Articles tagged with Protein Interactions
Researchers discovered a specific glycoprotein, RPTP zeta S3L, that connects to CD33 receptors in the brain, limiting its ability to clean up harmful proteins. This finding may lead to new drug targets and early diagnostics for Alzheimer's disease.
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
Researchers at Brookhaven National Laboratory have identified a zinc chaperone protein called ZNG1, which delivers zinc to the enzyme MAP1. This discovery reveals a key mechanism used by all living things to transport zinc, essential for survival and enzyme function.
The study reveals that ZNG1 is a protein that puts zinc into other 'client' proteins, playing a crucial role in regulating cellular zinc homeostasis. ZNG1's identification opens up a new area of biology for exploration and may be one of the most important regulatory strategies by which humans cope with severe zinc starvation.
A new study from Pennington Biomedical Research Center found that FGF21 is critical for extending lifespan and improving metabolic health in mice fed a low-protein diet. Without FGF21, mice fail to adapt to the diet and exhibit detrimental effects on health.
Researchers at Arizona State University have designed and constructed artificial membrane channels using DNA, allowing selective transport of ions, proteins, and cargo. The channels can be opened and closed with a lock and key mechanism, enabling diverse scientific domains such as biosensing and drug delivery applications.
A team of researchers at Université catholique de Louvain has discovered a way to block the spike protein of SARS-CoV-2, preventing infection and offering potential long-term protection against COVID. The breakthrough involves using multivalent glycoclusters that bind strongly to the virus's surface, effectively 'locking' it out of cells.
Researchers at the University of Missouri are applying AI to analyze protein dynamics, identifying potential target sites for new drug therapies. The approach can simulate protein changes related to conditions like cancer, enhancing the chances of successful therapies.
Researchers used Frontera supercomputer to model coronavirus-receptor interactions, discovering a 'one-two punch' combo that primes virus for fusion. The study provides new understanding of the mechanism behind increased virulence of variants such as delta and omicron.
Researchers at Stockholm University mapped physicochemical properties of proteins in 20,000 organisms, revealing a universal problem that has shaped the proteins of all cellular organisms. This balance between repulsive and attractive forces ensures functional control and is carefully tuned to an organism's environment and lifestyle.
Researchers from the US and Japan have discovered the mechanism of GTP recognition by a tumor-promoting kinase, leading to the evolution of a GTP sensor kinase. This finding could lead to the development of a new cancer-treating drug that targets PI5P4Kβ using GTP instead of ATP.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
The new computational tool, AF2Complex, predicts the structure of protein complexes and their interactions, offering insights into biomolecular mechanisms. The model is based on AlphaFold 2 and performs well in predicting protein structures and complex formations.
Researchers have deciphered the structure of the kinetochore corona, a complex protein assembly that plays a pivotal role in chromosome segregation. The study, published in The EMBO Journal, provides new insights into how this critical process is regulated and offers a framework for future studies on cell division.
Scientists at the University of Bath have developed a new technique called Transcription Block Survival (TBS) to accelerate the discovery of cancer-fighting drugs. TBS identifies molecules that can shut down dangerous proteins before they wreak havoc, by blocking their interaction with cell DNA.
Finnish researchers created a comprehensive map of molecular interactions between 58 human receptor tyrosine kinases (RTKs), revealing key insights into their functions and roles in disease. The study's findings can aid understanding of diseases linked to abnormal RTK activity, particularly cancer.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
The Protein Society has announced its 2022 award winners, who have made significant contributions to protein science. Professor David Goodsell and Professor Jin Zhang received the Carl Brändén Award and Christian B. Anfinsen Award respectively for their groundbreaking work in education and technological achievement.
The study reveals the structure of D13 and its role in assembling into a protein scaffold, which is critical for virus replication. The researchers discovered two ways the proteins interact to form a spherical honeycomb lattice, with a small helix structure playing a key role in assembly.
A multicenter study found mutations in the SARS-CoV-2 N protein associated with increased viral loads and severe disease symptoms. The changes enabled the virus to hijack host cell translation machinery, leading to a life-threatening cytokine storm.
