Articles tagged with Cancer Cells
Leukemia cells exhibit stiffer mechanical signatures compared to healthy cells. The study suggests that these mechanical data can be used to grade the loss of cell mechanical functions depending on leukemia progression. This approach may aid in cancer diagnosis and provide insights into disease evolution
Researchers report that two topical creams are effective in most primary, low-risk superficial BCC patients, with favorable comparison to photodynamic therapy. The study found high clearance rates for imiquimod and fluorouracil treatments, but noted a higher recurrence rate for fluorouracil.
Researchers at Center for Genomic Regulation discover a new pathway generating energy in the cell nucleus to deal with stressful situations and high levels of DNA damage. The key enzyme NUDIX5 is identified as crucial for nuclear ATP synthesis, which could lead to targeted cancer medicine and biomarker development.
Researchers discovered leukemia cells harvest mitochondria from normal cells during chemotherapy, allowing them to survive and thrive. This finding offers new hope for developing better treatments for acute myeloid leukemia by targeting the energy-boosting mechanism.
Researchers at the University of Chicago have developed a novel immunotherapy approach that activates the STING pathway, which has shown promising results in treating acute myeloid leukemia (AML) in animal models.
Researchers discovered that pancreatic cancers acquire metastatic capacity before transforming into cancer cells. Low miR-192 levels in tumor tissue are associated with rapidly progressing disease. miR-192 may serve as a clinical marker and potential therapeutic target for pancreatic cancer treatment.
For the first known time, researchers have tracked heme movement inside cells, revealing it is not always static. Labile heme serves as a nutrient and needs to be carefully trafficked through the cell to stay available.
Researchers have found that a combination of vitamin A and chemotherapy can reduce cancer cell proliferation and invasion in pancreatic cancer. The approach targets both cancer cells and surrounding stromal cells, blocking multiple cell signalling pathways used by cancer cells to become aggressive.
Researchers introduce a novel method for labelling individual cells using photobleaching, enabling precise targeting of unique cells in vast populations. This technology has the potential to transform our understanding of diseases by allowing researchers to study specific cells responsible for disease progression.
Researchers found that inhibiting an enzyme adds palmitate onto proteins creates dependence on EGFR signaling for survival. Inhibiting this enzyme makes cancer cells more sensitive to EGFR inhibitors, which could lead to a new treatment option for lung cancers.
Researchers at Lomonosov Moscow State University develop nanoparticles that can efficiently penetrate into cancer cells, emitting light to aid in early diagnosis. The particles can also be used as targeted drug delivery systems, offering a promising approach for cancer treatment.
Researchers at the University of Zurich have discovered a new way to kill off resistant leukemia cells via necroptosis, a cell death program that can bypass traditional apoptosis. SMAC mimetics, which activate necroptosis, showed promise in killing leukemia cells in 33% of patient samples tested.
Researchers have identified a new connection between inflammatory signals and cell division, revealing how cells adapt to environmental changes. The discovery sheds light on the underlying mechanisms of diseases such as Crohn's disease and cancer.
Researchers have discovered a tollerance mechanism in NK cells that restrains their ability to kill cancer cells. Increasing IL-15 levels may improve immune responses against tumors.
Researchers evaluated an IHC screening tool for ROS1 gene rearrangements in a cohort of 170 patients. The results showed high sensitivity and specificity rates, making it a feasible option for first-line screening in a lung cancer setting.
A study published in PLOS ONE found that gamma-retroviruses preferentially insert near cancer-associated genes, suggesting a new tool for identifying genes driving specific cancers. This discovery could lead to the identification of potential therapeutic targets.
Researchers have developed a technology allowing them to visualize single molecules of messenger RNA as they are translated into proteins in living mammalian cells. Initial findings suggest that this may shed light on neurological diseases such as Fragile X Syndrome and Alzheimer's, as well as cancer.
Researchers identified a vital supply route for cancer cells to obtain nutrients, blocking this pathway led to significant tumor growth reduction. The discovery offers new hope for developing targeted treatments with fewer side effects.
Researchers have identified a signaling pathway that prevents DNA damage during cell division, ensuring identical copies are passed on to daughter cells. Chromatin bridges can form if DNA replication is problematic, but these bridges do not always trigger an alarm signal.
Researchers discovered a tension-sensitive molecule, Stu2, that ensures correct chromosome distribution during cell division. This 'fail safe' mechanism helps prevent aneuploidy, a genetic abnormality common in tumor cells.
