Research on how proteins bind and work together. Covers membrane-protein assembly, viral infection, molecular imaging, and drugging difficult targets.
Researchers at the University of Notre Dame have developed a new analysis procedure to better understand how intrinsically disordered proteins (IDPs) function in cells. The study finds that most IDPs are more disordered than previously thought, which could lead to new strategies for preventing protein misfolding diseases.
Researchers at Goethe University Frankfurt have identified key molecules involved in regulating brain plasticity and memory. GRIP1, ephrinB2, and ApoER2 are found to interact and regulate AMPA receptor insertion at the synapse, influencing learning and memory.
A team of researchers, led by Tony Kim, has developed an innovative lab chip called the human-coronary-artery-on-a-chip to explore new treatments for atherosclerosis. The study aims to improve understanding of high-density lipoprotein (HDL) interactions with proinflammatory proteins and vascular tissues.
Researchers developed a new approach to analyze drug-protein interactions, revealing the specific amino acids involved in binding. This allows for more precise chemical requirements and stronger, selective drug candidates.
Researchers have identified proteins that control cell complexity in animals, revealing a key difference between humans and simpler organisms like fruit flies and sea urchins. The study found that specific genes interact with chromatin to regulate cellular processes, contributing to the increased complexity of mammals.
TSRI researchers studied the interactions between Avandia, a nuclear receptor, and coregulatory protein SRC-2, revealing how DNA binding affects drug potency and receptor shape. This knowledge could lead to designing new antidiabetic drugs with better efficacy and fewer side effects.
A new paper-based test developed by MIT researchers can diagnose Zika infection within 20 minutes, accurately distinguishing it from Dengue virus. The test uses antibodies specific to Zika virus's NS1 protein, avoiding false positives common with existing tests.
Researchers at NYU Dentistry have identified two proteins that regulate the formation of pearls, a process that could lead to the development of fracture-resistant materials. These materials could be used in dental implants, aerospace applications, or energy transmission.
Two studies of green algae reveal details about their ability to concentrate carbon dioxide from the air. Researchers found that the pyrenoid, a key organelle in photosynthesis, behaves like a liquid droplet that can dissolve and condense during cell division.
Protein add-ons play a crucial role in customizing protein interfaces, allowing proteins to interact specifically with their dedicated partners. The discovery sheds light on how proteins perform specialized functions and enables new avenues for understanding fundamental principles in nature.
A recent study has discovered an unexpected link between Parkinson's disease and prion diseases, revealing a complex interaction between α-synuclein and the prion protein. The findings suggest that α-synuclein deposits in brain cells can slow the progression of prion diseases.
Scientists at the Salk Institute have identified a key protein complex involved in regulating brain cell identity, with high levels of Nup153 found to be necessary for maintaining precursor status. This finding may provide new insights into the underlying causes of neurological disorders such as schizophrenia and Alzheimer's disease.
Researchers have visualized the intricate three-dimensional structure of three neural proteins and discovered their surprising cooperation in releasing chemical messages. The study suggests that the complex interaction locks down the SNARE proteins, requiring synchronization of neurotransmitter release.
Chinese scientists develop a new algorithm that leverages network structure characteristics to improve link prediction accuracy and robustness. Their experimental testing in various real-world networks yields better results than existing methods, leading to the creation of a novel method for predicting missing links.
Scientists have identified where laminin 511 interacts with integrins, crucial adhesion molecules that determine cell function and shape. The discovery reveals the gamma chain directly interacts with integrins, stabilizing the laminin-integrin bond.
Researchers at Boston Children's Hospital have developed a new DNA nanoswitch platform that can detect biomarkers associated with different diseases, viral strains, and genetic variabilities. The NLISA system uses gel electrophoresis to screen synthesized DNA reagents that change shape in the presence of a specific biomarker.
Researchers at Osaka University discovered a rare genetic variant, RTN4R, that may play a fundamental role in schizophrenia. This finding supports the hypothesis that myelin-related genes are associated with the disease.
A team of researchers led by Charles Weitz shows that a set of core clock proteins organize into molecular machines that control circadian rhythms. The findings provide a starting point for understanding the clock's machinery and its role in various conditions, including sleep disorders and cancer.
Researchers at Duke University mapped out the complex molecular circuitry of Francisella tularensis, a bacterium that causes tularemia and is considered one of the world's most infectious pathogens. By understanding how the bacteria becomes virulent, scientists can design new drugs to shut down its virulence.
A Japanese team of researchers has successfully developed a synthetic receptor nanocapsule that can selectively bind sucrose in water. The capsule's unique recognition system is based on CH-π interactions between sucrose and the inner walls of the nanocapsule, allowing it to capture sucrose with high yield and stability.
