Articles tagged with Protein Interactions
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study led by Prof. Erich Bornberg-Bauer revealed that de novo genes constantly emerge in non-coding DNA regions and can occasionally acquire functions in organisms over longer periods of time.
Researchers used a computer model to study the effect of increased cholesterol on a specific ion channel involved in regulating potassium levels in the heart. They found that increasing cholesterol levels made interactions with the channel more numerous, overwhelming it and interfering with its ability to open and close normally.
Researchers at EMBL have developed an interactive map of proteins involved in human cell division, allowing users to track protein dynamics and identify critical vulnerabilities. The tool has the potential to advance our understanding of cellular processes and disease mechanisms.
The TCS SP8 FALCON system enables fast fluorescence lifetime imaging and fluorescence correlation spectroscopy, allowing scientists to investigate protein environments with high accuracy. This technology facilitates advanced techniques in protein biology, including dynamic maps of protein interactions in living cells.
A study led by Professor Matthias Selbach found that minute changes in Glut1 protein structure can lead to severe cellular disturbances, causing genetic disorders. The research identified a mechanism where flexible regions of proteins interact with other molecules, disrupting cellular processes and leading to disease.
A study by Massachusetts General Hospital researchers found that the abnormal form of tau associated with Alzheimer's disease disrupts communication between a neuron's nucleus and cytoplasm. This disruption leads to brain cell dysfunction and death, contributing to neuronal loss in Alzheimer's disease.
Researchers at Washington University in St. Louis create 'blink' method to image amyloids, allowing for non-invasive visualization of these problematic proteins. The technique uses temporary fluorescence, causing amyloids to flash and enabling researchers to better understand their structure and behavior.
Researchers identify key host-virus protein interactions that enable Zika to evade immune signaling and proliferate. The study provides insight into the viral life cycle and potential targets for antiviral drugs.
Researchers captured detailed images of TRPV3, a skin-cell ion channel involved in temperature sensation. The study reveals how a mutation in the woolly mammoth's TRPV3 gene may have helped them adapt to cold environments and provides clues for new treatments of human skin diseases such as eczema and vitiligo.
Researchers at Ruhr-University Bochum have developed semi-synthetic enzyme systems using DNA, which can replace protein cofactors. This innovation aims to create more stable biocatalysts that can be used in industry for climate protection and economic gain.
Researchers at UNC School of Medicine discovered a rare gene mutation causing hydrops fetalis, a fatal condition in fetuses. The mutation impairs CLR receptor interaction with RAMP protein, disrupting adrenomedullin signaling and leading to fatal consequences.
A new study describes the structure of an ion channel responsible for detecting odors in insects, revealing how millions of receptor varieties evolved to accommodate diverse habitats. The discovery offers insights into insect olfaction and evolution, potentially leading to innovations for disease prevention and human benefit.
Researchers found that RUNX proteins bind to DNA damage sites and co-regulate the recruitment of DNA repair protein FANCD2. This discovery could lead to the development of synthetic-lethal approaches to attack RUNX-deficient cancers, including solid tumours of the breast and leukemia.
Researchers at the University of California - San Diego have discovered that eRNAs play a significant role in activating tumor-developing genes. The findings suggest that eRNAs are functional molecules, rather than mere reflections of enhancer activation or transcriptional noise.
Jianhan Chen is studying intrinsically disordered proteins (IDPs) with flexible 3D structural properties, which account for about one-third of all eukaryotic proteins. His project aims to develop computational methods to simulate flexible proteins and explore the fundamental principles of their structural disorder's effect on function.
A study published in Nature Communications provides new insight into the regulation of brain cell signaling, which may lead to better treatments for epilepsy and related disorders. By quantifying the interaction between two key proteins, researchers have identified a specific pattern that can be influenced to control brain activity.
Scientists used supercomputers to model HIV-1 replication and identified inositol hexakisphosphate as a key molecule promoting assembly and maturation. This discovery opens a door for developing new treatments and therapeutics.
Brazilian researchers have identified a key gene, ScGAI, that accelerates sugarcane growth by regulating developmental hormones such as ethylene and gibberellins. Silencing the gene in transgenic sugarcane lines resulted in increased culm volume and rapid internode elongation.
Researchers have identified two protein domains that mediate toxicity in ALS and FTLD, revealing a key role for stress granules in disease progression. The study provides new insights into the molecular mechanisms underlying these neurodegenerative diseases.
Researchers have identified a human protein, DDX3, that is exploited by arenaviruses to promote viral growth and evade the immune system. This discovery suggests DDX3 could serve as a potential target for new anti-arenavirus strategies.
