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Molecular sleuths track evolution through the ribosome

A new ribosome study sheds light on the oldest branches of evolutionary life, suggesting that differences in ribosomal structure between bacteria and archaea are molecular fossils of early evolution. The research confirms and extends Carl Woese's early work on finding signs of evolution in the ribosome.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalProceedings of the National Academy of Sciences·DateAug 18, 2008

New and sharper X-rays of cell's ribosome could lead to better antibiotics

Scientists have captured high-resolution snapshots of the bacterial ribosome, allowing them to build more detailed models and gain insights into how specific antibiotics work. The new data reveals the ribosome's structure and function during protein manufacturing, including its ability to withstand stress and neutralize negative charge.

SourceUniversity of California - Berkeley·JournalScience·DateNov 3, 2005
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New technique rapidly detects illness-causing bacteria

A new biosensor can detect fewer than 100 cells of a pathogen in just half an hour, making it faster and more efficient than traditional gene amplification techniques. The method uses ribosomal RNA to identify specific microbe sequences, allowing for quick identification of illness-causing bacteria.

SourceCornell University·DateJul 18, 2005

Yale scientists identify structure for RNA quality control

Researchers at Yale University have identified a molecular mechanism for RNA quality control, which involves the protein Ro recognizing and binding to misfolded RNAs. This discovery sheds light on how cells handle abnormal RNAs that are not translated into proteins.

SourceYale University·JournalCell·DateJun 1, 2005

Scientists target microbe with sleeker antisense agent

Researchers at the University of Rochester have created a remarkably short antisense compound that targets Pneumocystis carinii, an opportunistic pathogen causing pneumonia in people with weakened immune systems. The breakthrough marks a step toward designing drugs that knock out vital sections of molecules essential for the microbe's ...

SourceUniversity of Rochester·JournalProceedings of the National Academy of Sciences·DateJun 25, 1999

Unprecedented View Of RNA Structure Captured

Researchers at Johns Hopkins University have made a groundbreaking discovery, capturing the first atomic-level resolution of a protein-RNA complex from the ribosome. The study reveals the intricate 3D structure of RNA and how it's held together by a protein lynchpin.

SourceJohns Hopkins University·JournalScience·DateMay 14, 1999
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