Articles tagged with Cancer Cells
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Scientists at Johns Hopkins have discovered a drug combination that specifically targets the metabolic pathways of pancreatic cancer cells. By combining an experimental drug with metformin, researchers were able to shrink tumors by at least 50% in animal models, providing new evidence for treating this aggressive form of cancer.
Researchers created novel scaffolds with aligned ceramic nanofibers to control stem cell development and cancer cell behavior. The unique hybrid nano-network selectively guides stem cells towards specific lineages while suppressing inflammatory factors in cancer cells.
Fascin protein plays a crucial role in deforming the cell nucleus to navigate through tight spaces. The study suggests that this ability may be exploited by cancer cells to invade tissues, making fascin a potential target for therapy.
A new study by Queen Mary University of London found that certain Barrett's Oesophagus cells can be identified as 'born to be benign' or 'bad', allowing for early detection and prevention of oesophageal cancer. The test uses genetic analysis of individual cells, predicting future risk regardless of time since abnormal cell appearance.
Cancer cells counteract telomere breakdown by building them up with the enzyme telomerase. A new study using CRISPR gene editing technology reveals telomerase's mechanism, allowing scientists to identify potential targets for anti-cancer drugs.
Researchers at the University of Manchester have discovered a new test that can detect cancerous cells in the blood, offering a promising breakthrough in diagnosing and treating childhood leukemia. The test uses special structures called extracellular vesicles that are released by cancer cells and can be traced in the blood.
Researchers have developed a novel method to rapidly screen hundreds of chemicals for their anti-cancer properties by harnessing the power of knotted DNA structures. By detecting the activity of an enzyme crucial to cancer cell survival, this technique offers a promising tool for identifying potential new treatments.
Researchers at Thomas Jefferson University found that cold plasma can promote bone formation by enhancing cell/matrix attachments and increasing focal adhesion kinase activation. The study suggests that the technology could be used to improve bone healing in various medical applications.
Cancer cells use DR6 to kill endothelial cells, allowing them to slip through the vascular wall and form metastases. This process is known as necroptosis, which enables cancer cells to overcome an endothelial cell layer in the laboratory and in living organisms.
Pancreatic cancer cells use stellate cells to scavenge for energy, increasing mitochondrial metabolism and tumor cell growth. Alanine is the key fuel source that promotes tumor proliferation.
CNIO researchers identified a biochemical mechanism that enables cancer cells to survive without glucose, triggering a switch in proteins that control nutrient stress. This finding may help understand the resistance of cancer cells to anti-angiogenic agents and their ability to thrive in low-oxygen environments.
Researchers at Université de Genève have developed an antibody that blocks the migration of cancer cells, preventing their spread and proliferation. The 'H225' antibody reduces cancerous cell transit into organs by over 50% and limits cell proliferation, offering a promising new therapeutic strategy against lymphoma.
Researchers at the University of Copenhagen have developed a method that kills cancer cells using nanoparticles and lasers. The treatment has been tested on mice and shown to be effective in destroying cancer tumors without causing major side effects.
Cancer cells use oxygen gradients to navigate and spread through the body, according to a new study published in PNAS. Researchers at Johns Hopkins University found that cancer cells migrate from low-oxygen areas to higher oxygen concentrations, allowing them to reach blood vessels and metastasize.
Researchers at UC Berkeley have found a new cancer drug target that controls only a few percent of the body's proteins, potentially allowing for a more specific anti-cancer effect. The target is a protein called eIF3d that binds to specialized mRNAs and triggers translation of growth-promoting proteins.
Scientists at the University of Sussex are developing new cancer drugs that target DNA damage response pathways to selectively kill cancer cells. These drugs aim to maximize DNA damage or prevent its repair, leading to cancer cell death while minimizing harm to healthy tissues.
The study found treating colon cancer cells with a combination of curcumin and silymarin resulted in increased cell death and inhibition of cell multiplication. The researchers believe phytochemicals could provide an alternate therapeutic approach to cancer treatments.
Researchers have developed a new method to analyze scrambled cancer genomes, allowing for the simultaneous identification of two types of genetic changes and their connections. This tool, called Weaver, may help identify characteristics that distinguish cancers and inform personalized treatments.
A new compound, mitoiron claw, protects skin cells from UVA-induced mitochondrial damage, preventing cell death and cancer. The researchers hope to see the compound added to sunscreens within 3-4 years.
Biophysicists at FAU discover that plastic cell deformation is caused by microscopic damage to the cytoskeleton. This finding helps characterize diseased cells more accurately, enabling better understanding of cancer, lung diseases, and heart diseases.
