Articles tagged with Transcription Factors
Researchers at Weill Cornell Medicine found a new way to target mantle cell lymphoma by inhibiting the activity of FOXO1 protein, which coordinates gene expression. The discovery could lead to new treatments and improved understanding of how this type of lymphoma develops.
Scientists at KAUST have identified dynamic regions, called cryptic binding sites, that can be targeted by drugs to treat cancer. The study reveals how molecular motion influences ligand binding to BTB domains, a critical part of many proteins involved in disease.
Researchers created predictable, novel expression patterns of fluorescent proteins using engineered gene circuits. They also redesigned root architecture by tuning the number of root branches using similar gene circuits.
Researchers identified 257 rhizoplane microbial biomarkers associated with six key agronomic traits, revealing a complex association between millet genotype, root microbiome, and crop growth. The study provides insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet.
In a new study, researchers found that immune T cells lacking the key transcription factor Satb1 are more susceptible to suppression by regulatory T cells, leading to transplant tolerance. The study provides insight into the mechanism behind transplantation tolerance and may lead to the development of new immunosuppression regimens.
A study reveals that alveolar macrophages, responsible for filtering bacteria and viruses from the lungs, fail to function properly when lacking a crucial transcription factor called C/EBPb. This leads to an accumulation of surfactant in the lungs, causing pulmonary alveolar proteinosis (PAP), a hitherto incurable disease.
A University of Ottawa research team has made new discoveries on how motor skills are learned and stored in the brain. By studying mice, they found that a specific transcription factor called NPAS4 regulates gene changes in inhibitory neurons, leading to the formation of learning-associated neuron ensembles.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
Scientists have identified a key gene that can improve wheat grain yield by increasing the number of spikelets per spike. The discovery provides a promising solution to address the food security crisis and could lead to significant improvements in wheat yields.
Researchers created a detailed map of how immune genes function together, shedding light on the basic drivers of immune cell function and immune diseases. The study found interconnected regulatory networks that can help explain why mutations in different genes lead to the same disease or how drugs impact multiple immune proteins.
Scientists have made a breakthrough in understanding cannabis biology by using firefly genes to study trichome development and cannabinoid synthesis. By cloning promoters and expressing firefly luciferase, researchers can evaluate signals that orchestrate cannabinoid production and trichome development.
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
Scientists have identified the DOMINANT AWN INHIBITOR (DAI) gene in sorghum, which regulates the absence and shortening of awns. The gene encodes a protein that negatively regulates awn formation as a transcription factor, with implications for breeding modern awnless cultivars.
The study found that mice lacking both Runx1 and Runx2 in CAR cells showed a significant reduction of HSPCs and immune cells, along with an increase in fibrosis. The researchers suggest that Runx1 and Runx2 may be potential targets for the diagnosis and treatment of myelofibrosis.
Researchers used heterochronic parabiosis to connect old and young mice, revealing key mediators of systemic rejuvenation. Aged stem cells in bone marrow were revitalized by exposure to young blood, regaining lymphoid differentiation potential.
Researchers used worms to study how hunger signals in the gut communicate with the brain, leading to riskier behavior. The findings suggest that proteins in intestinal cells move dynamically to transmit signals about hunger, driving worms to cross toxic barriers.
A team of researchers at UC Riverside has discovered that a protein complex called CAF-1 controls genome organization to maintain lineage fidelity in blood stem cells. The study found that CAF-1 keeps specific genomic sites compacted and inaccessible to transcription factors, ensuring the expression of lineage-specific genes.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
High blood pressure can cause long-lasting changes in the structure of vascular smooth muscle cells, stiffening arterial walls and increasing the risk of cerebrovascular disease. Researchers found that a signaling pathway triggered by E–T coupling is involved in this process, leading to inflammation and vascular remodeling.
Researchers from the Chinese Academy of Sciences have developed a method to overcome the tradeoff between rice yield component traits, including panicle number and size. By modifying the cis-regulatory region of the Ideal Plant Architecture 1 gene, they increased grain yield by 15.9% while maintaining tiller number.
Scientists have developed a novel approach to targeting transcription factors, which could lead to new therapies for cancer and other diseases. A peptide designed to target the Mediator complex has been shown to selectively inhibit p53, a critical gene in human development and stress response.
