Articles tagged with Venom
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A study analyzing media reports of snakebites in the US found that 92.4% occurred under natural conditions, while only 7.6% were intentional bites. The majority of bite victims were unaware of the snake's presence and suffered lower extremity bites.
Researchers discovered a specific protein in spider venom that stimulates pain-sensing nerves, underlying abdominal pain in irritable bowel syndrome patients. Developing molecules to block this protein could lead to novel treatments for the condition.
Researchers at Scripps Research Institute develop a method to rapidly identify and optimize venoms for therapeutic use, finding potential treatments for multiple sclerosis and rheumatoid arthritis. They create a library of venom genes and use a cell-based selection system to find potent molecules that block key targets.
A new study from Ohio State University reveals rattlesnake venom's regional variations effectively counter squirrel defenses, indicating co-evolutionary adaptation. The research found significant variation in venom activity and resistance across populations, with snakes best suited to their local opponents.
Researchers have identified a core component of a conotoxin from marine snail venom that retains its pain-relieving properties after simplification. This modified conotoxin successfully treated pain in a laboratory rat model similar to human irritable bowel syndrome.
A new database provides critical information on the distribution of banded sea kraits, seven species that feed almost exclusively on eels. The venomous snakes' powerful toxin holds potential for developing treatments for cancer, neurological disorders, and heart disease.
Researchers developed a new method to produce coral snake antivenom using synthetically designed DNA, bypassing the need for venom collection from snakes. The approach resulted in a neutralization rate of 60% against coral snake venom, offering a promising alternative to traditional methods.
Researchers convert tarantula toxins into painkillers by targeting neural receptors, providing an alternative to current treatments with limited pain relief and side effects. The study reveals the importance of cell membranes in peptide toxin activity and opens opportunities for designing new drugs.
Researchers at the University of Hawaii developed innovative experiments to test first-aid measures for box jellyfish stings, finding that tried-and-true methods like vinegar and hot water immersion are effective in reducing venom toxicity. The study also introduced a new therapeutic called Sting No MoreTM, which inhibits venom directly.
Monash University researchers have solved the X-ray crystal structure of stonefish venom's lethal factor, providing insight into a crucial human immune response. The discovery aims to develop immunosuppressants to improve transplant therapy success rates for leukaemia treatment.
Researchers have created a comprehensive catalog of known animal toxins and their physiological effects on humans, summarizing nearly 42,723 effects on the body. The Venom Knowledge Base (VenomKB) may spur the discovery of new compounds and medical treatments for various diseases.
Researchers found that ancient venomous groups evolve slowly under purifying selection, while recent lineages diversify rapidly under positive selection. This reveals a new theory of venom evolution, proposing a 'two-speed' mode where toxins expand and then are preserved through purifying selection.
The study identifies the exact composition of sea snake venom, making the development of synthetic antivenoms more realistic. This could lead to a future production of synthetic antivenoms for as little as $10-100, potentially saving millions of lives.
Researchers found that Brazilian wasp venom's MP1 toxin selectively kills cancer cells by interacting with abnormally distributed lipids on their surface. The peptide creates gaping holes, allowing critical molecules to escape and potentially leading to new anticancer drug development.
Scientists have identified a new species of pre-mammal, Ichibengops, which lived around 255 million years ago. The species features a unique groove above its teeth, potentially for transmitting venom.
Researchers have identified two species of Brazilian frogs that are venomous, using their heads as a weapon to deliver toxic secretions. The discovery sheds light on the biology of amphibians and their interactions with predators in the wild.
Researchers have discovered thousands of new peptide toxins in the venom of a single type of Queensland cone snail, opening up promising leads for new pain and cancer treatments. The study's innovative method allows for deeper analysis of venom toxins than ever before.
Researchers have discovered that spider and centipede venom originated from an insulin-like hormone, with similar molecular shapes between the toxins and the hormone. This finding has potential applications in developing new pharmaceuticals and bioinsecticides, as well as solving agricultural and medical problems.
A promising new antivenom derived from opossum serum has shown promise in neutralizing snake venom, with potential for widespread distribution and a single injectable dose. The peptide-based treatment could save thousands of lives worldwide without the side effects of current treatments.
Research identified seven compounds that block key pain signals to the brain, offering hope for new painkillers. The compounds show high levels of stability and potency, making them promising candidates for treating chronic pain.
