Articles tagged with Cancer Cells
Scientists at Albert Einstein College of Medicine have discovered a compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, BTSA1, works by triggering apoptosis in cancer cells through the BAX protein, leaving healthy cells unscathed.
Researchers found that a protein named ZATT can eliminate DPCs with the help of another protein TDP2. Understanding how TDP2 and ZATT work together may improve cancer patient health outcomes. The discovery could lead to development of new drugs targeting these defenses.
Researchers found that cancer cells 'recharge' by transferring power-generating mitochondria from healthy bone marrow cells, supporting leukaemia growth. Inhibiting a specific enzyme reduced mitochondrial transfer and slowed cancer growth.
New research explains why mTOR inhibitors can't fully eliminate cancer cells. The drugs target a cell regulator called mTOR, which controls mitochondrial structure and function, ultimately protecting cells from death.
Researchers discovered how TORC1 protein complexes regulate cell growth in response to sugar availability. In the absence of sugar, these complexes self-assemble into massive tubular structures that halt cell growth. The formation and disassembly of these tubules can be easily observed in living cells.
Researchers discovered that chromatin fragments outside the nucleus activate a DNA-sensing pathway, leading to chronic inflammation and tissue damage. The study aims to develop small molecules targeting this inflammatory pathway to treat age-related diseases.
Researchers have identified a distinctive epigenetic event in immune cells that differentiate in the tumoral microenvironment, making them tolerant to cancer cells. The study found that DNA methyltransferase 3A is responsible for the acquisition of suppressive properties in these cells.
Researchers have engineered smart protein molecules called iSNAPS that can rewire macrophages to ignore a 'don't eat me' signal from cancer cells, allowing them to engulf and destroy cancer cells. This breakthrough could lead to a new method of re-engineering immune cells to fight cancer and infectious diseases.
Researchers discovered Hu-Kaiwen ink can kill cancer cells without harming normal tissues, offering an alternative to expensive and toxic PTT. The traditional Chinese ink absorbs near-infrared light and heats up when exposed to a laser, demonstrating its potential as a non-toxic photothermal therapy agent.
Researchers discovered anastasis has two distinct stages and cells hold onto pro-survival molecules even when dying. The study's findings suggest this process may enable cancer cells to bounce back after treatment, raising questions about the long-term cellular effects of anastasis.
A study published in Cancer Research found that inhibiting two metabolic enzymes, NADK and KHK, reduced the growth of KRAS-mutant colorectal cancer cells in mice by approximately 50%. The research also identified new genes that, when inactivated, increased tumor growth in KRAS-mutant cancers.
The UA Cancer Center's research may lead to ways to target metastatic tumors by altering the depth of quiescence in cancer cells. This could make it easier for chemotherapy drugs to target and kill these cells.
The University of Texas at San Antonio has received a $354,617 grant to support the development of a novel microscope for detecting prostate cancer through urine samples. This noninvasive approach aims to improve accuracy compared to current clinical practices.
Researchers at McGill University have discovered that mitochondria play a key role in preventing cells from dying when nutrients are scarce. The findings suggest that targeting the mTOR pathway could lead to the development of new cancer therapies that promote cell death.
Researchers have uncovered a new mechanism by which cancer cells evade the immune system, recruiting group 2 innate lymphoid cells to suppress an essential anticancer immune response. Depleting these cells or blocking key molecules restored anti-cancer immunity and extended survival in mouse models.
Researchers at the University of Warwick have discovered a way to program cells using genetic engineering, enabling them to control actions such as fighting disease. The technique uses a common molecule called RNA, which can be engineered into sequences similar to computer code to instruct cells to perform specific actions.
Researchers at NUS combine artemisinin, an anti-malarial drug, with Aminolaevulinic acid (ALA), a photosensitiser, to enhance its anti-cancer properties. This novel combination therapy kills colorectal cancer cells and suppresses tumour growth with fewer side effects.
Researchers at Duke Cancer Institute identified a natural compound, koningic acid, that selectively shuts down the Warburg Effect in cancer cells. This phenomenon, where cancer cells voraciously consume glucose for energy, is controlled by an enzyme called GAPDH.
Theranostics combines predictive biomarkers and precise therapy to target cancer cells, minimizing side effects. The field is expected to change nuclear medicine from 'nuclear radiology' to true 'nuclear medicine,' with potential for cures.
Researchers have identified a molecule called miR-124 in non-small cell lung cancer cells that plays a regulatory role in programmed cell death. The findings may offer a new target in the fight against non-small cell lung cancer, particularly for mesenchymal-like cells resistant to chemotherapy.