Scientists have discovered a novel protein NDB1 that inactivates MYB1, a key regulator of nitrogen assimilation in plants. This finding could lead to improved biomass production and crop yields by manipulating NDB1. Researchers are now exploring the potential to boost plant growth through NDB1 manipulation.
In a study published in Nature Communications, researchers uncovered the molecular players involved and how timing is controlled for creating neural diversity. Single-cell RNA sequencing technology revealed a temporal patterning gene network in Drosophila medulla neuroblasts, including nine new transcription factors.
Researchers at Tohoku University create a novel method to quantify transcription factor activity in live organisms using viruses. This breakthrough enables scientists to understand how diseases develop and potentially treat them.
Researchers mapped the molecular changes that orchestrate embryonic mouse cell differentiation into diverse cell types. The study provides a roadmap of mouse embryogenesis, which will help researchers understand the molecular programs controlling cell emergence and tissue organ formation.
Researchers identified a critical region of CmMYB1 and the CmNDB1 protein that negatively regulate nitrate assimilation genes under nitrogen-repleted conditions. This study provides valuable insights into molecular functions and mechanisms in plants, shedding light on the regulation of transcription under specific nitrogen levels.
A team of researchers from Charité – Universitätsmedizin Berlin have elucidated the process underlying drug resistance in aggressive pancreatic cancer. They found that inhibition of the RUNX1 protein limits cancer growth and may lead to effective treatment options.
Researchers discovered a bZIP23-PER1A module that regulates rice seed vigor, improving crop quality. They found two cultivars with huge phenotypic differences, Kasalath and Jigeng88, and identified a novel detoxification pathway to enhance seed vigor.
Codiak BioSciences' exoASO-STAT6 demonstrates potent anti-tumor efficacy by reprogramming tumor-associated macrophages to an M1 phenotype, showing promise as a monotherapy candidate for hepatocellular carcinomas and other cancers. The company plans to initiate Phase 1 clinical trials in the first half of 2022.
A recent study revealed that current tomato cultivars are vulnerable to the emerging ToBRFV, a damaging virus affecting tomatoes and other crops. The research also developed a molecular detection tool to identify infectious virus particles carried on contaminated seeds.
Researchers discovered a protein called PHR regulates arbuscular mycorrhiza (AM) symbiosis based on phosphate availability. AM promotes phosphate uptake and other nutrient absorption, enhancing plant resistance to stressors.
Dresden researchers reveal how liquid-like protein droplets collectively read DNA regions to switch on genes. Thousands of individual transcription factors work together, interacting and identifying clusters of binding sites on the DNA surface.
Researchers discovered the ZIP-1 gene acts as a cell's first-line response to infection, controlling immune responses to viruses and other threats. The finding could have implications for identifying similar genes that control immune responses in humans.
Plants respond to heat stress by activating a molecular defense pathway involving brassinosteroids, which increase heat stress resistance. Researchers at TUM discovered the role of transcription factor BES1 in this process.
Scientists have identified the transcription factor Blimp1 as a new critical regulator of tumor-infiltrating regulatory T cells. Disrupting Blimp1 in these cells remodels the tumor microenvironment and augments the response to immunotherapy, promoting improved tumor control and anti-tumor immunity.
Researchers from the University of Tsukuba found that the FoxO-KLF15 axis regulates macronutrient metabolism in the liver in response to changes in insulin levels. This pathway promotes the conversion of protein to carbohydrate and prevents the conversion of carbohydrate to fat during fasting, but shuts down during feeding.
Researchers at JGI have developed a new protocol to study the effects of genetic variations on traits, using DNA affinity purification sequencing technology. The protocol allows for rapid capture of transcription factor binding locations in the genome, providing insights into gene regulation and function.
An international research team discovered a new rare disease caused by a disrupted Helios-dependent epigenetic regulation mechanism, leading to T and B cell defects. The study highlights the importance of Helios in immune homeostasis and suggests potential therapeutic targets for immunodeficiency and malignancy.
Researchers found that dual-regulation by two distinct groups of splicing factors ensures phase-separation of large exon-containing transcription factors. SRSF3 overrides the splicing-suppressive activity of hnRNP K on large exons.
Two Gladstone scientists, Leor Weinberger and Vijay Ramani, received NIH Director's Awards to fund groundbreaking research on a single-administration antiviral for COVID-19 and a molecular strategy to fight cancer. Their work has implications for treating various diseases, including cancers.
