Articles tagged with Cancer Cells
Researchers have discovered that STING triggers pro-apoptotic responses in T cells, which may lead to new treatments for T-cell lymphomas. The study also found that delivering a small molecule that activates the STING pathway can prevent the growth of T cell-derived tumors in live animals.
Researchers at Children's Hospital Los Angeles are studying the role of extracellular vesicles, or exosomes, in cancer metastasis. Exosomes, released by cancer cells, can modify the behavior of surrounding cells, making them hospitable to cancer growth.
Scientists have created genetically encoded fluorescent sensors to measure GTP levels in cells, which can help identify potential anti-cancer compounds. This breakthrough discovery may lead to new treatments for various diseases by regulating cell movement, growth, and differentiation.
Researchers have discovered a class of compounds that selectively inhibit fibrosis-initiating TGF-β pathways in fibroblasts, without affecting non-fibrogenic cells. These trihydroxyphenolic compounds may provide an opportunity to treat fibrosis with fewer side effects.
Researchers found melatonin boosts immune response against cancer cells, inhibits growth and protects healthy cells from chemotherapy effects. Timing of melatonin treatments is crucial for their anticancer effects due to its role in regulating circadian rhythms.
Researchers at New Zealand's University of Otago have discovered that Natural Killer (NK) cells act as helper cells to start the immune response, patrolling the body to destroy abnormal cells. The NK cells' ability to recognize fragments of tumor cells released into the blood enhances the immune system's recognition of these fragments,...
The study found that regular CT scans may not be necessary for follow-up, suggesting a conservative approach to monitoring the disease. The findings challenge standard clinical practice guidelines recommending chest CT scans every three to six months in the first two years after surgery.
A study by University of Warwick finds a previously overlooked section of gene fusion FGFR3-TACC3 worsens cancer cells. Preventing cell signalling from this fusion may not be effective in cancer treatment research.
A new microfluidic cell culture device allows researchers to study the development of drug resistance in cancer cells in real-time. The system, developed by Princeton University and Johns Hopkins Medical Institute, provides a tool for preclinical cancer drug development and screening.
Researchers at Kyoto University developed a tiny 'body-on-a-chip' device to test the side effects of anti-cancer drugs on human cells. The device revealed that a metabolite of the drug caused toxicity in heart cells, leading to improved pre-clinical testing for these medications.
Researchers at TU Dresden and HTW Dresden found that cancer cells' adaptability affects tumour spread in complex environments, while simplicity worsens spreading. A theoretical approach to suppressing cancer cell plasticity has been proposed for further research.
Researchers at The Institute of Cancer Research found a genetic weakness, BTK addiction, that makes oesophageal cancer cells sensitive to ibrutinib. This discovery could lead to a new approach to treatment for oesophageal cancer patients with MYC mutations.
A new treatment combines gold nanostars and immunotherapy to treat cancer. The treatment successfully cured two mice and vaccinated one mouse against the disease. By destroying tumors and triggering the immune system, the treatment activates immunity against remaining cancerous cells.
Researchers have discovered that cancer-fighting T cells can recognize infected cells with much less evidence of cancer than previously believed. The study, which used optical tweezers to apply a tiny amount of force to the T cells, found that they can bind to just two peptides for activation
A little-studied gene SLC13A5 may explain how liver cancer cells obtain energy to proliferate. Suppressing SLC13A5 in human hepatocellular carcinoma cell lines resulted in slower growth and division of cancer cells.
Researchers identified a 'killer peptide' released by therapy-sensitive cancer cells, which can kill therapy-resistant cells and inhibit metastasis. The peptide enters only cancer cells, preserving healthy tissue.
Researchers at the University of Bradford have discovered a new drug candidate, HXR9, that targets HOX genes to prevent cancer cell growth and induce apoptosis. Combining HXR9 with another drug shows enhanced results in reducing cancer growth.
Research funded by Cancer Research UK identified NOX4 as a common mechanism responsible for cancer-associated fibroblasts (CAFs) formation in tumours. Targeting this enzyme could lead to new treatments and improve existing therapies.
Researchers at Purdue University have discovered a mechanism to deliver tumor-suppressing microRNAs without toxic delivery vehicles. They conjugated the microRNA to a folate molecule, which targets cancer cells while avoiding healthy cells.
A recent analysis of published studies found that higher alcohol intake increases the risk of basal cell carcinoma by 7% and cutaneous squamous cell carcinoma by 11% for every 10 gram increase per day. The study suggests that limiting alcohol consumption may help reduce skin cancer risk.
Researchers discovered how DNA damage cues immune cells to arrive at cancer cells, leading to increased tumor response. Inhibiting cell division can prevent micronuclei formation and reduce immune responses to cancer cells.
Researchers discovered that innate immune system's DNA-sensing mechanism controls cellular senescence, promoting the secretion of inflammation-mediating proteins. This process plays a role in various contexts of senescence, including oxidative stress, oncogene signaling, and irradiation.
Cancer cells use exosomes and semiochemicals to suppress the immune response, allowing them to multiply unopposed. Researchers have identified multiple new therapy approaches, including inhibiting PD-L1 receptors and blocking the recognition of Y RNA messages.
