Articles tagged with Peptides
Scientists at Kumamoto University have developed a novel peptide vaccine that improves obesity-related dyslipidemia and may be cost-effective. The vaccine targets angiopoietin-like protein 3 (ANGPTL3) and has been shown to reduce dyslipidemia in mice, producing antibodies that last for six months.
Researchers at the University of Bath have optimised a peptide that prevents alpha-synuclein misfolding, a key feature of Parkinson's disease. The new molecule, 4654W(N6A), has shown significant promise in lab experiments and could lead to the development of a disease-modifying treatment.
Researchers at the University of Oklahoma have discovered a new protein fragment that could improve cartilage regeneration and reduce the need for osteoarthritis treatments. The protein fragment, developed by Handan Acar and Amgad Haleem, aims to help the body heal itself by elicititing a response from stem cells.
Researchers at USC developed a new peptide that stimulates the host's immune response to fight bacterial infections, offering an alternative to antibiotics. The peptide, MTD12813, is highly effective in clearing infections and modulates inflammation, reducing the risk of complications.
A team of researchers has extracted and analyzed ancient proteins and DNA from nearly 4,000 bone fragments at Denisova Cave, yielding five human bones with intact biomolecules, dating back to 200,000 years ago. The findings provide robust insights into the first occupants of the cave and their archaeological signature.
A new type of PRRT, <sup> 177 </sup> Lu-DOTA-LM3, has been shown to be safe and effective in treating neuroendocrine neoplasms. The therapy achieved complete remission in some patients and was well-tolerated by most patients.
Scientists at Tokyo Institute of Technology developed a new peptide sensor to detect and quantify water-soluble synthetic polymers in wastewater. The technique uses machine learning algorithm to identify and discriminate between different polymers.
Researchers develop a technique to scan and sequence single proteins, one amino acid at a time, using nanopore DNA sequencing technology. This breakthrough opens the way for single-molecule protein sequencing and cataloguing proteins inside a single cell.
Researchers at Children's Hospital of Philadelphia have developed a novel therapy that targets proteins essential for tumor growth and survival. Using a multi-omics approach, they identified peptides unique to neuroblastoma tumors, which are then targeted by peptide-centric chimeric antigen receptors (PC-CARs).
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers have identified a gene called Nup54 that plays a crucial role in regulating female reproductive behaviors in fruit flies. This discovery provides new insights into the molecular mechanisms underlying sexual conflict and its impact on evolution.
Scientists have identified specific peptides in milk that relieve stress and enhance sleep. The study found that one of these peptides, YPVEPF, increased sleep duration by over 400% in mice.
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
A peptide-drug conjugate called CBX-12 has been shown to enhance the efficacy of immune checkpoint inhibitors in preclinical cancer models by targeting the acidic environment of cancer cells. The treatment exhibited significantly delayed tumor growth, improved survival, and complete tumor regressions compared to immunotherapy alone.
Researchers at Uppsala University have designed new antibodies that bind to both large and small aggregates of the amyloid-beta protein, potentially providing a more effective treatment for Alzheimer's disease. The new antibody format is stronger in binding to clumps and can also target smaller aggregates.
Scientists use specific self-assembling peptides to organize silica nanoparticles into larger structures, demonstrating a new approach to self-assembly. The researchers' method enables the creation of novel materials with various applications, including drug delivery systems and nanocatalysts.
A new study found that a subtilisin-like proteinase from Bacillus pumilus 3-19 exhibits proteolytic activity in Pichia pastoris, dependent on incubation time and signal peptide choice. The production of this enzyme makes the system promising for developing new feed additives for animal husbandry.
Researchers designed novel molecules that bound tightly to SARS-CoV-2's molecular scissors, inhibiting the virus's replication. The breakthrough could lead to new treatments for COVID-19.
A new biomimetic system mimics the body's own receptors for anesthetics, providing prolonged nerve blockade with minimal toxicity. The system consists of nanostructures that bind to tetrodotoxin and slowly release it, allowing for long-lasting pain relief without systemic toxicity.
Researchers found that certain peptides associated with migraine pain can regulate insulin production in mice, potentially preventing type 2 diabetes. The study suggests that these peptides could be developed into therapeutic strategies to control blood sugar levels, while minimizing the risk of migraines.
Researchers from ETU LETI and Institute of Highly Pure Biopreparations proposed a new-generation biochip for multiparametric express-testing using molecular recognition and direct fluorimetry. The device selectively detects cardiac markers without fluorescent labels, reducing background fluorescence to 30%.
