Articles tagged with Structural Biology
Researchers from the University of Tsukuba have identified a soil microorganism that initiates the breakdown of carminic acid, a natural red dye extracted from insects. The discovery provides insight into the chemical reaction and its occurrence in nature.
McGill University scientists created a new glass and acrylic composite material mimicking nacre for exceptional strength and durability. The material is three times stronger and five times more fracture-resistant than regular glass, with potential applications in phone screens and other industries.
Actin filaments generate pushing forces to move the cell membrane. The capping protein regulates filament growth, promoting branching near the membrane through the Arp2/3 complex. A high-resolution structure reveals that capping protein blocks nucleation-promoting factors via a tiny 'tentacle' extension.
Scientists at CIBFar have discovered the molecular mechanism of SARS-CoV-2's main protease, which enables the virus to replicate in host cells. The study provides valuable insights into the process and has immediate applications for developing antiviral drugs.
Researchers have simulated the SARS-CoV-2 spike protein structure and found that glycans play a crucial role in cell entry. Disrupting these structures could potentially halt virus transmission. The study provides insight into potential targets for COVID-19 treatment and vaccine development.
Scientists at the University of Kent have developed a mathematical formula that describes the shape of any bird's egg in nature. The formula is based on four parameters and can be applied across multiple disciplines, including food research, mechanical engineering, and agriculture.
Yang Gao's lab has received a $1.9 million NIH grant to investigate the mechanisms of proteins that produce copies of genomic DNA, with potential implications for cancer treatment. The research aims to understand how DNA replication and repair processes can be targeted to develop new therapies.
Researchers have developed an approach that predicts accurate structures computationally, overcoming the problem of determining molecular shapes. The algorithm succeeds even when learning from only a few known structures, making it applicable to difficult-to-determine molecules.
A new machine learning method called ARES significantly improves the computational prediction of RNA structures, outperforming other approaches in a community-wide challenge. ARES learned to make predictions based solely on atomic structure and accurately predicted complex RNAs larger than those it was trained on.
A multidisciplinary team reveals two structural points in the Spike protein of SARS-CoV-2 that allow the virus to deceive the immune system. These mutations can be detected and inform strategies to control the pandemic.
Researchers at Berkeley Lab have made significant breakthroughs in developing a highly effective COVID-19 antibody therapy and an efficient thermoelectric system that can convert waste heat to electricity. The new antibody, S309, has been shown to neutralize all known SARS-CoV-2 strains and may be more difficult for new mutants to escape.
Flipon genetics proposes that evolution happens on a faster time scale than Darwin imagined, with rapid adaptations occurring in real-time within individuals. This is achieved through the simple sequence repeats of DNA, which can adopt alternative shapes and transmit adaptations to offspring.
Scientists identified five human monoclonal antibodies that can neutralize multiple beta-coronaviruses by targeting a conserved structure in the spike protein. These antibodies showed promise in reducing viral load and enhancing immune responses in hamsters, providing potential inspiration for broadly protective vaccines.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
The study describes the three-dimensional structure of the MUTYH protein and its interaction with PCNA, a key player in DNA replication. The researchers found that mutations in the MUTYH gene reduce its binding affinity to DNA and destabilize its structure, leading to decreased DNA repair activity.
The AlphaFold Protein Structure Database provides the most accurate and complete picture of human proteins, enabling researchers to accelerate discovery and advance scientific knowledge. The database covers all ~20,000 human proteins and offers a treasure trove of data that could unlock future advances in AI-enabled biology.
UT Southwestern researchers report the first structural confirmation that endogenous molecules can trigger innate immunity in mammals through the TLR4?MD-2 receptor complex. The discovery has wide-ranging implications for treating and preventing autoimmune diseases such as multiple sclerosis.
Researchers created designed and biologically active 2-D and 3-D protein arrays using DNA-based assembly, maintaining structural stability and biological activity. The method has potential applications in structural biology, biomaterials, nanomedicine, and biocatalysis.
Researchers John Schwabe and Daniel Panne have been awarded £3.89 million to investigate gene regulation, with a focus on histone deacetylase complexes and DNA folding. The study aims to understand how genes are regulated and its potential in treating diseases such as cancer and Alzheimer's.
The Protein Data Bank (PDB) is celebrating 50 years of sharing scientific knowledge, with millions of users accessing its data for fundamental biology, energy, and biomedicine. The event highlights the PDB's role in understanding protein folding, including SARS-CoV-2, and structural biology's impact on medicine and drug discovery.
