Articles tagged with Cancer Cells
A study led by Raffaella Sordella proposes a novel theory on how cancers circumvent targeted therapy killing power. The research suggests that genetic diversity in tumor cells, caused by non-genetic mechanisms, can help them survive and eventually relapse.
Scientists have identified a cellular fuel sensor, AMPK, as a key regulator of the extracellular matrix and integrin function, which could lead to novel treatments for cancer and tissue fibrosis. The study reveals that AMPK's absence leads to increased adhesion and matrix production.
Researchers at Kumamoto University have discovered the key to hMTH1's ability to hydrolyze multiple oxidized dNTPs with high efficiency. The protonation state of specific aspartate residues plays a crucial role in this process, allowing for targeted inhibition of cancer cells.
Researchers at Kent State University created a nano cage to study G-quadruplex formation, a genetic factor associated with cancer cell growth. The discovery may lead to new understanding of how cancer develops and provide potential treatments.
A study published in Nature Genetics reveals that large regions of the human genome have built-in variability in reversible epigenetic modifications, which enables cancer cells to proliferate and adapt. This variation can make cancer cells more resistant to chemotherapy and treatment.
Researchers have developed a new method to deliver large and diverse cargos directly into cells with high efficiency and no lasting damage. The team used gold pyramid-shaped microstructures and nanosecond laser pulses to create brief pores in the cell membrane, allowing molecules to diffuse into the cell.
Researchers at Aarhus University have described the structure and organization of the DNA control protein Rad26, revealing how kinase Rad3 is recruited to damaged DNA. This new knowledge may lead to the development of Rad3 inhibitors that make cancer cells more susceptible to chemotherapy.
Scientists identify a molecular pathway that enables prostate cancer cells to escape the primary tumor and form secondary tumors. This discovery holds promise for developing new therapeutic strategies to stop cancer cells from spreading, offering hope for improved treatment options for patients with metastatic prostate cancer.
A University of Queensland-led study reveals how cobras evolved their potent flesh-eating venom alongside distinctive hoods and warning colors. The research found that cobras' venom is used both for predation and defense, with increased potency linked to warning strategies.
Researchers at Scripps Research Institute have discovered a disordered protein, CITED2, that outcompetes another protein, HIF1α, for cellular binding targets. This finding has implications for future cancer drugs, suggesting a more efficient approach to interrupting cancer cell survival mode.
The SETD8 enzyme regulates cellular senescence, a process where cells stop proliferating due to age or stress. Lowering SETD8 increases protein synthesis and growth arrest in senescent cells, promoting metabolic activities.
Scientists explore ways to improve health span by clearing out senescent cells and reprogramming them. Researchers also examine re-purposing existing drugs and using computer power to fight aging.
Researchers have found that T cells soften after activation, allowing them to elicit a stronger response. They identified drugs that can help either activate or suppress T cell responses, providing a new approach to manipulating the immune system.
Researchers at Queen Mary University of London have identified a new protein that plays a crucial role in the aging process and early cancer development. The protein, integrin beta 3, helps regulate cellular senescence by transmitting signals to surrounding cells.
Scientists discovered that obesity disrupts the balance of 'guardian immune cells,' which maintain a delicate balance between immune systems. In healthy states, these cells protect against inflammation and metabolic disease, but in obese individuals, they lose their regulatory function.
A new study identifies Gamma Delta T cells as adaptable immune cells with immunological memory against previous infections and cancerous targets. This finding challenges traditional views of these cells as 'natural born killers' and presents opportunities for developing new cell therapies and vaccines.
Researchers at Duke University have developed a new laser technique to measure the stiffness of individual cancer cells, which is correlated with cellular disorder. This technique has the potential to enable high-throughput screening for early cancer detection, allowing for rapid and accurate diagnosis.
A new compound developed by the Deshaies group inhibits Rpn11 activity, causing massive accumulation of dysfunctional proteins in cancer cells. This leads to catastrophic stress and cell death, making it a promising alternative to existing cancer drugs.
Researchers have shed new light on the molecular pump MRP1, which expels cancer drugs from cells. The pump's unique structure features two-part pocket allowing it to accommodate various substances.
A new tool using nuclear magnetic resonance (NMR) measures hydrogen atoms to study metabolism and determine metabolic fluxes. This technique has been validated on human cancer cells and holds potential for understanding the mechanisms behind diseases like diabetes.
