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Articles tagged with Ph Domains

UTSA researchers discover new method to inhibit cholera infection

Researchers at UTSA have discovered a novel strategy to inhibit the spread and infection of Vibrio cholerae, the bacteria responsible for cholera. They identified a peptide-binding domain that can disrupt the virulence of V. cholerae, preventing intestinal colonization and biofilm formation.

SourceUniversity of Texas at San Antonio·JournalProceedings of the National Academy of Sciences·DateNov 7, 2023

Atomic-level insights gained for a key lipid-binding protein implicated in cancer

Researchers at Sanford Burnham Prebys have gained atomic-level insights into how PLEKHA7 interacts with the cell membrane to regulate intercellular communications. The study identifies hotspots within PLEKHA7 as potential targets for cancer drugs, particularly in advanced colon, breast, and ovarian cancers.

SourceSanford Burnham Prebys·JournalStructure·DateApr 20, 2021

Scripps research scientists identify new regulatory mechanism for critical protein signaling domain

Researchers at Scripps Institute have discovered a new regulatory mechanism for the binding of proteins to membranes through PH domains. IP4, a small soluble molecule, enhances this process, and its inhibition can block T cell maturation and lead to immunodeficiency in animal models.

SourceScripps Research Institute·JournalScience·DateApr 5, 2007

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.