Case Western Reserve University researchers identified why colorectal cancer cells depend on glutamine and developed a way to starve them. In a mouse model, exposing tumors with PIK3CA mutation to glutamine metabolism inhibitors suppressed tumor growth, providing a promising new therapeutic avenue for colorectal tumors.
Researchers at Caltech investigate the genetic switch that directs cells to become T cells, discovering a multi-tiered process involving four proteins that work together in three distinct steps. This finding has potential applications in boosting T-cell populations and fighting diseases such as AIDS.
Researchers at Duke University Medical Center discover that genetic mutations in pericyte cells lead to osteosarcoma and soft-tissue sarcoma. Activating beta catenin with lithium appears to limit cancer growth, offering new potential treatment options.
A team of researchers from TUM has identified a molecular signaling pathway for programmed cell death that is suppressed in leukemia cells. This discovery offers new insights into the mechanisms underlying cancer progression and may lead to targeted treatment options.
Researchers have identified a new class of molecules called selenocompounds that can kill multidrug-resistant cancer cells by blocking their defenses against chemotherapy drugs. The most active molecule worked almost four times better than the reference compound and induced cell suicide in cancer cells with similar potency.
Researchers found that mitochondrial stress triggers metabolic shifts through the p53 protein in cancer cells, leading to increased glycolysis and possible new targets for therapy. The study suggests that markers of metabolic stress could serve as a biomarker for cancer aggressiveness.
Researchers have identified NEAT1 as a key player in the survival of cancer cells, but its loss increases chemosensitivity and cell death. This discovery may lead to the development of new drugs targeting NEAT1 to enhance cancer treatment.
Scientists studied how cancer cells divide in capillaries using transparent nanofilms. Cell structures changed significantly, with membrane blebbing helping keep genetic material stable for healthy cell division.
Researchers at UT Southwestern Medical Center have developed a new method to detect telomere length, which can influence cancer progression and aging. The new approach uses non-radioactive probes, increasing sensitivity and stability, and may help slow or stop cancer cell growth.
A new tool for precision medicine has been developed through epigenetic analysis, which addresses key limitations of genetic testing. This technology provides unprecedented insights into disease mechanisms and can help identify suitable treatments for individual patients.
A team of researchers at KIT developed a 3D model for prostate cancer research using cryogels, which can replicate natural processes and examine tumor development. The model has been recognized as the top story on Prostate Cell News.
A new study reveals that a single gene can drive prostate differentiation in seminal vesicle epithelial cells, suggesting potential insights into prostate cancer development. The research found that inducing expression of the Nkx3.1 gene caused seminal vesicle cells to convert into a prostate-like state.
Researchers develop Poisson filter, a single-gene noise filter that can cancel out molecular environment effects, enabling context-independent behavior in biological circuits. The filter has potential to improve specificity and efficacy of synthetic biology applications such as new therapeutics or biosensing.
Researchers found that cancers in several species of bivalves are caused by independent clones of cancer cells with distinct genetic profiles. In one species, cross-species transmission was observed, revealing a previously unknown mechanism of disease spread among marine animals.
Researchers have discovered a new molecular mechanism that directs cellular DNA repair proteins to lesions in DNA, making it an attractive target for cancer therapy. By understanding how this mechanism works, scientists can design small molecule inhibitors that block the function of TONSL protein and promote cancer cell death.
The 2016 Blavatnik National Awards recognize David Charbonneau's exoplanet discoveries, Phil Baran's natural product synthesis research, and Michael Rape's fundamental discoveries in ubiquitylation. The three Laureates receive $250,000 cash awards to support their future work.
Researchers have discovered new drugs that can break resistance to Gab2 in CML cells, a type of blood cancer. The study found that sorafenib and axitinib are effective in treating CML model systems, providing potential alternatives for patients who have developed resistance to existing medications.
Researchers identified TIP60 as an enzyme required for HIF1A activity in human colorectal cancer cells, showing its potential as a target for cancer treatment. The study also revealed the molecular mechanisms by which TIP60 promotes HIF1A activity and highlights the importance of basic research in cancer discovery.
A ketogenic diet has shown promise in reducing tumor size and progression in ovarian cancer, with a new clinical trial aiming to replicate these results in humans. The trial aims to investigate the effects of a low-carbohydrate diet on ovarian cancer patients' quality of life and cancer-related measures.
Researchers at the University of Oklahoma have developed a new mass spectrometry technique that can quantify anti-cancer drugs in individual cancer cells. This breakthrough technology aims to improve treatment efficacy and reduce toxicities for cancer patients.
