SLAS Discovery highlights innovative screening platforms accelerating therapeutic discovery for neurodegenerative diseases, including a newly identified link to Alzheimer's progression. The journal showcases novel technologies and approaches to understand and treat human disease, advancing life sciences discovery and technology.
This volume of SLAS Technology highlights novel laboratory technologies, open-source software, and disease-specific tools for advancing life sciences research and development. The journal emphasizes the importance of education, knowledge exchange, and global community building to drive innovation in biomedical research.
Volume 39 of SLAS Discovery highlights novel assays and AI-assisted workflows to accelerate personalized cancer immunotherapy. The journal aims to advance life sciences discovery through education, knowledge exchange, and global community building.
The latest SLAS Technology volume showcases how AI, automation, and portable technologies are transforming drug discovery and diagnostics. This advancement enables the development of innovative therapeutic solutions and improved patient care.
The latest volume of SLAS Discovery highlights advances in 3D cell culture and novel technologies for drug discovery. Small molecule cytokine antagonists and a versatile ELISA for PPI inhibitor screening are among the key findings.
Twelve life science startups have been selected for the Innovation AveNEW program at SLAS Europe 2026. The companies will showcase their products and services in a specially designated area on the exhibition floor, engaging with purchasing influencers and decision-makers from over 40 countries.
This issue highlights advancements in drug discovery, synthetic biology, and laboratory digitalization. SLAS Technology emphasizes scientific and technical advances that enable improved biomedical research and development.
The Society for Laboratory Automation and Screening (SLAS) has developed a comprehensive framework to educate scientists on laboratory automation, addressing the growing gap between technology adoption and training pathways. The project aims to create shared standards for automation education, expanding access to training across instit...
The Society for Laboratory Automation and Screening (SLAS) has welcomed Madeline M. Farley, Ph.D. as its new Scientific Director. She brings over fifteen years of experience in academic research and preclinical development to the role.
The latest issue of SLAS Technology highlights significant advancements in biomedicine and diagnostics, with AI-powered tools achieving 99.9% accuracy in detecting monkeypox. Additionally, the journal showcases innovative lab technologies, including multi-camera zebrafish assays and infection-proof titanium implants.
The journal features novel FAK-paxillin inhibitors, a venom toxin screening platform, and AI-driven solubility prediction for compound discovery. SLAS Discovery highlights innovative technologies to understand and treat human disease.
The Society for Laboratory Automation and Screening's two scientific journals, SLAS Discovery and SLAS Technology, have achieved substantial impact factor increases due to open access publishing. This shift has led to higher citations and visibility for authors, with SLAS Technology experiencing a notable rise of 1.2 points to 3.7.
Researchers tackle pressing challenges in drug discovery with innovative approaches, including high-throughput TRIP13 inhibitors and tau aggregation blockers. The journal focuses on advancing life sciences discovery and technology via education, knowledge exchange and global community building.
This issue of SLAS Technology features a high-precision microfluidic flow splitter that outperforms commercial alternatives, enabling even flow division and simplifying multi-inlet perfusion. The journal showcases technological leaps in the life sciences, including rapid pathogen detection and AI-driven insights into schizophrenia.
The Society for Laboratory Automation and Screening (SLAS) has awarded a $100,000 Graduate Education Fellowship Grant to Vasu Rao of the University of Michigan. Rao's research aims to develop new methods for understanding non-model bacteria using artificial intelligence and laboratory automation.
The latest SLAS Technology issue highlights recent breakthroughs in skin cutaneous melanoma, glycan-bead coupling, and acoustic ejection mass spectrometry. Researchers adapt technological advancements for life sciences exploration and experimentation in biomedical research and development.
Researchers develop an in vitro model to study tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The approach offers a short timeline for generating data and facilitates the study of potential therapeutic interventions.
This special collection in SLAS Discovery highlights the significant impact of high-content imaging in basic and translational research. Researchers have made advancements in cell painting and phenotypic profiling, offering new therapeutic approaches for diseases such as Gaucher's.
The SLAS Technology October 2023 issue focuses on reducing laboratory automation waste through machine learning and novel systems. Researchers adapt technological advancements for life sciences exploration and experimentation, enabling improved biomedical research and development.
A special issue of SLAS Discovery magazine highlights the Virginia Drug Discovery Consortium's efforts to promote drug discovery and development in Virginia. The issue features original research, protocols, and perspectives on novel technologies and approaches for understanding and treating human disease.
The August 2023 issue of SLAS Technology features original research articles on nanodiamonds, automated buffer exchange, and epidermal growth factor. A new scheduling method called SAGAS is proposed to optimize life science experiments in laboratory automation.
The latest issue of SLAS Discovery features novel technologies and approaches to develop and characterize chemical and biological tools for human disease treatment. The journal reports on high-throughput screening-related research, including fluorescence polarization assay use and glycomimetics.
A proof-of-concept study demonstrates the effectiveness of two supporting matrices in growing spheroids derived from patient cells for 3D drug sensitivity and resistance testing. This finding offers promising prospects for automating this process in drug testing.
The June special issue of SLAS Technology highlights the latest developments in bioprinting, a transformative technology poised to revolutionize many aspects of medicine. Bioprinting is advancing at a rapid pace, with novel materials, fabrication techniques, and bio-ink compositions being developed.
A new automated algorithm enhances the assessment of human neuron survival in synucleinopathy by tracking cell death and markers of neuronal fitness. The developed method offers improved accuracy and consistency compared to manual counting.
Researchers developed a high-throughput assay to analyze CAR-T cells' effects on 3D tumor spheroid models using plate-based image cytometry. This study demonstrates the potential benefits of this method for assessing potency, specificity, and location of CAR-T cells in relation to spheroids.