The Cedars-Sinai Heart Institute is developing a biological pacemaker that can treat patients with slow heartbeats. The device turns normal heart cells into pacemaker cells using gene therapy, potentially replacing electronic pacemakers one day.
Researchers from Aarhus University have found a protein called IFI16 that plays a significant role in the innate immune system's defence against cancer and viruses. The discovery may lead to the development of new immunotherapies for cancer treatment.
Researchers developed nanostraws that can sample a single cell at a time without damaging it, allowing for long-term non-destructive monitoring of cellular processes. This technique could inform cancer treatments and help develop patient-specific organs by understanding how stem cells evolve.
Researchers used super-resolution imaging to map the organization of cadherin-based adhesions in cells. The study revealed a multi-layered structure with compartments separated by an interface layer containing vinculin, which plays a key role in fine-tuning mechanical properties.
Researchers have witnessed Organo-Osmium FY26 targeting and destroying cancer cells from the inside by attacking their weakest part. The compound is 50x more active than current cancer drugs like cisplatin.
Researchers at MIT have developed a new portable technology called Seq-Well, which enables rapid analysis of large numbers of cells for single-cell RNA sequencing. This breakthrough allows scientists to easily identify different cell types found in tissue samples, facilitating the study of immune cell responses and cancer treatment.
Telomeres are protective caps on chromosomes that protect DNA ends from damage. Brian Luke's research focuses on the non-coding RNA TERRA, which plays a crucial role in telomere function. His lab will also investigate telomere looping, a mechanism that protects chromosome ends from degradation.
Researchers at OIST have developed a novel technique that targets lipid rafts on cancer cell membranes to block migration. The molecule works by physically pinning the cancer cell, causing it to rupture and leading to cell death.
IFT20 protein plays a crucial role in the formation of invadopodia, structures that enable tumor cells to break through barriers and infiltrate surrounding tissues. The discovery sheds light on the molecular mechanism underlying cancer cell invasion.
A new mathematical model reveals that metronomic chemotherapy's benefits rely on the normalization of tumor blood vessels, improving drug delivery and immune cell activity. The approach aims to alleviate abnormal tumor blood vessel structure and function, reducing proliferation of stem-like cancer cells.
Researchers from the University of Jena investigate the effects of five types of nuts on colon cancer cells, finding that they activate the body's defences to detoxify reactive oxygen species. Nuts stimulate the activity of protective enzymes catalase and superoxide dismutase, inducing programmed cell death in cancer cells.
Researchers at Whitehead Institute have identified essential genes in human cancer cells, revealing potential vulnerabilities for new therapies. By analyzing genetic interactions, they discovered a genetically defined subset of cancers that could be exploited with existing treatments.
Researchers discovered LSD binds at an angle, trapping it in the receptor, and part of the protein folds over, sealing it inside. This explains why LSD trips last for a full day despite small doses.
Researchers define how anti-cancer molecules work, binding to microtubules and destabilizing cell growth. The study's findings can be used to optimize and develop new, safer drugs.
Researchers at the University of Illinois used a novel imaging technique to visualize microscopic shifts in metabolism and vesicle production in tumor cells. The study found that these changes can precede larger-scale events in the tumor environment, potentially preparing the way for cancerous cells to spread and metastasize.
A new screening method combining CRISPR genome editing with single-cell RNA sequencing enables the simultaneous analysis of thousands of genes in individual cells. This approach, called CROP-seq, allows researchers to study complex biological mechanisms and identify novel drug targets more efficiently than traditional methods.
Cholesterol is found predominantly in the outer layer of cell membranes, where it transmits signals across the membrane. In cancer cells, high levels of cholesterol are associated with suppressed growth activity, suggesting a new way to treat cancer through pharmacological modulation.
Researchers have found a protein called BCL-2 crucial in controlling the reservoir of NK cells, which may be vulnerable to new medicines that inhibit it. Boosting NK cell numbers with IL-15 could offer a valuable approach to boosting immunity against viral infections or cancer.
Researchers at Kumamoto University find that interleukin-6 (IL-6) helps cancer cells survive radiation therapy by suppressing oxidative stress through the Nrf2-antioxidant pathway. This discovery offers new potential therapies targeting IL-6 to combat radioresistant cancers.
Researchers found that cells with an extra chromosome grew more slowly and formed smaller tumors than comparable cells with normal chromosome number. However, after weeks of growth, these cells rapidly evolved to acquire new mutations that enabled them to grow rapidly.
Researchers at TSRI have discovered a protein called TZAP that regulates telomere length, which is crucial for determining cell lifespan and preventing cancer. Understanding this process opens up new avenues for studying aging and developing treatments.
