How animals find their way
A Collaborative Research Centre investigates animal navigation using the Earth's magnetic field. The study focuses on vertebrates, including birds and fish, aiming to protect endangered migratory species.
Protein Interactions
Articles tagged with Protein Interactions
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Aging | The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability
Researchers identified USP7 as a novel cyclin F-interacting protein that stabilizes cyclin F protein. The study also found that USP7 regulates cyclin F mRNA, with pharmacological inhibition resulting in downregulation of cyclin F mRNA.
IU researchers identify protein that contributes to tau neurotoxicity in Alzheimer’s disease
Researchers from Indiana University School of Medicine identified the protein bassoon as a key contributor to tau neurotoxicity in Alzheimer's disease. The study found that bassoon stabilizes the tau seed, allowing it to propagate in the brain and exacerbate neurodegeneration.
Nerve cell discovery may lead to better treatment for diseases of the nervous system
Scientists at King's College London and the University of Bath have made a groundbreaking discovery about a molecule that plays a crucial role in nerve cell development. The study found that this molecule, known as SNRNP70, is not only present in the nucleus but also in the cytoplasm of nerve cells, where it shapes messenger RNA strand...
How to study ‘big’ molecules without breaking them apart
A new technological advancement at the University of Oklahoma will enable scientists to study whole macromolecular structures without deconstructing them. This breakthrough, supported by a $50,000 NIH grant, aims to analyze proteins as intact molecules, improving our understanding of their modifications and interactions.
Copper a clue in the fight against cancer
Researchers discovered that the Memo1 protein binds copper ions, blocking toxic redox reactions that damage or kill cancer cells. The protein's interaction with copper also protects against metastasis formation in breast cancer cells. This finding opens up potential new treatments for cancer.
Research at Jacobs University: Coffee could offer protection from catching COVID-19
Researchers at Jacobs University have found that a compound in coffee, 5-caffeoylquinic acid, can inhibit the interaction between the SARS-CoV-2 spike protein and the ACE-2 receptor, potentially providing protection against COVID-19. The study's findings suggest that regular coffee drinkers may be less likely to contract the virus.
Hormone therapy could lower risk of immunotherapy-associated myocarditis in women
A new preclinical study discovered the underlying cause of gender differences in immunotherapy-associated myocarditis and identified potential treatment strategies. Hormone therapies targeting the endocrine-cardiac-immune pathway may reduce this risk without affecting treatment efficacy.
A ‘door’ into the mitochondrial membrane
A new study has discovered that MTCH2, a protein essential in various cellular processes, acts as a 'door' for proteins to access the mitochondrial membrane. The finding opens up potential avenues for cancer treatments by harnessing apoptosis, a programmed cell death mechanism.
Landscape of molecular contacts: How the coronavirus SARS-CoV-2 communicates with human cells
A team of scientists has identified over 200 direct protein-protein contacts between the SARS-CoV-2 virus and human cells, shedding light on the mechanisms underlying severe COVID-19. The study reveals chains of connections between viral proteins and infection-relevant human genes, with implications for disease severity and treatment.
Rutgers researchers develop method with single-molecule precision to engineer enzyme ‘stickiness’
The Rutgers team developed an analytical toolkit to measure protein-carbohydrate interactions with single-molecule precision. By adjusting the 'stickiness' of enzymes, they aim to enhance cellulose decomposition for biofuels production and improve healthcare targeting protein-based drugs.
The missing link: Fatty acid metabolism impacts plant immunity
A recent study by Zhenzhen Zhao and colleagues found that Arabidopsis plants lacking Acyl Carrier Protein 1 (ACP1) are more resistant to bacterial pathogen Pseudomonas syringae. ACP1 is essential for maintaining hormone homeostasis, which affects plant stress responses.
Complex regulation controls mediator of cancer growth
The study reveals how the activating partner PI5P interacts with two different regions of regulatory protein UHRF1, showing its role in modulating complex proteins. This finding could breathe new life into the search for UHRF1-directed medicines.
'Game-changing' study offers a powerful computer-modeling approach to cell simulations
A new study proposes a powerful computer-modeling approach to cell simulations, reaching unprecedented simulation timescales at all-atom resolution. The technique combines advantages of protein docking and molecular simulations, enabling faster and more precise treatment of human disease.
