Articles tagged with Proteomes
Researchers have identified a new class of small molecules that boost the cell's natural recycling machinery to destroy an immune-modulating enzyme called IDO1. This approach takes a bolder approach than traditional drug design, eliminating disease-causing proteins altogether and opening up new possibilities for cancer treatment.
A new study found that proteins containing a widespread structural motif are more likely to misfold in E. coli. Essential proteins with the motif are more likely to be rescued by chaperones, suggesting an evolutionary mechanism to repair them.
Researchers identified 251 genetic variants that significantly affect circulating protein levels in Greenlanders, showing stronger genetic control over certain proteins in the Inuit population. The study uncovered 70 previously unreported associations and found links between Arctic-adapted genes and disease development.
Researchers at Charité – Universitätsmedizin Berlin have developed a method to predict the effects of mutations in yeast by analyzing the proteome. The study reveals that small genetic mutations can have significant impacts on cell growth, especially under altered conditions.
A new study has mapped thousands of proteins in human blood to reveal unique molecular fingerprints for each individual. This atlas will enable blood tests to distinguish troubling signs from common ones, and provide a baseline for comparison that healthcare providers can use to flag early deviations.
Researchers identified 33 plasma proteins that differ significantly in patients with ALS, suggesting the disease could be detected up to 10 years before symptoms appear. Machine learning models showed strong performance in separating ALS cases from non-ALS cases, with an accuracy of over 98.3%.
Researchers at Purdue University have developed a new method to study biochemical processes that impair the immune system's ability to recognize and kill cancer cells. The method involves tracking RNA-binding proteins and extracellular vesicles, which can compromise immunotherapy.
A study by DGIST researchers reveals that protein-absorptive microplastics disrupt brain cell functions and induce inflammatory responses. The research team used proteomics analysis to examine how microplastics bind to proteins and alter cellular functions.
Aging and depression are linked to complex brain-body communication, with organs aging at different rates and influencing disease susceptibility. Dr. Hamilton Oh's research reveals how immune cells and metabolic organs amplify or dampen mood symptoms, offering novel therapeutic targets.
Researchers developed a serum proteomics-based prediction model to identify biomarkers involved in ADPKD progression. The study identified 29 proteins linked to immune system, fat transport, and metabolism, which can predict kidney function decline rate. This breakthrough could lead to more accurate and earlier diagnosis of ADPKD.
Researchers discovered a potential vulnerability in P. falciparum by inducing protein aggregation, leading to reduced parasite growth. The study may lead to novel antimalarial strategies targeting the parasite's internal protein folding machinery.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
Penghu 1, discovered on the seabed of the Penghu Channel in Taiwan, is revealed to be a Denisovan mandible dating back to 10,000 years ago. The fossil's molecular identification sheds light on the mysterious distribution and appearance of Denisovans in eastern Asia.
Researchers have created a comprehensive database of protein changes in mice tissues due to aging, providing new insights into age-related diseases. The study reveals proteins that increase with age and improve understanding of the molecular mechanisms underlying aging.
A new proteomics study explores the relationship between protein and transcript levels in young-adult and old mice bones. The research identifies key targets associated with bone mineral density and aging, shedding light on protein-specific changes that occur with age.
A study published in ACS' Journal of Proteome Research found six proteins that could be used as targets for diagnosing and treating early-onset preeclampsia. These proteins may be linked to cardiovascular complications or the estrogen cycle, suggesting a promising first step toward improved detection and treatment.
Researchers validate increase of specific t-Cys sites associated with aging in human proteome, suggesting potential role in age-related diseases. The study expands beyond classical proteinopathic paradigms, highlighting trioxidized cysteine as a key molecular mechanism underlying aging.
Researchers developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets. PHAb10 and PHAb11 showed robust antibacterial activity against various bacterial species, including those resistant to traditional antibiotics.
A study by TUM researchers discovered four subtypes of Amyotrophic Lateral Sclerosis (ALS) with different molecular processes, including sex differences. The findings suggest repurposing an approved cancer drug targeting the MAPK pathway as a promising therapeutic approach for ALS.