Researchers found that chronic cigarette smoke exposure leads to epigenetic changes in lung cells, silencing protective genes and priming them for cancer. These changes can be reversed by quitting smoking, suggesting a potential strategy for reducing lung cancer risk.
Researchers have identified a protein called glypican-2 as a promising target for immunotherapy in treating high-risk childhood cancers. The protein is necessary for tumor growth and is overexpressed on cancer cells, making it an attractive target for therapies that harness the immune system.
Scientists at Johns Hopkins Kimmel Cancer Center found that cigarette smoke triggers epigenetic changes in human airway cells, sensitizing them to genetic mutations. These changes precede and silence key tumor suppressor genes, leading to increased KRAS signaling and cancer development.
Computer simulations reveal that turbulence in plasma jets emerges from heat-induced sound waves, offering a new understanding of plasma's therapeutic properties. This insight may lead to more consistent and effective medical therapies, including wound healing and cancer treatment.
A recent study found that chronic cell death promotes the development of liver cancer by causing remaining cells to divide at higher rates. The researchers also identified caspase 8 as an enzyme playing a dual role in this process, involving both apoptosis and DNA repair.
Researchers from MSU have discovered a novel mechanism of carotenoid transfer between two proteins, opening doors for the development of water-soluble protein complexes to deliver antioxidants to cells. This discovery may lead to new therapeutic applications, such as protecting healthy tissue during cancer treatment.
Researchers have discovered that STING triggers pro-apoptotic responses in T cells, which may lead to new treatments for T-cell lymphomas. The study also found that delivering a small molecule that activates the STING pathway can prevent the growth of T cell-derived tumors in live animals.
Researchers at Children's Hospital Los Angeles are studying the role of extracellular vesicles, or exosomes, in cancer metastasis. Exosomes, released by cancer cells, can modify the behavior of surrounding cells, making them hospitable to cancer growth.
Scientists have created genetically encoded fluorescent sensors to measure GTP levels in cells, which can help identify potential anti-cancer compounds. This breakthrough discovery may lead to new treatments for various diseases by regulating cell movement, growth, and differentiation.
Researchers have discovered a class of compounds that selectively inhibit fibrosis-initiating TGF-β pathways in fibroblasts, without affecting non-fibrogenic cells. These trihydroxyphenolic compounds may provide an opportunity to treat fibrosis with fewer side effects.
Researchers found melatonin boosts immune response against cancer cells, inhibits growth and protects healthy cells from chemotherapy effects. Timing of melatonin treatments is crucial for their anticancer effects due to its role in regulating circadian rhythms.
Researchers at New Zealand's University of Otago have discovered that Natural Killer (NK) cells act as helper cells to start the immune response, patrolling the body to destroy abnormal cells. The NK cells' ability to recognize fragments of tumor cells released into the blood enhances the immune system's recognition of these fragments,...
The study found that regular CT scans may not be necessary for follow-up, suggesting a conservative approach to monitoring the disease. The findings challenge standard clinical practice guidelines recommending chest CT scans every three to six months in the first two years after surgery.
A study by University of Warwick finds a previously overlooked section of gene fusion FGFR3-TACC3 worsens cancer cells. Preventing cell signalling from this fusion may not be effective in cancer treatment research.
A new microfluidic cell culture device allows researchers to study the development of drug resistance in cancer cells in real-time. The system, developed by Princeton University and Johns Hopkins Medical Institute, provides a tool for preclinical cancer drug development and screening.
Researchers at Kyoto University developed a tiny 'body-on-a-chip' device to test the side effects of anti-cancer drugs on human cells. The device revealed that a metabolite of the drug caused toxicity in heart cells, leading to improved pre-clinical testing for these medications.
Researchers at TU Dresden and HTW Dresden found that cancer cells' adaptability affects tumour spread in complex environments, while simplicity worsens spreading. A theoretical approach to suppressing cancer cell plasticity has been proposed for further research.
Researchers at The Institute of Cancer Research found a genetic weakness, BTK addiction, that makes oesophageal cancer cells sensitive to ibrutinib. This discovery could lead to a new approach to treatment for oesophageal cancer patients with MYC mutations.
A new treatment combines gold nanostars and immunotherapy to treat cancer. The treatment successfully cured two mice and vaccinated one mouse against the disease. By destroying tumors and triggering the immune system, the treatment activates immunity against remaining cancerous cells.
