Articles tagged with Toxins
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A world-first therapeutic for treating sleep apnea and weak muscle conditions will be showcased at Bio Digital. Developed by RMIT University, the patented technology uses modified tetanus toxin molecules to effectively tone muscles, offering a promising alternative to cumbersome airway pressure machines.
Researchers at the University of Bern have discovered how Clostridium perfringens causes fatal intestinal bleeding in piglets. The toxin attaches to CD31, a key molecule on endothelial cells, leading to cell death and damage to blood vessels.
Researchers have identified specific compounds from the Brazilian peppertree that reduce the virulence of antibiotic-resistant staph bacteria. The triterpenoid acids block the ability of bacteria to produce toxins, allowing the immune system to heal wounds more effectively.
A study published at Digestive Disease Week found that nearly 83% of 9/11 first responders had fatty liver disease, compared to 24-45% in the general population. The research highlights the link between toxin exposure and non-alcoholic fatty liver disease among first responders.
Researchers recreated DNA damage caused by tobacco smoke in laboratory-grown human bladder tissues. The study found that while direct DNA damage from smoke toxins is unlikely to cause bladder cancer, they may accelerate other DNA-damaging events.
Researchers at Boston Children's Hospital developed a new version of botox B with improved binding to nerves, leading to more effective paralysis, longer-lasting results, and reduced systemic toxicity. The enhanced toxin showed higher therapeutic efficacy and better safety range in a mouse model.
Researchers have introduced a novel total synthesis method for tetrodotoxin, a strong nerve toxin with potential as a pain reliever for cancer treatment. The new route enables easy and reliable production of the compound.
Researchers have identified a crucial role for the typhoid toxin protein in delivering toxins to host immune cells and disrupting their function. The study's findings suggest that targeting specific sugars on immune cells could prevent the bacteria from entering and infecting them, paving the way for new treatment options.
Researchers discovered a species group of snakes in western China and Japan changed their primary diet from frogs to earthworms and firefly larvae, gaining access to the same toxic compounds. This marks the first documented case of an vertebrate predator adapting to an invertebrate prey for defense.
A simple portable test can detect deadly mushroom toxins in minutes, aiding doctors in diagnosing amatoxin poisoning. The test's sensitivity allows for detection of the toxin in urine, potentially improving patient outcomes and increasing safe mushroom foraging.
Researchers found microcystin concentrations in 95% of participants' nasal passages, with higher levels among occupationally exposed individuals. Aerosolized cyanotoxins represent a significant route of exposure and should be included in risk assessments.
Researchers at UC San Diego created transgenic fruit flies to study the effects of CDTa toxin on host cells, revealing a collapse of networks essential for nutrient absorption. The fly model mimics symptoms in human C. difficile-infected patients, offering a potential avenue for novel therapies.
Researchers at the Technical University of Berlin introduce a new method to synthesize α-amanitin, a highly selective inhibitor of RNA polymerase II. This synthetic route allows for large-scale production and could lead to cancer treatment advancements.
Researchers develop animal-free antitoxin to block diphtheria toxin, reducing animal suffering and increasing safety. PETA-funded project uses human blood cells to create effective treatment with no risk of allergic reactions.
Researchers have identified the structure of a lethal toxin produced by C. difficile bacteria, paving the way for new drugs to neutralize it. The finding uses cryo electron microscopy and X-ray crystallography to map out delivery and binding components of the toxin.
Scientists combined advanced molecular imaging techniques to characterize and understand how Clostridium difficile toxins work, providing a new target for effective treatment of the most dangerous strains. The study's findings will guide the design of drugs targeting C. difficile infections.
New studies reveal a link between natural foodborne toxins and vaccine resistance, as well as increased risk of cancers, cardiovascular and neurological illnesses. Aflatoxin and lead contamination pose significant threats to public health worldwide.
A Portland State University study found that vape additives, particularly terpenes, can form more toxins than the main psychoactive chemical THC when inhaled. The researchers discovered that vendors were adding up to 30% more terpenes to their products, which can impact flavor and smell but also pose health risks.
A study suggests that immunity-related genes from ancient times may be protecting humans today against modern pollutants like cigarette smoke and diesel fumes. Researchers found that certain genes, such as AHR, have been beneficial in responding to airborne toxins for thousands of years.
Researchers tested an Automated Wearable Artificial Kidney (AWAK) device for effective toxin removal in patients with kidney failure. The study found no serious adverse events, improving portability and flexibility of treatment.
Scientists have discovered that human gut bacteria require a unique genetic code to thrive, which is different from person to person. The study found that immunity genes from one bacterium are often shared by others, suggesting a complex and adaptive immune system in the gut.
