A Phase III trial demonstrated a significant increase in average time to progression with sunitinib treatment compared to placebo, leading to improved overall survival. Treatment with sunitinib was well-tolerated, with common side effects including fatigue and diarrhoea.
A German-Swedish team has identified a single gene, DCDC2, as an important factor in the emergence of dyslexia. The gene appears to affect the migration of nerve cells in the developing brain, with frequent changes found among dyslexics.
A new drug, clopidogrel, has been shown to significantly reduce deaths from heart attacks, with a 9% decrease in mortality rates compared to placebo. The treatment also resulted in a 14% reduction in repeat heart attacks during the study period, highlighting its potential to save thousands of lives each year.
A new study by Conservation International and WWF reveals significant discrepancies between CITES and US Customs data on international wildlife trade, with figures varying wildly from 5,200 percent. The study identifies widespread errors and inefficiencies in recordkeeping, hindering effective conservation efforts.
Researchers at Oregon State University have cultured SAR11 bacteria in a lab to study its unique 'proteorhodopsin' gene. The findings suggest that this gene may serve as an auxiliary energy system for the cells when faced with starvation, benefiting ocean life.
A Stanford study finds that certain tryptophan metabolites can alleviate symptoms of multiple sclerosis, a condition affecting over 2.5 million people worldwide. The research suggests that diet and immunity are linked, with tryptophan playing a pivotal role in immune system regulation.
Researchers found that alum and polyacrylamide were highly effective in removing dissolved phosphorus and suspended sediment in river waters entering the lake. This treatment could help meet California's growing population needs, support commercial growth, and develop the region as a water-sports recreational area.
Scientists have captured high-resolution snapshots of the bacterial ribosome, allowing them to build more detailed models and gain insights into how specific antibiotics work. The new data reveals the ribosome's structure and function during protein manufacturing, including its ability to withstand stress and neutralize negative charge.
Researchers aim to mass produce technologies for consumer market, focusing on fundamental research and nanofabrication techniques to improve hydrogen storage and generation from solar cells. The grants are part of a $64 million DOE initiative aiming to make vehicles powered by hydrogen fuel cells available and affordable by 2020.
Researchers discovered divergent neuronal pathways at the melanocortin-4 receptor (MC4R), controlling food intake and energy expenditure. The study provides new insights into the intricate process of maintaining stable body weight, with potential implications for obesity treatment.
Three finalists, Pingxi Xu, Justin Blau, Paul Frankland, and Johanna Montgomery, have made significant contributions to understanding insect behavior through pheromone signaling. Their research has the potential to develop sustainable methods of pest control and improve human health by preventing disease.
Researchers mapped Hox protein expression patterns to understand motor neuron wiring and diversification. The code governs columnar, divisional, and pool identities, enabling precise connections between neurons and muscles.
Researchers have discovered that inflammation in the brain can cause toxic nerve impulses that inflict injury on neurons and disrupt function. Chemical preconditioning, induced by small amounts of stress, may be able to prevent this damage and preserve neurologic function, offering a new path for treating neurodegenerative diseases.
Anke Meyer-Baese is developing computer software to mimic the way a radiologist analyzes all of that information -- and to do it better and faster. The goal is to provide doctors with a new tool to better diagnose breast cancer using MRI technology, which holds promise in detecting hard-to-find cases.
Researchers have developed a new sensor based on a human organ that can detect specific frequencies of sound waves. The device, which is a microelectromechanical system, has three main benefits over existing artificial cochlea designs: mass production potential, comparable size, and efficiency.
A recent study found that waist-to-hip ratio is a stronger predictor of heart attack than BMI in diverse ethnic populations. The researchers discovered that larger waist size was harmful, while larger hip size was protective, leading to substantial reassessment of obesity's importance for cardiovascular disease worldwide.
The Geneva summit aims to address critical issues in preventing the spread of H5N1 influenza, including early detection of new clusters, effective surveillance systems, and strategies to avoid resistance to antivirals. The event seeks to promote global cooperation and coordination in addressing this pandemic threat.
