Pattern Recognition Receptors

AI-informed approach to CAR design enhances bi-specific CAR T cells

St. Jude researchers developed a computational method to design tandem CARs that target two cancer-related proteins, overcoming previous challenges and function better in treating animal models of cancer. The approach demonstrated improved surface expression and anti-tumor function, clearing tumors in four out of five mice.

SourceSt. Jude Children's Research Hospital·JournalMolecular Therapy·TypeExperimental study·DateAug 13, 2025

Plant receptors that control immunity and development share a common origin

Researchers have discovered that plant immune receptors and growth-related proteins share a common evolutionary ancestry, allowing for the creation of hybrid receptors with enhanced functionality. This breakthrough could lead to the development of disease-resistant crops by isolating and engineering immune receptors from various plants.

SourceRIKEN·JournalNature Communications·TypeExperimental study·DateFeb 1, 2024

A gene from 28 million years ago protects today’s plants against caterpillars

Scientists have identified a single 28-million-year-old receptor gene that allows plants to recognize and respond to caterpillar peptides, a common threat. This ancient gene has evolved over time, with some plant species losing it, and its reintroduction through breeding or genetic engineering could protect crops against failure.

SourceeLife·JournaleLife·DateNov 15, 2022

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The gut microbiota protects against viral infections by keeping the immune system alert

The study found that gut microbiota releases membrane vesicles containing bacterial DNA, which triggers the cytosolic cGAS-STING-IFN-I axis to protect distal organs against viral infections. Antibiotic treatment impairs this ability, making mice more susceptible to viral infections.

SourceStockholm University·JournalImmunity·DateMay 10, 2022