Researchers discovered that Shiga toxin subtype 2a enhances E. coli O157 colonization and facilitates effective cattle-to-cattle transmission. This finding highlights the importance of understanding Shiga toxin activity and its role in animal reservoirs to reduce human health threats.
Researchers genetically engineered fruit flies to mimic the monarch butterfly's ability to eat milkweed without dying. The flies store toxins in their bodies and retain them through metamorphosis, making animals that eat them likely to vomit.
Researchers used CRISPR technology to study the genetic changes that allow monarch butterflies to survive toxic milkweed by editing genes into laboratory fruit flies. This breakthrough reveals a key adaptation in the evolution of these iconic insects.
Researchers discovered a novel weapon in bacteria arsenal that mimics common antibiotics, potentially filling gap left by antibiotic resistance. The 'toxic arrowhead' VgrG2b targets cell envelope and prevents division, causing cells to bulge and explode.
Researchers found that microcystin can significantly amplify non-alcoholic fatty liver disease even at low levels. The toxin was processed differently in the kidneys of mice with pre-existing liver disease, suggesting a need for special preventative guidelines.
Researchers found that exposure to BMAA, a toxin produced by algae, can alter the structure of protein SOD1, leading to neurodegenerative disease ALS. The study suggests that studying patterns of SOD1 modifications may aid in developing lifestyle and preventative interventions for sporadic ALS.
Scientists have discovered how the typhoid toxin hijacks DNA repair machines and accelerates cellular aging, making cells more susceptible to infection. This breakthrough could lead to earlier diagnosis and faster treatment for typhoid sufferers, a major killer in low- and middle-income countries.
A new vaccine candidate has been developed to treat and prevent toxic shock caused by invasive streptococcal disease. The 'J8' vaccine candidate has shown a 1000-1,000,000 fold reduction of bacterial burden in treated mice.
Research by Ohio State University found that low-income and African-American communities continue to face disproportionate levels of air pollution, exacerbating existing health disparities. The study's findings suggest that efforts to control pollution are not effectively addressing these inequities.
Researchers have discovered a key toxin in the Legionella bacteria that enables its growth and infection in human cells. The toxin, SidJ, targets innate immune pathways and has a kinase fold, making it an attractive target for therapeutic intervention.
A new study by researchers from the University of California, Irvine has shed light on the weaknesses of TcdB, a toxin primarily responsible for devastating Clostridium difficile infection (CDI). The study provides a blueprint for the development of next-generation vaccines and therapeutics with enhanced potency and broad-reactivity.
A small study suggests that treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life in women with endometriosis. The treatment showed long-lasting benefits, with many patients reporting pain relief lasting at least six months.
Researchers at Stanford University discovered a new form of cell communication, where individual cells coordinate their ultrafast contractions to release paralyzing toxins in sync. The phenomenon was found to occur through hydrodynamic flows, allowing cells to sense and respond to their environment.
Researchers discovered a new species of bacteria living inside algae that produces toxic compounds for the sea slug's defense. The three-way symbiotic relationship allows the slug to obtain food and defensive chemicals while the algae benefits from chemical production and the bacteria receive a home and nutrients.
A new study reveals a frog protein that can detect and neutralize a poisonous compound produced by red tides and other harmful algal blooms. The protein, saxiphilin, acts as a 'toxin sponge' that sops up and sequesters the deadly microbial poison.
New guidelines recommend nucleic-acid amplification tests (NAAT) for diagnosing Clostridioides difficile infection. NAAT testing practices are considered the most effective, with a recommended algorithm combining GDH/TOXIN/NAAT tests.
Scientists at the University of Toledo discovered that rice husks can remove microcystin, a toxin released by harmful algal blooms, with up to 95% efficiency. The treatment uses organic rice husks treated with hydrochloric acid and heated to 250 degrees Celsius.
A recent study discovered amyloid plaques in the brains of stranded dolphins in Florida and Massachusetts, similar to those found in humans with Alzheimer's disease. The presence of these plaques, along with an environmental toxin produced by cyanobacterial blooms, highlights the potential risks of toxic exposures in marine environments.
A machine learning approach using high-quality animal model data sheds new light on the biology of the liver and kidneys after toxin exposure, revealing nine distinct patterns of response to chemical exposure that may be broadly relevant to studies of human disease. The analysis highlights defense mechanisms and novel biomarkers, provi...
Researchers at Binghamton University discovered how a Gram-negative bacterium delivers toxins that make us sick. The study found that the communication molecule inserts itself into the membrane to physically stimulate vesicle production, which contains highly concentrated toxins.
