Articles tagged with Peptides
Researchers have developed a multi-component hydrogel scaffold to mimic the amyloid-beta containing microenvironment associated with AD. The study found elevated levels of neuroinflammation and apoptosis markers in healthy neuronal progenitor cells cultured within this environment.
Researchers found GLP-1 receptor agonists lower risks of certain obesity-associated cancers in patients with type 2 diabetes, suggesting potential benefits for cancer prevention in high-risk populations. The study provides preliminary evidence supporting further preclinical and clinical studies to prevent specific obesity-linked cancers.
A study published in JAMA Ophthalmology found an association between semaglutide and nonarteritic anterior ischemic optic neuropathy, a condition that can cause vision loss. The observational study suggests caution when prescribing semaglutide to patients at risk of this condition.
Researchers at Karolinska Institutet developed nanorobots that target and kill cancer cells using a 'kill switch' activated in low pH environments. The study achieved a 70% reduction in tumour growth in mice, paving the way for further investigation into its potential as a cancer treatment.
A novel peptide, KS-133, has been developed to target genetic mechanisms associated with schizophrenia. The nanoparticle-based drug delivery system, where KS-133 is encapsulated with a brain-targeting peptide, shows effective distribution in the brains of mice and improves cognitive functions in mice with induced schizophrenia.
Researchers at U of T have developed a deep-learning model called PepFlow that can predict the full range of conformations for peptides, which are shorter than proteins but perform similar biological functions. The model combines machine learning and physics to capture precise and accurate conformations within minutes.
Researchers have developed a route to modify peptides to target disease diagnostics and drug discovery, focusing on protein-protein interactions (PPIs). By modifying a small peptide sequence, the team showed it binds more quickly and strongly to specific PPI targets.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
Researchers at the University of British Columbia have developed oral insulin drops that can be easily absorbed by the body, potentially replacing insulin injections. The drops contain a unique cell-penetrating peptide that helps insulin navigate through cells and reach the bloodstream quickly.
The study explores the convergence of peptide self-assembly and 3D printing, enabling the creation of complex biological structures and organs. The technology has vast applications in regenerative medicine, personalized healthcare, and drug delivery.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
Researchers identify REF1 as a key local wound signal governing plant regenerative responses. Its application has improved transformation efficiency in crops like soybeans and wheat.
The study found a substantial increase in glucagon-like peptide-1 receptor agonist (GLP-1RA) dispensing among adolescents and young adults between 2020 and 2023. This trend is particularly notable for females, emphasizing the need for targeted education on sex-specific safety risks, such as concerns during pregnancy.
Researchers at Bielefeld University discovered that certain gluten-derived molecules, including the 33-mer deamidated gliadin peptide (DGP), form nanosized structures that accumulate in gut epithelial cells and lead to leaky gut syndrome. This triggers chronic inflammation and autoimmune responses in celiac disease patients.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
A team of researchers from Osaka University used machine learning to identify a highly effective boron-based catalyst for chemical transformations of amino acids and peptides. The new catalyst generates only water as a coproduct and promotes high-yield reactions with minimal environmental impact. By leveraging computational methods, th...
A region in alpha-synuclein protein aggregates has been identified as a potential therapeutic target to prevent conversion into toxic amyloid fibrils, which accumulate in the brains of people suffering from Parkinson's disease. The discovery opens the door to developing new therapeutic strategies for inactivating these toxic forms.
Researchers at Rice University have developed a novel fabrication process to create aligned peptide nanofiber hydrogels, which can guide cell growth in a desired direction. The study revealed that cells need to be able to 'pull' on the peptide nanofibers to recognize alignment, and excessive rigidity can prevent this.
Researchers at NJIT are developing a hydrogel therapy that prevents viruses like SARS-CoV-2 from attaching to and entering cells. The peptides in the gel form a 'molecular mask' that muffles the virus's action, providing a potential first line of defense against biological threats.
A recent study found that preoperative GLP-1 receptor agonist use is not associated with an increased risk of postoperative respiratory complications. The results suggest liberalizing withholding guidelines for these medications may be beneficial.