The March special issue of SLAS Discovery introduces protocol articles highlighting detailed scientific methods and procedures in drug discovery. The issue covers topics such as 3D imaging, cancer treatments, and high-throughput screening, emphasizing transparency and rigor in research methodology.
The article analyzes digital microfluidics' (DMF) benefits for bacterial protocols, highlighting its versatility and potential applications in synthetic biology and diagnostics. DMF's electrostatic forces manipulate microdroplets on a plate, enabling sample preparation and nucleic acid detection.
The SLAS Discovery Editor's Top 10 for 2022 showcases articles on COVID-19 drug discovery, 3D organoid systems, and treatments for diseases such as autism spectrum disorder and obesity. These top articles demonstrate the impact of high-throughput screening approaches and innovative technologies in advancing scientific collaboration.
A new high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of ERAP1 has been developed, demonstrating improved stability, reproducibility, and robustness compared to existing assays. The assay's ability to detect other difficult targets makes it a valuable tool in drug discovery.
A new method for creating freestanding hydrogel lumens that can accurately replicate blood vessels and facilitate vasodilation research. This approach allows researchers to study vasodilation in a more efficient and effective manner, overcoming limitations of existing methods.
A new neuronal cell-based reporter system has been developed to identify compounds that inhibit histone deacetylase 2 (HDAC2) with minimal effect on its partner enzyme HDAC1. This innovation holds promise for dementia drug development by targeting the root cause of memory impairment.
A new experimental device has been developed to generate temperature gradients on a microtiter plate, allowing for the simultaneous testing of different temperatures. This innovation solves a common challenge in biological studies of living cells, unlocking new possibilities for studying cellular growth and development.
Few studies utilize high-throughput screening (HTS) and high-content screening (HCS) techniques in anti-obesity drug discovery due to a lack of original data or experimental design information. This limits the development of effective pharmaceutical treatments for obesity-related diseases.
Researchers developed a label-free SERS method to detect the cysteine residues of the SARS-CoV-2 spike protein subunit, allowing consistent detection in human blood plasma, mucus, and saliva samples. This technique holds potential for diagnosing SARS-CoV-2 and other viral infections in remote areas.
Researchers developed a high-throughput spheroid-based migration assay using tissue-mimicking ECM to accurately recreate cell migration. This new method enables studying of cell motility and cancer metastasis, potentially benefiting cancer research.
Researchers have developed a new method to detect metal impurities in high-throughput screening, reducing false positive hits and saving time and resources. The technique uses acoustic mist ionization mass spectrometry to identify eight different metal contaminants, outperforming previous methods.
The June issue of SLAS Discovery focuses on the role of microRNAs in cancer progression, particularly Kaposi’s sarcoma-associated herpes virus-derived miRNA K12-1. Researchers have also developed a new software workflow called Screener to automate data analysis from automated patch clamp electrophysiology platforms.
The SLAS Technology April issue delves into the potential of single-cell transcriptomics for producing transcriptomes from heterogeneous samples. Kind et al. present a new process that reduces sequencing library preparation time by over 75% using the 10X Genomics Single Cell 3' kit.
The April issue of SLAS Discovery highlights innovative approaches to accelerating lead identification for pancreatic cancer therapies. Authors explore the potential of completely scaffold-free 3D models and automated organoid assays to improve disease modeling and drug discovery.
The February issue of SLAS Technology features an article on biosensor detection of airborne respiratory viruses, highlighting the effectiveness of this technology in identifying pathogens. Additionally, the issue includes an article on simple assessment of viability in 2D and 3D cell microarrays using single-step digital imaging.
A new platform was established for induced pluripotent stem cell research using Maholo LabDroid, demonstrating superior reproducibility and flexibility. The system enabled the cultivation of undifferentiated iPSCs for 63 days and achieved high differentiation rates with minimal variability.
The article presents a new plate-based image cytometry method to measure endothelial barrier function, which can be adapted for high-throughput and high-content screening. This approach shows promise in addressing the need for efficient pharmacological therapies for acute respiratory distress syndrome (ARDS).
This special collection highlights the use of biophysical methods in identifying and characterizing molecules in early drug discovery, including graphene bioelectronic sensing technology and mass spectrometry. It also showcases a fully automated acoustic ejection mass spectrometry technology for high-throughput screening.
A team of researchers developed a high-throughput biochemical assay to assess small molecule impact on SARS-CoV-2 nonstructural protein 14, identifying potential inhibitors from FDA-approved drugs. The study aims to deliver therapeutics for the SARS-CoV-2 virus, targeting its critical methyltransferase activity.
The Society for Laboratory Automation and Screening (SLAS) has announced its transition to a Gold Open Access publishing model with Elsevier. This change aims to increase public access to innovative life sciences research and drive citations for both SLAS Discovery and SLAS Technology journals.
The June edition of SLAS Discovery features the cover article on developing high-throughput biochemical assays to assess small molecule impact on SARS-CoV-2 nonstructural protein 14. The issue also includes nine original research articles, covering topics such as HIV latency reversal, kinase inhibitors, and drug combination screening.
The June edition of SLAS Technology features protocols for controlled cell seeding, splitting and expansion of human fibroblasts, induced pluripotent stem cells, and neural progenitor cells. Researchers have made significant improvements in forming complex 3D structures but face challenges in automating assay protocols.
The April edition of SLAS Discovery features research on PROTACs, targeting protein degradation, and kinase family profiling. Authors apply the Four Pillars Framework to expedite PROTAC development and inform pharmacokinetic-pharmacodynamic understanding.
The April issue of SLAS Technology explores the therapeutic potential of reactive oxygen species (ROS) in applications ranging from wound healing and hair growth enhancement to cancer treatment and stem cell differentiation. However, limitations in controlling the temporal pattern of ROS release hinder their clinical translation.