“The results indicated a significant increase in cumulative t-Cys levels and the total number of t-Cys residues in aging and aged mice proteomes compared to young groups.”
BUFFALO, NY- August 27, 2024 – A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15 on July 25, 2024, entitled, “ Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms .”
Oxidative stress (OS) - characterized by an imbalance between oxidants and antioxidants - leads to the formation of oxidative posttranslational modifications (PTMs), including those involving cysteine (Cys) residues in aging proteomes. Specifically, the formation of trioxidized Cys (t-Cys) results in permanent protein damage. Recent findings in rodents have revealed that irregular regulation of t-Cys residues in the aging proteome disrupts homeostatic phosphorylation signaling, leading to alterations in proteins similar to those caused by phosphorylated serine (p-Ser) residues.
In this perspective, researchers José Antonio Sánchez Milán, María Mulet, Aida Serra and Xavier Gallart-Palau from University Hospital Arnau de Vilanova (HUAV) and University of Lleida (UdL), present novel data, validating the increase of specific t-Cys sites associated with aging in a blood-related circulating human proteome.
"The scope and findings included here support the hypothesis that t-Cys residues may serve as important mechanistic and biological markers, warranting further exploration in the context of unhealthy aging and age-related major diseases.”
Continue reading: DOI: https://doi.org/10.18632/aging.206036
Correspondence Authors: Aida Serra - aida.serra@udl.cat , and Xavier Gallart-Palau - xgallart@irblleida.cat
Video short: https://www.youtube.com/watch?v=roO_8WMGak8
Keywords: oxidative stress, unhealthy aging, t-Cys, aging diseases, aging proteome
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The journal Aging aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)
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Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms
25-Jul-2024
The authors assert that they possess no conflicting interests with respect to the information and findings disclosed. The interpretations presented in this work are founded on the knowledge of the authors and scientific data collected and are those of the authors, not necessarily those of the governmental organizations that financed the study.