A new model suggests that antibodies select antigens based on their surface characteristics, similar to a child playing on stepping stones. The researchers used DNA origami to simulate the behavior of antibodies and found that they tend to favor closer antigen distances.
Scientists have discovered a promising strategy to treat Ebola virus infections by targeting cellular protein GSPT1, which the virus hijacks for polymerase function. An experimental drug CC-90009 degrades GSPT1, halting viral multiplication.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
The newly developed KANPHOS database provides comprehensive information on kinase-associated protein phosphorylation, facilitating research into neural signaling pathways. The database contains information on phosphoproteins, phosphorylation sites, and participant kinases, allowing for searches based on various parameters.
The blood-brain barrier is regulated by a signaling pathway involving vitronectin and integrin α5, which inhibits transcytosis and maintains barrier integrity. The findings offer insights into the microenvironment's role in maintaining the barrier's permeability.
UC Riverside scientists developed a technique to map tryptophan production, opening the door to new treatment drugs. By understanding how bacteria make tryptophan, researchers can create enzymes that shut down this process, killing invasive bacterial cells without affecting human cells.
Researchers found that tannic acid targets the RBD protein and enzymes involved in viral entry and replication, suggesting its potential as a preventative or therapeutic agent. The polyphenol's low toxicity and anti-inflammatory properties make it an attractive alternative to existing antivirals.
Scientists have discovered that mRNA modifications play a crucial role in the brain's reward learning process and transporting mRNAs to synapses. The study found that removing these modifications impaired flies' ability to learn essential survival skills, highlighting the importance of these modifications in animal function.
A UC Riverside-led team developed a theory and performed simulations to understand how viruses package their genetic material. The research reveals that capsid proteins are inclined to form shells around viral RNAs due to lower stress distribution, which can aid in designing nanocontainers for drug delivery.
Researchers discovered that bacteria suppress membrane protein transport in response to stress, using alarm hormones to regulate the process. This allows the microorganisms to slow down their cellular processes and recover when conditions become more favorable.
The researchers discovered two modes of transport that influence whether and how proteins attach themselves to a surface. The team found that rougher surfaces promote longer flights, while less hydrophobic surfaces facilitate quicker localized adsorption/desorption.
Researchers have identified a crucial nuclear transport mechanism essential for organ growth and development, involving the protein YAP. The study shows that YAP interacts with importin-7 to control its nuclear entry, regulating cell and tissue growth, and potentially targeting diseases such as atherosclerosis and cancer.
Researchers from CCDC, Exscientia, and Oxford University have developed an automated method for informing the design of compound selectivity across protein families. The 'Hotspot API' uses ensemble hotspot maps to quantify the propensity for compounds to exploit interactions in preferred binding sites.
Researchers at University of Texas at Austin create first-ever biologically authentic computer model of HIV-1 virus liposome, shedding light on replication and infectivity. The study reveals key characteristics of the liposome's asymmetry and its role in shaping macroscopic properties.
Researchers have identified a key brain protein to target for new customized drug therapies treating adverse symptoms of developmental disorder subtypes. The study found that mutations in ARHGEF9 lead to intellectual disability through impaired α2 subunit function, which is a central hub for many neurological symptoms.
Researchers developed artificial Sars-CoV-2 virions to study the spike protein's interaction with host cells and its ability to evade the immune system. By understanding this mechanism, they hope to develop targeted therapies and vaccines.
A team of scientists from Martin-Luther-University Halle-Wittenberg and the Max Planck Institute discovered the essential final step in mRNA production. The process involves 16 proteins that precisely control the structure of mRNA, which determines protein function and disease risk.
The study of MUNC long non-coding RNA reveals the importance of experimentally determining its structure to identify functional domains. The researchers found that two structural domains, including six common 'hairpins,' were crucial for regulating gene expression and muscle cell differentiation.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Researchers have discovered new details about HIV's structure, including the position of envelope spike proteins and glycan shields. The findings may help in designing a vaccine that can protect against AIDS.
