Articles tagged with Pharmacology
Dr. Blagosklonny discusses the potential of combining rapamycin with other modalities to live long enough to benefit from future discoveries in cellular reprogramming. He emphasizes that Altos Labs needs to develop rapamycin-based drug combinations to achieve additional decades of life extension, potentially within 3-5 years.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
Researchers at the University of Missouri are applying AI to analyze protein dynamics, identifying potential target sites for new drug therapies. The approach can simulate protein changes related to conditions like cancer, enhancing the chances of successful therapies.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
Scientists discover that activating TAK1 in skeletal muscle promotes muscle growth and prevents atrophy, with implications for treating conditions like cancer, COPD, and genetic diseases. The research also highlights the importance of maintaining healthy neuromuscular junctions.
Researchers developed a disposable electrochemical sensor using graphite-based molecularly imprinted polymers to detect theophylline levels. The sensor can identify low concentrations of theophylline (2.5 μg/mL) in whole blood within 3 seconds, enabling real-time monitoring and potential overdose prevention.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a new technique to easily visualize viruses using an optical microscope, called the Gires-Tournois immunoassay platform. The platform uses 'slow light' technology to detect coronavirus particles by slowing down light that gets reflected around them.
A new study found that antidepressant use over two years does not significantly impact physical or mental health-related quality of life in individuals with depression. Long-term studies are needed to evaluate the effects of non-pharmacological interventions.
Researchers are developing radioconjugate drugs that combine radiation with a tumor-targeting agent to selectively kill cancer cells. Two approved drugs, Lutathera and Pluvicto, demonstrate the potential of this therapy, which could change the future of cancer treatment.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
Researchers at Tokyo University of Science discovered that disulfiram inhibits FROUNT protein and chemokine signaling pathways, reducing anxiety levels in mice. The study suggests a potential breakthrough anti-anxiety medication with safe and effective treatment for elderly patients suffering from anxiety and insomnia.
The Paul Scherrer Institute and Italian Institute of Technology have developed a novel substance called Todalam that disables tubulin, a protein essential for cell division. In cell cultures, Todalam kills cells, making it a promising starting point for developing an anti-cancer drug.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers have made significant advancements in understanding the cellular level of ion channels, which are fundamental to sensing environmental signals. The discovery of fundamental ion-channel sensors for temperature and pressure has led to new treatments for conditions like stroke, hypertension, and Alzheimer's disease.
A recent study conducted by researchers at the University of Bristol has discovered a potential link between insomnia and an elevated risk of developing type 2 diabetes. The research suggests that poor sleep quality may contribute to insulin resistance and glycemic control issues.
A team from Goethe University has identified the spatial structure of the mannitol-synthesizing enzyme MtlD in Acinetobacter baumannii, which is crucial for its survival. This discovery could lead to the development of customized substances to inhibit the enzyme and combat this hospital pathogen.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
A new animal study suggests that combining marijuana compounds like CBD and THC with opioids may not increase the risk of addiction. The research found that these compounds do not enhance the rewarding effects of opioids, which could lead to a lowered risk of addiction or physical dependence.
Researchers project COVID-19 deaths in US states after lifting nonpharmacologic interventions. The study found significant differences in mortality rates among states, highlighting the need for targeted health policies.
Researchers have identified formononetin as a potential therapeutic for treating food allergies, which affect nearly 10% of the world population. The plant compound has been shown to decrease IgE production and influence gene and protein targets regulated in food allergy and mast cell diseases.
The study reveals a narrowing gap between cancer profiles in China and the USA, with converging trends in lung, breast, and colorectal cancers. China's cancer burden is expected to rise, while the US has seen reduced rates since the 1990s due to effective prevention strategies.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
Researchers verified the cause of allergic disorders by identifying plasma B cells secreting E-type immunoglobulin in the thymus of mice models. The study found that thymus-derived E-type immunoglobulin promotes food-induced anaphylactic reactions by increasing mast cell numbers in the intestine.
A report by the British Pharmacological Society and Royal College of Physicians recommends integrating pharmacogenomic testing to ensure medicines work safely and effectively for individual patients. The UK is a world leader in genomic medicine, and expanded testing would further demonstrate this leadership.
Researchers at UVA Health System discovered a cluster of cells in the brainstem that controls the body's response to severe blood loss. The study found that re-activating these neurons can restore blood pressure and heart rate in lab rats, offering new hope for treating traumatic injuries.
A POSTECH research team has developed a technology to select genes from animal models that accurately mimic human diseases. This allows for the prediction of success or failure of animal disease models before making them, leading to more effective new drugs.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
A new study led by UC San Francisco reveals that 87% of seniors with dementia would stop at least one medication if their doctor said it was possible. Polypharmacy contributes to challenges with adherence and adverse interactions, but most patients are willing to reduce their medications.
Researchers at UCSF develop a new cancer treatment that targets RAS-mutated tumors by exploiting their high levels of ferrous iron. The treatment, TRX-cobimetinib, is more effective and tolerable than current treatments like cobimetinib, which can cause serious side effects in normal tissues.
The Experimental Biology (EB) 2022 meeting explored diverse topics such as race and mental health in STEM, artificial intelligence in computational pathobiology and new insights at the leading edge of circadian physiology. Highlights from EB 2022 include symposia on GPCRs and G-protein signaling.
Researchers have identified a protein in tick saliva that can relieve chronic pain and itching, offering a potential alternative to traditional painkillers. The findings could lead to a new medication that is more effective and safer than current options.
