Articles tagged with Structural Biology
A standardized protocol for FRET has been established, enabling precise measurement of distances within biomolecules. This breakthrough methodology can overcome size and stability limitations of other structural biology methods, leading to targeted drug development and new research opportunities.
A study published in Nature Structural & Molecular Biology reveals that the Arp8 module of the INO80 complex serves as a linker DNA sensor driving chromatin remodelling. This process enables gene expression adaptations by stimulating nucleosome repositioning, which has implications for cancer therapy.
Jianhan Chen is studying intrinsically disordered proteins (IDPs) with flexible 3D structural properties, which account for about one-third of all eukaryotic proteins. His project aims to develop computational methods to simulate flexible proteins and explore the fundamental principles of their structural disorder's effect on function.
A research team has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. Understanding this process may help develop new therapies for cancer treatment.
Researchers have created the highest-resolution image yet of the Zika virus, providing a detailed atomic model that enables efficient vaccine and antiviral compound design. The discovery was made possible by the stability of the Zika virus compared to its flavivirus cousins.
The new Pacific Northwest Center for Cryo-EM will provide state-of-the-art technology and training to researchers nationwide. The facility will enable scientists to see molecules in breathtaking detail, with resolution near atomic levels, revolutionizing the understanding of disease at the molecular level.
Recent discoveries on proteoglycan roles in bone and tooth development have been made, challenging previously held views of their structural function. The symposium aims to provide an update on these findings, which have significant implications for mineralized tissue biology and craniofacial development.
Researchers at Helmholtz Munich have discovered a new cofactor, NUFIP2, that works with Roquin to regulate the immune response. This cooperative regulation helps limit immune responses to specific reactions and prevents inflammatory reactions.
Scientists from Waseda University and others have successfully visualized the structure of heterochromatin using cryo-electron microscopy. The study sheds light on how heterochromatin regulates genes and its connection to various diseases, including cancer and virus infections.
Researchers developed a new approach to identify protein structure from sole sequence information by analyzing paired mutations across thousands of protein family members. This method identified sequence covariations that uncover the protein's macrostructure and its fundamental structural and functional units.
A study published in Nature Structural & Molecular Biology reveals the mechanism by which PHF1 increases PRC2 activity, allowing for efficient gene regulation across different species. The findings suggest that stable PRC2 chromatin interactions mediated by PHF1 are key to increased lysine trimethylation and gene repression.
The NIH has awarded a $6.5 million grant to Berkeley Lab to integrate existing synchrotron structural biology resources, establishing the ALS-ENABLE center to guide researchers in determining biological structures. The initiative will provide rapid response crystallography, high-quality small-angle X-ray scattering, and specialized cry...
The OU research group, led by Ann West, has received a five-year, $10.5 million NIH COBRE grant to support structural biology research and build on Phase I successes with 57 research publications and over $7 million in new grants awarded.
Researchers at ETH Zurich have discovered a mechanism used by bacteria Amoebophilus to shoot micro-daggers that pierce the digestive compartment of an amoeba, allowing it to escape digestion and thrive. The study reveals new insights into bacterial evolution and opens up possibilities for other structural biology investigations.
The University of Oklahoma offers an NSF Undergraduate Research Program in Structural Biology, providing students with a nine-week research experience. The program helps students develop critical thinking and problem-solving skills through presentations and poster sessions.
Scientists have gained insight into the NS5 protein of Zika virus, a crucial enzyme involved in viral replication. The study reveals its structure and function, as well as comparisons with other related viruses, which will aid in the search for compounds to halt virus reproduction.
A team of researchers has elucidated the molecular architecture of the nuclear lamina in mammalian cells using cryo-electron tomography. The study reveals a 14nm-thick layer with threadlike structures called lamin filaments, which assemble into polymers consisting of type A and B lamin proteins.
Researchers design a pod-like casing with liquid-crystal elastomers and molecular switches, demonstrating the ability to produce powerful movement at the molecular level. The device uses light-triggered re-arrangement of molecular switches to drive twisting helices in opposing directions, resulting in the bursting of the casing.
An international team has made a breakthrough by trapping an intermediate in the mechanism of heme peroxidase enzymes and determining its structure using neutron beams. This finding could change our understanding of how these enzymes work, shedding new light on their role in biochemical processes.
A public database of macromolecular diffraction experiments has been developed to archive raw data and metadata from X-ray crystallographic studies. The resource contains 3070 experiments with partially curated metadata, aiming to improve protein structure-determination methods and ensure the availability of orphan data.
