2024
A team from the University of Tsukuba has discovered that the enzyme ELOVL6 plays a significant role in the development of acute myeloid leukemia, a type of blood cancer. The study found that high levels of ELOVL6 are linked to shorter survival rates for leukemia patients.
SourceUniversity of Tsukuba·JournalLeukemia·DateMay 24, 2023
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A study by researchers from the University of Tsukuba found that ELOVL6 deficiency increases ceramide levels, leading to enhanced airway inflammation and reduced treatment efficacy in patients with severe asthma. Modulating lipid composition may provide a novel approach for treating resistant asthma.
SourceUniversity of Tsukuba·JournalJournal of Allergy and Clinical Immunology·DateJan 22, 2023
Engineered duckweed produces up to 10% oil content, a 100-fold increase over wild-type plants, with synergistic effects seen when combining gene modifications. The oil-rich plant can be easily harvested for biofuels or bioproducts, reducing competition with food crops and environmental waste.
SourceDOE/Brookhaven National Laboratory·JournalPlant Biotechnology Journal·TypeExperimental study·DateOct 11, 2022
Researchers have identified compounds that interfere with fungal enzymes required for fatty acid synthesis, potentially overcoming resistance to current treatments. These compounds show promise as antifungal agents, effective even against drug-resistant strains of fungi.
SourceAmerican Chemical Society·JournalACS Infectious Diseases·DateNov 17, 2021
Researchers at UCLA's Jonsson Comprehensive Cancer Center found that inhibiting fatty acid synthesis in brain cancer cells can lead to massive cell death, especially in tumors with amplified EGFR signaling. This discovery suggests a new treatment approach for glioblastomas and potentially other cancers.
SourceUniversity of California - Los Angeles·JournalScience Signaling·DateDec 14, 2009
Researchers found that liver cells express CB1 receptors, which activate a signaling pathway increasing fatty acid synthesis. This activation is similar to brain and may be a target for metabolic regulation and appetite control.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 2, 2005
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