Articles tagged with Lipid Rafts
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Researchers at Osaka University identified Src as a key molecule in the process of epithelial cells becoming invasive and cancerous. The study found that CDCP1 forms a molecular scaffold that activates Src, promoting cancer cell invasion.
New research identifies persistent Gαs associated signaling changes in lipid rafts following drug withdrawal as the cause of antidepressant withdrawal syndrome. This finding has significant implications for developing personalized treatment for depression.
Researchers at University of California San Diego School found that controlling cholesterol in microglia can alleviate chronic pain, a common side effect of chemotherapy. They developed a novel therapeutic approach using a modified version of apoA-I binding protein to reverse the harmful effects of excessive cholesterol.
New research investigates how viruses trick cells into forming lipid rafts, allowing them to enter and infect the human body. The study suggests that understanding this process could lead to innovative approaches to fight viral infections.
Researchers at University of Illinois Chicago found increased amounts of unmodified tubulin in depressed individuals' cells compared to non-depressed individuals. Tubulin's modification plays a crucial role in harnessing Gsa signaling molecules, which are involved in neurotransmitters like serotonin.
A modified form of tubulin traps signaling molecules, reducing brain messaging in people with depression. Tubulin levels may provide a diagnostic marker and target for antidepressant treatment.
A study from George Washington University found that apolipoprotein A-I binding protein (AIBP) inhibits HIV-1 replication by targeting lipid rafts and reducing virus-cell fusion. This innate immunity factor provides a novel target for developing new therapeutic approaches to inhibit HIV infection.
Researchers develop new model to simulate lipid raft formation on a nanometric scale, confirming high dynamicity and existence of 10 nanoseconds. Cholesterol discovered to destabilize membranes and enable nanotubes to leave cells in milliseconds.
Researchers create new model to study lipid rafts in living cells, revealing the role of cholesterol in their formation and behavior. This breakthrough sheds light on diseases like Parkinson and Alzheimer, where lipid rafts are thought to play a key role.
Researchers found ketamine's rapid antidepressant effect is linked to the fast release of G proteins from membrane patches. This allows for better communication among brain cells, alleviating depressive symptoms. The long-lasting effects may be due to slow G protein re-entry into lipid rafts.
Researchers at Scripps Research Institute discovered that lipid rafts on cell surfaces act as compartments to keep enzymes from mixing with their binding partners. Disrupting these rafts through touch triggers a signal that communicates the touch to responsive proteins in the cell.
Researchers identified a mechanism of action for selective serotonin reuptake inhibitors that explains their delayed effectiveness in treating depression. The study found that SSRIs accumulate in lipid rafts and reduce levels of signal molecules, contributing to the delay in symptom reduction.
Research reveals that lipid rafts are essential for the renewal of brain neurons in Alzheimer's disease by modulating the aberrant autophagic-lysosomal pathway. The study highlights a possible mechanism underlying the clearance of Alzheimer's disease products, implicating the autophagic-lysosomal pathway.
A GW researcher has found a connection between the pathogenesis of prion disease and HIV, discovering that impairment of cellular cholesterol metabolism is key to their development. The study suggests that stimulation of ABCA1, a cellular cholesterol transporter, could inhibit conversion of prions into a pathogenic form.
Researchers at University of Illinois Chicago discovered a new biomarker for depression by analyzing the location of a protein in the brain. The study found that depressed individuals have a greater proportion of Gs alpha protein confined to lipid rafts, which can be used to predict the efficacy of antidepressant therapy.
Researchers developed a new mouse model that mimics the effects of low-dose aspirin therapy, exploring its impact on blood clotting and reproductive functions. The study suggests that low-dose aspirin treatment may prevent preeclampsia without compromising reproductive function.