Rho Family

ROP signaling: Origin at dawn of multicellular plant life

Researchers found that ROP proteins evolved during the transition from unicellular to multicellular plant life. ROP proteins are highly conserved between land plants and streptophyte algae, excluding certain species. The study suggests that ROP signaling may have contributed to the evolution of multicellularity in plants.

SourceGregor Mendel Institute of Molecular Plant Biology·JournalCurrent Biology·TypeExperimental study·DateNov 30, 2023

Miracle math determines the dynamically coordinated regulation of edge velocity by Rho GTPases

A new study develops an algorithm to decode the coordinated regulation of cell-edge velocity by Rho GTPases, revealing specific characteristics of each enzyme. The model predicts edge velocity from activity time series with high accuracy.

SourceNara Institute of Science and Technology·JournalCell Reports·DateMar 16, 2023

Oncotarget: Simvastatin is a potential candidate drug in ovarian clear cell carcinomas

Ovarian clear cell carcinoma (OCCC) remains a rare subtype with poor prognosis. Simvastatin efficiently controlled OCCC proliferation and migration, demonstrating potential as a candidate drug.

SourceImpact Journals LLC·JournalOncotarget·DateFeb 1, 2021

Gone fishin' -- for proteins

Researchers used a new microscopic 'fishing' technique to snag thousands of proteins key to the cell skeleton. The team identified hundreds of individual proteins with yet-to-be-defined roles, including a protein called SLK that forges the link between RhoA and ERM.

SourceUniversity of Montreal·JournalNature Cell Biology·DateDec 23, 2019

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