Researchers at Brigham and Women's Hospital have identified LIPE, a lipase that degrades triglycerides, as a promising candidate therapeutic target for Parkinson's disease. Inhibiting LIPE reduced alpha-synuclein inclusions and alleviated neurodegeneration in patient-derived neurons and a C. elegans model of toxicity.
SourceBrigham and Women's Hospital·Journalnpj Parkinson s Disease·TypeExperimental study·DateJun 9, 2022
Researchers designed artificial peptides that can bind to viral proteins, blocking entry into cells and causing viruses to clump together. These 'miniproteins' were found to be thermostable and safe for use in humans, with promising results in lab tests and animal models.
SourceIndian Institute of Science (IISc)·JournalNature Chemical Biology·DateJun 4, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at the University of Warwick have identified a novel cellular process called Golgiphagy that helps regulate the degradation of the Golgi complex in cells. This discovery opens new avenues for understanding the underlying mechanisms of diseases such as cancer, Alzheimer's, and Parkinson's.
SourceUniversity of Warwick·JournalCell Reports·DateMay 31, 2022
Researchers from Arizona State University investigate autoantibodies in healthy individuals, revealing their pervasiveness and role in human health and disease. The findings aim to improve diagnostics and therapeutics for a range of illnesses.
SourceArizona State University·JournalCell Reports·TypeMeta-analysis·DateMay 31, 2022
A new interactive web portal, SpUR, catalogues over 1,000 splicing events found in cancers, highlighting their role in tumor development and progression. The database provides a platform for researchers to study RNA dysregulations in cancer and develop RNA-based anti-cancer drugs.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Cell Biology·DateMay 26, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers discovered a specific glycoprotein, RPTP zeta S3L, that connects to CD33 receptors in the brain, limiting its ability to clean up harmful proteins. This finding may lead to new drug targets and early diagnostics for Alzheimer's disease.
SourceJohns Hopkins Medicine·JournalJournal of Biological Chemistry·DateMay 25, 2022
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
The study reveals that ZNG1 is a protein that puts zinc into other 'client' proteins, playing a crucial role in regulating cellular zinc homeostasis. ZNG1's identification opens up a new area of biology for exploration and may be one of the most important regulatory strategies by which humans cope with severe zinc starvation.
SourceVanderbilt University Medical Center·JournalCell·TypeExperimental study·DateMay 17, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers at Brookhaven National Laboratory have identified a zinc chaperone protein called ZNG1, which delivers zinc to the enzyme MAP1. This discovery reveals a key mechanism used by all living things to transport zinc, essential for survival and enzyme function.
SourceDOE/Brookhaven National Laboratory·JournalCell Reports·TypeExperimental study·DateMay 17, 2022
A new study from Pennington Biomedical Research Center found that FGF21 is critical for extending lifespan and improving metabolic health in mice fed a low-protein diet. Without FGF21, mice fail to adapt to the diet and exhibit detrimental effects on health.
SourcePennington Biomedical Research Center·JournalNature Communications·TypeExperimental study·DateMay 13, 2022
Researchers at Arizona State University have designed and constructed artificial membrane channels using DNA, allowing selective transport of ions, proteins, and cargo. The channels can be opened and closed with a lock and key mechanism, enabling diverse scientific domains such as biosensing and drug delivery applications.
SourceArizona State University·JournalNature Communications·TypeExperimental study·DateMay 10, 2022
A team of researchers at Université catholique de Louvain has discovered a way to block the spike protein of SARS-CoV-2, preventing infection and offering potential long-term protection against COVID. The breakthrough involves using multivalent glycoclusters that bind strongly to the virus's surface, effectively 'locking' it out of cells.
SourceUniversité catholique de Louvain·JournalNature Communications·TypeExperimental study·DateMay 10, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at the University of Missouri are applying AI to analyze protein dynamics, identifying potential target sites for new drug therapies. The approach can simulate protein changes related to conditions like cancer, enhancing the chances of successful therapies.
SourceUniversity of Missouri-Columbia·JournalNature Communications·DateMay 5, 2022
Researchers used Frontera supercomputer to model coronavirus-receptor interactions, discovering a 'one-two punch' combo that primes virus for fusion. The study provides new understanding of the mechanism behind increased virulence of variants such as delta and omicron.