Researchers at Oregon State University solved a longstanding puzzle concerning kinesins, tiny motors that interact with microtubules inside cells. By altering the design of these motor proteins, scientists can develop new cancer therapies by targeting specific waist regions.
A Kanazawa University-led team used high-speed atomic force microscopy to study GroEL's mechanism, finding two alternative pathways for the protein-GroES interaction. The research suggests a more active role for the football-shaped structure in protein folding, challenging conventional models of molecular chaperone function.
Scientists adapted thermal proteome profiling technique to study bacteria's protein behavior, revealing novel drug resistance mechanisms and insights into bacterial cell function. The technique allows researchers to investigate thousands of proteins simultaneously, offering potential breakthroughs in understanding antibiotic resistance.
A research team at TUM has reconstructed the protein complex responsible for transport within cilia, crucial for cellular movement and organ development. The study reveals a minimal combination of four proteins that start the engine of intraflagellar transport.
A recent Penn Medicine study found that nearly all major neurodegenerative diseases share common 'proteinopathies' present in varying degrees across different diseases, expanding the potential for combination therapy targeting multiple disease proteins.
Researchers at Florida State University develop novel, modular scheme for producing large quantities of 5-8-5 ring structure, opening door to new medicinal compounds. The simplified methodology could aid scientists in understanding potential medicinal properties of synthetic products.
Researchers revealed the structural fold of S. agalactiae CAMP factor, composed of 5+3 helix bundles, with N-terminal bundle responsible for membrane permeabilization and C-terminal bundle for host receptor binding. The study clarifies the molecular mechanism of co-hemolytic activity.
Researchers have identified a way to slow the spread of the flu virus by altering molecular interactions between the virus and host genes. Altering these interactions can stunt viral replication, according to new research published in Nature Communications.
Scientists have developed a powerful method to create synthetic orthogonal receptor-ligand pairs that bind with high selectivity, triggering intended functions without interfering with natural activities. This design approach can be used to reprogram cellular functions in cell-engineering applications.
Researchers discovered that Kapβ2, a nuclear localization signal, plays a crucial role in transporting the FUS protein into the nucleus. The study found that when this system fails, FUS proteins aggregate and form toxic droplets, contributing to neurodegenerative diseases like familial ALS.
Scientists found a unique feature in the 'antennae' of photoreceptor cells, which helps explain why certain mutations cause blindness. The discovery sheds light on the molecular mechanisms underlying human retinal disease.
Researchers found that neurogranin and FMRP proteins quickly form a complex to enable memory encoding within minutes of encountering a novel context. This process is crucial for understanding how abnormalities in these proteins contribute to human neuropsychiatric disorders.
Researchers developed a mid-infrared biosensor that distinguishes multiple biomolecules in heterogeneous biological samples without labeling. The sensor can resolve protein-lipid interactions and monitor dynamics of vesicular cargo release, inaccessible to standard label-free techniques.
Repeated exposure to large quantities of alcohol in fruit flies reduces the activity of a protein regulating communication between neurons. This study provides new insight into the neurobiology of alcohol tolerance, revealing that ethanol interferes with neurotransmitter release and Unc13 protein function.
A novel mechanism of action has been identified for the treatment of inflammatory bowel disease, showing promise for a new therapeutic approach. The study discovered that an orally active small molecule, ER-464195-01, suppresses leukocyte adhesion by binding to calreticulin and inhibiting integrin activation.
Researchers discovered that tau protein mutations can increase cancer risk by up to 3.72 times, highlighting a new association between neurodegenerative disorders and cancer. The study's findings suggest that clinicians should monitor patients with tau mutations for their cancer risk, in addition to attending to neurodegeneration.
Researchers have discovered that mosquito saliva can trigger a prolonged immune response in humans, detected up to 7 days after a bite. The study found that the proteins in mosquito saliva interact with human immune cells, leading to changes in cytokine levels and T helper cell responses.
Researchers discovered a protein 'piston' that facilitates rapid electron transfer in photosynthesis. The piston-like motion of PSI subunit is thought to stimulate electron transfer and provide insights into artificial photosynthesis.
Researchers have created a near-atomic-resolution model of tau-microtubule interactions, revealing how tau stabilizes microtubules and forms aggregates that contribute to neurodegenerative diseases. The study provides insight into the mechanisms underlying tauopathies, such as Alzheimer's disease.
A team of scientists at FAU has discovered how protein molecules regulate the formation of myelin sheaths in the nervous system. The study found that Nfat proteins are essential for successful interaction between other protein molecules, and their inhibition can lead to myelin loss and neurological disorders like multiple sclerosis.
