Articles tagged with Metabolism
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study by UNICAMP researchers found that women with a history of yo-yo dieting have increased body fat, worse metabolic indicators, and reduced brown fat activity. The 'yo-yo effect' impairs metabolism and reduces BAT activity in women.
A new scientific review summarizes 12 human clinical trials on the cardiometabolic effects of wild blueberries, finding improvements in blood vessel function and beneficial changes to the gut microbiome. Regular consumption of one cup per day may support overall health benefits.
A new study from the University of Victoria found that higher insulin levels at age 47 predicted younger onsets of hot flashes and night sweats. Insulin may be a stronger predictor of hot flashes when taking other metabolic variables into account, while body mass index (BMI) appeared more closely associated with estrogen level changes.
Researchers identify acetylation as a fine cellular regulatory mechanism that affects pyruvate kinase function and stability. The study reveals isoform-specific regulation of PKM by acetylation, which helps understand how cancer cells proliferate.
Researchers have identified three new skin-protective compounds called oryzaceramides A, B, and C from rice bran by-products. These acylated glucosylceramides play a crucial role in maintaining epidermal integrity and demonstrate significant skin barrier-enhancing effects.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers at Northwestern University discovered a hidden molecular control switch inside the protein TRPM5, which regulates taste, blood sugar control and gut health. The switch can be activated or inhibited by small molecules, unlocking new opportunities for therapeutic development.
Researchers at Northwestern University and Stanford University develop a new artificial metabolism that converts waste carbon dioxide into acetyl-CoA, a universal metabolite used by all living cells. The system, called Reductive Formate Pathway (ReForm), uses engineered enzymes to perform metabolic reactions never seen in nature.
Researchers will investigate how HIV and cancer drugs damage brain cells over time, identifying potential early biomarkers of neurotoxicity. They will use human brain organoids grown in the lab to mimic brain physiology.
Researchers discovered metabolites in fossilized bones of animals that lived 1.3 to 3 million years ago, providing insights into their health, diets, and environments. The findings revealed warmer and wetter conditions compared to today.
Researchers identified a specific type of gut bacteria, Turicibacter, that promotes metabolic health and reduces weight gain in mice. The bacterium produces fatty molecules that are absorbed by the small intestine, improving ceramide levels and preventing excessive weight gain.
Researchers found that higher levels of theobromine are associated with slower biological aging in humans, as measured by epigenetic markers such as DNA methylation and telomere length. The study suggests that theobromine may support healthy aging by influencing molecular epigenetic processes.
Researchers at University of California San Diego School of Medicine discovered that immune cells can slow fat breakdown when exposed to physiological stressors, helping early humans preserve energy stores. This finding provides new insight into the underlying metabolism of obesity and other metabolic disorders.
A new study describes a three-hit metabolic signaling model that reframes autism as a treatable disorder of cellular communication and energy metabolism. The model suggests that up to half of all autism cases might be prevented or reduced with prenatal and early-life interventions.
A study by Van Andel Institute scientists found that reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively. The researchers discovered that a low-fat, high-protein diet given once a day promotes the formation of ketones, which act as a cellular fuel for T cells to become more effective tumor fighters.
Researchers mapped NBCn1's structure-function properties to understand how breast cancer cells thrive in hostile environments. The study provides insights into the protein's dynamics and ion transport pathways, paving the way for designing drugs that target this transporter.
Two Russian scientists' conceptual similarities challenge conventional aging views. Their ideas about hyperfunction and elevation remain relevant to modern research. Golubev explores the historical connections between Dilman and Blagosklonny, highlighting their contributions to aging science.
A new study suggests that sweat can reveal information about a person's health, including hormone levels, medication doses, and early detection of diseases like diabetes and cancer. Wearable sensors using artificial intelligence can detect specific metabolites in sweat, providing personalized health insights.
A controlled feeding study out of South Dakota State University shows that older adults who reduced ultra-processed foods naturally consumed fewer calories, lost weight and abdominal fat, and showed improvements in insulin sensitivity and inflammation. This study provides evidence that the Dietary Guidelines for Americans can deliver s...
