Articles tagged with Cancer Cells
Researchers at TSRI have solved a long-standing mystery about the 'relief-valve' that protects cells from swelling. The study reveals that VRAC is a complex structure with five protein subunits, which determines its relief-valve properties. Different cell types may need different forms of VRAC to cope with their environments.
A study has identified the replication stress response protein SMARCAL1 as a key player in the Alternative Lengthening of Telomeres (ALT) pathway, which is active in approximately 10% of all cancers. This pathway allows cancer cells to maintain telomere length and avoid cell death, making it a potential target for new therapies.
Researchers found that epigenetic marks play a crucial role in determining individual predisposition to obesity, even in genetically identical mice and human twin pairs. The study reveals a key role for Trim28 deficiency in explaining individual differences in obesity.
Researchers at University of Tsukuba have successfully developed a new type of anticancer agent, gatastatin, targeting γ-tubulin. This γ-tubulin specific inhibitor has shed light on the importance of γ-tubulin function in microtubule stability during late stages of cell division.
Melbourne researchers discovered a protein called Hhex that puts the brakes on leukemia cell growth and division. Targeting this protein could lead to new therapies for acute myeloid leukemia (AML), an aggressive blood cancer with poor prognosis.
Researchers found that DNA methylation patterns in leukemia cells can vary significantly across different cell maturation stages. However, the 'cancer-typical' methyl patterns discovered so far are actually indicative of the normal development process rather than cancer-specific changes.
Researchers developed an algorithm called Mogrify that predicts the unique set of cellular factors required for converting one human cell type to another. This breakthrough has significant implications for regenerative medicine and lays the groundwork for further research into cell reprogramming.
Researchers developed logic gates that can operate inside cells and interact with native messenger RNA, enabling a foundation for bio-computers to sense, analyze, and modulate molecular information. The tools could provide a basis for creating circuits with many inputs to control cellular behavior in response to stimuli.
New research reveals that skin bacteria toxins can advance cancer cell growth by manipulating the immune system. The study found that certain staphylococcus bacteria produce toxins that enable cancer cells to override the immune defense mechanism, leading to more aggressive disease progression.
A novel RNA delivery system has successfully halted the proliferation of a cancer-related protein in white blood cells, offering hope for treating MCL. The system uses nanoparticles coated with antibodies to deliver siRNAs that target the faulty gene causing the disease.
Researchers at CNIO have identified a protein called BPTF that is essential for MYC to cause cancer in mouse models, suggesting it could be a new target for future anti-cancer drugs. Inhibiting BPTF reduces the aggressiveness of tumours.
Researchers found that e-cigarette vapor damaged human cells, causing DNA breaks and cell death. The study suggests that e-cigarettes are not as safe as their marketing claims, and may contain previously undiscovered carcinogenic components.
Researchers have discovered a new mechanism behind chromothripsis, a phenomenon where cells undergo multiple mutations due to telomere crisis. This chain of events can create chromothripsis, leading to cancer, and may inform early diagnosis methods.
Researchers discovered an unexpected link between two common prostate cancer treatments, radiation and androgen ablation. This connection allows doctors to better determine which treatment will benefit individual patients, potentially leading to improved prostate cancer treatments.
Scientists at the University of Copenhagen have made a groundbreaking discovery in cancer therapy, revealing a new chemical reaction that enables more accurate treatment. This breakthrough has the potential to improve patient outcomes and reduce damage from traditional radiation therapy.
The ASCB's Celldance Studios released three new award videos featuring eye-popping live cell imaging, showcasing cancer research breakthroughs and the dynamic cell membrane. The videos capture moments of metastasizing cancer cells breaking through blood vessel walls and the exploration of churning lipids and proteins on the cell surface.
A recent study published in Endocrinology Today holds promise for cancer patients undergoing chemotherapy to protect their fertility and defense systems. Researchers found that the potent humanin analogue (HNG) protected male germ cells and white blood cells, reducing infertility and infection susceptibility.
Researchers have identified 335 genes that regulate the formation and function of extracellular vesicles (EVs), tiny bubbles released by cells. EVs can promote tissue repair or carry disease signals for cancer and neurodegenerative diseases like Alzheimer's. Understanding EV biology could lead to new therapeutic treatments.
Researchers identify two cancer phenotype clusters based on endocytic dysfunction in non-small cell lung cancers, one marked by KRAS mutations and the other by epithelial changes. This study provides a new approach to distinguishing cancer subtypes using endocytic activity.
Researchers have found that a cancer drug can neutralize the toxic RNA responsible for myotonic dystrophy type 1. The study used actinomycin D to inhibit toxic expansions in DNA, correcting mis-splicing and reducing symptoms.
