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Mapping of the gene network that regulates glycan clock of ageing

A new study has identified three genes, MANBA, TNFRSF13B, and EEF1A1, as crucial in the regulation of IgG galactosylation, a trait associated with ageing. The research used GWAS to analyze IgG glycosylation phenotypes in a large sample size, increasing the understanding of this complex posttranslational modification.

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Sugar rush: scientists discover key role of glucose in brain activity

Researchers at Gladstone Institutes have made a groundbreaking discovery about how neurons consume and metabolize glucose, a process crucial for maintaining normal energy levels. The study found that neurons rely on glycolysis to break down glucose, and its disruption can lead to severe learning and memory problems in mice.

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A sugar hit to help destroy cancer cells

Researchers at USC Viterbi's Mork Family Department of Chemical Engineering and Materials Science have discovered a fatal vulnerability in many cancer cells: their inability to adapt to alternative sugars like galactose. The discovery could lead to new metabolic treatments for cancer, targeting cells with specific genetic mutations.

Seaweed as biofuel? Metabolic engineering makes it a viable option

A University of Illinois research team has developed a strain of yeast that can efficiently ferment galactose, a key component of seaweed, making it a viable option for biofuel production. The discovery improves the economic viability of marine biofuels by increasing fermentation rates and reducing production costs.

Flies offer insight into human metabolic disease

Scientists have developed flies with genetic changes similar to those found in patients with galactosemia, allowing researchers to study the disease and develop potential treatments. These models can help understand how sugar metabolism leads to disease and open the door to novel drug discovery.

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A new type of genetic variation could strengthen natural selection

Scientists have discovered a new type of genetic variation that suggests natural selection can act on gene networks, maintaining alternative states within a single species. This finding may be crucial for understanding how pathogens adapt to new stresses and could provide significant advantages in the battle against diseases.

Sweet as can be: How E. coli gets ahead

Researchers discovered that E. coli has a protein that recognizes the rarer furanose form of galactose, allowing it to exploit this additional nutrient source. This adaptation enables E. coli to grow faster and persist in the gut at the expense of other species.

New yeast trick for eating favorite food: Details in Nature paper

UC San Diego bioengineers identified a previously unknown mechanism allowing yeast to shut down galactose metabolism when glucose is present. This discovery provides new insights into gene regulation and could lead to understanding of human metabolic diseases like diabetes.

Researchers quantify more noise in gene expression

A team of researchers at UCSD has quantified more noise in gene expression, discovering significant fluctuations within individual cells and variations between identical cells. This study provides a mathematical description of 'extrinsic noise,' a larger component of variation in gene expression.

See Spot work

Researchers at Cold Spring Harbor Laboratory have discovered that Spot 42, a small RNA, differentially regulates gene expression in the E. coli galactose operon through an antisense mechanism. The study provides mechanistic insight into the process and answers long-standing biological questions.

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