Articles tagged with Sh2 Domains
Researchers identified SH2 domains as lipid-binding modules for cell signaling. The interaction is evolutionarily conserved and plays a crucial role in controlling intracellular signal transmission.
Researchers have identified mutations in the STAT3 protein that can block its ability to act as a transcription factor, suggesting a basis for new cancer treatments. The discovery reinforces the importance of targeting transcription factors like STAT3 in fighting cancer.
A study in Cell Communication and Signaling reveals an extensive interactome of over 500 novel interactions between SH2 domains and phosphotyrosine peptides. The researchers identified six general classes of SH2 domain specificity, which may control the selectivity of individual domains.