Research on how proteins bind and work together. Covers membrane-protein assembly, viral infection, molecular imaging, and drugging difficult targets.
The study found that HIV-1 Tat protein expression leads to perturbations in the human cellular proteome, affecting gene expression and cellular processes. This has significant implications for understanding HIV-1 latency reversal and potential therapeutic strategies.
Scientists have created an accurate 3D model of an intrinsically disordered protein using supercomputing and neutron scattering experiments. The ensemble of its atomic-level structures reveals new information about its biological function, including transient ordered structures.
Researchers at The Wistar Institute developed a novel anticancer molecule targeting the MFF-VDAC1 complex to regulate mitochondrial cell death. The compound effectively delivered potent anticancer activity in preclinical models of various cancer types.
Researchers at Moffitt Cancer Center have identified a new mechanism controlling DNA repair, where βarrestin-1 targets 53BP1 for protein degradation. This finding provides a novel strategy for developing therapeutic agents with radiation protection properties.
Charcot-Marie-Tooth disease causes damage to the peripheral nervous system, affecting balance and motor skills. Researchers found that mutated enzymes take on an unusual shape, leading to unwanted interactions with nearby proteins and potential disease severity.
Rice chemists disentangled the mysterious interactions between bovine serum albumin and gold nanorods, revealing multilevel chirality and a possible way to sense single proteins' handedness. This discovery could lead to the development of drug-sensing tools with improved accuracy.
Researchers discovered a new function in the BAG4 protein, which regulates potassium transport and optimizes water use by plants. This finding is crucial for developing crops resistant to drought conditions.
Researchers from North Carolina State University have shown that the E75 protein plays a critical role in regulating biological rhythms in Daphnia magna. Suppression of E75 results in longer molt cycles and reduced numbers of offspring. The study highlights the potential impact of environmental stressors on population sustainability.
Researchers will image protein structures at an atomic scale, gaining insight into disease mechanisms and developing new diagnostic and treatment strategies for Alzheimer's, Parkinson's, and Lewy body dementia.
Scientists genetically modified mycoparasites to express Green Fluorescent Protein, revealing they can live up to 21-days on host plant surfaces without harming the environment. The study showed that these mycoparasites cannot spread in sterile soil or decomposing leaves, addressing concerns about their impact.
Biologists at Columbia University created a detailed map of protein-protein interactions between human-infecting viruses and infected cells. The study revealed insights into Zika virus infection and HPV's role in cancer, with potential implications for diagnostics and vaccine development.
A new tool called ProtFus screens scientific literature to validate predictions about fusion protein activity, which can help improve personalized cancer treatment. The tool identified 2,908 interactions across 18 cancer types, aiding in the study of alterations of protein networks for individual patients.
Scientists at EPFL have found a way to generate over 9,000 macrocyclic molecules below 1 KDa with high structural diversity. The new method enables the discovery of surprisingly efficient macrocyclization reactions, leading to the identification of binders for different disease targets.
Researchers at Cornell University have discovered that combining proteins from two lethal viruses can enhance their pathogenic potential. The team found that a hybrid protein pair has greater fusion capability, which could be leveraged to stop viral-cell fusion and develop more effective vaccines.
A research team from Aalto University developed a novel strategy to create virus-based materials for catalysis. The new phthalocyanine derivative was synthesised and combined with tobacco mosaic virus, resulting in a highly ordered fibrous material that remains active despite being immobilised.
Researchers discovered physical interactions between proteins and DNA that help explain why genetic condensates cluster along super enhancers, stimulating gene transcription. The study provides a fundamentally new approach to deciphering gene control in the 'dark matter' of our genome.
Researchers have demonstrated that energetic interactions between hydrogen cyanide and water can form precursors to RNA and proteins. The study provides new potential pathways for the formation of life's building blocks, without requiring high-energy photons or metal catalysts.
Researchers explore new tools and strategies to interpret multiomics data, revealing insights into bacterial strains and cancer phenotypes.
Researchers at Aarhus University have discovered a key player in legume-rhizobial symbiosis, enabling the transfer of biological nitrogen fixation to non-legume crops. This breakthrough could help smallholder farmers increase crop yields without relying on fertilizers.
The nascent polypeptide-associated complex (NAC) identifies and sorts nascent polypeptide chains inside the ribosomal tunnel. NAC inserts its β-subunit into the tunnel to sense translation activity and regulate protein biogenesis.