SourceUniversity of Texas at Austin, Texas Advanced Computing Center·JournalNature Communications·TypeComputational simulation/modeling·DateMay 4, 2022
Researchers at Stockholm University mapped physicochemical properties of proteins in 20,000 organisms, revealing a universal problem that has shaped the proteins of all cellular organisms. This balance between repulsive and attractive forces ensures functional control and is carefully tuned to an organism's environment and lifestyle.
SourceStockholm University·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis·DateMay 2, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers from the US and Japan have discovered the mechanism of GTP recognition by a tumor-promoting kinase, leading to the evolution of a GTP sensor kinase. This finding could lead to the development of a new cancer-treating drug that targets PI5P4Kβ using GTP instead of ATP.
SourceUniversity of Cincinnati·JournalStructure·TypeExperimental study·DateMay 2, 2022
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
SourceArizona State University·JournalNature Communications·TypeExperimental study·DateApr 28, 2022
The new computational tool, AF2Complex, predicts the structure of protein complexes and their interactions, offering insights into biomolecular mechanisms. The model is based on AlphaFold 2 and performs well in predicting protein structures and complex formations.
SourceGeorgia Institute of Technology·JournalNature Communications·TypeComputational simulation/modeling·DateApr 18, 2022
Researchers have deciphered the structure of the kinetochore corona, a complex protein assembly that plays a pivotal role in chromosome segregation. The study, published in The EMBO Journal, provides new insights into how this critical process is regulated and offers a framework for future studies on cell division.
SourceMax Planck Institute of Molecular Physiology·JournalThe EMBO Journal·TypeExperimental study·DateApr 8, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Scientists at the University of Bath have developed a new technique called Transcription Block Survival (TBS) to accelerate the discovery of cancer-fighting drugs. TBS identifies molecules that can shut down dangerous proteins before they wreak havoc, by blocking their interaction with cell DNA.
SourceUniversity of Bath·JournalJACS Au·TypeExperimental study·DateApr 7, 2022
Finnish researchers created a comprehensive map of molecular interactions between 58 human receptor tyrosine kinases (RTKs), revealing key insights into their functions and roles in disease. The study's findings can aid understanding of diseases linked to abnormal RTK activity, particularly cancer.
SourceUniversity of Helsinki·JournalEMBO Reports·DateApr 7, 2022
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
SourceGIST (Gwangju Institute of Science and Technology)·JournalJournal of Cheminformatics·TypeComputational simulation/modeling·DateApr 5, 2022
The Protein Society has announced its 2022 award winners, who have made significant contributions to protein science. Professor David Goodsell and Professor Jin Zhang received the Carl Brändén Award and Christian B. Anfinsen Award respectively for their groundbreaking work in education and technological achievement.
SourceThe Protein Society·TypeNews article·DateApr 4, 2022
The study reveals the structure of D13 and its role in assembling into a protein scaffold, which is critical for virus replication. The researchers discovered two ways the proteins interact to form a spherical honeycomb lattice, with a small helix structure playing a key role in assembly.
SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalNature Communications·TypeExperimental study·DateMar 31, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A multicenter study found mutations in the SARS-CoV-2 N protein associated with increased viral loads and severe disease symptoms. The changes enabled the virus to hijack host cell translation machinery, leading to a life-threatening cytokine storm.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Communications·TypeObservational study·DateMar 27, 2022
A new model suggests that antibodies select antigens based on their surface characteristics, similar to a child playing on stepping stones. The researchers used DNA origami to simulate the behavior of antibodies and found that they tend to favor closer antigen distances.
SourceKTH, Royal Institute of Technology·JournalNature Computational Science·TypeObservational study·DateMar 24, 2022
Scientists have discovered a promising strategy to treat Ebola virus infections by targeting cellular protein GSPT1, which the virus hijacks for polymerase function. An experimental drug CC-90009 degrades GSPT1, halting viral multiplication.
SourceLa Jolla Institute for Immunology·JournalCell Reports·TypeExperimental study·DateMar 22, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
The newly developed KANPHOS database provides comprehensive information on kinase-associated protein phosphorylation, facilitating research into neural signaling pathways. The database contains information on phosphoproteins, phosphorylation sites, and participant kinases, allowing for searches based on various parameters.
SourceFujita Health University·JournalCells·TypeExperimental study·DateMar 16, 2022
The blood-brain barrier is regulated by a signaling pathway involving vitronectin and integrin α5, which inhibits transcytosis and maintains barrier integrity. The findings offer insights into the microenvironment's role in maintaining the barrier's permeability.