A new pathway has been discovered to explain how excessive alcohol consumption damages the liver, specifically through mitochondrial dysfunction. By targeting an enzyme called MATα1, researchers believe they can develop a new treatment for people suffering from alcohol-associated liver disease.
A team of researchers has identified over 250 gene activators in human cells, expanding our understanding of transcriptional regulation and its role in cancer. The study also reveals new insights into how proteins interact with each other to regulate gene expression, potentially leading to the development of targeted therapies.
A comprehensive study has revealed over 7,000 human transcription factor (TF) protein-protein interactions, with most playing important roles in transcriptional regulation. The study identifies groups of TFs with specific biological functions, such as chromatin remodelling and RNA splicing.
Scientists at the University of Münster and Max Planck Institute have clarified the molecular basis for cellular degradation processes by elucidating the 3D structure of Mon1/Ccz1. The complex determines which vesicles deliver their content to the lysosome, a key step in protein regulation.
Dorothee Dormann and Rosa Rademakers are collaborating on a research project to understand the causes of frontotemporal dementia, a group of brain disorders affecting the frontal and temporal lobes. The researchers aim to identify the role of the FUS protein in this disease and its interactions with other proteins.
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
Researchers found that mitochondria can respire away harmful substances to protect protein folding, revealing an unexpected 'patron saint' role. This mechanism is triggered by reductive stress and protects proteins destined for export, showcasing the flexibility of plant mitochondria.
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
A new study by Washington State University scientists reveals that viral proteins interact with each other to disable plant defenses, allowing viruses to hijack their hosts. When some of these proteins are disabled, the virus cannot move from cell to cell, highlighting a promising approach to prevent crop losses.
Researchers at the University of Oklahoma have developed a molecular framework that solves the challenge of predicting peptide structures. The framework bridges experimental and computer sciences, enabling the use of machine learning and artificial intelligence to model peptide structures for materials engineering.
Scientists at MIT have developed a screening method to study protein-protein interactions, which are crucial in understanding disease mechanisms. The researchers created a synthetic molecule that binds tightly to a protein implicated in cancer metastasis, providing a potential tool for disrupting disease-causing interactions.
Researchers at the University of Missouri identified 46 specific mutations in the Omicron variant that enable it to evade pre-existing antibodies. These mutations are particularly prevalent in the region where antibodies bind to the virus, making them a key target for future antiviral treatments.
A team of Weill Cornell Medicine investigators created a comprehensive atlas, called Tau interactome, that maps all the Tau protein's interactions with other proteins in human neurons. They found that mutations diminish Tau-mitochondrial protein interaction may hamper energy production and lead to cognitive decline.
Scientists at Scripps Research have devised a method that can rapidly characterize antibodies using high-resolution, low-temperature electron microscopy (cryo-EM). This technique enables the identification of specific antibodies in fraction of time needed for traditional approach.
Northwestern University scientists have identified a key mechanism used by the Zika virus to evade the antiviral response of host cells. The study reveals how the virus suppresses interferon signaling to gain access to cells, providing a new target for antiviral therapeutics.
Biologists at the University of Leeds created high-resolution images of the foot-and-mouth disease virus, revealing fibril structures that play a key role in replication. These findings could lead to new antiviral treatments for diseases caused by the virus.
Researchers found that knocking down LCDR in lung cancer cells promotes apoptosis, providing a potential new target for diagnosis and treatment. Additionally, targeting LCDR shows promise as a therapeutic strategy and has diagnostic value for lung adenocarcinoma.
Researchers at VTC have developed a promising three-pronged approach to treating glioblastoma, a lethal brain cancer. By inhibiting two specific proteins with temozolomide, they created an effective 'triple combinational therapy' that overcame chemoresistance.
Scientists have discovered a new layer of regulation in plant-microbe interactions using peanut studies. An antisense long-noncoding RNA, DONE40, was found to bind to a protein involved in epigenetic control, suggesting a conserved function across plants and animals.
Researchers have discovered a new mechanism for regulating organelle contacts, essential for producing specific lipids in nerve cells. The study reveals that phosphorylation of a protein at the peroxisomes can block interaction with the endoplasmic reticulum.