Researchers at Aarhus University have made a comprehensive description of the proteins in gila lizard venom, which could lead to the development of new types of drugs. The study identified nineteen new proteins with potential pharmaceutical applications, including treatments for blood clots and pain relief.
Researchers discovered that coral snake venom's toxins permanently activate crucial nerve cell proteins, preventing reset and causing deadly seizures. The toxins target GABA(A) receptors, making them 100 times tighter than known compounds, leading to permanent opening of the receptor's pore.
A study isolated the domain IV paddle of scorpion venom and found it remained sensitive to scorpion venom even when bound to a chip. This breakthrough could lead to faster identification of drugs that target this region, modifying sodium channel activity in beneficial ways.
A new study reveals that cone snails add a unique form of insulin to their venom cocktail, which disrupts blood glucose levels and causes hypoglycemic shock in fish. The snail insulin may help unlock secrets of insulin function and energy metabolism.
Researchers at Florida Atlantic University have discovered new compounds in cone snail venom that target alpha3beta4 nicotinic receptors, associated with lung cancer and nicotine addiction. The study aims to develop new treatments for these diseases using marine animal-derived compounds.
A recent study found significant variation in eastern diamondback rattlesnake venom linked to geography, highlighting the need for tailored antivenom production. In contrast, coral snakes' venom is uniform across their range.
A large-scale survey of venom variation in two snake species reveals no local co-adaptations in eastern coral snakes, challenging traditional views on venom evolution. The consistent venom mix across Florida will aid antivenom development and inform conservation efforts for the declining eastern diamondback rattlesnake.
A UT Arlington team developed a new model for snake venom evolution, suggesting that venom genes evolved independently in distinct lineages of reptiles. The study found similar expression levels of venom gene families in python oral glands and brain tissue, challenging the traditional view of a core venom system developing first.
The first myriapod genome sequence has been completed, revealing new insights into the biological evolution and unique characteristics of venomous centipedes. The genome sequence uncovered clues about their absence of vision and circadian rhythm, as well as their ability to detect chemicals in air.
A new study using forensic DNA tests successfully identified the species of venomous snakes that bit people 100% of the time. The test has the potential to improve care for patients affected by deadly snakebites in countries where this is a major health risk.
Scientists have devised a method to target venom proteins specifically to malignant cells while sparing healthy ones, reducing or eliminating side effects. The approach involves using tiny nanometer-sized particles to treat breast and melanoma cancer cells in the laboratory.
Scientists have found that venom proteins in invasive lionfish may be acting as ciguatoxin mimics, leading to false positives in testing. Cooking or boiling lionfish samples before testing can help ensure safe consumption.
Researchers found that despite similarities in body forms, look-alike snakes from the two continents differ dramatically in diet. Australian elapid snakes specialize in lizards and other snakes as prey, while their North American counterparts focus on invertebrates such as insects and spiders.
Researchers identified diverse mechanisms driving venom variation in closely related snake species, impacting venom-induced haemorrhage and coagulation pathologies. This study highlights challenges to developing broad-spectrum snakebite treatments due to conventional antivenom limitations.
Researchers have tested a nasally administered antiparalytic drug, neostigmine, on mice injected with high doses of Indian cobra venom and found that 10 out of 15 mice survived treatment within 10 minutes. The study's results support the idea that fast and accessible treatment can increase survival rates in snakebite victims.
A research team analyzed centipede venom protein and peptide sequences to catalog, categorize, and reconstruct their evolutionary histories. They identified 60 unique venom protein and peptide families from just five species investigated, including 11 new protein families showcasing novel centipede venom ways.
Dr. Kevin Conway and his team have made two groundbreaking discoveries in the study of Western Atlantic Clingfishes. The researchers identified a new species of clingfish less than an inch long and discovered a unique venom gland in a well-studied group of fish, highlighting the vast diversity and complexity of marine ecosystems.
Scientists have discovered fossils of elapid snakes, including cobras and sea snakes, in Africa dating back to 25 million years ago. The findings suggest that seasonal habitats may have given rise to active hunters earlier than previously reported.
A University of Texas at Austin study reveals that crazy ants can neutralize fire ant venom, making them nearly invincible in battles over food resources. This detoxification process allows crazy ants to dominate and displace fire ants in the southeastern US ecosystem.
Researchers from LSTM and international biologists sequenced the king cobra genome, showing dynamic evolution and adaptation in its venom system. The study reveals rapid expansion of gene families that produce venom toxins, providing snakes with a highly toxic protein mixture.
