Articles tagged with Protein Expression
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A genetic study of an Antarctic 'antifreeze fish' has revealed a small set of genes that dominate the transcriptional process, enabling it to survive in cold, oxygen-rich environments. The study found high expression of proteins responding to environmental stress, such as heat shock proteins and ubiquitins.
Researchers have discovered a novel mechanism in gene expression where non-coding RNAs create access to DNA, allowing transcriptional activation proteins to initiate gene expression. This process involves the transient synthesis of non-coding RNAs that unfurl tightly wound DNA, enabling gene expression.
Claudin-1 expression transformation is positively correlated with gastric carcinoma invasiveness and metastasis. The study found that the transformed rate of claudin-1 expression significantly relates to the degree of differentiation and depth of invasion in gastric carcinomas.
A team of scientists found that genes controlling heme synthesis in red blood cells also control a gene and protein causing Parkinson's disease. The study suggests that targeting the GATA-1 and GATA-2 proteins may lead to new treatments for the neurological disorder.
A study found that higher levels of liver protein fetuin-A are associated with an increased risk of developing type 2 diabetes in older adults. The researchers measured fetuin-A levels in 519 diabetes-free individuals aged 70-79 years and found a significant association between fetuin-A and the development of diabetes.
Research suggests that enhancing neprilysin production can reduce plaque formation and neuron death associated with Alzheimer's disease, but at the cost of shortening lifespan. Over-activation of neprilysin also reduces CREB protein activity and increases age-dependent axon pathology.
Researchers discovered that HIV protease inhibitors can prevent photoreceptor apoptosis in mouse models of retinal detachment, reducing the cause of vision loss. CD133 expression was found not to be restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells can initiate tumors.
Researchers suggest a novel approach to reducing VEGF-induced vision loss by targeting Src kinases, offering a potential alternative to painful eye injections. Leaky Ca2+ release channels in the brain and heart may also contribute to seizures and irregular heartbeats in individuals with certain inherited disorders.
Researchers at the University of Western Ontario have received $10.5 million in funding to study a protein that may control regeneration in spinal cord injuries. The discovery aims to understand how scar tissue inhibits nerve growth and develop effective treatments for the estimated 12,000 annual spinal cord injuries in Canada and the US.
Researchers have discovered a protein profile in the blood that can help diagnose and treat chronic sinusitis with a totally objective test. This breakthrough may aid in more effective management of the disease, which is characterized by recurring nasal congestion, difficulty breathing, and sinus pressure.
Researchers have discovered a fusion protein that may contribute to Cockayne syndrome, a debilitating disorder marked by premature aging and neurodegeneration. The study suggests that the CSB gene's continued expression of CSB-related proteins or protein fragments plays a crucial role in the disease's development.
Research reveals that overexpression of Slug protein is associated with adenocarcinoma progression, potentially leading to E-cadherin silencing and loss of cell-cell adhesion. Understanding this mechanism may provide a therapeutic platform for oesophageal cancer treatment.
Researchers have identified three new ERK pathway proteins related to CagA-induced disease, which may serve as potential cancer-associated proteins. The study used SELDI-TOF-MS technology to analyze protein expression changes in AGS cells transfected with the CagA gene.
Scientists discovered microRNA-223, which controls the production and activation of granulocytes in the innate immune response. Absence of microRNA-223 increased tissue inflammation and damage.
A new study reveals that increased expression of the protein sFRP-1, an inhibitor of cell signaling through WNT proteins, is responsible for elevated intraocular pressure in individuals with glaucoma. Restoring WNT signaling may offer a novel treatment approach to manage the disease.
VEGF-B has been shown to inhibit apoptosis in retinal cells and brain cells in mouse models of injury and stroke, suggesting its potential as a new treatment for neurodegenerative diseases. Autophagy is also identified as a virulence-associated trait and survival mechanism for the fungal pathogen Cryptococcus neoformans.
Researchers have identified 30 new proteins that interact with the amyloid precursor protein, shedding light on its functional role in Alzheimer's disease. Additionally, a study found low variation in platelet protein expression within the elderly population, suggesting potential for clinical biomarkers.
Researchers found that Gas6 protein increases cell signaling in response to Epo treatment and treats both chronic and acute anemia in mice. Additionally, mice deficient in Gas6 have decreased sensitivity to Epo and reduced ability to recover from anemia.
Smoking before or during pregnancy may decrease fertility in female offspring, according to a new mouse study. The study found that exposure to environmental toxins like polycyclic aromatic hydrocarbons (PAHs) can reduce the number of follicles in female mice, leading to reduced fertility.
Researchers identified a mechanism that represses dendritic cell function in melanoma, which could be targeted for treatment. A new approach to treating myotonia in individuals with DM1 was also discovered using morpholino antisense oligonucleotide.