A Northwestern-led synthetic biology research team has developed a new biotech technique called GlycoSCORES that promises to accelerate research into protein therapies. The technique uses cell-free protein synthesis, protein glycosylation, and mass spectrometry to rapidly screen sequences for making glycoproteins.
A recent study found that erythropoietin (EPO) helps protect and repair vulnerable preterm brains by modifying genes essential for neurogenesis. The research, conducted at Children's National Hospital, identified five key genes involved in the development of the nervous system and responding to environmental stressors.
Researchers capture images of measles viruses as they emerge from infected cells, gaining insights into the internal organization and potential antiviral strategies. The study reveals a scaffold-like matrix protein acting as a framework for viral assembly.
Scientists at Brookhaven National Laboratory uncover how membrane proteins organize three enzymes involved in building lignin, a crucial cell-wall component. The discovery sheds light on the metabolic pathway channeling carbon into lignin precursors, potentially leading to new ways to promote carbon storage or biofuel production.
Talin and α-catenin proteins unfold through stable 3-helix intermediates, enabling recruitment of other binding partners and regulating protein function.
Cadm1 protein interacts with Kaposi's sarcoma viral proteins to promote inflammation and cancer growth in KSHV-infected cells. This discovery could lead to a new therapy targeting human protein CADM1 in viral-mediated cancers.
Researchers have developed a new method for weighing single molecules using light scattering, enabling the measurement of mass with high accuracy. This breakthrough has potential applications in fields such as protein-protein interactions, drug discovery, and point-of-care diagnostics.
Researchers are using machine learning techniques to analyze protein dynamics data and uncover hidden cause-effect relationships. Their study reveals that the signal initiated at the stimulation site of a protein weakens as it moves away from the stimulation site.
The study reveals that the glucocorticoid receptor (GR) can directly bind to DNA at NF-kappaB sites, one at a time, turning down inflammation genes. This finding could lead to reinterpretation of previous studies and potential development of targeted drugs.
A team of researchers from the Wellcome Sanger Institute has discovered a human receptor protein on the surface of cells that malaria parasites interact with as they navigate through the body. This finding provides a key clue in understanding how to develop an effective malaria vaccine, potentially saving millions of lives.
A new study identifies the cells responsible for producing the small protein Flowering Locus T (FT), which triggers the flowering process in plants. The research reveals an extensive intercellular signaling system that regulates FT production, shedding light on how plants control their flowering times.
Researchers solved the structure of a key nervous system protein in complex with various drugs, enabling precise targeting. The discovery aims to develop medications with regulated action and fewer side effects by controlling which proteins are affected.
Researchers have discovered a detailed structure of ISRIB, a brain-boosting experimental drug that eliminates learning and memory deficits in mice with concussions. The new atomic-scale protein structure reveals how ISRIB interacts with its target, potentially leading to tailored treatment for cognitive disorders.
A study has characterized the physical mechanism that enables a widespread bacterial pathogen to adhere to human host tissues. The researchers used atomic force microscopy and molecular dynamics simulations to reveal a unique cooperation of non-covalent hydrogen bonds in the adhesion process.
Researchers discovered a unique mechanism involving intrinsically disordered polypeptides in nuclear pore complexes that enable rapid recognition and binding of transport factors. This 'fuzzy' interaction allows for specific and speedy cell signaling, preventing DNA data breaches by viruses or faulty functioning.
Researchers at Penn State have identified key steps and proteins involved in cellulose synthesis, a crucial process for biofuels. The study's findings may lead to more efficient breakdown of cellulose for renewable energy production.
A team of scientists discovered a gene that helps rice plants grow in salty soil. The gene, STRK1, increases the plant's tolerance to salt stress by reducing reactive oxygen species.
Researchers discovered that Chlamydia trachomatis proteins interact with host cell proteins to regulate the bacterium's exit from infected cells via lysis or membrane-bound package. Calcium ion signaling plays a crucial role in this process, and disruptions to this pathway significantly inhibit extrusion.
The Protein Society has awarded three researchers with prestigious prizes: Jane and Dave Richardson, Yifan Cheng, and Susan Marqusee. The winners have made groundbreaking contributions in protein structure determination, cryo-EM, and protein folding. Their work has significantly advanced our understanding of biology.
Scientists have developed a way to stabilize proteins outside of their native environments, creating mats that can trap chemical pollution. The research demonstrates a unique path toward exploiting protein power in synthetic systems.