Articles tagged with Anaphase
Researchers report that pevonedistat inhibits NEDD8-activating enzyme, leading to cell cycle arrest and anaphase catastrophe in malignant T-cells. This effect may be coupled with immunomodulatory activity, suggesting pevonedistat as a potential therapeutic approach for T-cell lymphoma.
Researchers at Brown University have discovered a unique interaction among proteins that could be a target for new cancer therapy. Ki-67 and RepoMan bind to PP1 in an unusual way, forming a 'hairpin' shape on the surface of PP1.
Researchers at Stowers Institute for Medical Research have developed a novel approach to count fluorescent molecules in a cluster, resolving the long-standing debate on centromere structure. By applying this method to yeast cells, they found that centromeric nucleosomes change their structure during cell division.
Researchers have identified a new molecular mechanism underlying Anaphase B, a previously understudied stage of cell division. The discovery has implications for understanding chromosome abnormalities and their link to cancer.
Exposure to cigarette smoke condensate breaks both strands of DNA and compromises chromosome integrity in human fibroblasts. This can lead to genetic imbalances and increased cancer risk due to the formation of anaphase bridges and reactive oxygen species.