Scientists have solved the X-ray crystal structure of an enzyme that produces a broad-spectrum antibiotic called obafluorin. This breakthrough provides a detailed molecular structure of the enzyme's three-dimensional space and sheds light on its mechanism, which could lead to the creation of new antibiotics with novel structural classes.
Researchers at LMU Munich discovered that myosin VI directly engages with the plasma membrane, dynamically altering its shape. This interaction enables important cellular processes such as endocytosis and membrane protrusions.
A new study from KAUST has improved the efficiency of protein-induced fluorescence enhancement (PIFE) by identifying conditions that lead to either enhanced or quenched fluorescence. By understanding these conditions, researchers can better interpret laboratory results and gain more precise insights into molecular events.
Researchers develop LOCKR, a dynamic designer protein that can modify gene expression, redirect cellular traffic, and control protein binding interactions. This breakthrough technology has the potential to revolutionize synthetic biology and enable new therapies for diseases such as cancer and autoimmune disorders.
A molecule called GM1 ganglioside has been shown to inhibit the toxic effects of alpha-synuclein, a protein that forms clumps in Parkinson's disease. This discovery supports GM1 as a potential treatment for slowing disease progression and improving motor symptoms.
The University of Tokyo researchers modeled the amyloid beta sheets causing Alzheimer's disease and found that atoms too far apart can still influence each other through electron neighborhoods. This discovery may help predict the true structure and behavior of molecules based on their chemical sequence.
Researchers at PSU and UTMB will investigate the structure of Sulfolobus spindle-shaped virus 1, which thrives in high-temperature acidic environments, to better understand protein interactions and viral evolution. The study may also reveal connections to HIV and potential anti-HIV drug development.
Researchers at UC San Francisco identified functionally distinct composite clusters of genes corresponding to synaptic transmission, metabolism, cell cycle, and immune response. These changes occurred extensively in AD patients and may help streamline clinical trials recruitment efforts.
Researchers discovered hundreds of previously unknown protein interactions through a new statistical model applied to the human genome. These findings may open new routes to develop drugs against deadly pathogens like M. tuberculosis.
Researchers engineered artificial proteins to self-assemble on a crystal surface, creating new biomolecules with customized colors, chemical reactivity or mechanical properties. The design enables the creation of novel materials and filters, such as tiny sensors and electronic circuits.
A new study reveals that protein-linked sugars play a critical role in the uptake of alpha-synuclein proteins, which are associated with Parkinson's disease. The research identifies neurexin 1β as a key regulator in this process and suggests potential therapeutic targets for treating the disease.
Researchers at LMU discovered that Toxoplasma gondii utilizes a previously unrecognized mode of motility, where it secretes membrane material and recycles it into the cell membrane through endocytosis. This process generates a 'fountain-like' flow of membrane material that contributes to the parasite's propulsion along the substrate.
A team of researchers has identified the atomic interactions that stabilize the liquid, yet condensed phase of FUS, a protein associated with ALS and frontotemporal dementia. Understanding these molecular interactions could lead to the development of therapeutics to prevent disease-associated aggregation.
The New York Genome Center has received a $1.5 million grant from the Chan Zuckerberg Initiative to develop a single-cell analysis toolkit. The project will leverage multimodal methods to identify disease-causing genes and extract more information at reduced cost.
Scientists have identified a rare genetic mutation causing a fatal respiratory disorder that affects newborns. Using CRISPR/Cas9 gene editing technology, researchers developed a mouse model of the disease and discovered a critical link between FOXF1 mutations and STAT3 deficiency.
Scientists at the University of Konstanz develop a new method to study the interaction between p53 and poly(ADP-ribose) and DNA, providing insights into molecular reactions to cellular stress and cancer development. The research reveals distinct changes in protein structure induced by these interactions.
A team of researchers from the University of Würzburg has discovered a connection between two important regulators of cell division in lung cancer. The interaction between YAP and MMB protein complexes may be a key target for cancer therapy.
A team of researchers collaborated with Foldit players to design synthetic proteins, with 56 of the designed proteins found to be stable. The designs were able to adopt their intended structures, suggesting that the gamers had produced realistic proteins.
Scientists use pattern recognition to understand and predict behavior of disordered strands of proteins and polymers. By analyzing the precise sequence of charged monomers, researchers can design new materials with improved properties.
A team at Washington University School of Medicine has created a detailed picture of the chikungunya virus latched onto a protein found on cells in joints. This image promises to accelerate efforts to design drugs and vaccines to prevent or treat arthritis caused by chikungunya or related viruses.