Chemists have developed a technique to create a spectrum of glowing dyes, offering scientists a way to adjust the properties of existing dyes deliberately. This expanded palette could help researchers better illuminate the inner workings of cells.
Researchers discovered how a bacterial protein loosely binds to a mineral, allowing the bacterium to breathe in oxygen-deprived conditions. The study revealed that this protein interacts relatively weakly with the mineral, requiring less binding energy than typical proteins.
Researchers at Karolinska Institutet have developed a technique to monitor the maturation process of the immune system in leukaemia patients after stem cell transplantation. This study identifies patterns linked to clinical complications and provides new knowledge on the regulation and dysregulation of the immune system.
Researchers at CRI have developed a new system, CAPTURE, to analyze the entire set of factors that regulate our DNA. This approach offers possibilities to study how different proteins control genome function in cancer and stem cells, and may lead to finding new drug targets.
Researchers at EPFL studied the TADs involved in digit development, finding that they can host multiple associations between genes and enhancers. Disrupting the 3D structure of chromatin leads to remodeling of TADs, with CTCF mediating long-range DNA contacts.
Researchers from Princeton University discovered that ISWI chromatin remodelers use the 'acidic patch' to remodel chromatin. The study reveals that this feature is a general requirement for chromatin remodeling to occur, and certain chemical modifications can enhance or inhibit ISWI remodeling activity.
Methylation and S-nitrosylation are conserved protein modifications that regulate abiotic stress responses in plants. NO positively regulates PRMT5 activity through S-nitrosylation, leading to proper splicing-specific pre-mRNA processing and enhanced tolerance to stress.
Biomedical engineers found that different beta subunits attach to the main protein in a unique way, affecting the channel's control over the heartbeat. This discovery could lead to precision medicine and therapies tailored to individual needs.
A team of researchers has decoded the complex interplay of three components in a protein network regulating programmed cell death, also known as apoptosis. Their findings suggest that interaction between Bcl-2 proteins is key to understanding this process and its link to diseases such as cancer.
Scientists from University of Washington and University of Toronto have developed new high-throughput approach to test folding stability of thousands of computationally designed proteins. This study led to the design of 2,788 stable protein structures with potential bioengineering and synthetic biology applications.
Researchers have identified an anti-CRISPR protein that can block the Cas9 component of CRISPR-Cas9 from interacting with DNA, reducing off-target cuts. This protein, AcrIIA4, was found to inhibit CRISPR-Cas9's ability to cut target DNA while still allowing on-target editing.
Scientists have made a groundbreaking discovery using real-time monitoring to quantify cooperativity in hydrophobic interactions, demonstrating its critical role in stabilizing macromolecular assembly. The study's innovative microfluidic device enables precise tracking of solute molecule aggregation at sub-microsecond timescales.
Using supercomputer simulations, researchers have discovered that kinks in DNA can significantly reduce energy and pressure, allowing it to fit into a micron-sized space. The findings provide new insights into how cells pack DNA and could lead to advances in understanding biological phenomena.
Researchers from the University of Freiburg have discovered over 900 mitochondrial proteins in baker's yeast using quantitative mass spectrometry and bioinformatics methods. This extensive dataset provides a foundation for understanding the biology of mitochondria in various organisms, from yeast to humans.
Studying pea genetics and environmental factors, researchers found that pea yield is affected by both genetics and environment, but environment has a larger impact. The study also identified pea varieties with higher protein and resistant starch content, which can benefit human health and the environment.
Researchers identified that the CMG2 protein binds and controls collagen VI levels, leading to its accumulation in tissues causing painful deformities. The study provides new insights into the physiological function of CMG2 and demonstrates its interaction with collagen VI.
Scientists have discovered a way to revive mixed folded proteins by applying an electrostatic interaction between folded or denatured proteins and alumina nanoparticles. This breakthrough could simplify and reduce the production costs of drug proteins for Alzheimer's and Parkinson's treatment.
Researchers from ITMO University and Hebrew University have developed a method to recover protein structure after chemical denaturation, working for both specific molecules and multiprotein systems. The technology simplifies and cheapens the production of drug proteins for Alzheimer's and Parkinson's treatment.
Researchers at Nagoya University identified Dmt as a fruit fly protein related to sororin that is crucial for sister chromatid cohesion. The study shows that Dmt localizes to the joining point of chromatin and requires interactions with cohesin.
A new method developed by UK scientists makes peptide stapling cheaper and more versatile, allowing for easier manipulation of peptides in drug discovery. The approach enables the constraining, delivering, and unconstraining of peptides, improving their pharmacokinetic properties and potential as drugs.