Coronavirus formation is successfully modeled
Researchers at the University of California, Riverside successfully modeled the formation of SARS-CoV-2 using coarse-grained models, revealing key ingredients and components contributing to its packaging. The study could inform the design of effective antiviral drugs to arrest coronaviruses in their assembly stage.
AI-based screening method could boost speed of new drug discovery
Researchers developed an AI-based screening method that models drug and target protein interactions using natural language processing techniques. The technique achieved high accuracy in identifying promising drug candidates, which can accelerate the exploration of new medicines and repurpose existing ones.
Cell membranes play a larger role than thought in allowing spike proteins on viruses to infect cells
Cell membranes facilitate viral infection by allowing spike proteins to bind and enter cells. The study identifies the role of cell membranes in SARS-CoV-2 variant infections, providing insights into potential therapeutic targets.
Biologists glean insight into repetitive protein sequences
Researchers analyzed proteins from eight species and found that low-complexity regions (LCRs) share similar roles across species, helping proteins join larger-scale assemblies. They also discovered species-specific LCR sequences corresponding to unique functions, such as forming plant cell walls.
Study identifies key protein that drives rheumatoid arthritis damage
A study at Washington State University has identified sulfatase-2 as a critical protein driving damage caused by rheumatoid arthritis. The discovery sheds light on molecular processes behind inflammation in the disease and could lead to improved treatments.
New in-silico-designed protein ‘probes' could pave the way to early diagnosis of neurodegenerative diseases
A team of researchers has designed in silico molecular probes to track the progress of a misbehaving protein linked to neurodegenerative diseases like ALS and FTD. The probes can detect TDP-43 aggregates at high resolution, paving the way for early diagnosis.
Analyzing the potential of AlphaFold in drug discovery
A new study from MIT reveals that computer models predicting molecular interactions, like AlphaFold, need improvement to help identify drug mechanisms of action. Researchers improved the performance of these models using machine-learning techniques, but more work is needed.
Researchers identify key factor in exosome-mediated viral transmission from insects to plants
Exosomes have been identified as possible vehicles for virus transmission, and a recent study found that the saliva protein exportin 6 plays a crucial role in this process. The researchers isolated exosomes from the saliva of insect vectors and showed that they can transport plant virions into rice plants.
Bacterial pore formers pack a punch, one molecule at a time
Researchers developed a single-molecule technique to investigate how bacterial proteins form pores in mammalian cells. They tracked the assembly of perfringolysin O protein and found that it forms pores even before complete ring formation is completed.
UBC researchers discover ‘weak spot’ across major COVID-19 variants
Researchers at UBC have discovered a key vulnerability across all major COVID-19 variants that can be targeted by neutralizing antibodies. The 'master key' identified is the antibody fragment V H Ab6, which effectively neutralizes SARS-CoV-2 by attaching to the epitope on the spike protein.
New research model illuminates how organs communicate with each other
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
Peptide delivered by nasal spray can reduce seizure activity, protect neurons in Alzheimer’s, epilepsy
Researchers developed a peptide that can be administered through nasal spray to reduce seizure activity and protect neurons in both Alzheimer's and epilepsy. The A1R-CT peptide inhibits neurabin, a protein that prevents the overactivation of neurons, allowing for increased action by adenosine receptors.
New study shows how microglia are prompted to change their state to adapt to different areas of the brain
A new study published in Nature reveals that microglia cells change their molecular state to match neighboring neurons, influencing neural circuit function. The researchers found that different types of cortical neurons recruit specific numbers of microglia, which then adapt to the neuron's environment.
Oncoscience | SLFN11’s surveillance role in protein homeostasis
SLFN11 acts as a surveillance factor for protein homeostasis by alleviating proteotoxic stress derived from protein synthesis and maturation. Its lack makes cells vulnerable to anticancer drugs inducing ER and proteotoxic stress, leading to chemoresistance. SLFN11 is also involved in regulating immune response and inflammation.
Using light to restore cell function
University of Cincinnati researchers have discovered a technique using light-activated proteins to normalize dysfunctional mitochondria in cells. This method has the potential to treat certain diseases, including cancer and neurodegenerative disorders.
Enzyme, proteins work together to tidy up tail ends of DNA in dividing cells
Researchers have discovered the mechanism behind enzyme Polα-primase and protein CST's interaction at the ends of chromosomes. The findings reveal an unprecedented role for CST in facilitating Polα-primase activity, shedding light on telomere replication and cell division.