Researchers at University of Texas M. D. Anderson Cancer Center have developed a new method for developing immunotherapy drugs using engineered peptides. The approach improved tumor control and prolonged survival in preclinical models of breast cancer.
Researchers have developed an AI pipeline to identify molecular interactions crucial for developing new treatments and understanding diseases. The AF-CBA Pipeline offers unparalleled accuracy and speed in pinpointing the strongest peptide binders to specific proteins.
Researchers developed a multifunctional drug delivery system that can carry both hydrophilic and hydrophobic compounds, overcoming previous limitations in conventional methods. The system utilizes switchable peptide-stabilized emulsions, allowing for precise release of drugs in tumor cells.
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
A team of scientists discovered new fusion sites in protein evolution that enable faster and more targeted drug development. By combining evolutionary processes with synthetic biology, they created customized biological drugs with improved therapeutic properties.
Researchers have developed a method to identify extremophiles using protein fragments, leading to the discovery of two new 'extremophile' microbes from high-altitude lakes in Chile. This breakthrough could potentially help scientists search for extraterrestrial life and explore Earth's biodiversity.
A new platform has been developed to identify and optimize peptides targeting the SARS-CoV-2 envelope protein, a potential drug target for treating COVID-19. The study uses synthetic peptides to inhibit the virus's entry into host cells.
Researchers at Leibniz-HKI deciphered the function of Candidalysin's unusual protein structure, which reduces pathogenicity and opens up new treatment options. Nanobodies neutralize the toxin, blocking its activity and inhibiting tissue damage.
Researchers from Tohoku University developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of peptides with a glycine amino acid, achieving site-selective modification and stable carbon-carbon bonds. The method shows potential for labeling diverse peptides and larger proteins for purification,...
Researchers from Nano Life Science Institute discovered how genetically designed peptides form single-molecule thick crystals on graphite surfaces. The behavior is directly related to their molecular architecture, with negatively charged and positively charged peptides forming unique oblique lattices.
Scientists successfully synthesized pantetheine, a chemical essential for all living things, in lab conditions mimicking early Earth. The compound is crucial for metabolism and may have played a role in the emergence of life on Earth.
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. This discovery could be useful in treatment to reverse Alzheimer’s Disease impact by degrading amyloid plaques.
Researchers have developed a novel biohybrid catalyst that uses an anchor peptide to oxidize polystyrene microparticles, making them degradable. The catalyst accelerates the formation of polar OH groups through reaction with Oxone, allowing for efficient breakdown and degradation of polystyrene.
Researchers found that widely used machine learning tools produce biased results for immunotherapy research, as they rely heavily on datasets from higher-income communities. This can lead to ineffective treatments for lower-income populations. The study highlights the need for accurate and unbiased data in machine learning models.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Researchers have developed a new urine-based test for early detection of ovarian cancer using nanopore sensing technology. The method can simultaneously identify multiple peptides, including those derived from LRG-1, and shows promise for improving 5-year survival rates by up to 75%.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
Researchers at Cleveland Clinic have developed a peptide therapeutic that blocks aggressive cancer cells from multiplying rapidly. The treatment disrupts the molecular processes behind cancer growth and induces tumor cell death, making it a promising new strategy for treating triple-negative breast cancer.
Three different HIV antibodies independently protected monkeys from acquiring SHIV, providing statistically significant protection and dose-dependent effect. The findings support the HIV fusion peptide as a promising preventive vaccine target.
Researchers from Brazil have discovered two novel peptides with biotechnological potential in the venom of the pit viper Cotiara and the South American bushmaster. The peptides, including Bc-7a and Lm-10a, show promise as potential treatments for high blood pressure.
Researchers at CiQUS developed a novel cyclic peptide that forms nanotubes on demand when light-irradiated. This allows for precise control over the artificial cytoskeleton's structure and function.
Researchers have developed a new method to generate cyclic peptides that can target diseases and be administered orally, overcoming challenges in protein binding. The approach enables high-throughput screening and has shown substantial bioavailability in rats, opening possibilities for treating various diseases.
