Articles tagged with Peptides
The Estee Lauder Companies' New Incubation Ventures has launched a breakthrough prize for innovative active ingredient companies, R&D labs and scientists pushing the boundaries of Indian consumers. The prize program aims to discover and support the next generation of Indian beauty brands.
Scientists develop a method to construct crystalline artificial steric zippers in peptide β-sheets, paving the way for novel therapeutic strategies and materials. The research utilizes metal ions to prevent aggregation and form needle-shaped crystals with specific structural characteristics.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
The study, published in Advanced Functional Materials, reveals a novel light-activated material that can be used to effectively reshape and thicken damaged corneal tissue, promoting healing and recovery for patients with keratoconus. The technology has tremendous potential to impact millions of people suffering from corneal diseases.
Researchers developed a bioinformatic tool that selects parts of proteins to elicit strong immune responses. This approach, grounded in immunological theory, was four times more efficient than current methods, suggesting better vaccine protection against diseases.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
Researchers at the University of Tennessee have developed a vegan way to prevent freezer burn and ice damage by breaking down soy proteins into peptides that slow ice crystal growth. The study, published in ACS Journal of Agricultural and Food Chemistry, shows promise for preserving frozen vegan foods.
Researchers discovered a novel peptide, T14, that is detectable in human keratinocytes and inversely related to age, with higher levels found in chronically photosensitive individuals. The study suggests that monitoring T14 levels may offer insights into the link between degenerative diseases and epidermal cell profiles.
Researchers found a peptide from venomous fish Thalassophryne nattereri that controls lung inflammation and airway hyperreactivity. The molecule, TnP, inhibited cytokine production and prevented mucus-producing cell hyperplasia, making it a potential candidate for treating asthma.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
A new study published in Journal of Leukocyte Biology found that age and sex differences contribute to increased inflammation in older female mice. The research team discovered that immune cells entering areas where they shouldn
Researchers have developed an effective treatment that accelerates recovery after stroke by modulating astrocyte reactivity and cortical connectivity. The treatment, which involves administering a molecule called C3a in nasal drops, has shown positive results in mice with stroke, offering new hope for faster and better recovery.
A new study published in the Journal of the American Heart Association found that elevated levels of two protein biomarkers associated with heart damage were linked to undetected or symptomless cardiovascular disease in adults with Type 2 diabetes. The study analyzed health information and blood samples from over 10,300 adults and foun...
Researchers used AI models to predict effective peptide sequences for safe drug delivery in eye cells, promising new treatments for glaucoma and macular degeneration. The model accurately predicted a peptide sequence that bound to melanin, releasing medications over several weeks.
Researchers developed a computational platform called IRIS to discover tumor antigens from alternative RNA splicing, expanding cancer immunotherapy targets. Hundreds of predicted TCR targets were found to be presented by human leukocyte antigen molecules.
The study revealed lower age-standardized rate of NENs incidence in China (1.14 per 100,000) compared to the USA (6.26 per 100,000). The most common sites for primary NEN tumors progressed were found to be the pancreas, stomach, lungs, and rectum.
Researchers developed a living yeast-based dual biosensor that can detect peptide variants with a visible readout, enhancing the capabilities of their original biosensor. The new sensor can distinguish between specific peptide variants using a protease-cleaving catalytic enzyme.
A team of researchers has identified a peptide that disrupts the interaction between alpha-synuclein and a protein subunit of cellular machinery, reducing its levels and promoting cell clearance. The study suggests a new therapeutic avenue for Parkinson's disease and other neurodegenerative conditions.
Scientists discovered a way to regulate the mechanical strength and recoverability of peptide hydrogels by manipulating incubation temperature and time. By controlling droplet formation, they created fibril networks with optimal properties for various applications.
Researchers at ETH Zurich have decoded details of how cyclic peptides cross cell membranes, providing a new understanding of their mechanism. This knowledge can help speed up drug discovery by identifying ideal side chains for these molecules.
Researchers at MIT have found a way to reverse neurodegeneration and symptoms of Alzheimer's disease by interfering with an overactive brain enzyme called CDK5. The peptide treatment reduced neurodegeneration, DNA damage, and improved behavior in mice with Alzheimer's.
A novel database, CycPeptMPDB, has been created to facilitate the development of drugs based on cyclic peptides. The database contains information on thousands of cyclic peptides and their membrane permeability values, enabling researchers to select candidate peptides that can penetrate human cell membranes.