Researchers found that senescent blood vessel cells play a key role in developing metabolic disorders like diabetes. Transplanting these cells into lean mice caused inflammation and metabolic dysfunction.
A new study led by Prof. Maayan Salton and Dr. Tal Schiller found that gestational diabetes alters the placenta's genetic messages, causing hundreds of errors in protein synthesis. The key protein SRSF10 appears to contribute to this process, suggesting a potential therapeutic target for mitigating its effects.
A human clinical trial found that consuming black cumin seed powder daily for 8 weeks significantly reduced blood triglycerides, LDL and total cholesterol levels. The study also showed an increase in HDL cholesterol levels, associated with a lower risk of heart problems.
Researchers tracked eight short-finned pilot whales in Hawaiian waters, finding they dive approximately 39 times a day to consume an average of 4 squid per dive. The team estimated the total annual consumption to be around 88,000 tonnes of squid, which is sufficient for the local population.
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
Researchers have identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant. The global constraint principle unifies two classic biological laws and provides a fresh perspective for looking at growth across all forms of life.
A new study uses fruit flies to explore the relationship between sleep and diet, finding that energy deprivation leads to increased feeding and sleeping behavior. The researchers propose that correcting sleep habits may help alleviate eating and metabolic disorders.
Research links low body weight in young Japanese women to reduced gut microbial diversity, with an increased presence of inflammatory species. The study suggests that improving eating habits could lead to improvements in gut microbiota and body weight.
A research team discovered that leucine prevents the degradation of specific mitochondrial proteins, enabling efficient energy production. This mechanism allows cells to adapt to increased energy demands during periods of nutrient abundance.
A multidisciplinary research team discovered that liver alterations associated with metabolic dysfunction can cause cognitive and neurological impairments. The effects were reversed by a therapy targeting the liver, establishing a 'liver-brain axis'. This finding opens up new therapeutic avenues for treating metabolic liver disease.
Scientists have discovered how a tungsten-containing enzyme in a microbe converts toxic waste gases into ethanol, offering a promising solution for sustainable fuel production. The breakthrough reveals the mechanism behind this process, enabling the production of valuable chemicals and fuels.
A recent study reveals that loss of liver growth hormone (GH) signaling contributes to the development of lean metabolic-associated fatty liver disease. The researchers developed a mouse model with hepatic GH receptor knockout and found that CD36-mediated lipid uptake and C/EBPβ-driven lipogenesis form a central regulatory hub driving ...
Researchers found that TRF1 protein loss led to leaner mice with altered metabolic profiles, including lower LDL cholesterol levels and improved blood sugar regulation. These benefits occurred without any detectable shortening of telomeres.
A study from the Champalimaud Foundation found that when fruit flies are deprived of essential amino acids, their brains upregulate two olfactory receptor genes involved in smell, leading to a refined sense of smell that guides them to protein-rich yeast and gut bacteria. This interplay between smell and taste regulates feeding behavior.
Researchers at St. Jude Children's Research Hospital found that metabolism guides the activation states of regulatory T cells, which dampen inflammation. The study reveals a link between mitochondrial function and lysosome activity in controlling these immune cells.
Researchers have discovered that HSL plays an unexpected role in the nucleus of fat cells, helping maintain healthy adipose tissue. This new understanding challenges 60 years of certainty about fat metabolism and offers avenues for better understanding metabolic diseases such as obesity.
A new study from UC San Francisco found that saturated fat affects the behavior of a protein called PER2, which orchestrates fat metabolism and circadian rhythms. Mice eating a diet high in hydrogenated fats struggled to adapt to winter, whereas those on unsaturated fat diets adjusted easily.
Recent discoveries on the molecular regulation of cholesterol metabolism have far-reaching implications for human diseases. Four interconnected modules of cholesterol metabolism are outlined, including hepatic de novo synthesis, intestinal absorption, and reverse transport via HDL.
Researchers at Redoxoma found that mitochondrial potassium channels regulate heat production in brown adipose tissue, a process critical for regulating energy expenditure and promoting metabolic health. Closing the channel is necessary for maximum thermogenesis.
Scientists worldwide are calling for accelerated development and standardization of energy metabolism measurement technologies to address global challenges. The conference highlighted the importance of understanding how organisms utilize energy, crucial for tackling climate change and public health crises.