Researchers used FDG-PET imaging to monitor atezolizumab, an immune checkpoint inhibitor, in NSCLC patients. The study found that higher baseline tumor volumes were predictive of reduced patient survival, and further increase in tumor volume after treatment was associated with decreased survival.
Researchers block glutamine breakdown in liver cancer cells, preserving normal cells, and reduce tumor development in mice. The study identifies LRH-1 as the key protein involved and suggests it as a new target for treating liver cancer.
A new mutation in the ZBTB7A gene boosts energy metabolism in leukemia cells, promoting their growth and survival. This discovery offers a promising therapeutic target for treating acute myeloid leukemia (AML) patients.
Researchers have identified essential aspects of the regulation of the anti-tumor protein p53, with surprising results suggesting that only a few ribosomal proteins are required to maintain nucleolar structure. This discovery has significant implications for cancer research and development of new biomarkers.
A $1.7 million NIH grant will help a Florida State University scientist uncover how cancer-causing viruses manipulate cell communication through exosomes. The research could lead to more effective and less harmful ways to treat diseases like cancer.
Researchers at Kyoto University have identified a genetic mechanism that could predict effectiveness of cure for certain cancers. Genetic alterations affecting the PD-L1 protein allow cancer cells to escape immune detection, but these abnormalities were found in many common cancer types.
Researchers discovered leukemia cells harvest mitochondria from normal cells during chemotherapy, allowing them to survive and thrive. This finding offers new hope for developing better treatments for acute myeloid leukemia by targeting the energy-boosting mechanism.
Leukemia cells exhibit stiffer mechanical signatures compared to healthy cells. The study suggests that these mechanical data can be used to grade the loss of cell mechanical functions depending on leukemia progression. This approach may aid in cancer diagnosis and provide insights into disease evolution
Researchers at Center for Genomic Regulation discover a new pathway generating energy in the cell nucleus to deal with stressful situations and high levels of DNA damage. The key enzyme NUDIX5 is identified as crucial for nuclear ATP synthesis, which could lead to targeted cancer medicine and biomarker development.
Researchers at Lund University discovered that cancer cells can accumulate fat droplets, making them more aggressive and increasing their ability to spread. The fat serves as fuel for the stressed cells, allowing them to grow and spread.
Researchers at the University of Chicago have developed a novel immunotherapy approach that activates the STING pathway, which has shown promising results in treating acute myeloid leukemia (AML) in animal models.
Researchers report that two topical creams are effective in most primary, low-risk superficial BCC patients, with favorable comparison to photodynamic therapy. The study found high clearance rates for imiquimod and fluorouracil treatments, but noted a higher recurrence rate for fluorouracil.
Researchers discovered that pancreatic cancers acquire metastatic capacity before transforming into cancer cells. Low miR-192 levels in tumor tissue are associated with rapidly progressing disease. miR-192 may serve as a clinical marker and potential therapeutic target for pancreatic cancer treatment.
For the first known time, researchers have tracked heme movement inside cells, revealing it is not always static. Labile heme serves as a nutrient and needs to be carefully trafficked through the cell to stay available.
Researchers introduce a novel method for labelling individual cells using photobleaching, enabling precise targeting of unique cells in vast populations. This technology has the potential to transform our understanding of diseases by allowing researchers to study specific cells responsible for disease progression.
Researchers have found that a combination of vitamin A and chemotherapy can reduce cancer cell proliferation and invasion in pancreatic cancer. The approach targets both cancer cells and surrounding stromal cells, blocking multiple cell signalling pathways used by cancer cells to become aggressive.
Researchers found that inhibiting an enzyme adds palmitate onto proteins creates dependence on EGFR signaling for survival. Inhibiting this enzyme makes cancer cells more sensitive to EGFR inhibitors, which could lead to a new treatment option for lung cancers.
Researchers at Lomonosov Moscow State University develop nanoparticles that can efficiently penetrate into cancer cells, emitting light to aid in early diagnosis. The particles can also be used as targeted drug delivery systems, offering a promising approach for cancer treatment.
Researchers at the University of Zurich have discovered a new way to kill off resistant leukemia cells via necroptosis, a cell death program that can bypass traditional apoptosis. SMAC mimetics, which activate necroptosis, showed promise in killing leukemia cells in 33% of patient samples tested.
Researchers have identified a new connection between inflammatory signals and cell division, revealing how cells adapt to environmental changes. The discovery sheds light on the underlying mechanisms of diseases such as Crohn's disease and cancer.