Articles tagged with Peptides
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Researchers have developed an AI pipeline to identify molecular interactions crucial for developing new treatments and understanding diseases. The AF-CBA Pipeline offers unparalleled accuracy and speed in pinpointing the strongest peptide binders to specific proteins.
Researchers developed a multifunctional drug delivery system that can carry both hydrophilic and hydrophobic compounds, overcoming previous limitations in conventional methods. The system utilizes switchable peptide-stabilized emulsions, allowing for precise release of drugs in tumor cells.
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
A team of scientists discovered new fusion sites in protein evolution that enable faster and more targeted drug development. By combining evolutionary processes with synthetic biology, they created customized biological drugs with improved therapeutic properties.
Researchers have developed a method to identify extremophiles using protein fragments, leading to the discovery of two new 'extremophile' microbes from high-altitude lakes in Chile. This breakthrough could potentially help scientists search for extraterrestrial life and explore Earth's biodiversity.
Researchers at Leibniz-HKI deciphered the function of Candidalysin's unusual protein structure, which reduces pathogenicity and opens up new treatment options. Nanobodies neutralize the toxin, blocking its activity and inhibiting tissue damage.
A new platform has been developed to identify and optimize peptides targeting the SARS-CoV-2 envelope protein, a potential drug target for treating COVID-19. The study uses synthetic peptides to inhibit the virus's entry into host cells.
Researchers from Tohoku University developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of peptides with a glycine amino acid, achieving site-selective modification and stable carbon-carbon bonds. The method shows potential for labeling diverse peptides and larger proteins for purification,...
Researchers from Nano Life Science Institute discovered how genetically designed peptides form single-molecule thick crystals on graphite surfaces. The behavior is directly related to their molecular architecture, with negatively charged and positively charged peptides forming unique oblique lattices.
Scientists successfully synthesized pantetheine, a chemical essential for all living things, in lab conditions mimicking early Earth. The compound is crucial for metabolism and may have played a role in the emergence of life on Earth.
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. This discovery could be useful in treatment to reverse Alzheimer’s Disease impact by degrading amyloid plaques.
Researchers have developed a novel biohybrid catalyst that uses an anchor peptide to oxidize polystyrene microparticles, making them degradable. The catalyst accelerates the formation of polar OH groups through reaction with Oxone, allowing for efficient breakdown and degradation of polystyrene.
Researchers found that widely used machine learning tools produce biased results for immunotherapy research, as they rely heavily on datasets from higher-income communities. This can lead to ineffective treatments for lower-income populations. The study highlights the need for accurate and unbiased data in machine learning models.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Researchers have developed a new urine-based test for early detection of ovarian cancer using nanopore sensing technology. The method can simultaneously identify multiple peptides, including those derived from LRG-1, and shows promise for improving 5-year survival rates by up to 75%.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
Three different HIV antibodies independently protected monkeys from acquiring SHIV, providing statistically significant protection and dose-dependent effect. The findings support the HIV fusion peptide as a promising preventive vaccine target.
Researchers at Cleveland Clinic have developed a peptide therapeutic that blocks aggressive cancer cells from multiplying rapidly. The treatment disrupts the molecular processes behind cancer growth and induces tumor cell death, making it a promising new strategy for treating triple-negative breast cancer.
Researchers from Brazil have discovered two novel peptides with biotechnological potential in the venom of the pit viper Cotiara and the South American bushmaster. The peptides, including Bc-7a and Lm-10a, show promise as potential treatments for high blood pressure.
Researchers at CiQUS developed a novel cyclic peptide that forms nanotubes on demand when light-irradiated. This allows for precise control over the artificial cytoskeleton's structure and function.
Researchers have developed a new method to generate cyclic peptides that can target diseases and be administered orally, overcoming challenges in protein binding. The approach enables high-throughput screening and has shown substantial bioavailability in rats, opening possibilities for treating various diseases.