Research reveals that statins cause skeletal muscle damage through the activity of the gene atrogin-1. Inhibiting this gene's function could help protect against the side effect. Separate studies also link low levels of protein SHGB to metabolic syndrome and show how excess sugar contributes to its development.
Researchers developed a new virotherapeutic targeting cancer cells expressing E2F and EGFR proteins, showing antitumor effects in mice and rabbits. The virus demonstrated high selectivity for cancer cells in tumor-bearing rabbits and human tissue samples.
A study has identified mimecan and TXNDC5 as potential biomarkers for early detection of colorectal cancer. The research found that these proteins are differentially expressed in colorectal adenoma, a precursor lesion to the disease.
Researchers found that immunosuppressive drugs suppress beta-cell regeneration in diabetic mice, raising questions about the potential of successful regenerative islet transplantation. Meanwhile, a new study demonstrated that eIF4E-specific antisense oligonucleotides reduce tumor growth without causing damage to normal tissues.
Researchers discovered a genetic variation that causes overexpression of Neuregulin 1 type 4 in the human brain, which may contribute to schizophrenia. This study provides new insight into the disease's underlying biology and could lead to improved therapies.
Researchers have discovered a new enzyme, UBE1L2, that plays a crucial role in protein degradation and is highly expressed in the testis. This finding challenges the long-held assumption that protein degradation is initiated by only one enzyme, suggesting a more complex process involving two proteins.
Scientists have identified a key mechanism in the malaria parasite that allows it to adapt to infected individuals by switching on and off protein expression. The study reveals that 7 genes can be silenced without compromising the parasite's ability to enter red blood cells.
Research suggests that tonsils may facilitate oral HIV transmission through their unique gene expression profiles, which include higher levels of immune function-related genes and lower levels of antiviral proteins. This makes the tonsil tissue more permeable to pathogens, increasing its vulnerability to infection.
Researchers at Penn School of Medicine have discovered a potential new target for treating muscular dystrophy by targeting the 'brake' on utrophin gene expression. The study proposes using drugs to remove this brake, increasing utrophin production as a possible therapy for Duchenne muscular dystrophy.
Scientists at Fred Hutchinson Cancer Center discovered a modified version of antimycin that selectively kills cancer cells with high levels of survival proteins Bcl-2 and Bcl-xL. The compound's unique mechanism provides a therapeutic window, making it a potential targeted molecular therapy to enhance cancer treatment effectiveness.
Researchers discovered that genes have internal clocks regulated by coactivators, controlling protein production and preventing cancerous growth. The coactivator's clock is set off through the addition of phosphate and ubiquitin molecules, with a fixed lifespan to prevent continuous activation.
A new study by VCU researchers identifies the mechanism of action used by anti-cancer drug sorafenib, which inhibits protein translation and reduces expression of pro-survival factors. This finding may lead to the development of novel regimens combining sorafenib with other molecularly targeted agents.
A recent study identified a gene mutation that contributes to human cognition, which is exclusive to humans. The mutation affects the splicing pattern of the neuropsin gene, creating a longer protein involved in learning and memory.
Triple-negative breast cancer cells are sensitive to cisplatin due to increased expression of delta-Np63 and TAp73 proteins. Cisplatin releases TAp73 from delta-Np63, leading to cell death. This study suggests using cisplatin as an early treatment option for individuals with triple-negative breast cancer.
Researchers at Vanderbilt University found that treatment with TGF-beta inhibitors may help prevent cancer metastasis in patients. Additionally, a study from the University of Michigan discovered that a negative feedback pathway involving leptin receptor signaling may contribute to leptin resistance in obese individuals.
A therapeutic peptide, 37AA, has been developed to target the protein p73, which can induce tumor cell death. The study found that the peptide killed both p53-sufficient and p53-deficient human tumor cell lines. Additionally, a tissue-resident population of mesenchymal stem cells (MSCs) was discovered in transplanted human lungs, with ...
Most individuals with acute myeloid leukemia (AML) express CDX2, a protein regulating HOX family genes. Reducing CDX2 levels decreases AML cell proliferation, supporting its causal role in leukemogenesis.
Researchers identified a protein called MARCO that helps immune cells in the lungs clear oxidants, protecting against lung damage. HDL proteins were also found to have anti-inflammatory properties, suggesting new potential treatments for diseases like asthma and COPD.
A novel transgenic mouse model shows that the circadian liver clock can drive gene expression in the absence of systemic cues, while systemic cues can also synchronize peripheral clocks. This suggests a complex interplay between local and systemic control mechanisms.