Scientists have identified two new gorgonian soft coral species in the eastern Pacific, adding to the genus Eugorgia's range. The newly described species, E. beebei and E. mutabilis, exhibit vibrant white coloration, with the latter displaying a unique color-changing ability.
New research found that scorpions choose their strongest defensive behavior based on both physical characteristics and performance measurements. The study also revealed a correlation between scorpion shape, pinch force, and venom strength when defending themselves from predators.
A new protein in Australian tarantula venom has been found to be highly toxic to the cotton bollworm, a major pest affecting crop yields. The orally active insecticidal peptide-1 (OAIP-1) shows potency similar to synthetic insecticides, offering potential for bioinsecticide applications.
University of Arizona researchers have discovered a new secret in spider venom, finding that the venom produces a different chemical product in the human body than previously thought. This discovery has implications for understanding how brown recluse spider bites affect humans and developing possible treatments.
Dr. John Eng's research on gila monster venom led to the discovery of Exendin-4, a compound that stimulates insulin-producing cells and regulates blood sugar levels, improving the lives of millions of diabetics worldwide.
A new species of scorpion has been discovered in the Ecuadorian Andes, featuring a unique reddish-brown coloration with three longitudinal brown stripes. This discovery expands our knowledge of scorpion diversity in the region, which is considered a global epicenter of biodiversity.
Researchers have discovered that parasitic wasps can drain calcium from fruit fly blood cells to suppress their immune systems. This finding provides new insights into how pathogens break through a host's defenses and could lead to the development of new treatments for human immune disorders.
A new engineered protein from a reaper spider's venom may offer a promising candidate for therapeutic serums or vaccination against other venoms. The protein provides effective protection against the effects of pure spider venom in animal models.
Researchers have discovered that saw-scaled viper venom contains both anticoagulants and coagulants, which can be used to develop new treatments for blood disorders. The venom's toxic clotting factors were found to be lethal to mice, making them a promising area of study.
The Brazilian Journal of Venomous Animals and Toxins including Tropical Diseases has moved to BioMed Central's open access publishing platform, expanding the publisher's portfolio to 250 journals. The journal will publish research on all aspects of toxins, venomous animals, and tropical diseases.
Researchers found that administering zinc to human blood and mice treated with the venom's compound could slow down pore-forming process in cells. Zinc gluconate treatment increased survival times in mice, suggesting a potential therapeutic option. The study proposes zinc as a life-saver for victims of Australian box jellyfish stings.
Researchers have identified three active variants of a conotoxin that blocks the transmission of pain signals in nerves. These venomous peptides, derived from cone snails, show great promise for developing new painkillers with minimal dependency and faster degradation rates.
A study published in PLOS ONE found that worker ants can paralyze and kill termites without direct contact, thanks to their potent venom. The researchers discovered three functions of the ant venom: attracting nestmates, repelling alien ants, and killing termites.
A group of researchers at UCSF has discovered why the bite of a small Texas coral snake can be so painful. The venom contains toxic chemicals that bind to acid receptors on human nerve endings, triggering severe pain signals to the brain.
Researchers discovered that mast cells release protein MCPT4, degrading Gila monster venom helodermin, reducing morbidity and mortality. This mechanism also applies to scorpion venom, providing a natural defense against deadly toxins.
The US Food and Drug Administration approved Anascorp, a scorpion antivenom produced in Mexico, to treat patients suffering from scorpion sting. The drug was tested in clinical trials conducted through the University of Arizona and showed dramatic results in alleviating symptoms and reducing scorpion venom levels.
Research suggests that venom-targeted proteins evolve rapidly in mammals that eat snakes, implying a defensive role for venom. This finding contradicts the traditional view that venom evolves as a feeding adaptation.
Researchers developed an affordable antivenom against the Papuan taipan, a lethal snake, to address chronic shortages in developing countries. The project demonstrates the potential of international cooperation in producing high-quality antivenoms at an affordable price.
Researchers investigated snake venom's surface tension and viscosity, discovering that these properties facilitate the venom's entry into wounds. The team found that snakes developed optimal fang groove geometry and a special property of their venom to allow for efficient delivery of deadly poison.
Michigan State University researchers found that scorpion venom selectively targets insect sodium channels, making it a valuable tool for developing new insecticides. The study aims to understand how insects develop resistance and create alternatives to control resistant pests.