Zarbio and Georgia State University scientists propose a framework for understanding Alzheimer's disease, linking molecular mechanisms, beta-amyloid biomarkers, and diagnosis. The Amyloid Degradation Toxicity Hypothesis resolves long-standing paradoxes in AD research.
Researchers at NTNU have developed a new method to study how bacterial signaling proteins react to treatment, paving the way for effective killing of MRSA. The method has shown a combination of two substances kills MRSA more effectively than when used separately.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Scientists have introduced a new class of protease-activity sensors using gold nanoparticles equipped with peptide DNA, which can detect multiple active proteases in parallel. The method works at room temperature and does not require complicated sample preparation or elaborate instruments.
Scientists at IPC PAS create peptide-based sensors to detect inflammation and chronic diseases, offering a promising alternative to traditional methods. The study uses phage-display method to identify CRP-binding peptides, achieving higher affinity and detection efficiency than antibodies.
Researchers developed GraphNovo, a program that provides accurate understanding of peptide sequences in cells, improving immunotherapy for unique cases. The AI model enhances de novo peptide sequencing accuracy, filling gaps with precise mass data.
Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
Researchers at UTSA have discovered a novel strategy to inhibit the spread and infection of Vibrio cholerae, the bacteria responsible for cholera. They identified a peptide-binding domain that can disrupt the virulence of V. cholerae, preventing intestinal colonization and biofilm formation.
The brain natriuretic peptide (BNP) is a peptide that plays a crucial role in activating atopic dermatitis, or eczema. In a mouse model of AD, mice without BNP exhibited reduced thickened skin and itching compared to control mice with BNP.
Researchers at IISc have developed a novel method to improve pharmacokinetic properties of macrocyclic peptides, which are used in pharmaceutical industries worldwide. By substituting oxygen with sulphur in the backbone of these peptides, they increase resistance to digestive enzymes and lipophilicity, thereby boosting bioavailability.
Researchers have created artificial hybrid molecules combining DNA and peptides, paving the way for the development of viral vaccines and artificial life forms. These building blocks can be used to create nanomachines that drill through cell membranes or target cancerous tumors, holding promise for combating difficult-to-cure diseases.
Researchers at Chalmers University of Technology have shown that graphene oxide nanoflakes can reduce the accumulation of misfolded amyloid peptides in yeast cells, which are similar to human neurons affected by Alzheimer's disease. This suggests that graphene oxide may hold great potential for treating neurodegenerative diseases.
A team of researchers at ETH Zurich has developed a suction cup capable of delivering large molecule medications like peptides to the bloodstream through the mucosal lining of the cheek. The device uses an endogenous agent to fluidise cell membranes, allowing the drug to penetrate deeper tissue layers and enter the bloodstream directly.
Researchers have discovered a peptide that stabilizes the normal structure of alpha-synuclein protein, preventing misfolding and toxic clumps. This breakthrough could lead to new therapeutic developments for neurodegenerative diseases like Parkinson's.
UAB researchers have designed minimal nanozymes with the capacity to capture carbon dioxide, applicable for environmental remediation and biotechnology research. These new molecules are formed by peptides of only seven amino acids and can act as metalloenzymes, opening up possibilities in extreme temperatures and pH values.
Researchers at the University of Alabama at Birmingham found that BNP levels are high in end-stage heart failure patients with cardiogenic shock, but no longer a reliable predictor of clinical outcomes after ventricular assist device (VAD) implantation. This study suggests reevaluating routine use of BNP testing for these patients.
A new study by University of Missouri biochemist Steven Van Doren reveals the fusion peptide's crucial role in virus attachment and cell penetration. This research could inform the development of more effective vaccines capable of fighting all types of coronavirus infections.
The study reveals two OsRALF peptides essential for pollen tube germination and elongation, crucial for double fertilization. Exogenous application of these peptides enhances pollen tube elongation, while inhibiting germination at higher concentrations.
The Estee Lauder Companies' New Incubation Ventures has launched a breakthrough prize for innovative active ingredient companies, R&D labs and scientists pushing the boundaries of Indian consumers. The prize program aims to discover and support the next generation of Indian beauty brands.