E-MAP technique enables researchers to analyze epistatic interactions between genes in a systematic way, revealing new insights into protein functions and evolutionary processes. By quantifying the effects of interacting mutant genes, E-MAPs help optimize drug treatments and improve our understanding of biological systems.
A recent Gallup survey found that 53% of adults with sleep problems are not receiving treatment, while 77% express concerns about long-term effects of prescription sleep aids. Worry is a common factor interfering with nearly 40% of older adults' ability to fall asleep, especially among primary caregivers.
A new theoretical model helps explore the fate of CO2 injected into oceans under various temperature and pressure conditions. Liquid CO2 would need to be injected to a depth of at least 800 meters to keep it from escaping, according to Zhang's model.
Researchers discovered that alpha-synuclein, a disease-causing protein, has a protective effect against nerve damage in Parkinson's disease. This finding was made by studying mutant mice that were bred to have different levels of alpha-synuclein and cysteine-string-protein-alpha, a co-chaperone.
Researchers at Yale University have devised a way to predict the microstructure of crystals as they form in materials. This new method enables the estimation of grain size and subsequent material properties dependent on microstructure, opening up possibilities for tailoring material characteristics.
A study found that HIV-positive patients with end-stage liver disease have a high risk of early death, likely due to weakened immune systems. The authors recommend closer monitoring and earlier transplant evaluation for these patients to minimize the risk.
A new study published in Cell identifies RISC as a three-protein complex responsible for microRNA production and specificity in gene silencing. The complex, consisting of Dicer, Argonaute 2, and TRBP enzymes, oversees the creation of microRNAs and guides them to target specific messenger RNAs.
Dr. Harold F. Dvorak, M.D.'s groundbreaking work on vascular permeability factor/vascular endothelial cell growth factor (VEGF) has led to significant clinical benefits in cancer patients. His discovery has enabled the development of anti-VEGF therapies with outstanding clinical antitumor activity.
ECCO 13 study investigates post-treatment parenthood success rates in Hodgkin's lymphoma patients, with radiotherapy and chemotherapy linked to higher pregnancy success. The research highlights the importance of preserving fertility in young cancer survivors.
A study found that Chronic Obstructive Pulmonary Disease (COPD) affects around 1,000 people in Latin American cities. The disease prevalence varies greatly between cities, with rates ranging from 7.8% to 20%. Altitude is a key factor contributing to the high COPD rates in Latin America.
Researchers at NSBRI have developed an ultrasound training method that reduces learning time to two-to-three hours a year. The program uses computer-based instruction and remote guidance to enable non-physicians to assess and manage emergency medical conditions in space, sports, and emergency response situations.
Researchers have discovered a unique layer of molten rocks beneath the Tibetan Plateau, explaining its massive rise over millions of years. The study also reveals that this geological makeup is typical of the entire Himalayan range, not just Tibet.
Researchers found that resveratrol, a compound in red wine, significantly reduces amyloid-beta peptide levels in cells. The compound is believed to stimulate the degradation of these peptides by the proteasome, a multi-protein complex. However, it remains unclear whether eating grapes can effectively prevent Alzheimer's disease.
Researchers at the University of Kentucky developed carbon nanotube membranes that allow for fast transit approaching the speed of biological channels. The membranes' scalable fabrication enables industrially useful chemical separations.
Wildlife Conservation Society's field vets collected samples from hundreds of wild birds affected by H5N1 strain, helping to develop a human pandemic influenza vaccine. The collaboration highlights the importance of protecting wildlife diversity and monitoring their health for potential benefits to humankind.
Researchers developed a genetic profile of ovarian cancer that predicts survival and identifies key genes involved in chemotherapy response. The study used microarray analysis to identify a gene expression profile known as the Chemotherapy Response Profile, which confirms the importance of genes such as BAX.
Researchers discovered Klotho protein increases cell resistance to oxidative stress by detoxifying harmful reactive oxygen species. This finding may lead to the development of anti-aging drugs, potentially useful as medicines.
The SAGE Center will foster interdisciplinary research on the human mind, integrating social sciences, arts, humanities, and natural sciences. Michael Gazzaniga aims to build a powerful new center focused on understanding the unique nature of the human mind.