Scientists have developed stable peptide mimics called peptoids to treat viruses and prevent infections. Peptoids, such as those tested against SARS-CoV-2 and HSV-1, could one day cure or prevent many kinds of infections, including COVID-19.
Researchers at Virginia Tech have developed a scalable method to harvest exosomes from unpasteurized cow's milk, enabling the production of purified exosomes for oral drug delivery. The new protocol advances pharmaceutical applications for fragile drugs and opens up a wide range of clinical applications.
Researchers assessed effectiveness of T-cell immune response to 11 SARS-CoV-2 variants, identifying HLA gene variants with significantly changed virus peptides. The T-cell COVID-19 Atlas portal (T-CoV) provides a comprehensive resource for understanding the impact of viral mutations on immunity.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
Researchers have developed a neural network model called BiteNetPp to detect protein-peptide binding sites, enabling the design of peptide-based drugs. The model consistently outperforms existing methods and can analyze a single protein structure in under a second, making it suitable for large-scale studies.
Researchers at Imperial College London have created a metal-based molecule that inhibits the build-up of amyloid-β peptides associated with Alzheimer's disease. The molecule was shown to be non-toxic to human brain-like cells and cross the blood-brain barrier in mice using focused ultrasound.
Scientists at Tokyo Institute of Technology developed a computational method to predict the cell-membrane permeability of cyclic peptides, exhibiting promising accuracy. The protocol has potential to aid in designing and discovering cyclic peptide drugs with high cell-membrane permeability.
Researchers discovered that physical load stimulates bone growth through the expression of osteocrin (OSTN), a peptide produced by osteoblasts. OSTN is critical to regulating bone growth and physical endurance, with its expression decreasing when load is reduced and increasing with load stimulation.
The new MaxDIA software provides a computational workflow for data-independent acquisition proteomics, combining library-based and library-free approaches. This enables highly sensitive and accurate data analysis for thousands of proteins, opening up new possibilities for medical applications in personalized medicine.
Researchers develop a de novo peptide Y15 that readily forms secondary structures to enable bottom-up synthesis of functional protein assemblies in live cells. The peptide enables the formation of fibrous structures and clusters in test tubes and live cells, facilitating protein assembly and reconstitution of natural complexes.
A human endogenous peptide called LL-37 has been identified as a powerful blocker of toxic α-synuclein oligomers, which are responsible for neurodegeneration in Parkinson's disease. The discovery suggests that this naturally occurring molecule could be a safe and effective therapy to slow down the progression of the disease.
Scientists at the University of Tennessee Institute of Agriculture are working on developing biobased peptides to restrict ice crystal growth in freezing temperatures. Successful methods could improve frozen food quality, increase crop resistance to freezing temperatures, and enhance biomedical research.
A naturally occurring peptide in sunflower seeds has been identified as a potential drug for treating abdominal pain or inflammation. The peptide selectively activates pain transmission pathways without causing opioid side effects, reducing the risk of dependency and overdose.
Researchers have developed a novel synthesis method using peptides to create green gold nanoparticles, which can target and destroy cancer cells using near-infrared light. The findings provide an easy and eco-friendly protocol for Au nanoparticle synthesis, opening doors to non-toxic nanoparticle therapeutic agents.
A team of researchers from the University of Queensland has discovered a venomous caterpillar that produces peptides with high potency against nematode parasites and disease-causing pathogens. The study also unlocks a source of bioactive peptides with potential uses in medicine, biotechnology, and scientific tools.
Researchers at King Abdullah University of Science & Technology (KAUST) create a biomaterial that supports the growth of bone marrow precursor cells and forms tubular blood vessels, mimicking natural bone tissue architecture. This breakthrough enables the development of 3D disease models for tissue engineering and biomedical research.
Researchers have determined how peptides derived from PEDF protect neuronal cells in the retina layer, which could lead to treatments for degenerative retinal diseases such as age-related macular degeneration. The study found that these peptides work by binding to a protein receptor and processing omega-3 fatty acids like DHA.
Researchers developed a cell-penetrating peptide to prevent septic shock in animal models. The treatment shows promise in protecting patients with metabolic syndrome and those at risk of severe COVID-19 complications.
Researchers at the University of Göttingen have developed a non-toxic method to label peptides and investigate their mechanism of action. The new technique allows for efficient screening of molecules important for the adaptive immune system, which can help fight infections and cancer.