Researchers at the University of Illinois have identified a novel class of ribosomal peptides called daptides, which exhibit hemolytic activity. This discovery opens up new avenues for therapeutic development and highlights the vast potential of undiscovered RiPP classes.
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
Researchers discovered over 500 non-canonical protein-derived peptides that could be recognized by T-cells, but found no spontaneous immune response. Three novel T-cell receptors were identified for specific non-canonical HLA-I tumor ligands with promising tumor specificity.
Researchers from Tokyo Institute of Technology discovered that amide-to-ester substitutions can significantly improve cyclic peptides' membrane permeability, making them suitable for clinical and therapeutic applications. The study used enhanced sampling molecular dynamics simulations to unravel the mechanism behind this effect.
Researchers have discovered how peptides can self-assemble on solid surfaces, enabling the design of hybrid biomolecular nanodevices. The breakthrough uses peptide engineering and molecular recognition to create a seamless interface between biology and technology.
Researchers at the University of Nebraska-Lincoln have discovered that the orientation of a single amino acid in peptides can direct activation to specific neurons, influencing communication among brain cells. This finding has far-reaching implications for understanding and regulating signaling processes in the brain.
A phase two trial found that exenatide significantly reduced brain pressure and monthly headaches in seven patients with Idiopathic Intercranial Hypertension (IIH). The study showed a rapid action of the drug, with results indicating significant reductions in brain pressure and headache days compared to the placebo arm.
Researchers at Rutgers University identified a peptide called Nickelback, which could become a biosignature to detect planets on the verge of producing life. The peptide, composed of 13 amino acids and two nickel ions, was found to be a simple yet potent catalyst for metabolic processes.
Researchers found that cholesterol increases the toxicity of a peptide implicated in Alzheimer's progression, altering its secondary structure and forming small, toxic clusters called oligomers. A diet rich in cholesterol may contribute to Alzheimer's disease development by changing the lipid composition of neuronal membranes.
Researchers at the University of Sheffield's Institute of Translational Neuroscience have discovered a novel way to block the transportation of mutant RNA and toxic repeat proteins that lead to the death of nerve cells in most common forms of motor neurone disease (MND) and frontotemporal dementia (FTD). Using a peptide, they found tha...
Researchers have created a simple and inexpensive method to disinfect drinking water using silver sulfide quantum dots encased in a peptide coat. When exposed to near-infrared light, these nanoparticles kill bacteria with high efficiency, making them a promising alternative to traditional methods.
CHOP researchers have identified variants of a chaperone molecule that can enhance the loading of peptides across different HLA types, which could be used in cell therapy and immunization applications. The study found that chicken-derived TAPBPR proteins can react with multiple HLA allotypes and stabilize the empty MHC-I groove, boosti...
Scientists create wearable sensors using biodegradable nanowires that can detect various chemical tracers, including those associated with asthma and kidney disease. The breakthrough represents a new paradigm in electrical engineering, offering a sustainable alternative to traditional silicon-based nanowires.
Researchers have discovered thousands of new miniproteins in human organs, which challenge the assumption that they are insignificant and functionless. The proteins were found to interact with older proteins, suggesting a key role in cellular functions.
Researchers discover abiotic peptide chain formation from glycine in space conditions, shedding light on the origin of life. The study shows that small clusters of glycine molecules exhibit polymerization upon energy input.
Researchers at Rice University have developed a self-assembling peptide ink that enables the 3D printing of complex structures with cells, which can then be used to grow mature tissue in a petri dish. The ink allows for control over cell behavior using structural and chemical complexity.
Researchers developed a 'scanning and direct derivatization' method to target polymyxin, an antibiotic of last resort, for treating diseases resistant to conventional drugs. The method generated hundreds of peptide derivatives with varying effects, accelerating drug development.
Researchers found that seminal fluid protein sex peptide alters the female fly's behavior by changing the expression of genes involved in metabolism and the circadian clock. Post-mating, sex peptide increases egg-laying, aggression, activity and feeding while reducing sleep and interest in mating.
A recent study found that consuming soy flour rich in B-conglycinin can reduce LDL cholesterol levels and lower the risk of metabolic diseases. The protein inhibits HMGCR, a liver enzyme involved in triglyceride and low-density lipoprotein metabolism.