Researchers used a novel deep proteomics approach to investigate the effects of aging and resistance training on skeletal muscle. The study found that aging predominantly affects non-contractile proteins, while resistance training has minimal effects on protein abundance.
Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins. The study identified over 600 new effector proteins that could be used therapeutically, including those that can efficiently degrade or stabilize target proteins.
Researchers have mapped the protein composition of brain endothelial cells, revealing dysregulation of key molecules involved in cellular processes. This study provides a framework for understanding endothelial signaling pathways during aging and serves as a data basis for future analyses of brain endothelial function.
Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.
The A3D-MOBD is a comprehensive database for studying protein aggregation in twelve model organisms. It contains over half a million predictions of protein regions prone to forming aggregates, providing insights into the basis of this phenomenon.
Researchers found a total of 4,721 proteins altered with age in the murine ovary, including upregulated ECM proteins associated with fibrosis. Age-dependent changes also affect immune response pathways and unique immune cell populations.
Researchers identified a protective protein whose level declines with sleep deprivation, leading to neuronal death. PTN levels could serve as an indicator of cognitive impairment resulting from insomnia.
Researchers at UNC School of Medicine identified molecular pathways critical for heart development, revealing that the mevalonate pathway regulates embryonic heart cell cycling and signaling molecules. This study provides a foundational data set to identify biological causes of congenital heart disease.
A team of researchers conducted the largest proteomic study on yeast cells to gain a detailed picture of previously unknown gene functions. The study revealed general principles governing protein expression and identified thousands of proteins with their biophysical properties.
The team developed a technology to globally assess Fe-S cluster binding in an entire proteome without laborious protein purification or radioisotopes. The study found differential sensitivity of iron-sulfur clusters to iron limitation and pathway impairment, prioritizing iron-sulfur cluster delivery in E. coli.
Researchers identified 92 proteins in the spider's venom, including cysteine-rich peptides with potential therapeutic applications. The toxins were found to be effective in paralyzing crickets and may become active ingredients for pharmaceuticals and biological insecticides.
A new cancer protein profile database has been created by KTH Royal Institute of Technology, mapping 1,463 proteins to 12 different cancer types. This database allows for the identification of individual cancer types using just a drop of blood, providing a promising new approach to cancer prediction and diagnosis.
A recent study published in Nature Communications reveals that nascent peptide chains with N-terminal sequences rich in aspartic acid or glutamic acid can lead to abortion of translation in eukaryotic cells through intrinsic ribosome destabilization (IRD). This phenomenon is associated with biased amino acid usage in proteomes, where t...
KU and UChicago researchers are working on identifying human gene sequences that respond to drug therapies through RNA splicing. They hope to overcome the 'undruggable proteome' problem, where approximately 70% of proteins cannot be targeted by drugs.
Researchers found 560 proteins were differentially expressed, with 32 significantly altered, in reductive stress hearts. The proteome signature revealed oxidative stress-related pathways and mitochondrial dysfunction.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
A proteomic study of 2,002 tumors identified 11 distinct molecular subtypes across 14 tissue-based cancer types, including breast, lung, and brain cancers. These subtypes provide new insights into the deregulated pathways and processes in tumors that make them cancerous.
Scientists at the Max Planck Institute of Biochemistry have discovered a new subtype of acute myeloid leukemia (AML) characterized by high amounts of mitochondrial proteins and altered mitochondrial metabolism. This subtype, called Mito-AML, shows clinical resistance to chemotherapy and can be effectively combated with inhibitors again...
Researchers found that non-mutated Apolipoprotein E was strongly enriched in dementia patients' brains, correlating with dementia diagnosis. Even those without the disease-driving APOE ε4 allele showed significant levels of ApoE peptides.
Researchers are developing new methods to identify and characterize unknown proteins, including those with multiple forms and modifications. Artificial intelligence-based tools are also helping predict protein structures and functions, providing clues to their roles in health and disease.
A new approach has been developed to identify proteins affected by pollutants and chemicals, allowing for early detection of harmful biological effects. The method, called PISA, can be used to study the interactions between chemicals and proteins, revealing potential toxicity pathways.
Researchers identified six human blood proteins, including serum albumin and immunoglobulin G, in the red paint of a 1000-year-old gold mask. The presence of bird egg proteins suggests the use of a binding material to preserve the paint on the metal surface.