Researchers discovered that Kinesin-14 protein helps cells bundle growing microtubules into organized structures by guiding their growth in parallel. This mechanism is conserved throughout evolution and found in various animal cells, including humans and flies.
Researchers have gained structural insights on a key protein from Aedes aegypti, the mosquito species most often linked to Zika. The study suggests compounds targeting this protein could kill mosquitoes and reduce cases of Zika and other illnesses.
The study provides a roadmap for targeting ZIP4, which is overexpressed in pancreatic cancer and plays a critical role in zinc transport, offering new hope for treating diseases like acrodermitis enteropathica and pancreatic cancer.
Enrico Di Cera's work on the Structural Biology Data Grid allows researchers to share and reproduce findings faster, advancing the field of structural biology. The grid supports archiving of raw experimental datasets, enabling rapid access for validation and improving existing models.
Researchers have visualized the self-assembly of protein facets in bacterial microcompartments, revealing a honeycomb pattern and selective arrangement. The study provides new clues for designing novel compartments or nanoscale architectures, potentially aiding in toxin removal or product production.
Researchers have uncovered the atomic-level structure of the bluetongue virus, providing a detailed understanding of its mechanism of entry into host cells. This breakthrough could lead to the development of more effective vaccines and treatments against this devastating disease.
A team from the University of York has developed user-friendly software called Privateer to analyze and study sugar molecules. This will enable scientists to better exploit carbohydrates in medicines, which have been poorly defined in databases.
Researchers create Bose-Einstein condensate in a biological protein using terahertz radiation, demonstrating Fröhlich condensation. This phenomenon could lead to new medical applications and ways to control chemical reactions in industry.
A team of engineers at the University of California, Riverside has developed a new type of lithium-ion battery anode made from portabella mushrooms. The mushroom-based material is highly porous and allows for increased electrolyte-active material over time, making it a potential replacement for traditional graphite anodes.
Researchers discovered that sponges construct their skeletons through a complex process involving dynamic transport and cementation of spicules. The findings reveal a fundamentally new mechanism of forming animal body shape and may inspire interdisciplinary studies in fields like bioengineering and architecture.
Researchers at the University of Leeds captured images of motor protein dynein in action using electron microscopes. The study revealed a hinge between the motor's arms and its track, allowing flexibility in movement.
A new study has provided never-before-seen details of the human body's cellular switchboard that regulates sensory and hormonal responses. The research, led by Eric Xu at the Van Andel Research Institute, used SLAC's X-ray laser to complete the first 3-D atomic-scale map of a key signaling protein called arrestin.
Researchers developed an RNA dynamics model using beads and springs, achieving accurate predictions comparable to Molecular Dynamics simulations. The model's simplicity allows for near real-time processing and may be a viable alternative to expensive computer simulation methods.
Researchers have discovered that spider and centipede venom originated from an insulin-like hormone, with similar molecular shapes between the toxins and the hormone. This finding has potential applications in developing new pharmaceuticals and bioinsecticides, as well as solving agricultural and medical problems.
Researchers have determined the basic structural organization of the dynein-dynactin complex, a molecular motor responsible for cellular activities such as cell division and intracellular transport. The findings shed light on diseases like Alzheimer's, Parkinson's, and ALS, and could lead to new treatments.
Researchers found no knots in RNA structures among 6,000 known chains. Instead, naturally occurring RNAs tend to form simple geometric configurations.
Researchers at Arizona State University have discovered a novel mechanism driving the evolution of green-to-red photoconvertible phenotype in green fluorescent proteins. The study reveals that hinge migration, driven by long-range dynamic motions, can lead to the acquisition of red fluorescence.
Researchers at Scripps Research Institute reveal new insights into nicotinamide nucleotide transhydrogenase (TH), a metabolic enzyme found in most forms of life, shedding light on its structure and function. The discovery sheds light on TH's dynamic structure and how it alternates functions to maintain cell health.
Scientists have developed a method to observe DNA double strand breaks, a process that lasts microseconds. They also created slow-motion films of the reaction by altering temperature and pH balance.
Six faculty members at Albert Einstein College of Medicine have been named 2014 AAAS Fellows, recognized for their contributions to various fields including virology, cell biology, and cancer research. The awardees include Aviv Bergman, Margaret Kielian, Richard Kitsis, U. Thomas Meier, Robert Singer, and Jan Vijg.