Scientists have successfully determined the high-resolution three-dimensional structure of proteins inside living eukaryotic cells. This breakthrough technique promises insight into disease-causing proteins and novel drug screening applications.
A new research training group will investigate intrinsically disordered proteins, crucial for human function and disease development. The group aims to unravel protein structures and functions using state-of-the-art techniques.
Researchers have deciphered the structure of a complex involved in regulating the immune system, finding new molecular targets for fighting autoimmunity. The discovery has implications for treating autoimmune disorders such as lupus and may lead to the development of new drugs targeting this complex.
Researchers from Far Eastern Federal University suggest developing a 'bioengineering memory' in plants to improve stress resistance. They propose adjusting SWI/SNF chromatin-remodeling proteins and signaling subsystems using advanced genomic editing technologies like CRISPR-Cas9.
The NMR structure study provides unprecedented insights into the molecular mechanism of Ixolaris' action on Factor Xa, a key enzyme in blood clotting. The results may lead to the development of specific inhibitors that can prevent thrombosis without interfering with other enzymes.
Researchers found an interaction between BRD4 and the enzyme MTHFD1 from folate metabolism, which links gene regulation to transcriptional control. This discovery promises new approaches in cancer combination therapy for aggressive tumors.
Researchers found that viruses, like respiratory syncytial virus, form protein corona layers on their surface when interacting with host biological fluids. These layers enhance viral infectivity and facilitate the formation of amyloid plaques associated with neurodegenerative diseases like Alzheimer's.
Researchers are using novel experimental approaches to understand autism spectrum disorder, including studying networks of interacting genes and protein regulation. These studies aim to identify common molecular mechanisms underlying the disorder, which could lead to new treatments.
Researchers identified a protein called gravin as key to regulating beta-adrenergic receptor expression on heart cells. Elevated adrenaline levels in heart failure desensitize receptors, reducing heart function. Researchers seek to develop treatment targeting this mechanism.
A study found that host-cell enzymes PARP12 and PARP14 play a crucial role in combating mutant coronavirus replication. The macrodomain of the virus is required to prevent these enzymes from inhibiting viral replication and enhancing the production of antiviral proteins.
The dengue virus uses nonstructural protein 1 (NS1) to replicate in infected cells, with a key role in viral RNA replication and formation of the membranous replication organelle. A novel interaction between NS1 and NS4A-2K-4B is required for viral RNA replication but not for replication organelle formation.
Protein shapes are crucial for determining their role and effectiveness in the body. Researchers at Purdue University have created a new method to map and classify 3D surface shapes of proteins, which will aid in understanding protein structures and functions.
Researchers have found that the structure, concentration and interactions of tannins in wine influence dryness perception. Trained sensory panelists perceived Cabernet Sauvignon as dryer due to its higher tannin content, while added tannins didn't change dryness perception in Pinot Noir.
Scientists have successfully assembled protein cages that can be readily disassembled yet withstand extreme conditions. The breakthrough uses gold to overcome geometrical and complexity challenges in creating these nanoscale structures.
Researchers at Gladstone Institutes reveal acetylation and phosphorylation tag-team to guide RNA polymerase through transcription steps. This regulation enables cells to efficiently coordinate gene expression and respond to external stimuli.
Researchers studied Rho GTPases and IQGAPs proteins to understand cancer metastasis. The study revealed the interaction between these proteins activates mechanisms triggering metastasis in cells.
Researchers discovered that Entamoeba histolytica, a parasite causing severe gut disease, hides from the immune system by 'cell nibbling' and displaying human proteins on its surface. This camouflage protects it from complement proteins, allowing it to survive in the body.
Scientists discovered that sex and diet substantially affect the proteome, a collection of proteins in an animal cell. Understanding these interactions may lead to personalized treatments for humans. The study analyzed large public datasets on human and mouse proteotypes, diet, and genetic status.
Scientists at Cincinnati Children's Hospital Medical Center have discovered how a rare nerve tumor works and found a potential new way to fight it. The study identifies a key protein called Merlin and its connections to other proteins in the brain, which may lead to a breakthrough in treatment.
Researchers at NTU have developed a sustainable method to increase seed oil yield in crops such as canola, soybean and sunflower. The new genetic modification involves modifying the key protein Wrinkled1, resulting in larger oil reserves in seeds, which could lead to higher economic gain and increased production of biofuel.