SourceHarvard Medical School·JournalNeuron·TypeExperimental study·DateMar 15, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
UC Riverside scientists developed a technique to map tryptophan production, opening the door to new treatment drugs. By understanding how bacteria make tryptophan, researchers can create enzymes that shut down this process, killing invasive bacterial cells without affecting human cells.
SourceUniversity of California - Riverside·JournalProceedings of the National Academy of Sciences·DateMar 10, 2022
A UC Riverside-led team developed a theory and performed simulations to understand how viruses package their genetic material. The research reveals that capsid proteins are inclined to form shells around viral RNAs due to lower stress distribution, which can aid in designing nanocontainers for drug delivery.
SourceUniversity of California - Riverside·JournalACS Nano·TypeComputational simulation/modeling·DateMar 9, 2022
Researchers found that tannic acid targets the RBD protein and enzymes involved in viral entry and replication, suggesting its potential as a preventative or therapeutic agent. The polyphenol's low toxicity and anti-inflammatory properties make it an attractive alternative to existing antivirals.
SourceInstitut national de la recherche scientifique - INRS·JournalInternational Journal of Molecular Sciences·DateMar 9, 2022
Scientists have discovered that mRNA modifications play a crucial role in the brain's reward learning process and transporting mRNAs to synapses. The study found that removing these modifications impaired flies' ability to learn essential survival skills, highlighting the importance of these modifications in animal function.
SourceUniversity of Birmingham·JournalNature Communications·TypeExperimental study·DateMar 9, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers discovered that bacteria suppress membrane protein transport in response to stress, using alarm hormones to regulate the process. This allows the microorganisms to slow down their cellular processes and recover when conditions become more favorable.
SourceMax-Planck-Gesellschaft·JournalNature Communications·TypeExperimental study·DateMar 7, 2022
The researchers discovered two modes of transport that influence whether and how proteins attach themselves to a surface. The team found that rougher surfaces promote longer flights, while less hydrophobic surfaces facilitate quicker localized adsorption/desorption.
SourceRice University·JournalThe Journal of Chemical Physics·TypeExperimental study·DateMar 7, 2022
Researchers have identified a crucial nuclear transport mechanism essential for organ growth and development, involving the protein YAP. The study shows that YAP interacts with importin-7 to control its nuclear entry, regulating cell and tissue growth, and potentially targeting diseases such as atherosclerosis and cancer.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Communications·TypeExperimental study·DateMar 4, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers from CCDC, Exscientia, and Oxford University have developed an automated method for informing the design of compound selectivity across protein families. The 'Hotspot API' uses ensemble hotspot maps to quantify the propensity for compounds to exploit interactions in preferred binding sites.
SourceCCDC - Cambridge Crystallographic Data Centre·JournalJournal of Chemical Information and Modeling·DateMar 2, 2022
Researchers at University of Texas at Austin create first-ever biologically authentic computer model of HIV-1 virus liposome, shedding light on replication and infectivity. The study reveals key characteristics of the liposome's asymmetry and its role in shaping macroscopic properties.
SourceUniversity of Texas at Austin, Texas Advanced Computing Center·JournalPLOS Computational Biology·TypeComputational simulation/modeling·DateFeb 23, 2022
Researchers developed artificial Sars-CoV-2 virions to study the spike protein's interaction with host cells and its ability to evade the immune system. By understanding this mechanism, they hope to develop targeted therapies and vaccines.
SourceMax-Planck-Gesellschaft·JournalNature Communications·TypeExperimental study·DateFeb 22, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers have identified a key brain protein to target for new customized drug therapies treating adverse symptoms of developmental disorder subtypes. The study found that mutations in ARHGEF9 lead to intellectual disability through impaired α2 subunit function, which is a central hub for many neurological symptoms.
SourceUniversity of Nevada, Las Vegas·JournalNature·DateFeb 22, 2022
A team of scientists from Martin-Luther-University Halle-Wittenberg and the Max Planck Institute discovered the essential final step in mRNA production. The process involves 16 proteins that precisely control the structure of mRNA, which determines protein function and disease risk.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalGenes & Development·TypeExperimental study·DateFeb 21, 2022
The study of MUNC long non-coding RNA reveals the importance of experimentally determining its structure to identify functional domains. The researchers found that two structural domains, including six common 'hairpins,' were crucial for regulating gene expression and muscle cell differentiation.
SourceUniversity of Alabama at Birmingham·JournalCell Reports·TypeExperimental study·DateFeb 21, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Researchers have discovered new details about HIV's structure, including the position of envelope spike proteins and glycan shields. The findings may help in designing a vaccine that can protect against AIDS.