Researchers found that voluntary running exercise mitigates cafeteria diet-induced behavioral changes via hormonal and microbial pathways. The study revealed specific metabolites, such as anserine and indole-3-carboxylate, were decreased by the cafeteria diet but partially restored by exercise.
A study published in Science Advances found that the ketogenic diet can have potentially dangerous impacts on metabolic health, including impaired blood sugar regulation and fatty liver disease. Mice fed the diet developed severe metabolic complications, with some changes starting within days.
A new study published in PNAS found that physical activity increases total daily energy expenditure without reducing it elsewhere. The research showed a clear link between being more active and spending less time sitting still.
A recent study found that fish oil supplements can lower cardiovascular disease risk even in healthy individuals, with effects varying greatly between people. The study showed that EPA supplementation improved blood lipid profiles and reduced lipoprotein attachment to arterial walls.
Research finds that Akkermansia muciniphila alleviates hepatic fibrosis through propionate-driven antioxidant defense, improving liver function and reducing extracellular matrix accumulation. The study suggests a potential microbiota-based therapeutic strategy to combat liver fibrosis.
The four-day training program equipped postdoctoral fellows with state-of-the-art methods for clinical research in obesity, metabolism and nutrition. Participants deepened their skills in gold-standard methodologies crucial for advancing clinical and translational research.
Researchers found that a combination of nicotinamide, a-lipoic acid, thiamine, pyridoxamine and piperine reduced AGEs, sticky plaque-like molecules, to curb hunger, lower insulin resistance and extend lifespan in mice. The compounds also reversed some molecular hallmarks of hypothalamic aging.
Isha Jain wins NIH Transformative Research Award to develop new targeted treatments using modern science and techniques, potentially leading to personalized vitamin-based therapies for genetic disorders. Her lab has made key discoveries on oxygen levels and tissue damage, aiming to fine-tune these processes for disease treatment.
Researchers found that specific bacteria, such as Haemophilus parainfluenzae and Fusobacterium species, are associated with AIG-related neuroendocrine tumors. The study suggests that changes in host metabolism occur before alterations in the gastric microbiota, potentially creating a microenvironment that favors tumor growth.
A new dual-imaging system simultaneously maps retinal structure and capillary oxygen levels in live mice, allowing researchers to study vision-threatening diseases like glaucoma and diabetic retinopathy. This non-invasive approach offers a powerful tool for elucidating local capillary values and tracking changes in retinal oxygenation.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers develop a novel biochar-based catalyst that transforms harmful pesticide residues into ammonium nitrogen, a nutrient essential for plant growth. The approach eliminates pesticide residues from soil while boosting lettuce growth, offering a potential tool for sustainable agriculture.
A new study analyzing the dietary choices of wild woodrats reveals that individual diets may not be as diverse as previously assumed. The research suggests that the costs of specializing on one food source or diversifying one's diet have a strong impact on an animal's ability to survive and thrive.
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Scientists discovered that metabolism plays a signalling role during embryonic development, controlling the tempo of growth. By modulating metabolism, they identified a key metabolite FBP regulating the segmentation clock, which impacts spatial patterns of body segments.
A Chinese Medical Journal study reviews the association between lipid metabolism and Parkinson’s disease. The research highlights how lipid disruptions contribute to α-Syn aggregation, mitochondrial dysfunction, and neuroinflammation, suggesting lipids as a promising therapeutic target for PD.
Researchers at WashU Medicine discovered a novel way brown fat burns calories and improves metabolic health by exploiting cellular parts called peroxisomes. Mice with increased peroxisome activity showed improved insulin sensitivity and weight control on high-fat diets.
A new clinical trial found that feeding blueberries to infants as their first solid food can reduce allergy symptoms and support long-term health. The study suggests early introduction of blueberries may improve infants' immune systems and gut health.
Researchers discovered a new reductive uric acid pathway that functions without oxygen, which builds upon current knowledge of uric acid degradation. The study found that this pathway produces a metabolite called yanthine, which is elevated in patients with gout and could serve as a biomarker for diagnosing or monitoring the condition.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.