A team of researchers discovered that KNOX and BELL transcription factors evolved to activate zygotes in plants, later shifting their role to maintain organ development in land plants. The study used the liverwort Marchantia polymorpha as a model organism.
A study by MedUni Wien researchers has discovered that the transcription factor BATF3 and its target genes play a crucial role in the growth of tumour cells in anaplastic large cell lymphoma. The findings suggest that targeting the IL-2R system could be an effective therapeutic approach, with promising results in animal models.
Researchers at St. Jude Children's Research Hospital found that the tumor suppressor gene PTEN controls rhabdomyosarcoma cell identity and that enhancing PAX7 expression can maintain tumor cell existence, providing a potential treatment target for rhabdomyosarcoma.
Researchers found that Atf1 and Rst2 transcription factors reciprocally bind to DNA in fission yeast cells responding to glucose scarcity. This unique mechanism prevents both proteins from binding alone and integrates independent activation pathways.
A new study reveals that the TCF7L2 gene plays a key role in smooth muscle cell death and replenishment, potentially reducing aortic aneurysm risk. Researchers analyzed blood samples from over 1,300 individuals with aortic aneurysms and found a significant genetic link to the disease.
Scientists from UCLA Jonsson Comprehensive Cancer Center identified TAF12 as critical to the formation of preinitiation complexes, which are necessary for gene transcription. Eliminating TAF12 destroys preinitiation complexes and drastically reduces genome-wide transcription.
A new machine learning algorithm, BITFAM, helps identify transcription factor activity in individual cells, providing insights into gene regulation. This system can aid researchers in understanding biological functions and developing new treatments for diseases.
The study reveals that Meis transcription factors are crucial for the formation and antero-posterior patterning of limbs. Genetic deletion of all four family members showed that these proteins are essential for limb development.
Researchers at the John Innes Centre identified a key gene controlling grain elongation and glume characteristics in Polish wheat, which could lead to improved productivity and sustainability in wheat production. The discovery highlights the importance of understanding genetic control of agronomic traits for major crops like wheat.
A research team identified a new factor in the immune system's signal transmission that contributes to psoriasis development. The 'c-Jun' protein in dendritic cells promotes psoriatic skin inflammation, which can be alleviated by inhibiting this protein.
Scientists at BIH have found a new metabolite, S-2-hydroxyglutarate, that regulates endothelial cell quiescence and prevents excessive vessel growth. This discovery brings the researchers closer to developing targeted therapies for vascular diseases.
The study identified several cellular pathways that change when a tumor becomes aggressive, and developed a simple system to model their effect. The model integrated different types of experimental data, including transcription factors, to predict which targets are important for colorectal cancer aggressiveness.
Scientists studying early-budding trees have identified a key gene, EBB3, that regulates bud-break in response to temperature changes. This discovery could lead to genetically modified crops more resilient to warmer winters and late frosts.
Researchers found that SKN-1B controls behaviors like foraging, eating and resting in nematode worms, which may regulate food-sensing and fullness in humans. The study proposes a similar transcription factor, Nrfs, as a potential target for developing drugs controlling overeating.
A study by Kumamoto University researchers found that the molecule Folliculin (FLCN) acts as a gatekeeper to maintain separation between blood and lymphatic vessels. The discovery sheds light on how these two vessel types form independent networks, with potential implications for cancer metastasis and treatment of lymphedema.
Plant cells use pioneer transcription factor LEAFY to access genes that are otherwise inaccessible due to tightly packed chromatin. This allows for changes in cell identity and fate, enabling plants to adapt to environmental conditions.
A new study reveals that pioneer transcription factors help unspool tightly wound coils of DNA, allowing genetic blueprints to be read and proteins to be made. The researchers found that one pioneer factor can interact with two different remodelers to regulate transcription, a process deeply conserved across species.
A joint research team developed DeepTFactor, a deep neural network predicting transcription factors from protein sequences. The tool uses three parallel convolutional neural networks and predicted 332 transcription factors of Escherichia coli K-12 MG1655.
A team of researchers at Duke University has developed a new method to program stem cells into desired cell types using CRISPR gene editing. By analyzing the transcription factors key to making each cell type, they improved the accuracy of model cells grown from stem cells.
Scientists create a system to quickly and easily convert human stem cells into various cell types, including neurons and blood vessels. The researchers identified 290 DNA-binding proteins that reprogram stem cells into target cells within four days.