The resolution of a molecular orchestra
A new photoswitching fingerprint analysis overcomes the sub-10 nm resolution barrier in super-resolution microscopy, enabling the imaging of dynamic interactions with other molecules in cells. This breakthrough reveals molecular functions and architectures at the nanoscale, shedding light on cellular processes such as learning and memory.
What new cell biology can AI reveal just by looking at images? A lot!
A team of Chan Zuckerberg Biohub scientists developed a deep-learning method, dubbed
KAIST research team proves how a neurotransmitter may be the key in controlling Alzheimer’s toxicity
A KAIST research team has discovered a new role for somatostatin, a protein-based neurotransmitter, in reducing the toxicity caused by Alzheimers disease. When somatostatin is met with copper and Aβ proteins, it attenuates the toxicity and agglomeration of metal-Aβ complexes.
Evolutionary model predicts partitioning of molecules within cells
Researchers developed a computer model to investigate complex fluids and droplet formation in living cells. The study reveals that even weak interactions can lead to robust emergence of complex behavior, such as droplet formation, which has significant implications for understanding cellular mechanisms.
SARS-CoV-2 variants have developed resistance to human interferons
Researchers at CU Anschutz Medical Campus investigated SARS-CoV-2 variant interactions with diverse interferons, finding the virus has adapted to evade this key front-line defense. The study suggests COVID-19 clinical trials on interferons may need to be reinterpreted based on circulating variants.
Mayo Clinic researchers pinpoint genetic variations that might sway course of COVID-19
Scientists analyzed DNA sequence data from nearly 71,000 people worldwide and identified mutations in ACE2 and TMPRSS2 genes that affect protein expression, influencing COVID-19 susceptibility and severity. The study suggests a potential new diagnostic method based on host cell variation rather than the evolving virus.
Protein discovered in Parkinson’s disease could lead to new treatments
A team of scientists has discovered a key link between the protein αSyn and Parkinson's disease, finding that it interacts with immune responses in neurons. This interaction may play a critical role in the development of the disease, suggesting a potential new approach for treatments by targeting inflammatory pathways.
Putting the brakes on "budding" viruses
Researchers have published the first-ever look at a key stage in the life cycles of measles and Nipah viruses, revealing how future therapies might stop these viruses. The study identifies how paramyxoviruses utilize a host cell lipid for viral spread, providing a new target for developing inhibitors of the assembly process.
LJI scientists discover clue to stopping Lassa virus infection
Researchers at La Jolla Institute for Immunology have identified a critical protein, GSPT1, that facilitates Lassa virus infection. Targeting this protein with an existing drug candidate, CC-90009, shows promise in reducing Lassa virus growth without cell toxicity.
BETting on COVID-19: Study probes role of BET proteins in coronavirus infection
Gladstone researchers discovered that BET proteins play two distinct roles in interacting with SARS-CoV-2 infected human cells: giving the virus a window into cells while helping our cells defend themselves. Blocking certain BET proteins worsens disease symptoms, highlighting the need for targeted therapeutics.
Adhesion from cold to hot
Researchers have developed a supramolecular adhesive that exhibits outstanding gluing properties across a wide range of temperatures. The new adhesive consists of a protein and crown ether component, which form a tight interlocking structure through molecular interactions, resulting in exceptional adhesion even at low temperatures.
Visualization of binding processes of cell-cell adhesion molecules in solution
The study reveals multiple dimeric structures of cadherins in solution, including W-, cross-, and S-shaped dimers. The researchers propose a novel conformation, the S-shaped dimer, and suggest that binding mechanism progresses through sliding motion followed by flipping motion to form stable SS-dimers.
What the mechanical forces behind protein folding can tell us about metastatic cancer
Scientists use a unique tool to apply mechanical forces that affect protein folding, revealing talin's interaction with tumor-suppressing protein DCL1. This discovery provides insight into the antitumor effect of DCL1 and potential new treatments for metastatic cancer.
Protein parts must indeed wiggle and jiggle to work right, new research suggests
Researchers at Johns Hopkins Medicine have probed the atomic structure of proteins, finding that wiggling and movement play a critical role in their ability to function. The study's findings may help scientists design new drugs that can modify or disrupt protein movements to alter their functions.