Researchers have discovered a new antibody that effectively regresses lung tumors in mice with two types of lung cancer driven by mutant forms of the EGFR protein. The study highlights the potential therapeutic benefits of this antibody, ch806, for treating patients with specific lung cancer mutations.
Researchers found that increased HO-1 expression and carbon monoxide administration protect mice from MS. Mice lacking HO-1 develop more severe disease, but administering carbon monoxide reverses symptoms in already affected mice.
Researchers uncover that junk DNA can generate microRNAs, regulating protein production, contradicting previous assumptions. The discovery expands our understanding of functional genomics and sheds light on the mysterious role of non-coding sequences in human development and disease.
A study published in the Journal of Clinical Investigation has identified four proteins crucial for Entercoccus faecalis to form biofilms and cause endocarditis. Rats infected with E. faecalis lacking these proteins suffered less severe infections, suggesting potential new treatments.
Researchers discovered that Antarctic midge larvae continuously produce heat-shock proteins to withstand environmental stresses, whereas adult midges only express these proteins during extreme stress. This unique mechanism offers the larvae protection and allows them to thrive in Antarctica's harsh conditions.
In a study published in JCI Journals, researchers found that calcineurin is essential for complete lung development in mice. Mice lacking calcineurin function died shortly after birth due to lung failure.
GlycoFi and Dartmouth researchers engineered yeast cells to produce a broad repertoire of recombinant therapeutic proteins with human sugar structures. This achievement eliminates the need for mammalian cell culture, improving control over glycosylation and performance characteristics of therapeutic proteins.
Researchers at the Weizmann Institute successfully silenced two additional virulence genes in amoebae, rendering them harmless while preserving surface antigens. The disabled amoebae may serve as a live vaccine to combat life-threatening amoebic diseases.
Researchers found that Terry's brain underwent axonal re-growth, allowing for basic motor function and speech recovery. The study suggests a method to monitor brain function and track potential recovery in severely brain-damaged patients.
A new study discovered that BMP4 signaling is necessary and sufficient for the proliferation of pancreas progenitor cells, leading to an increase in Id expression. The researchers also found that inhibition of BMP4 results in a decrease in proliferating duct cells and an increase in the expression of a bHLH protein-dependent factor PAX6.
Researchers found eight proteins with significantly different expression in patients with head and neck cancer, correctly classifying 82% of participants. The protein fingerprint also showed promise in detecting specific types of cancer and monitoring treatment responses.
Researchers have developed imaging methods to track gene expression and protein production in individual cells, providing precise data on single molecular events. This breakthrough enables the study of low-abundance proteins and sheds light on cellular regulation.
Researchers isolated genes from the starlet sea anemone to understand body-plan patterning. They found that two types of proteins encoded by these genes are expressed differently in anemones compared to bilateral animals like flies and frogs, suggesting an ancient function for this signaling system.
Researchers identified altered expression of proteins involved in muscle differentiation, leading to reduced myoblast differentiation potential. Forced expression of MyoD or desmin restored this defect, providing new mechanistic insight into LMNA mutations contributing to muscular dystrophy.
Researchers used a fruit-fly model of Alzheimer's disease to examine the relationship between cell-division proteins and neurodegeneration. They found that abnormal expression of these proteins accompanied neuronal death in their fly model, which was prevented by blocking the cell cycle or feeding anticancer drugs.
A study published in JCI Journal reveals that alpha-basic-crystallin is overexpressed in breast cancer tumors and triggers tumor development. The protein causes dysregulated growth, changes in cell structure, and diminished programmed cell death, ultimately leading to poor clinical outcomes.
A study by David L. Rimm and colleagues found that high biomarker antibody concentrations were associated with low patient survival in breast cancer patients, while low concentrations were linked to good outcomes. Another study examined the impact of long-term storage on circulating DNA levels in lung cancer patients.
Researchers at St. Jude Children's Research Hospital discovered that histone deacetylase enzymes cooperate with CBP/p300 histone acetylases to trigger expression of genes responding to hypoxia. The study suggests that developing new therapies targeting both mechanisms may enhance treatment efficacy for solid tumors.
Researchers discovered that disrupting p53 activity in neurons extends lifespan and increases stress resistance in adult fruit flies. The study suggests that targeting p53 activity in different cell types may offer a way to prevent tumors while preserving healthy aging.
Researchers at Temple University School of Medicine have discovered a novel protein, p27SJ, extracted from St. John's Wort that suppresses HIV-1 gene expression and inhibits its replication. The study reveals that the protein interacts with both cellular proteins and viral proteins to block viral replication.
A recent study contradicts earlier research suggesting that the neural development protein Oct-6 could be a marker for schizophrenia and bipolar disorder. Contrary to previous results, researchers found no difference in Oct-6 protein or mRNA expression between patients with these disorders and healthy individuals.