Researchers at Kazan Federal University and Chinese Academy Sciences have developed peptide nanoparticles that can be visualized in living cells using hyperspectral microscopy. These nanoparticles have the ability to scatter light efficiently, allowing for non-fluorescent labeling of cells.
A research team identified the structure of hetero-oligomers causing Alzheimer's and Parkinson's diseases to overlap. The study reveals that these aggregates have more degrees of freedom, allowing peptides to be loosely packed on their surface.
MUSC researchers develop peptide siRNA carriers that improve gene silencing and deliver siRNA into cancer cells. The modified carriers, such as RD3AD, use filopodia entry to efficiently deliver the therapeutic molecules.
A Stanford bioengineer has developed peptide-like molecules called peptoids that can retain therapeutic properties against viruses, offering a new approach to treating infectious diseases. The peptoids work by disrupting the virus's outer membrane, making them promising antiviral agents.
Researchers have developed new peptide markers to identify African bovid species, enabling more accurate analysis of ancient animal remains. The discovery sheds light on subsistence strategies and paleoenvironments in Iron Age Zambia.
A team of scientists from Pompeu Fabra University has developed a peptide that allows delta-9-tetrahydrocannabinol (THC) to fight pain in mice without cognitive side effects. The peptide, which interrupts the interaction between THC and serotonin receptors, improves memory capacity while providing analgesia.
Researchers have developed a peptide that enables THC to fight pain without the cognitive side effects associated with cannabis. In mice, the optimized peptide showed improved memory and reduced immune response, making it an ideal drug candidate for reducing cognitive side effects from cannabis-based pain management.
Researchers have developed a bicyclic peptide that binds to and inhibits the oncogenic protein beta-catenin, which is associated with certain types of tumor. The peptide's unique hairpin shape and cyclic nature mimic natural protein structures, making it an attractive starting point for developing new antitumor drugs.
A team of scientists from the University of Warwick used phage display to discover a small peptide that can bind to ice, which has potential applications in preserving frozen cells and foods. The discovery highlights the power of biotechnology tools in discovering new materials with unique properties.
Researchers have improved a method to prevent human parainfluenza virus attachment to cells, leading to 30% to 40% of childhood respiratory illnesses. The new peptide is more effective and persistent in rodent models.
Scientists have discovered a crucial aspect of peptide machinery, providing a breakthrough in re-engineering peptides. The study sheds light on how selectivity is achieved in the assembly lines that produce peptides, enabling single amino acid changes without altering multiple components.
Research suggests that bradykinin, substance P, and neurotensin may contribute to severe COVID-19 complications through mechanisms involving vascular permeability and cytokine storms. The review aims to bring awareness to these often-overlooked peptides, which may play a crucial role in disease management.
Researchers have identified a novel autoantigen in narcolepsy, which mimics a protein from the H1N1 virus. Immune cells in narcolepsy patients mounted stronger responses against viral peptides and human proteins, leading to the discovery of a self-protein that triggers an autoimmune response.
Researchers from Kumamoto University have successfully developed oral insulin using DNP peptides and zinc insulin hexamers. This breakthrough aims to improve the quality of life for diabetics who struggle with painful self-injection therapy.
Researchers have identified the activation mechanism of SHP2, a key player in cancer development. The study reveals that flexible beta sheets, not previously thought to be crucial, open in the presence of a peptide, triggering SHP2 activation.
A new mitochondrial peptide called MOCCI regulates inflammation of blood vessels and immunity after viral infection. Researchers discovered that MOCCI dampens the activity of Complex IV in mitochondria to reduce inflammation.
Scientists have observed unusually fast picosecond electron transfer in peptides mediated by hydrogen bonds, a rate 1 million times faster than previously known. This discovery has the potential to improve chemical transformations, energy conversion, electronic devices, and photonic technologies.
A team of scientists from UNIGE has identified a crucial role for a micro-peptide in determining the sperm that will fertilize an egg in Drosophila females. The peptide plays a key part in the competition between spermatozoa from different males, and its absence leads to reduced fertility in subsequent matings.
Researchers develop a new bioprinting process using ultrashort peptides, overcoming challenges in cell survival and creating complex scaffolds that facilitate long-term cell growth. The technology enables the creation of tissue models for high-throughput drug screening and diagnosis.
A novel mechanism has been identified that might explain why a rare mutation is associated with familial Alzheimer's disease. The presence of the S198P mutation resulted in elevated levels of A? peptides due to rapid folding of APP, leading to faster production and deposition of A? peptides.