Articles tagged with Ph Domains
Researchers at UTSA have discovered a novel strategy to inhibit the spread and infection of Vibrio cholerae, the bacteria responsible for cholera. They identified a peptide-binding domain that can disrupt the virulence of V. cholerae, preventing intestinal colonization and biofilm formation.
Researchers at Sanford Burnham Prebys have gained atomic-level insights into how PLEKHA7 interacts with the cell membrane to regulate intercellular communications. The study identifies hotspots within PLEKHA7 as potential targets for cancer drugs, particularly in advanced colon, breast, and ovarian cancers.
Researchers at Scripps Institute have discovered a new regulatory mechanism for the binding of proteins to membranes through PH domains. IP4, a small soluble molecule, enhances this process, and its inhibition can block T cell maturation and lead to immunodeficiency in animal models.