Researchers from Goethe University Frankfurt discovered a novel biomarker, SAMHD1, that enables accurate prediction of therapy responders and non-responders in acute myeloid leukaemia (AML) patients. This biomarker can guide cytarabine-based chemotherapies to only those patients likely to respond, sparing others from toxic side effects.
Two studies reveal that cancer cells can tolerate genetic mutations by inactivating the BCL9L gene and slowing down division to avoid mistakes, allowing them to thrive and evolve. This understanding may lead to new ways to target cancer cells and improve treatment efficacy.
Scientists have discovered a unique 'gear' in the molecular motor protein KlpA that enables it to switch direction of movement, allowing chromosomes to be properly divided during cell division. This finding could lead to novel treatments for certain types of cancers.
Researchers aim to remove senescent cells, which accumulate with age, to regrow hair, improve organ function and combat aging. However, hurdles include safety issues, off-target effects and high costs, limiting translation to humans.
A combination of metformin and syrosingopine drives cancer cells to programmed 'suicide' by blocking their energy supply, inhibiting growth and inducing tumor cell death. The treatment shows promise for targeting the energy needs of tumor cells.
A study published in Nature discovered that fat utilization is required for the development and growth of lymphatic vessels, a key route for cancer cell spread. Researchers found that inhibiting fat usage can control lymphatic vessel growth, offering new avenues for preventing metastasis and treating complications like lymphedema.
Researchers discovered an obesity-linked protein FTO's role in leukemia cell growth, survival, and drug response. FTO modulates gene expression by altering RNA modification, leading to cancer-promoting effects.
Scientists from the Niels Bohr Institute have identified a new way to control the production of important proteins that regulate the immune system. The discovery could provide a new opportunity to fight diseases such as cancer, Alzheimer's, and diabetes by controlling the cell's genetic response.
A protein called Peroxiredoxin 1 (PRDX1) has been identified as a key player in protecting telomeres from oxidative damage. By analyzing the protein composition of telomeres across the cell cycle, researchers found that PRDX1 functions as an antioxidant enzyme, preserving telomeric DNA for extension by telomerase.
Researchers found that a high-fat, low-sugar diet for 72 hours prior to diagnostic imaging improved the accuracy of diagnosing cardiac sarcoidosis. This technique minimizes indeterminate findings and allows clinicians to better monitor patient progress under treatment.
Researchers at the Salk Institute have discovered that intermittent expression of genes normally associated with an embryonic state can reverse the hallmarks of old age. This approach resulted in the rejuvenation of mice with a premature aging disease, countering signs of aging and increasing their lifespan by 30%. The early-stage work...
A team of scientists from Helmholtz Zentrum München has isolated and characterized therapy-resistant leukemia cells, which are responsible for relapse in the disease. These cells can be eliminated using modern genetic engineering techniques, offering a new approach to prevent disease relapse.
Researchers found that KRAS mutant cancer cells form more stress granules in response to chemotherapy, making them harder to kill. A new compound target, 15-d-PGJ2, may help improve treatment outcomes by blocking this coping mechanism.
Researchers have developed a new technique to switch key biomolecules on and off, allowing them to study the effects of kinases as they work in living cells. This breakthrough could lead to the discovery of novel drug targets for cancer treatment.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have made a groundbreaking discovery in cancer treatment. They developed novel Iridium(III) complexes that utilize red light to attack and kill cancer cells, providing a promising new approach for photodynamic therapy (PDT).
Researchers at La Jolla Institute for Immunology found that the loss of TET proteins hinders T cell maturation and promotes aberrant proliferation, leading to a lethal disease resembling lymphoma. The study's findings suggest that TET proteins serve as tumor suppressors and may help block malignancy in cancers marked by TET mutations.
Researchers at UT Southwestern Medical Center found that intermittent fasting inhibits the development and progression of acute lymphoblastic leukemia (ALL), a type of childhood leukemia. However, fasting was ineffective against another type of blood cancer commonly affecting adults, acute myeloid leukemia (AML).
Researchers have made a major discovery about how cells control when to divide, revealing a key part of the cellular machinery that prevents cells from dividing until DNA is properly aligned. This finding could lead to new treatments for cancer by forcing cancer cells into premature division and killing them.
Scientists have discovered a new class of compounds that can be used to target cancer cells with greater specificity. The technology uses naturally occurring enzymes to trigger the release of therapeutic payloads only at cancer sites.