The PROTEIN-ID project aims to create a device that can read the fingerprint of proteins and identify their sequence, enabling rapid detection of diseases. The innovative device will use spectroscopic techniques, machine learning, and nanoscale sensors to analyze protein structures.
A new public platform catalogs and curates data on salivary proteins, providing rich evidence for noninvasive diagnostics and precision medicine. The Human Salivary Proteome Wiki aims to harness the full potential of saliva for diagnosis, risk prediction, and therapy.
Researchers have mapped 90% of the human proteome, revealing key interactions between proteins that influence human health. This breakthrough has implications for understanding COVID-19 and developing precision medicine.
Researchers have identified specific proteins in bones that can help estimate the post-mortem submerged interval, which is challenging due to various environmental factors. The study found that certain proteins decrease or modify over time, providing potential biomarkers for estimating the length of time a body has been underwater.
Researchers defined the proteome of neural stem cell niches and compared it to other brain regions to identify key regulators for neurogenesis. The findings suggest that the unique niche environment allows neurogenesis in the adult mammalian brain, and may contribute to the stiffness of neural stem cell niches.
A new co-regulation map of the human proteome has been created, enabling the prediction and assignment of functions to uncharacterized human proteins. The map reveals unexpected partnerships between proteins, including peroxisomal membrane protein PEX11β with mitochondrial respiration factors.
Researchers analyzed sweet potato leaves and roots to gain a better understanding of their protein makeup. They identified 3,143 unique proteins from leaves and 2,928 from roots, providing new insights into the plant's genome.
Scientists discovered that sex and diet substantially affect the proteome, a collection of proteins in an animal cell. Understanding these interactions may lead to personalized treatments for humans. The study analyzed large public datasets on human and mouse proteotypes, diet, and genetic status.
Researchers analyzed human plasma proteins over time, identifying 30 proteins regulated by the circadian clock and affecting cancer, immune function, and metabolism. Circadian misalignment altered glucose homeostasis and energy metabolism pathways.
Researchers have discovered how nutmeg helps protect the liver, using a mouse animal model of liver toxicity. The spice was shown to restore healthy levels of lipids and acylcarnitines, and a specific compound, myrislignan, had a strong protective effect against liver damage.
The symposium presented new discoveries about oral exRNA biology, including its use as a biomarker for diagnosing disease and tracking its progression. The study of salivary proteome and its diagnostic applications was funded by the National Institute of Dental and Craniofacial Research.
Researchers used fruit fly hybrids to discover the proteome's plasticity during development, which may provide insights into rapid phenotypic variation and disease mechanisms. The study also sheds light on how proteins interact with each other and how the proteostasis network coordinates protein synthesis, folding, and degradation.
A team of researchers has created the first atlas of the healthy human heart's protein composition, which will aid in identifying differences between healthy and diseased hearts. The study found that despite functional differences between the right and left halves of the heart, they share similar protein compositions.
Researchers evaluated the impact of eating dried cranberries on gut microbiome health, finding positive but statistically insignificant changes. The study's findings motivate further exploration into the role of dried cranberries in whole-body health.
Researchers identified protein patterns in bones that change with age, suggesting potential biomarkers for determining age in human remains. The study's findings have implications for forensic science and may help reconstruct ancient species relationships.
Researchers created a detailed analysis of human proteins in cultivated cell lines, mapping them to cellular compartments and substructures with single-cell resolution. The study found that about half of the proteins are found in more than one compartment, shedding new light on cellular complexity.
A major milestone in proteomics research has been achieved with the creation of a vast library of over 330,000 synthetic peptides representing all canonical human proteins. This achievement is expected to enhance protein identification and quantification by alleviating current issues in this field.
The Human SRMAtlas provides highly specific mass spectrometry assays for targeted identification and reproducible quantification of any human protein. This resource enables the measurement of 99.7% of the annotated human proteins, revolutionizing systems-level understanding of physiology and disease.
Researchers create new tool to define metabolic differences between individuals, paving the way for precision medicine. By combining genetic and protein data, scientists can better understand how patients respond to medication and tailor treatments accordingly.