Scientists have unraveled a molecular mechanism of mRNA recognition, essential for understanding differential gene regulation in male and female organisms. This principle represents an essential and widespread mechanism of gene regulation in higher organisms.
A study at Oak Ridge National Laboratory reveals structural differences between normal and diseased forms of the huntingtin protein, which is involved in Huntington's disease. The researchers used neutron scattering to compare the structures over time, finding key discrepancies that support a growing focus on amyloid disorders.
A team of scientists has revealed the molecular mechanisms underlying Roquin's role in preventing autoimmune diseases. The study found that Roquin recognizes a range of RNA binding partners to control T-cell functions, regulating a larger number of genes than previously thought.
Research clarifies how bacterial red light photosensors change structure when sensing light, revealing amplification mechanism for rapid signal transmission. The study also sheds light on the molecular-level operating mechanisms of phytochrome proteins in plants.
The Price Family Foundation has awarded a $3 million grant to Albert Einstein College of Medicine and the University of Oklahoma to investigate the structural biology of anaerobic microorganisms, with a focus on combating C. difficile infections. The joint project aims to find better treatments for these life-threatening infections.
The University of Oklahoma and Albert Einstein College of Medicine will establish an Institute of Structural Biology to advance research on the impact of proteins. Researchers will target deadly diseases and search for new cures, gaining expertise in X-ray analysis and large-scale structural genomics.
Researchers at the University of York have discovered how one group of gut bacteria, Bacteroidetes, digest complex sugars found in fruits and vegetables. This understanding sheds light on nutritional issues like prebiotics and probiotics.
Researchers at Scripps Research Institute have developed a new method to map the 3D structure of membrane proteins, including the human serotonin receptor. This approach enables faster and more accurate imaging, potentially condensing the timeline for structural studies from months to days.
Researchers used X-ray laser to map the 3D structure of a key cellular gatekeeper, the human serotonin receptor. The breakthrough technique uses smaller crystals and produces high-resolution images, potentially condensing years-long studies into days.
Researchers have discovered that trees across species exhibit remarkably similar branching patterns, allowing scientists to infer a tree's function regardless of its shape or size. The study confirms a theory developed by UA ecology professor Brian Enquist and has implications for models used to assess forest ecosystems.
Researchers from UConn have captured the structural dynamics of a protein channel in the mitochondrion using fluorescent probes. The study reveals that the channel complex changes its structure in response to changes in the inner membrane's electrical field, providing new insights into how cellular transport systems harness energy.
Researchers identify unique properties of K11-linked polyubiquitin chains, suggesting new cellular processes involved in disease maintenance. These findings may lead to novel treatments for diseases like cancer and diabetes.
A team led by Peijun Zhang has described the 4-million-atom structure of HIV's capsid protein shell, revealing critical molecular interactions that could lead to new treatments. The findings may enable the development of drugs that disrupt the shell's assembly or disassembly, potentially stopping the virus from replicating.
Researchers at Helmholtz Centre and Technische Universität Darmstadt discover protein C4BP with eight 'arms' similar to a spider's web. This structure allows for potential use as a scaffold for drug transport, targeting pathogens more effectively.
Researchers propose a new theory of evolutionary development, suggesting that complex structures may emerge through the process of 'complexity by subtraction', where parts are lost or simplified over time. Computer models and trends in skull evolution support this idea, which challenges traditional incremental evolution.
Researchers at Virginia Tech Carilion Research Institute invent a way to directly image biological structures at their most fundamental level, providing a gateway to understanding dynamic systems in structural biology. The technique has successfully imaged viruses and other biological structures in their natural environments.
Researchers will use x-ray crystallography and NMR to understand the structural rules governing nuclear receptors' activity. The goal is to fill gaps in knowledge about these proteins' role in metabolism, cancer, inflammation, and bone health.
A University of Oklahoma research team has been awarded a $9.7 million NIH grant to study human diseases associated with aging, osteoporosis and diabetes. The grant will provide significant resources for investigators to pursue structure-based biomedical studies.
The university has upgraded its research facilities with a $2.7 million NMR spectrometer, allowing for faster and more detailed molecular imaging. This will enable researchers to study macromolecules at the molecular level, benefiting disease research and biological problem-solving.
University of Montreal researchers developed a strategy to monitor protein assembly by integrating fluorescent probes throughout the linear protein chain. This approach enables capturing snapshots of protein shape at each stage of assembly, shedding light on how proteins self-assemble into working nanomachines.