Zarbio and Georgia State University scientists propose a framework for understanding Alzheimer's disease, linking molecular mechanisms, beta-amyloid biomarkers, and diagnosis. The Amyloid Degradation Toxicity Hypothesis resolves long-standing paradoxes in AD research.
Researchers at NTNU have developed a new method to study how bacterial signaling proteins react to treatment, paving the way for effective killing of MRSA. The method has shown a combination of two substances kills MRSA more effectively than when used separately.
Scientists have introduced a new class of protease-activity sensors using gold nanoparticles equipped with peptide DNA, which can detect multiple active proteases in parallel. The method works at room temperature and does not require complicated sample preparation or elaborate instruments.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Scientists at IPC PAS create peptide-based sensors to detect inflammation and chronic diseases, offering a promising alternative to traditional methods. The study uses phage-display method to identify CRP-binding peptides, achieving higher affinity and detection efficiency than antibodies.
Researchers developed GraphNovo, a program that provides accurate understanding of peptide sequences in cells, improving immunotherapy for unique cases. The AI model enhances de novo peptide sequencing accuracy, filling gaps with precise mass data.
Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
Researchers at UTSA have discovered a novel strategy to inhibit the spread and infection of Vibrio cholerae, the bacteria responsible for cholera. They identified a peptide-binding domain that can disrupt the virulence of V. cholerae, preventing intestinal colonization and biofilm formation.
The brain natriuretic peptide (BNP) is a peptide that plays a crucial role in activating atopic dermatitis, or eczema. In a mouse model of AD, mice without BNP exhibited reduced thickened skin and itching compared to control mice with BNP.
Researchers at IISc have developed a novel method to improve pharmacokinetic properties of macrocyclic peptides, which are used in pharmaceutical industries worldwide. By substituting oxygen with sulphur in the backbone of these peptides, they increase resistance to digestive enzymes and lipophilicity, thereby boosting bioavailability.
Researchers have created artificial hybrid molecules combining DNA and peptides, paving the way for the development of viral vaccines and artificial life forms. These building blocks can be used to create nanomachines that drill through cell membranes or target cancerous tumors, holding promise for combating difficult-to-cure diseases.
Researchers at Chalmers University of Technology have shown that graphene oxide nanoflakes can reduce the accumulation of misfolded amyloid peptides in yeast cells, which are similar to human neurons affected by Alzheimer's disease. This suggests that graphene oxide may hold great potential for treating neurodegenerative diseases.
A team of researchers at ETH Zurich has developed a suction cup capable of delivering large molecule medications like peptides to the bloodstream through the mucosal lining of the cheek. The device uses an endogenous agent to fluidise cell membranes, allowing the drug to penetrate deeper tissue layers and enter the bloodstream directly.
Researchers have discovered a peptide that stabilizes the normal structure of alpha-synuclein protein, preventing misfolding and toxic clumps. This breakthrough could lead to new therapeutic developments for neurodegenerative diseases like Parkinson's.
UAB researchers have designed minimal nanozymes with the capacity to capture carbon dioxide, applicable for environmental remediation and biotechnology research. These new molecules are formed by peptides of only seven amino acids and can act as metalloenzymes, opening up possibilities in extreme temperatures and pH values.
Researchers at the University of Alabama at Birmingham found that BNP levels are high in end-stage heart failure patients with cardiogenic shock, but no longer a reliable predictor of clinical outcomes after ventricular assist device (VAD) implantation. This study suggests reevaluating routine use of BNP testing for these patients.
A new study by University of Missouri biochemist Steven Van Doren reveals the fusion peptide's crucial role in virus attachment and cell penetration. This research could inform the development of more effective vaccines capable of fighting all types of coronavirus infections.
The study reveals two OsRALF peptides essential for pollen tube germination and elongation, crucial for double fertilization. Exogenous application of these peptides enhances pollen tube elongation, while inhibiting germination at higher concentrations.