Researchers discovered that a specific osmolyte causes kidney cells to undergo an EMT transformation, leading to renal failure. The team found a way to prevent this change by arresting focal adhesion rearrangement, suggesting a new approach to enhance therapeutic value of common osmolytes.
A new study by University of Michigan researchers found that genetics play a crucial role in how our bodies respond to vaccines and booster shots. The team identified a specific form of an antibody-related gene that predicts whether boosting will be effective for increasing innate immune responses.
A team of researchers at MedUni Vienna's Center for Physiology and Pharmacology has discovered a key building block in immune cells that promotes immunotolerance and prevents T-cell attacks on the body's own tissues. The study suggests a potential new cell-based therapeutic approach to slow down autoimmune disease progression.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
Researchers at the University of Houston have identified a new biomarker, NPY1R, that predicts therapy outcome and has potential as a drug target in estrogen receptor-positive breast cancer. The study found that NPY1R expression is associated with favorable outcomes in Luminal A subtype breast cancer, but declines in resistant cases.
Dr. Jansen will test hypotheses on intracellular domain of pLGIC proteins, aiming to gain insights into assembly, chaperone-modulation and functional conformational transitions in various diseases. Her research focuses on neurotransmitter-gated ion channels and their interactions with RIC-3-like chaperone proteins.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
A special issue in Botany journal explores relationships among plants, people, science, and medicine, promoting decolonial approaches to ethnobotanical research. The collection highlights the healing potential of plants and emphasizes Indigenous-led projects on medicinally useful plants.
Researchers at NTU Singapore have developed a new method to generate sulphur pharmacophores, which are crucial for drug discovery. The method uses a catalyst called pentanidium and can produce multiple variations of pharmacophores, making the process more efficient and fruitful.
Researchers have discovered a streamlined two-step synthesis strategy to produce neoechinulin B and its derivatives, exhibiting strong anti-HCV and anti-SARS-CoV-2 activities. The novel process utilizes a piperazine-2,5-dione derivative and tetra-n-butylammonium fluoride (TBAF) as key reagents.
The Experimental Biology 2022 meeting will feature renowned speakers, including Nobel laureates and research pioneers, who will present the latest findings and trends in life sciences. Keynote presentations include talks on vaccine science, navigation, RNA splicing, pharmacology, and cancer classification.
Localis-rex identifies 32 locale-specific sensor proteins sensing hydroxynonenal, a lipid-derived electrophilic-metabolite, revealing new information on electrophile signaling and its impact on biological processes. The study also highlights the potential for covalent drug design and profiling of drug-sensitive cells.
A recent University at Buffalo-led study found that nearly 1 in 7 COVID patients in ICU experienced severe bleeding when given full-dose blood thinners. The research compared the safety and effectiveness of two blood clot treatment strategies, finding that a smaller dose was equally effective but carried less bleeding risk.
A study published in Nature Microbiology reveals that a class of microbial enzymes contributes to ulcerative colitis. Researchers identified an overabundance of proteases from the gut resident Bacteroides vulgatus in nearly 40% of patients, which can exacerbate the disease when not treated with protease inhibitors.
Researchers at UCI discovered that AdipoR1 protein deficiency leads to ceramide accumulation in the retina, causing progressive photoreceptor cell death. A pharmacological treatment combining desipramine and L-cycloserine reduced ceramide levels, protecting photoreceptors and improving vision.
A new study reveals that the Omicron variant is sensitive to inhibition by the interferon response, an unspecific immune reaction present in all body cells. This provides the first explanation for why COVID-19 patients infected with Omicron are less likely to experience severe disease.
A study found that cholinesterase inhibitors like donepezil increase the risk of overactive bladder in people with dementia. Galantamine and rivastigmine were not associated with this increased risk.
Complimentary press passes are available for the EB 2022 meeting, featuring cutting-edge research and live scientific sessions. The event will also offer virtual access to press materials.
Researchers developed a computer model of lipoprotein-associated phospholipase A2, shedding light on its mechanism and substrate specificity. This knowledge creates opportunities for therapeutic interventions against cardiovascular disease.
Researchers devised a novel approach to unify quality assessment of generic drugs developed through different processes. The 'population pharmaceutical quality assessment' method uses computational modeling to evaluate process information, providing a scientific tool for objective quality consistency evaluation.
Researchers from Ethiopia and Germany identified a traditional African medicinal plant that alleviates malaria symptoms in infected mice. The plant extract's active compound, anemonin, shows promise in treating the disease.
Scientists have found that the gene PBK is overexpressed in pulmonary hypertension, causing excessive cell proliferation and thickening of pulmonary artery walls. They are now exploring PBK inhibitors to reduce cell proliferation and improve heart and lung function.
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
Researchers discover novel compound AD732 with anti-inflammatory and analgesic properties, outperforming standard NSAIDs while causing minimal harm. The compound may be a safer alternative for treating pain and inflammation in difficult diseases like ulcerative colitis and Crohn's disease.
Scientists have discovered a new potential treatment to reverse antibiotic resistance in bacteria causing sepsis, pneumonia, and urinary tract infections. The indole carboxylates class of enzyme blockers can stop MBL resistance enzymes from working, allowing antibiotics like carbapenems to effectively target bacteria.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
The COVID-19 pandemic drove significant advancements in pharmaceutical technology, with mRNA-based vaccines proving highly effective. Oral antiviral pills, such as Merck's molnupiravir and Pfizer's PF-0732133, showed promise in reducing hospitalization and death rates among unvaccinated individuals.