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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Determining sex in ants

A noncoding gene has been identified as the deciding factor in determining sex in Argentine ants, with a specific genomic region being crucial to this process. The gene does not encode a protein but rather produces an RNA that influences sex determination.

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When mothers shut down the fathers’ genes in the embryo

Researchers found that Marchantia liverworts completely inactivate paternal genes in embryos, ensuring proper development. The mechanism involves Polycomb Repressive Complex 2 and maintains haploid dosage despite the short diploid phase.

Breeding plants with genes from one parent

Researchers at the University of California, Davis, have discovered a mechanism to eliminate half the genome in plants, making it easier to breed crops with desirable traits like disease resistance. This breakthrough could shorten breeding times by several generations.

Defining the centromere

Researchers from the Leibniz Institute of Plant Genetics and Crop Plant Research have discovered a chaperone protein that affects CenH3 loading to centromeres, crucial for kinetochore assembly. This finding has potential applications in plant breeding, particularly in haploid induction, which can speed up breeding processes.

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The genetics behind being Not Like Daddy

A study by Laurine Gilles and colleagues sheds light on the genetics behind haploid induction in maize, revealing the molecular identity of a key gene that promotes fertilization. The identification of 'Not Like Dad' is an important breakthrough to fully understand the process and translate this breeding tool to other crops.

Scientists generate a new type of human stem cell that has half a genome

Researchers at Columbia University Irving Medical Center have successfully generated a new type of human embryonic stem cell carrying a single copy of the human genome. These 'haploid' stem cells show potential as a powerful tool for genetic analysis in biomedical fields such as cancer research and precision medicine.

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Yeast's lifestyle couples mating with meiosis

Researchers found that Candida lusitaniae fuses its mating and meiosis programs, expressing genes associated with both processes during each. This 'coupling' offers the yeast an efficient way to split diploid products of mating, maintaining its haploid lifestyle. The discovery challenges understanding of fungal reproduction and evolution.

Study provides insights into plant evolution

Researchers identified a gene that regulates plant life cycle transition, providing insights into complex diploid body evolution. This discovery could lead to the development of apomixis, a technique for producing high-yielding hybrid crops more easily and cheaply.

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Chance discovery leads to plant breeding breakthrough

Plant biologists at UC Davis have discovered a reliable method for producing plants that carry genetic material from only one parent, which could dramatically speed up the breeding of crop plants. The technique uses genome elimination to eliminate half the chromosomes, resulting in haploid plants that are immediately homozygous.