Researchers captured the first cryo-electron microscopy snapshots of a key cellular receptor in action, providing near-atomic-resolution images. The study reveals how peptide hormones like GLP-1 bind to and transmit signals through G protein-coupled receptors.
A new study by Université de Genève researchers reveals the basic geometry of the gene-to-protein code, highlighting the mechanical basis for DNA's map of functional proteins. The research focuses on the segment of the gene coding the hinges of nano-machines, which are essential for protein function.
Researchers found that stem cells can produce anti-inflammatory cytokines, leading to improved tendon healing and matrix remodeling. The study suggests a new approach to treating tendon injuries and diseases by regulating inflammation.
Researchers identified a key protein, SMAD3, that facilitates pro-fibrotic TGF-beta signaling. By blocking this protein, they created a peptide-carrying SNX9 that prevents SMAD3 from entering the nucleus and impacting genes regulated by TGF-beta. This approach may lead to effective treatments for fibrosis-related diseases.
Researchers from the Bristol BioDesign Institute created a miniprotein with a stripped-down structure to investigate molecular forces that assemble and stabilize protein structures. They discovered subtle forces beyond hydrophobic interactions, which could lead to new drug targets.
Researchers at Harvard Medical School have created a high-throughput approach to map protein interactions, identifying over 56,000 unique interactions for nearly 6,000 proteins. The BioPlex network reveals functional roles for previously unknown proteins and links them to human diseases like cancer and hypertension.
Researchers from North Carolina State University have demonstrated that integrating molecular dynamics simulations and machine learning techniques can create more accurate computer prediction models. The new models, called 'hyper-predictive,' can quickly predict which new chemical compounds could be promising drug candidates. This is a...
A recent study found that plant and animal stem cells exhibit similar interaction patterns, explaining why plant cells can reprogram more easily. Researchers developed mathematical equations to analyze protein interactions, revealing key differences in cellular flexibility.
Moleculomics' new technology accelerates drug discovery by simulating protein interactions with chemicals, reducing development time and cost. The platform enables the high-throughput screening of candidate compounds against human proteins, identifying safe and toxic compounds.
A research team at Rockefeller University has identified a potent new weapon against the Zika virus: Z004, an antibody that neutralizes the virus and could be used to create a vaccine. The discovery was made by analyzing blood samples from people who had been infected with the virus.
Researchers at Columbia University have obtained detailed images of AMPA receptor interactions with regulatory proteins, revealing the structural changes that occur during desensitization. This knowledge may aid in designing targeted therapies for conditions like Alzheimer's, Parkinson's, epilepsy, and schizophrenia.
A new discovery in chemistry could lead to more specific and desired forms of drugs, with the creation of chiral molecular sieves that can sort and create left- and right-handed molecules. This breakthrough has broad implications for pharmaceutical companies and may improve medications such as ibuprofen.
The Rosetta Online Server (ROSIE) uses XSEDE's Stampede supercomputer to provide access to the Rosetta software suite for 3D structure prediction and high-resolution design of biomolecules. With over 5,000 users, ROSIE has enabled notable scientific advances in computational biology.
Sai Veeraraghavan, a research assistant professor at Virginia Tech Carilion Research Institute, has received the George Palade Award for his work on conductive behavior between heart cells. His novel analysis software, STORM-RLA, allows researchers to quickly parse through the locations of single molecules to determine protein interact...
Researchers developed a new virtual drug screening platform to predict interactions with TNF and RANKL proteins. Two promising molecules, T23 and T8, were identified as strong TNF inhibitors with low potential for side effects.
Charlotte Miton and Zach Schaefer have won the Protein Society's Year 2016 Best Paper award for their research on mutational epistasis and protein structure. Their study reveals that epistasis plays a major role in constraining evolutionary trajectories, with half of fixed mutations becoming positive at later rounds of evolution.
The 2017 winners of the Protein Society Awards include Dr. Billy Hudson, Dr. Lewis Kay, Dr. Juli Feigon, and others who were recognized for their groundbreaking research in protein science.
The American Association of Anatomists has awarded three young investigators for groundbreaking research in cell biology, comparative neuroanatomy, and developmental biology. Maria Barna, Gloria Brar, and Shigeki Watanabe have made significant contributions to biomedical science through their research.
Researchers use computer simulations to show how N-terminal sequence encourages aggregation of huntingtin protein fragments while polyproline inhibits it. This discovery offers a new target for drug development to halt Huntington's disease progression. The study also highlights the involvement of the cytoskeleton in the disease mechanism.
USC scientists discovered unexpected characteristics of the AT2 protein, which interacts with the angiotensin II hormone regulating blood pressure. The study reveals potential new paths to drugs controlling cardiovascular disease and pain, offering an important first step towards targeted therapies.