A recent study published in Nature Communications reveals that TET protein loss of function leads to rapid development of malignant cancer. The research found that mice lacking both Tet2 and Tet3 developed aggressive myeloid leukemia, highlighting the importance of TET proteins in maintaining genome stability and preventing cancer.
Two researchers at TU Dresden have been awarded EU funding to investigate neurogenesis and cell cycle regulation, aiming to produce human neurons and improve cancer treatment strategies. The projects will focus on understanding the biological rules of neurogenesis and the interaction between cell cycle machinery and redox systems.
Researchers create spatiotemporal genomic analysis (SAGA) technique to study differences in cellular behavior, including cell migration and response to chemotherapy. This approach may lead to new treatments that hamper metastasis.
Researchers have achieved unprecedented response rates of up to 93% and durable remissions of over two years in children with relapsed/refractory acute lymphoblastic leukemia. Similarly, patients with non-Hodgkin lymphoma responded well to personalized cellular therapy, with complete remissions seen in 14 patients.
Researchers have identified four potential treatment opportunities for acute myeloid leukemia, including compounds targeting metabolism, internal communications, and protein transport. These findings represent significant progress in seeking out new ways to approach an intractable cancer.
Researchers found that cancer cells need help from the surrounding tissue to establish and form a new tumor. The faster the surroundings change, the faster the cancer cells will grow. THSB2 protein helps cancer cells adapt their environment, activating fibroblasts to support cancer growth.
Researchers at UCLA have designed a new method for screening cancer cells using parallel microfiltration, which could lead to better treatments for various diseases. The study found that drug-resistant ovarian cancer cells are softer than their sensitive counterparts, and more invasive cells are also softer.
Researchers have developed a biodegradable liquid metal technique that uses 'nano-terminators' to target cancer cells. The liquid metal drug carriers enhance the effectiveness of anticancer drugs while minimizing long-term toxicity.
Monash University researchers have solved the X-ray crystal structure of stonefish venom's lethal factor, providing insight into a crucial human immune response. The discovery aims to develop immunosuppressants to improve transplant therapy success rates for leukaemia treatment.
Researchers at the University of Missouri have determined a detailed structural view of MMP7, an enzyme that makes cancer cells more aggressive and likely to spread. Understanding its structure could help prevent cancer cell signaling and slowing their growth.
Scientists have mapped out the human genome to identify essential genes for cell survival, revealing a core set of over 1,500 genes. The findings suggest that each tumor relies on a unique set of genes that can be targeted by specific drugs, offering hope for devising new treatments.
A team of U of T engineers has developed a way to grow cancer cells in the form of a rolled-up sheet that mimics the 3D environment of a tumour, offering a way to speed up drug development and ask new questions about cell behavior. The single-layer design makes it easier for other lab researchers to adopt the process.
A study reveals that yeast cells falsely perceive a specific pattern of stress as an ever-increasing ramp, leading to their self-destruction. The findings suggest that many cell types, including human cells, may be predisposed to misperceptions and could be fooled by carefully engineered illusions.
The International Society of Neurogastronomy Symposium brought together scientists, chefs, and patients to explore ways to improve quality of life for those with altered taste or smell. Chefs and neuroscientists collaborated on the 'Applied Neurogastronomy Challenge' to create dishes that appealed to cancer patients.
Researchers at IRCM identified the mechanism of action for a new target in immune-oncology treatments, focusing on natural killer cells and DNAM-1 protein. The discovery could lead to improved therapies using antibodies against TIGIT receptor.
Research suggests that healthy cells are optimized for a healthy ecosystem; changes in this ecosystem allow cancer-causing mutations to outcompete healthy rivals, leading to an increase in cancerous cells. Inflammation is a critical factor in this process, hurting the growth and maintenance of healthy B-cell progenitor cells.
A study at MD Anderson Cancer Center found that suppressing epithelial-to-mesenchymal transition (EMT) in combination with gemcitabine may boost the drug's effectiveness against pancreatic cancer. EMT suppression leads to impaired sensitivity to chemotherapy, causing poor prognosis and metastasis.
Researchers used dendrimers to track and isolate proteins involved in cell entry pathways, identifying 809 proteins. This technology could lead to more targeted drug delivery and improve our understanding of viruses.
Researchers found two clock-like mutational processes in human cells, correlated with age and potentially responsible for cancer and aging. The study analyzed 10,250 cancer genomes and identified 33 mutational signatures, revealing distinct mutation rates in different cell types.
Researchers have developed a novel protein from a bacterium that allows them to see early-developing cancer cells deeper in tissue using photoacoustic tomography. This technology provides a new tool for high-resolution imaging of cancer with genetic specificity, promising future studies and drug screening.