A recent study has shown that combining radiation therapy with an immune system-strengthening compound can increase the immune response against tumors, even those outside the radiation field. This breakthrough could lead to longer treatment durations and reduced side effects, as well as new curative options for patients.
A study by University of Minnesota researchers reveals a pathway that enables cancer cells to tolerate faulty DNA replication, potentially leading to new anti-cancer therapies. The discovery was made possible by the development of a tool to analyze protein regulation triggered by DNA errors.
A clinical trial has shown that 27 of 29 advanced leukemia patients went into remission after their T cells were genetically engineered to fight cancer. The therapy, known as CAR T-cell therapy, uses a synthetic receptor molecule to empower the T cells to recognize and kill cancer cells.
Alterations in chromatin structure are essential for cancer development, accelerating cell cycle progression and malignant transformation. Changes in epigenetic factors and histone variants confer to cancer cells the ability to reprogram their genomes.
Researchers at UT Knoxville have discovered a novel regulatory pattern for cytokinesis, the final stage of cell division, triggered by the signaling protein Cdc42. This finding has implications for understanding cancer and other diseases, where defects in Cdc42 control are associated.
Using a simple circuit pattern with three electrodes, researchers assign unique digital identification numbers to each cell passing through the channels on the microfluidic chip. This technique captures information about cell sizes and movement speeds, allowing for automated counting and analysis of cells sorted on the chip.
A biomarker associated with basal cell carcinoma, EZH2, has been identified in a study published in JAMA Oncology. Higher levels of EZH2 and Ki67 were found in more aggressive tumors, suggesting that the protein may serve as a marker for increased cancer recurrence or tumor aggressiveness.
Researchers at Fred Hutchinson Cancer Center are developing engineered T cells to recognize and attack cancer cells. Preliminary data from a clinical trial shows promising results in treating acute myeloid leukemia, with patients experiencing stable disease and significant tumor regression. Next-generation strategies aim to improve ant...
In a clinical trial, half of 25 patients with Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long as conventional chemotherapy. Several patients had no remaining evidence of disease. The results suggest that immunotherapy drugs may be effective for other virus-associated cancers.
Researchers developed Monovar to analyze multiple single cells, detecting subtle DNA changes that can inform personalized medicine and cancer care. The method shows promise for diagnosing and treating various diseases, including pre-natal genetic diagnosis.
Scientists have identified a mechanism behind pancreatic cancer's resistance to certain drugs and found a way to block it, making the cancer susceptible to formerly ineffective therapies. By targeting a protein called HuR, researchers can revive abandoned drugs and develop more effective combination therapies.
Researchers at EMBL have determined the structure of the nuclear pore complex's inner ring, a crucial component in controlling molecular traffic to the cell's nucleus. The discovery brings the nuclear pore into focus and holds potential implications for understanding its role in cancer and aging.
Researchers at UT Southwestern Medical Center identified molecular ties between cancer cell growth and heart cell enlargement, potentially leading to repurposed cancer treatments for heart disease. The study found that inhibiting enzymes called HDACs can blunt excess heart muscle cell growth and slow the spread of cancer.
Researchers at Queen Mary University of London have developed a modified flu virus that can re-sensitize resistant pancreatic cancer cells to chemotherapy. The virus enhances the efficacy of the drug by preventing cancer cells from repairing themselves, leading to increased cell killing with lower doses.
A new study reveals how cancer cells turn healthy cells to the 'dark side' by using a mutant KRAS gene to release unique growth signals. This discovery could open up new approaches to cancer treatment by understanding the communication loop between cancer-causing genes and healthy stromal cells.
Researchers at the University of Missouri have discovered a compound that not only lowers cholesterol but also kills prostate cancer cells. The study found that the compound, initially developed as a cholesterol-fighting molecule, reduced prostate cancer cell growth and caused cancer cell death in human and mouse models.
Researchers at Umeå University found that mutations in the SAMHD1 protein lead to an imbalance of DNA building blocks and increased mutation rates in colon cancer cells. This discovery suggests that changes in dNTP levels may contribute to the development of colon cancer.
Researchers have identified six newly discovered proteins that may help prevent diabetes, Alzheimer's disease, cancer, and other age-related illnesses. The tiny proteins are produced in the mitochondria of cells and play a significant role in metabolism and cell survival.
Chronic lymphocytic leukemia (CLL) researchers have improved their models of the disease by understanding how cancer cells differentiate into antibody-secreting plasma cells in mice. Patient-derived T cells play a crucial role in this process, and therapies promoting differentiation may offer new treatment options for CLL.