SourceUniversity of Washington·JournalCell·TypeImaging analysis·DateFeb 16, 2022
A new pathway has been discovered to explain how excessive alcohol consumption damages the liver, specifically through mitochondrial dysfunction. By targeting an enzyme called MATα1, researchers believe they can develop a new treatment for people suffering from alcohol-associated liver disease.
SourceCedars-Sinai Medical Center·JournalNature Communications·DateFeb 14, 2022
A team of researchers has identified over 250 gene activators in human cells, expanding our understanding of transcriptional regulation and its role in cancer. The study also reveals new insights into how proteins interact with each other to regulate gene expression, potentially leading to the development of targeted therapies.
SourceUniversity of Toronto·JournalMolecular Cell·TypeExperimental study·DateFeb 10, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A comprehensive study has revealed over 7,000 human transcription factor (TF) protein-protein interactions, with most playing important roles in transcriptional regulation. The study identifies groups of TFs with specific biological functions, such as chromatin remodelling and RNA splicing.
SourceUniversity of Helsinki·JournalNature Communications·DateFeb 9, 2022
Scientists at the University of Münster and Max Planck Institute have clarified the molecular basis for cellular degradation processes by elucidating the 3D structure of Mon1/Ccz1. The complex determines which vesicles deliver their content to the lysosome, a key step in protein regulation.
SourceUniversity of Münster·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 2, 2022
Dorothee Dormann and Rosa Rademakers are collaborating on a research project to understand the causes of frontotemporal dementia, a group of brain disorders affecting the frontal and temporal lobes. The researchers aim to identify the role of the FUS protein in this disease and its interactions with other proteins.
SourceJohannes Gutenberg Universitaet Mainz·DateFeb 1, 2022
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalChemical Reviews·DateJan 27, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers found that mitochondria can respire away harmful substances to protect protein folding, revealing an unexpected 'patron saint' role. This mechanism is triggered by reductive stress and protects proteins destined for export, showcasing the flexibility of plant mitochondria.
SourceUniversity of Münster·JournalThe Plant Cell·DateJan 26, 2022
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
SourceKumamoto University·JournalMaterials Today Bio·TypeExperimental study·DateJan 25, 2022
A new study by Washington State University scientists reveals that viral proteins interact with each other to disable plant defenses, allowing viruses to hijack their hosts. When some of these proteins are disabled, the virus cannot move from cell to cell, highlighting a promising approach to prevent crop losses.
SourceWashington State University·JournalFrontiers in Plant Science·TypeExperimental study·DateJan 25, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at the University of Oklahoma have developed a molecular framework that solves the challenge of predicting peptide structures. The framework bridges experimental and computer sciences, enabling the use of machine learning and artificial intelligence to model peptide structures for materials engineering.
SourceUniversity of Oklahoma·JournalScience Advances·DateJan 25, 2022
Scientists at MIT have developed a screening method to study protein-protein interactions, which are crucial in understanding disease mechanisms. The researchers created a synthetic molecule that binds tightly to a protein implicated in cancer metastasis, providing a potential tool for disrupting disease-causing interactions.
SourceMassachusetts Institute of Technology Department of Biology·JournaleLife·TypeExperimental study·DateJan 25, 2022
Researchers at the University of Missouri identified 46 specific mutations in the Omicron variant that enable it to evade pre-existing antibodies. These mutations are particularly prevalent in the region where antibodies bind to the virus, making them a key target for future antiviral treatments.
SourceUniversity of Missouri-Columbia·JournalJournal of Autoimmunity·DateJan 21, 2022
A team of Weill Cornell Medicine investigators created a comprehensive atlas, called Tau interactome, that maps all the Tau protein's interactions with other proteins in human neurons. They found that mutations diminish Tau-mitochondrial protein interaction may hamper energy production and lead to cognitive decline.
Scientists at Scripps Research have devised a method that can rapidly characterize antibodies using high-resolution, low-temperature electron microscopy (cryo-EM). This technique enables the identification of specific antibodies in fraction of time needed for traditional approach.
SourceScripps Research Institute·JournalScience Advances·DateJan 19, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Northwestern University scientists have identified a key mechanism used by the Zika virus to evade the antiviral response of host cells. The study reveals how the virus suppresses interferon signaling to gain access to cells, providing a new target for antiviral therapeutics.
SourceNorthwestern University·JournalJournal of Virology·DateJan 18, 2022