Scientists develop a method to construct crystalline artificial steric zippers in peptide β-sheets, paving the way for novel therapeutic strategies and materials. The research utilizes metal ions to prevent aggregation and form needle-shaped crystals with specific structural characteristics.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
The study, published in Advanced Functional Materials, reveals a novel light-activated material that can be used to effectively reshape and thicken damaged corneal tissue, promoting healing and recovery for patients with keratoconus. The technology has tremendous potential to impact millions of people suffering from corneal diseases.
Researchers developed a bioinformatic tool that selects parts of proteins to elicit strong immune responses. This approach, grounded in immunological theory, was four times more efficient than current methods, suggesting better vaccine protection against diseases.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
Researchers at the University of Tennessee have developed a vegan way to prevent freezer burn and ice damage by breaking down soy proteins into peptides that slow ice crystal growth. The study, published in ACS Journal of Agricultural and Food Chemistry, shows promise for preserving frozen vegan foods.
Researchers discovered a novel peptide, T14, that is detectable in human keratinocytes and inversely related to age, with higher levels found in chronically photosensitive individuals. The study suggests that monitoring T14 levels may offer insights into the link between degenerative diseases and epidermal cell profiles.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
Researchers found a peptide from venomous fish Thalassophryne nattereri that controls lung inflammation and airway hyperreactivity. The molecule, TnP, inhibited cytokine production and prevented mucus-producing cell hyperplasia, making it a potential candidate for treating asthma.
A new study published in Journal of Leukocyte Biology found that age and sex differences contribute to increased inflammation in older female mice. The research team discovered that immune cells entering areas where they shouldn
Researchers have developed an effective treatment that accelerates recovery after stroke by modulating astrocyte reactivity and cortical connectivity. The treatment, which involves administering a molecule called C3a in nasal drops, has shown positive results in mice with stroke, offering new hope for faster and better recovery.
A new study published in the Journal of the American Heart Association found that elevated levels of two protein biomarkers associated with heart damage were linked to undetected or symptomless cardiovascular disease in adults with Type 2 diabetes. The study analyzed health information and blood samples from over 10,300 adults and foun...
Researchers used AI models to predict effective peptide sequences for safe drug delivery in eye cells, promising new treatments for glaucoma and macular degeneration. The model accurately predicted a peptide sequence that bound to melanin, releasing medications over several weeks.
Researchers developed a computational platform called IRIS to discover tumor antigens from alternative RNA splicing, expanding cancer immunotherapy targets. Hundreds of predicted TCR targets were found to be presented by human leukocyte antigen molecules.
The study revealed lower age-standardized rate of NENs incidence in China (1.14 per 100,000) compared to the USA (6.26 per 100,000). The most common sites for primary NEN tumors progressed were found to be the pancreas, stomach, lungs, and rectum.
Researchers developed a living yeast-based dual biosensor that can detect peptide variants with a visible readout, enhancing the capabilities of their original biosensor. The new sensor can distinguish between specific peptide variants using a protease-cleaving catalytic enzyme.
A team of researchers has identified a peptide that disrupts the interaction between alpha-synuclein and a protein subunit of cellular machinery, reducing its levels and promoting cell clearance. The study suggests a new therapeutic avenue for Parkinson's disease and other neurodegenerative conditions.
Scientists discovered a way to regulate the mechanical strength and recoverability of peptide hydrogels by manipulating incubation temperature and time. By controlling droplet formation, they created fibril networks with optimal properties for various applications.
Researchers at ETH Zurich have decoded details of how cyclic peptides cross cell membranes, providing a new understanding of their mechanism. This knowledge can help speed up drug discovery by identifying ideal side chains for these molecules.
Researchers at MIT have found a way to reverse neurodegeneration and symptoms of Alzheimer's disease by interfering with an overactive brain enzyme called CDK5. The peptide treatment reduced neurodegeneration, DNA damage, and improved behavior in mice with Alzheimer's.