A new study published in Science magazine reveals that vitamin C can selectively kill colorectal cancer cells with certain mutations, such as KRAS and BRAF. The research found that these mutated cells take up oxidized vitamin C through a specific receptor, leading to oxidative stress that inactivates an enzyme required for growth.
Researchers developed bottle-brush nanotags to enhance cellular imaging by containing thousands of fluorophores, overcoming the limit of self-quenching and amplifying signal detection. The design permits the use of different dyes, enabling a wide range of colors for these fluorescent nanotags.
Researchers identify genetic mutations common to blood cancers in patients with unexplained low blood counts and cytopenias. The condition, clonal cytopenias of undetermined significance (CCUS), may represent early stages of subsequent blood cancers.
Researchers at UT Austin developed a nanoscale machine made of DNA that can autonomously walk in any direction, opening doors for cancer detection and therapeutic delivery. The DNA walker, with two legs connected by a torso, moves randomly and avoids re-tracing its steps, demonstrating a new level of complexity.
Researchers at University of Oxford have discovered a new treatment targeting cancer cells with specific SETD2 mutations. The innovative approach uses a drug inhibiting WEE1 protein, exploiting synthetic lethality to selectively kill cancer cells.
Researchers developed computational models to study cancer cells' genome structure, improving understanding of genetic changes. The approach uses statistical methods to reconstruct chaotic genomes and identify structural changes in tumour DNA.
Scientists have discovered a new function of the nuclear membrane: repairing catastrophically broken DNA strands. The membrane fixes heterochromatin breaks, preventing chromosome aberrations and potentially fatal cancer formation. This study may reveal how organisms become more predisposed to cancer as they age.
A study published in Molecular Cell reveals that cells have adaptive mechanisms to maintain perfect timing despite varying starting conditions. This finding has significant implications for understanding how cells avoid errors that promote cancer development and can inform the creation of robust mechanisms for synthetic life.
Autophagy has been shown to work in the cell nucleus, playing a role in guarding against the start of cancer. By degrading unwanted cellular bits and pieces, autophagy helps prevent cancerous growth, but its improper activation during normal aging leads to premature aging and age-related diseases.
Scientists at Virginia Tech Carilion Research Institute have discovered that a small shift in environmental factors can change how a cell in the immune system matures. They examined how interleukin-15 influences gene expression patterns in T helper cells, finding that it promotes a different kind of immune response similar to decreased...
Researchers at Penn State have discovered that a molecular motor can stimulate the growth of microtubules in cells, which could lead to new treatments for cancer. The study found that kinesin-5 molecules pause at the end of microtubules and generate pushing forces, allowing them to grow the microtubes.
Washington State University researchers have developed a unique protein cage to deliver chemotherapy directly to cancer cells, showing promising results in killing over 70% of lung cancer cells. The system selectively targets cancer cells without attacking healthy cells, potentially reducing side effects.
Scientists have created a highly specific chemical probe that switches off two important proteins implicated in cancer cell proliferation. The probe, CCT251545, selectively binds to CDK8 and CDK19, blocking the WNT signalling pathway and providing new insights into their role in driving cancer growth.
Scientists at MIT have found a mechanism by which cancer cells develop resistance to chemotherapy drugs. The MK2 pathway takes over when p53 is disabled, allowing cells to continue dividing even with extensive DNA damage. Measuring the levels of specific RNAs could help predict patients' response to chemotherapy.
Researchers discovered that lung cancer cells switch to using amino acid glutamine when glucose is scarce, allowing them to continue growing under starvation conditions. Blocking this enzyme PEPCK could slow tumor growth in mice, suggesting a promising new approach to treating non-small cell lung cancer.
Researchers at Emory University's Winship Cancer Institute have discovered a potential anticancer drug in orange lichens, called parietin. The pigment kills human leukemia cells and inhibits the growth of cancer cell lines, including lung and head and neck tumors.
Researchers discovered that intracellular receptor signalling sustains cancer cells detached from surrounding tissue. Preventing this signalling reduces the ability of cancer cells to survive and spread. This breakthrough opens a new perspective on integrin receptors' activity in cancer.
The Blue Brain Project digitally reconstructs a slice of juvenile rat brain containing over 31,000 neurons and 55 layers, enabling researchers to simulate neural activity and circuit-level behaviors
A team of researchers from Oxford University has identified a protein called PAT4 that tumours use to detect food supplies. Targeting this protein may restrict cancerous cells' ability to grow and improve survival rates.
Researchers have discovered a new molecular marker for killer cells, allowing for the prediction of infection course. The marker, CX3CR1 receptor, is associated with chronic infections, where immune system effectiveness is compromised.