Researchers from Ruhr-University Bochum and collaborators isolated a PS II transition complex with three helper proteins using cryo-electron microscopy. The study reveals a novel protective mechanism that prevents the formation of aggressive oxygen species during assembly, allowing for a more efficient and stable machine.
This year's award recipients demonstrate substantial and lasting impact on protein science, with notable achievements in education, technological advancement, and structural biology. Professor Sheila Jaswal and Petra Fromme are recognized for their exceptional contributions to protein research and education.
Researchers at Universidad Complutense de Madrid developed new image processing methods to enhance the analysis and three-dimensional reconstruction of biological macromolecules. The methods, published in Nature Communications, improved the visualization and quality of cryogenic electron microscopy-derived 3D reconstructions.
Researchers at Washington University in St. Louis have unveiled the core structure of cyanobacteria's light-harvesting antenna, revealing key features that collect energy and block excess light absorption. The study provides insights into future energy applications and helps explain how living organisms maximize photosynthetic efficiency.
Researchers find that inhibiting pro-IL-1α helps modulate NLRP3 inflammasome activation, reducing damage to mitochondria and alleviating inflammation. This discovery offers potential therapeutic applications for treating various diseases, including atherosclerosis, arthritis, and Alzheimer's disease.
Researchers at Washington University in St. Louis have developed a protein footprinting method called Fast Photochemical Oxidation of Proteins (FPOP) to investigate protein structure and interactions. FPOP offers advantages such as fast labeling time, irreversible nature, high sensitivity, and broad amino acid residue coverage.
Bioinformaticians at Friedrich Schiller University Jena developed a new method called CANOPUS that assigns structural properties to unidentified metabolites, increasing knowledge gained from examining molecules. The two-stage process uses machine learning methods to identify compound classes.
A team of researchers from the University of Barcelona has developed a new protocol combining multicomponent reactions with domino type processes to synthesize complex molecules. The study reveals a key principle that enables access to high structural complexity, offering a more efficient and sustainable synthetic pathway.
Researchers have mapped the molecular structure of a potent COVID-19 antibody, CV30, which neutralizes the virus by interfering with its surface spikes and inducing critical pieces to break off. The antibody's unique shape allows it to overlap with the virus's target site on human cells, blunting its ability to infect.
Researchers develop new approach to acquire structural data of membrane proteins, including GPCRs, using LCP crystallization and MicroED. This method enables the determination of detailed structures of previously inaccessible proteins.
Researchers use a new method to extract information from cryo-EM data, enabling the visualization of minimum free-energy pathways during simulations. This study demonstrates the potential of cryo-EM in understanding biological functions and has implications for drug discovery.
Researchers used cryo-electron microscopy to capture detailed conformational changes involving the β1-adrenergic receptor and its activation mechanism. The findings provide new details for improved therapeutic treatments for cardiac disease, a leading cause of death worldwide.
Researchers at Tokyo Tech developed a synthetic channel that can mimic natural ion channels, demonstrating self-assembling and functionally active orientation of artificial molecules in membranes. The study shows promising results for biomimetic regulation and potential applications in sensing and separation devices.
Structural biologists successfully modeled the novel coronavirus' vital proteins, which could lead to therapeutic breakthroughs. Advances in technology and expertise from similar coronaviruses enabled rapid progress in determining protein structures.
Researchers developed a process that reduces computational protein design work by using 3D structural models to project novel combinations of molecular blocks. This approach could ease the development of new medications and materials.
Researchers from TUM have identified a new role for the alpha-A-crystallin protein in protecting other proteins from oxidation, which may contribute to the prevention of cataracts and age-related blindness. The study reveals that oxidized alpha-A-crystallin can transfer disulfide bridges to other proteins, influencing their redox state.
Researchers created a green living material that demonstrates similar strength to cement-based mortar by combining sand, bacteria, and hydrogel. The material reproduces and can be controlled to maintain structural function and microbial survivability.
Researchers have identified the location of structural proteins in a pig ovary, paving the way for 3D printing an artificial ovary that can support eggs and hormone-producing cells. The technology has huge potential for girls who undergo fertility-damaging cancer treatments.
Researchers at McGill University have made significant strides in understanding the functioning of enzymes that produce antibiotics and therapeutics. The study found a surprising level of flexibility in the assembly line of nonribosomal peptide synthetases (NRPSs), which could lead to new therapeutic design possibilities.
