Articles tagged with Tyrosine Phosphatases
A study led by Cold Spring Harbor Laboratory researchers found that inhibiting the protein PTP1B improves learning and memory in an Alzheimer's disease mouse model. This suggests that PTP1B inhibition can also improve microglial function, clearing up Aβ plaques.
The article explores how automation and innovative screens are influencing the search for inhibitors and activators of protein tyrosine phosphatases, which have been implicated in many human diseases. The resulting compounds are facilitating exploration of fundamental cellular processes controlled by phosphatases in cancers.
The ASBMB-Merck Award lecture will focus on the role of protein tyrosine phosphatases (PTPs) in cellular signaling and cancer. Recent research has shown that PTPs can function as tumor suppressor genes, with the PTEN gene being a key example.