Researchers have discovered that cancer-fighting T cells can recognize infected cells with much less evidence of cancer than previously believed. The study, which used optical tweezers to apply a tiny amount of force to the T cells, found that they can bind to just two peptides for activation
A little-studied gene SLC13A5 may explain how liver cancer cells obtain energy to proliferate. Suppressing SLC13A5 in human hepatocellular carcinoma cell lines resulted in slower growth and division of cancer cells.
Researchers identified a 'killer peptide' released by therapy-sensitive cancer cells, which can kill therapy-resistant cells and inhibit metastasis. The peptide enters only cancer cells, preserving healthy tissue.
Researchers at the University of Bradford have discovered a new drug candidate, HXR9, that targets HOX genes to prevent cancer cell growth and induce apoptosis. Combining HXR9 with another drug shows enhanced results in reducing cancer growth.
Research funded by Cancer Research UK identified NOX4 as a common mechanism responsible for cancer-associated fibroblasts (CAFs) formation in tumours. Targeting this enzyme could lead to new treatments and improve existing therapies.
Researchers at Purdue University have discovered a mechanism to deliver tumor-suppressing microRNAs without toxic delivery vehicles. They conjugated the microRNA to a folate molecule, which targets cancer cells while avoiding healthy cells.
A recent analysis of published studies found that higher alcohol intake increases the risk of basal cell carcinoma by 7% and cutaneous squamous cell carcinoma by 11% for every 10 gram increase per day. The study suggests that limiting alcohol consumption may help reduce skin cancer risk.
Researchers discovered how DNA damage cues immune cells to arrive at cancer cells, leading to increased tumor response. Inhibiting cell division can prevent micronuclei formation and reduce immune responses to cancer cells.
Researchers discovered that innate immune system's DNA-sensing mechanism controls cellular senescence, promoting the secretion of inflammation-mediating proteins. This process plays a role in various contexts of senescence, including oxidative stress, oncogene signaling, and irradiation.
Cancer cells use exosomes and semiochemicals to suppress the immune response, allowing them to multiply unopposed. Researchers have identified multiple new therapy approaches, including inhibiting PD-L1 receptors and blocking the recognition of Y RNA messages.
Researchers at Nagoya University have created a high-speed cell sorting method that can sort large cells with high viability, purity and success rates. The technique uses microfluidic chip-based dual on-chip pumps to control flow, enabling rapid sorting of both small and large cells.
The study identified over 760 genes that cancer cells from multiple types strongly depend on for growth and survival. Many of these dependencies are specific to certain cancer types, while about 10% are common across multiple cancers, suggesting new therapeutic targets.
Researchers at Cold Spring Harbor Laboratory have discovered an epigenetic factor, FOXA1, that reprograms gene enhancers in cancer cells, allowing them to 'remember' an earlier developmental state and become metastatic. This mechanism is a major breakthrough in understanding the spread of pancreatic cancer.
Scientists have identified a crucial mechanism by which cells detect and respond to DNA damage, shedding light on the body's natural surveillance systems. This discovery may help explain how the human body keeps disease in check and could lead to new therapeutic approaches for cancer prevention.
Researchers at the Francis Crick Institute have worked out how major players in border formation between tissues keep cells in the right places. They found that ephrins and their Eph receptors trigger signalling inside both cells, stopping them from mixing, and that N-cadherin suppresses repulsion between like cells.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A new CU Boulder study reveals that a protein called CPR-4 is responsible for the radiation-induced bystander effect, which can damage healthy cells. Researchers hope to develop a medication to inhibit this effect, allowing doctors to minimize side effects and enhance cancer cell killing.
Researchers have identified a new mechanism for silencing imprinted genes in cells, which could shed light on developmental disorders such as Angelman syndrome. The discovery also raises questions about the difficulty of cloning mammals, with potential implications for treating developmental failures.
Researchers at Penn have developed a new approach to targeting cancer cells using engineered macrophages, which distinguish between healthy and cancerous cells. The treatment shows promise in regressing human tumors without toxicity.
Researchers found that inhibiting the partnership between Tregs and dendritic cells might lead to effective immunotherapy for pancreatic cancer. Blocking this relationship may enable the immune system to target pancreatic tumor cells more effectively, potentially slowing tumor growth.
Researchers at the Francis Crick Institute have uncovered a pathway controlling autophagy, a process that eliminates diseased cell parts. This finding may help prevent diseases like Alzheimer's and Parkinson's by targeting the disposal system.