Researchers at CRI identified a new metabolic pathway that allows cancer cells to survive in conditions toxic to normal cells. The study reveals that cancer cells use an alternate version of the pentose phosphate pathway and the Krebs cycle to defend against reactive oxygen species.
Two drugs, Vismodegib and Sonidegib, target the Hedgehog pathway to treat basal cell carcinoma, a common skin cancer affecting nearly 2.8 million Americans annually. The FDA-approved treatments have shown promise in shrinking tumors and improving response rates.
Researchers at VIB have discovered that killed tumor cells can be used as a vaccine to stimulate the immune system to prevent cancer cell growth. This finding opens up new perspectives for using necroptosis in immunotherapy and screening for cancer drugs that induce this type of immunogenic cell death.
Researchers at Washington University in St. Louis discovered that cancer cells can synthesize lipids from non-glucose sources, contradicting the long-held glucose hypothesis. This finding raises questions about diagnostic methods and treatment strategies for cancer.
Cells have evolved several tactics to cope with DNA lesions and replication stress, including fork repriming, fork reversal, and replisome dynamics. Improper repair of DNA lesions can lead to mutations and genetic abnormalities.
Researchers found that cancer cells have a resilient ability to repair nuclear envelope rupture during cell migration, but this process compromises genomic integrity. The study highlights a potential weakness in metastatic cancer cells and an opportunity for developing novel anti-metastatic drugs.
Researchers at Lomonosov Moscow State University found that heat shock triggers DNA damage response, leading to cellular senescence. The study's results may help develop new methods for curing cancer.
Researchers at the University of Georgia have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models. The treatment, which involves packaging and administering a small molecule called IPA-3, significantly slows the progression of cancer and forces cancerous cells to undergo apoptosis.
Researchers at ETH Zurich discovered that sulforaphane, a broccoli ingredient, increases the concentration of enzymes in colon cancer cells, making it more effective for chemotherapy. This natural compound can reduce medication doses and is non-toxic with no unwanted side effects.
A UC team created a new nanostructure that shows significantly higher properties for detecting and destroying cancerous cells, enabling targeted drug delivery. The discovery was made possible by complex calculations conducted by PhD student Zohre Gorunmez.
Researchers identified key proteins connecting genetic material to cell structures, enabling accurate DNA distribution during cell division. The findings resolve a longstanding puzzle in cell division and may provide insight into cancer susceptibility.
A recent study by MIT biologists found that cancer cells use amino acids to build new cell mass, contradicting the long-held assumption that glucose is the primary source. The largest contributors to cell mass were amino acids, making up 20-40% of total mass.
Scientists at St Jude Children's Research Hospital discovered a new pathway for mitochondrial cell death involving the BCL-2 ovarian killer protein. This mechanism is linked to cellular stress and may lead to new cancer treatments.
Researchers have discovered a key protein that drives blood cancer development and may prevent it with MCL-1 inhibitors. Seventy percent of human cancers have abnormally high levels of MYC, which forces cells into rapid growth.
Researchers at The Ottawa Hospital and University of Ottawa identified a compound called GSK-J4 that can kill a severe form of childhood leukemia. By targeting the TAL-1 gene, the compound stops cancer cell growth, showing promise for personalized treatment.
Researchers have discovered a trick used by lung cancer cells to hide from the immune system, specifically suppressing immunoproteasomes that signal T-cells to attack diseased cells. The study suggests it may be possible to enhance production of these proteins to override the cells' escape mechanism.
Brown University engineers developed a new technique to understand how cells move through complex tissues, building on mean deformation theory. The algorithm analyzed images of human neutrophils moving through collagen matrices, revealing differences in contractility and rotation between healthy and sepsis models.
Researchers found that cancerous mutations are linked to stiff tissues, where cells experience more nucleus deformation and damage. This constricted migration causes molecular damage, leading to genomic instability and increased mutation rates.
Researchers found that Porphyromonas gingivalis is present in 61% of patients with esophageal squamous cell carcinoma (ESCC), a type of esophageal cancer. The bacteria was only detected in 12% of tissues adjacent to the cancerous cells, suggesting it may be a risk factor for ESCC.
UT Southwestern Medical Center researchers have designed a powerful 3-D microscope capable of creating high-resolution images of living cancer cells in controlled microenvironments. The new approach enables detailed study of cell interactions with their environment, accelerating discovery in biology.
Researchers at Ohio State University have developed a DNA 'Trojan horse' that can deliver cancer drugs into resistant cells, effectively killing them. The capsule made of folded up DNA hides the invading force, allowing it to bypass cell defenses and accumulate in cancer cells.