Articles tagged with Semaphorins
A new study published in The Journal of Allergy and Clinical Immunology found that semaphorin protein contributes to allergic reactions and development of nasal polyps in patients with eosinophilic chronic rhinosinusitis. Elevated levels of semaphorin protein were associated with disease severity.
Researchers at Children's Hospital Los Angeles have identified a set of molecules that wire the body weight center of the brain. Blocking these signals causes connections to fail and leads to elevated body weight.
Researchers at Osaka University have identified Semaphorin 7a as a protein involved in treatment resistance in lung cancer cells with common EGFR mutations. High levels of Semaphorin 7a inhibit apoptosis, making it harder for cancerous cells to be eradicated.
Researchers have identified a new pathway guiding the development of the enteric nervous system, which is separate from the central nervous system. This pathway interacts with specific genes and proteins to cause Hirschsprung's disease, a rare condition that can be fatal if left untreated.
Researchers identify semaphorin 3A as a sensitive biomarker for early detection of acute kidney injury, which can help minimize damage and potentially reverse it with rapid intervention. High levels of the protein in urine are accurate at identifying injured kidneys within two hours after cardiopulmonary bypass surgery.
Researchers discovered how semaphorin proteins guide nerve cell projections with precision, enabling intricate connections in the nervous system. This finding has implications for developing treatment strategies for repairing and regenerating damaged or diseased nerve cells.
Researchers used a classic staining method to observe how semaphorin regulates the creation of synapses and their distribution in the brain involved in conscious thought. The discovery could have an impact on understanding early origins of neurological disorders like autism, schizophrenia, and epilepsy.
A recent study published in the Journal of Clinical Investigation sheds light on the mechanism underlying microglia's behavior in multiple sclerosis. Researchers found that controlled inflammatory responses can restore damaged myelin and nerve function, suggesting a potential therapeutic target for MS treatment. Additionally, studies o...
Researchers at Johns Hopkins Medicine have identified a protein called semaphorin 5A that prevents nerve growth after injury. By blocking its interaction with CSPGs, nerves can be freed to continue growing.
A research team at Johns Hopkins Medicine has discovered a new protein pair that stops blood vessels' growth in developing mice, shedding light on tumor development and nerve regeneration. The study, published in Science, reveals a unique mechanism of action for the protein Sema3E, which works differently from other semaphorins.
Researchers found that Semaphorin 3E (Sema3E) and plexin-D1 proteins work together to control vascular patterning in the developing embryo. Sema3E was shown to exert a 'repulsive' force, guiding blood vessels along their proper course and preventing abnormal growth.