Nuclear Localization Signaling | Topics

Decoding the language of cells: Unveiling the proteins behind cellular organelle communication

Emerging from a need to understand organelle interactions, researchers have developed OrthoID, a novel strategy that refines protein identification at organelle contact sites. This method uses mutually orthogonal binding pairs to label and isolate proteins involved in cellular communication.

SourcePohang University of Science & Technology (POSTECH)·JournalNature Communications·DateApr 12, 2024

Nanocontainers introduced into the nucleus of living cells

Researchers at the University of Basel have developed biocompatible polymer vesicles that can enter the cell nucleus, allowing for targeted drug delivery. The nanocontainers can be designed to transport therapeutic agents directly to the cell's control center.

SourceUniversity of Basel·JournalProceedings of the National Academy of Sciences·DateJan 27, 2020

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

The Opioid Growth Factor (OGF) and its receptor (OGFr) play a crucial role in regulating cell proliferation by modulating cyclin-dependent kinase inhibitors. The study found that transport of OGFr into the nucleus required two out of three nuclear localization signals, highlighting the importance of this pathway in cancer treatment.

SourceSociety for Experimental Biology and Medicine·JournalExperimental Biology and Medicine·DateApr 23, 2009