The study reveals the detailed 3D structure of the CysLT1 receptor, which plays a crucial role in inflammatory processes and allergic diseases like asthma. The researchers used advanced X-ray sources to determine the receptor's mechanism of operation, providing insights into improving asthma medications.
Researchers at Karolinska Institutet have uncovered a chromosome-wide mechanism that maintains balance in sex chromosomes' gene expression. The study found that genes on the X chromosome produce waves of gene products at a faster tempo, driven by special DNA elements called enhancers.
Researchers at OIST Graduate University revealed the flagellar hook's mechanics, showing how it acts as a dynamic joint to transmit torque and enable bacterial motility. The study provides insights into the hook's flexible and rigid structure, allowing for dynamic shifts in its conformation.
The study reveals the largest real-time structural changes in a molecule ever, showing how bacteriorhodopsin pumps protons from inside to outside through the cell membrane. This process creates a concentration gradient that the cell uses to gain energy for its metabolism.
Researchers at the University of Portsmouth used synchrotron X-ray computed tomography to examine the performance of four different bone-biomaterial systems. They found that strain can be used to understand and potentially predict clinical outcomes of biomaterials in a living body.
A team of scientists at Arizona State University has determined the structure of a massive photosynthetic supercomplex, uncovering crucial details about its functionality. The complex, composed of over 700 molecules, is unique in size and complexity, with 591 chlorophylls bound within.
Abnormal necroptosis function contributes to cancer cell survival and multiple sclerosis, Parkinson's disease. Controlling necroptosis may lead to new treatments for these diseases.
A team of scientists measured the puncture performance of viper fangs using a custom-built machine. The study found that the angle of the fang's tip contributes most to its sharpness, with narrower tips performing better than wider ones.
Researchers develop a new method to create detailed structural models of proteins using force-driven simulations, reducing computational power requirements. The technique, inspired by metallurgy, allows for faster computation and more accurate results than existing approaches.
The study analyzed 26 widely-used protein disorder prediction methods and found that they vary noticeably in performance. This thorough comparison provides valuable insights for protein scientists to make informed choices about which programs to use.
Researchers from Kanazawa University have discovered a novel system where a liquid-solid transition is driven by guest vapor, exhibiting selectivity for alkane vapors. This unique property enables the development of new vapor detection systems and adhesion materials.
The Ryerson-led research team developed a technique called F-Mode, which enables selective enhancement of features in biological structures based on size. This breakthrough has significant potential in ophthalmology, neurosurgery, and disease detection.
This year's awards recognize Professor Minoru Kanehisa for his work on the KEGG database, Professor Anthony Kossiakoff for his technological achievements in protein structure and function, Professor Hao Wu for her groundbreaking signal transduction research, Professor Shahriar Mobashery for his discovery of new antibiotics, and Profess...
Scientists from two French teams have identified 79 new 'sugar cleavers' enzymes using bioinformatics methods, expanding the known families to over 200. These enzymes can serve as tools in domains like bioenergy, cosmetics, and nutrition.
A team of researchers from TUM used computational screening and data mining to analyze 64,000 organic compounds, identifying key structural frameworks and functional groups that facilitate favorable charge transport. The study reveals the importance of molecular design in creating efficient electronic components.
Researchers at the University of Pennsylvania have developed a theoretical framework that describes how pollen patterns form through phase separation. This discovery provides new insights into the intricate structures found in nature and could lead to the development of innovative materials.
Researchers at the University of Geneva have developed a new technique called Ultrastructure Expansion Microscopy (U-ExM), which allows for the visualization of cellular structures and protein complexes at a nanoscale. This method enables the detection of biochemical modifications and mapping of large intracellular molecular complexes.
Researchers have gained a better understanding of how cells regulate hydrogen peroxide, an intracellular messenger linked to several diseases. This discovery may enable the development of more sensitive and specific fluorescent biosensors to visualize endogenous H2O2 in real-time.
Researchers discovered a self-protection mechanism in failing heart cells that triggers the regulation of genes promoting heart failure. The study reveals that one fragment of the protein junctophilin-2 protects against damage by traveling to the cell nuclei.
Researchers designed proteins that snap together spontaneously to form long, helical structures, mimicking natural protein filaments. The creation of these self-assembling filaments could lead to the development of new materials, including fibers stronger than spider silk and nano-scale wire circuitry.
Researchers at Siberian Federal University have created a new class of two-dimensional materials called circulenes, which exhibit high stability, symmetry, and optical properties. These materials show promise for nanoelectronics applications, including solar cells and organic LEDs, with advantages over traditional materials like silicon.