Changes in protein structure and assembly with fluoride nanoparticles and coexisting ions
A Tokyo University of Science study found that fluoride nanoparticles enhance β-sheet formation in amyloid β proteins, a common feature of Alzheimer's disease. The researchers also discovered that surrounding ions can control this process, paving the way for targeted treatments.
Action of drug compounds in tissue revealed by new technique
Researchers at the University of Birmingham developed a new technique using mass spectrometry to analyze drug-protein interactions in real tissue samples. This allows scientists to predict the therapeutic effect of drugs earlier, enabling more effective treatment options.
Poxvirus proteins enable early strike on immune defences
A new study identifies pox virus proteins that directly interfere with the body's innate immune system, allowing it to evade the host's defense mechanisms. The research team has discovered five 'redox' proteins that interact with Reactive Oxygen Species, which play a key role in destroying pathogens identified by the immune system.
New structure found in cells
A research team, led by Rohit Pappu and Anthony Hyman, found that protein molecules form dynamic clusters at low concentrations, which have structures that encode function. This discovery challenges the long-held assumption that there is no further structure underlying biomolecular condensates.
Moffitt researchers identify pathway that regulates angiogenesis in tumors
YAP1 controls angiogenesis by expressing genes involved in blood vessel formation, and its activity is regulated by PHD2 and VHL under normal oxygen conditions. In hypoxic conditions, YAP1's nuclear localization enables it to interact with HIF1α, leading to increased expression of pro-angiogenic proteins.
Cell biology: RNA granules on the spot
Researchers at LMU demonstrate that Staufen2 and Argonaute proteins form RNA granules that compete with each other to regulate protein translation in neurons. This competition regulates synaptic plasticity, particularly in dendrites and synapses, contributing to learning and memory.
On the way to cell-type materials
Physicists at University of Münster successfully reveal dynamic interaction of molecular shuttles using molecular-dynamic simulations. The study provides detailed insight into how embedded machines function and interact, enabling targeted control of transport properties and catalytic processes.
How bacteria adhere to cells: Basis for the development of a new class of antibiotics
Researchers have deciphered the exact bacterial adhesion mechanism using Bartonella henselae, revealing a key role for trimeric autotransporter adhesins and their interaction with fibronectin. Experimental blocking of these processes almost entirely prevents bacterial adhesion.
Zinc is a key regulator of sperm functions during sperm capacitation process
Researchers found that zinc ion serves as a master-regulator of various processes in sperm to facilitate fertilization. Zinc helps maintain sperm in the non-capacitated state, preventing premature capacitation during artificial insemination.
Investigators identify a new candidate therapeutic target for Parkinson’s disease
Researchers at Brigham and Women's Hospital have identified LIPE, a lipase that degrades triglycerides, as a promising candidate therapeutic target for Parkinson's disease. Inhibiting LIPE reduced alpha-synuclein inclusions and alleviated neurodegeneration in patient-derived neurons and a C. elegans model of toxicity.
Puzzling out the structure of a molecular giant
Researchers at the Kosinski Group used a combination of cryo-electron tomography, single particle cryo-EM, and integrative modelling to create the most complete model of the human NPC to date, covering over 90% of its core. This breakthrough enables scientists to understand the NPC's structure and function in greater detail.
Miniproteins that can launch two-pronged attacks on viral proteins
Researchers designed artificial peptides that can bind to viral proteins, blocking entry into cells and causing viruses to clump together. These 'miniproteins' were found to be thermostable and safe for use in humans, with promising results in lab tests and animal models.
Immune recognition of self and non-self explored in new study
Researchers from Arizona State University investigate autoantibodies in healthy individuals, revealing their pervasiveness and role in human health and disease. The findings aim to improve diagnostics and therapeutics for a range of illnesses.
Warwick researchers identify novel cellular process that help us understand the mechanisms of ageing-related diseases
Researchers at the University of Warwick have identified a novel cellular process called Golgiphagy that helps regulate the degradation of the Golgi complex in cells. This discovery opens new avenues for understanding the underlying mechanisms of diseases such as cancer, Alzheimer's, and Parkinson's.
New database to "SpUR" on cancer research
A new interactive web portal, SpUR, catalogues over 1,000 splicing events found in cancers, highlighting their role in tumor development and progression. The database provides a platform for researchers to study RNA dysregulations in cancer and develop RNA-based anti-cancer drugs.
Prilenia announces publication of data elucidating a mechanism for neuroprotective potential of pridopidine
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.