Researchers have identified a toxin in Mycobacterium tuberculosis that kills the bacteria if not neutralized by an antidote protein. This 'suicide' mechanism can be harnessed for therapeutic purposes to combat tuberculosis, which is a major cause of death worldwide.
Researchers have identified bacteria in Lake Erie that can degrade microcystin, a toxic toxin linked to liver cancer and other diseases. The bacteria, including Flectobacillus major and Pseudomonas lutea, can remove up to 19 parts per billion of microcystin from water supplies.
Research has confirmed the presence of neurotoxin BMAA in 89% of eastern Australian freshwater samples, with highest levels ever recorded. The toxin is produced by cyanobacteria and linked to neurodegenerative diseases such as ALS/MND worldwide.
A new class of centyrins shows promise in blocking the effects of severe S. aureus bacterial infections in mice and human cell experiments. Nearly all centyrins that bind to leukotoxins prevent toxins from attaching to and destroying cells, potentially addressing antibiotic resistance.
Alison Weiss awarded grant to study Shiga toxin producing Escherichia coli 0157:H7, also known as Hamburger E. coli, which causes bloody diarrhea and kidney failure. Her lab will use human intestinal tissue models to test potential treatments.
A meta-analysis of pooled clinical trial data supports the effectiveness of botulinum toxin injections in reducing the frequency of chronic migraine headaches, with significant reductions in headache frequency at both two and three months.
Researchers have created a genetically modified houseplant that can efficiently remove at least two toxins, formaldehyde and benzene, from the air. The plant's detoxifying potential was boosted by introducing a mammalian gene called CYP2E1 into its genome.
A recent study using CRISPR/Cas9 technology identified two factors necessary for Shiga and ricin toxins to enter cells: TMEM165 and TM9SF2. These proteins are found in the cell's Golgi apparatus and play a crucial role in glycosylation, a fundamental biological process that enables cells to create diverse molecules with varied function...
Researchers found that combining low doses of paraquat herbicide with sugar-binding proteins called lectins triggered Parkinsonism-like symptoms in rats. The study suggests that the toxin travels from the stomach to the brain, forming a misfolded protein alpha-synuclein that causes the disease.
Two clinical trials using botulinum toxin injections to suppress post-operative atrial fibrillation (POAF) showed promising results. Patients who received BTX injections during surgery had a sustained reduction in POAF incidence and overall burden over three years, accompanied by reduced hospitalization needs.
Some moth species use sound-absorbing scales to evade bats' echolocation. The scales vibrate at resonant frequencies that overlap with bats' biosonar range, creating acoustic camouflage.
Researchers at the University of Liverpool have uncovered a novel mechanism by which Streptococcus pneumoniae bacteria evade immune defenses. Pneumolysin toxin binds to a host cell receptor called Mannose Receptor C type-1 (MRC-1), suppressing inflammation and protective immunity, allowing the bacteria to survive in the airways.
Researchers studied bacterial ecological systems using experiments and computer models to investigate population dynamics, identifying key role of stochastic effects in early colony patterning. They also found that interactions between neighboring bacteria can amplify local variation, influencing competition outcomes.
A new Lake Erie Center for Fresh Waters and Human Health aims to study harmful algal blooms and their impact on human health. U-M researchers will lead a project to discover previously unknown toxins, with the goal of developing new medicines.
A new study by Northwestern University found that facial exercise after Botox injections can make wrinkle reduction occur one day sooner. The exercises included raised motions of the forehead and scowls, which improved forehead wrinkles by two to three days after treatment when followed by facial exercise.
A new study found that clay supplements can improve the immune response of dairy cows to aflatoxin exposure, leading to reduced inflammation and increased liver functionality. Cows fed higher doses of clay produced more milk with lower levels of aflatoxin M1.
A new study has identified a key factor in how Enterotoxigenic E. coli (ETEC) causes disease, giving scientists hope for a preventive vaccine. The researchers discovered that ETEC can sense oxygen levels to control toxin production, leading to breakthroughs in understanding the bacteria's virulence.
Researchers developed a theranostic complex that targets tumor cells with two toxic modules, showing high therapeutic efficacy and imaging contrast. The complex uses yttrium-90-doped upconversion nanoparticles and targeted toxin to inhibit tumor growth and reduce drug resistance.
A recent study by Ohio State University researchers found high levels of toxins in water near farm fields in rural Ohio, posing serious health risks to people, pets, and wildlife. The study highlights the need for judicious fertilizer use and measures to reduce animal waste contamination to control algal blooms.