Researchers developed peptide-based olfactory receptors on graphene surfaces to detect odor molecules. The new system showed highly selective and sensitive detection of various odor molecules, including limonene, menthol, and methyl salicylate.
A novel peptide, C6, has been found to suppress damaging lung inflammation in acute respiratory distress syndrome (ARDS), a condition that affects approximately 200,000 adults and 8,000 children each year. The peptide blocks voltage-gated proton channels, inhibiting inflammatory signaling pathways and reducing fluid buildup in the lungs.
Researchers at Bar-Ilan University have discovered a new molecular blocker that successfully halted breast cancer metastasis by targeting the Pyk2 and cortactin interaction. The study's findings provide significant hope for fighting breast cancer, as the blocker inhibited metastasis formation in breast cancer-bearing mice.
Researchers from ETH Zurich elucidated the structure and function of tryptophan C-mannosyltransferase (CMT), a glycosyltransferase enzyme involved in C-mannosylation. The study reveals the enzyme's novel mechanism, enabling precise understanding of protein sequences and sugar substrates.
A new approach to gene therapy for inherited blindness uses lipid nanoparticles to deliver mRNA inside the eye, targeting light-sensitive cells and creating proteins that edit vision-harming gene mutations. The technology has shown promising results in animal studies, including mice and nonhuman primates.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
Researchers at Princeton University have isolated a compound called cloacaenodin, which is a potent antibacterial peptide that can kill clinically relevant drug-resistant strains of Enterobacter. This discovery has significant implications for the treatment of bacterial infections and could lead to new antibiotic development.
A new project aims to develop a method for producing antimicrobial peptides, which have shown promise in overcoming antibiotic resistance. The peptides' ability to delay microbial resistance development makes them an attractive alternative to conventional antibiotics.
Researchers developed a new way to study the sensory system used by pathogenic bacteria to infect humans. They screened thousands of peptides against a bacterial sensor and discovered 13 new human antimicrobial peptides (AMPs) that activate the sensor. The findings suggest an arms race between humans and bacteria, with each evolving ne...
A new serological test, PepSeq, allows scientists to quickly test antibody binding against hundreds of thousands of protein targets, helping prepare for and respond to pandemics. The technology identifies specific antibodies that provide protection against infection, holding promise for developing effective vaccines and treatments.
Researchers demonstrate a new way to deliver medication to malignant brain tumors in mice, using a modified peptide that can penetrate the blood-brain barrier. The study shows promising results, with a 50% increase in survival rate for treated mice, and offers hope for future treatment breakthroughs.
Scientists have identified a single 28-million-year-old receptor gene that allows plants to recognize and respond to caterpillar peptides, a common threat. This ancient gene has evolved over time, with some plant species losing it, and its reintroduction through breeding or genetic engineering could protect crops against failure.
Researchers from the Technion and University of Tokyo have discovered cyclic peptides that bind to specific chains of ubiquitin proteins, disrupting DNA repair mechanisms and leading to cell death. This breakthrough could lead to more effective treatments against cancer cells than existing anti-cancer drugs.
Researchers have created a chemical tag that can be added to drugs, allowing them to enter blood circulation via the intestines. The tag, called EPP6, is a neutral peptide that can deliver drugs orally, potentially replacing injections for diabetes and cancer patients.
New insights into the processing of hormones in the human gut reveal dozens of peptides regulating appetite, bowel movement, and insulin secretion. By studying human intestinal organoids, researchers characterized potentially novel gut hormones, including glucagon, and explored its role in human physiology.
Researchers at UIC have developed a new method to study ribosome function by attaching peptides to tRNAs, providing high-resolution structures of the ribosome and its interactions with nascent chains. This breakthrough sheds light on protein synthesis and antibiotic resistance.
Researchers developed a small peptide that can directly kill bacteria and trigger plant defense tactics to prevent diseases like almond leaf scorch. The treatment significantly reduces pathogen population and disease symptoms, making it a promising approach for sustainable crop protection.
A novel oxytocin derivative, PAS-CPPs-oxytocin, has been shown to improve cognitive function in mice with Alzheimer's-like symptoms. The derivative is delivered via intranasal administration and shows increased brain penetration compared to traditional intracerebroventricular delivery.
A new approach combines an immunotherapy agent with a molecular delivery system that targets tumor acidity, successfully eradicating colorectal tumors in mice. The researchers believe this method may increase the effectiveness of STING agonist therapy for cancer patients.