Researchers at Nagoya University have created a high-speed cell sorting method that can sort large cells with high viability, purity and success rates. The technique uses microfluidic chip-based dual on-chip pumps to control flow, enabling rapid sorting of both small and large cells.
The study identified over 760 genes that cancer cells from multiple types strongly depend on for growth and survival. Many of these dependencies are specific to certain cancer types, while about 10% are common across multiple cancers, suggesting new therapeutic targets.
Researchers at Cold Spring Harbor Laboratory have discovered an epigenetic factor, FOXA1, that reprograms gene enhancers in cancer cells, allowing them to 'remember' an earlier developmental state and become metastatic. This mechanism is a major breakthrough in understanding the spread of pancreatic cancer.
Scientists have identified a crucial mechanism by which cells detect and respond to DNA damage, shedding light on the body's natural surveillance systems. This discovery may help explain how the human body keeps disease in check and could lead to new therapeutic approaches for cancer prevention.
Researchers at the Francis Crick Institute have worked out how major players in border formation between tissues keep cells in the right places. They found that ephrins and their Eph receptors trigger signalling inside both cells, stopping them from mixing, and that N-cadherin suppresses repulsion between like cells.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A new CU Boulder study reveals that a protein called CPR-4 is responsible for the radiation-induced bystander effect, which can damage healthy cells. Researchers hope to develop a medication to inhibit this effect, allowing doctors to minimize side effects and enhance cancer cell killing.
Researchers have identified a new mechanism for silencing imprinted genes in cells, which could shed light on developmental disorders such as Angelman syndrome. The discovery also raises questions about the difficulty of cloning mammals, with potential implications for treating developmental failures.
Researchers at Penn have developed a new approach to targeting cancer cells using engineered macrophages, which distinguish between healthy and cancerous cells. The treatment shows promise in regressing human tumors without toxicity.
Researchers found that inhibiting the partnership between Tregs and dendritic cells might lead to effective immunotherapy for pancreatic cancer. Blocking this relationship may enable the immune system to target pancreatic tumor cells more effectively, potentially slowing tumor growth.
Researchers at the Francis Crick Institute have uncovered a pathway controlling autophagy, a process that eliminates diseased cell parts. This finding may help prevent diseases like Alzheimer's and Parkinson's by targeting the disposal system.
Researchers from Kyoto University developed a new method to transfer genes into cancer cells using gold nanorods coated with oleate and DOTAP. The nanorods are activated by near-infrared laser heat, inducing cell death in surrounding cancer cells.
Scientists in Japan develop a method to image cancer at the single-cell level, revealing cancerous colonies in detail. The technique allows researchers to track cancer cells as they multiply and metastasize, providing insight into metastatic pathways.
Researchers have developed a method to visualize cancer metastasis in whole organs at the single-cell level, enabling early detection of dormant or resistant cancer cells. This breakthrough uses transparent mice and advanced imaging techniques to create 3-D maps of cancer cells throughout the body and organs.
Researchers have developed a new method to detect genetic changes in cancer cells using Hi-C, which can identify major genome rearrangements and copy number variations with high accuracy. This approach has the potential to aid targeted treatments and enhance cancer diagnosis.
Research sheds light on how conserved mechanism regulates development and cancer; implications for new cancer therapies. TUTase enzymes interact with let-7, a small RNA molecule important in development and cancer.
Researchers at Ulsan National Institute of Science and Technology have developed a novel method to control cellular fate by introducing organelle-localized self-assembly of peptide amphiphiles. This approach enables targeted cancer chemotherapy by activating the intrinsic apoptotic pathway against cancer cells, reducing side effects.
Researchers discovered the role of TERRA in repairing critically short telomeres, which play a key role in determining cellular senescence. The study provides new insights into the regulation of cell senescence and survival in ageing and cancer.
Researchers at Kanazawa University have successfully imaged the dynamics of nuclear pores in colon cancer cells, revealing a new 'nano dying code' that could lead to novel treatments. The study uses high-speed Atomic Force Microscopy (HS-AFM) to visualize the structure and dynamics of nuclear membrane pores at the nanoscale.
A multimodal optical spectroscopy probe has been developed to detect brain, lung, colon, and skin cancer cells with nearly 100% sensitivity. The probe's high accuracy enables surgeons to minimize cancer cells during surgery, improving patient outcomes and reducing the risk of recurrence.
Researchers at Stanford University developed a new tool to efficiently slice cells in half, enabling faster and more standardized study of single-cell wound repair. The 'cellular guillotine' cuts Stentor cells up to 200 times faster than previous methods with similar survival rates.
Researchers at OIST have discovered a new photosensitizer that targets brain cancer cells with improved efficiency, using the naturally occurring amino acid taurine to enhance its effectiveness. The study shows promise for developing more effective brain cancer treatments through photodynamic therapy.
Scientists have identified specific areas within cells where hormones can transmit information to exact locations. Targeted therapeutics could be more effective by activating enzymes in these regions. The study also highlights the importance of insulating signal effects to reduce side effects.
A study by the Stowers Institute for Medical Research found that cancer cells often lose copies of repetitive sequences known as ribosomal DNA, which may enable faster proliferation but also render them more sensitive to DNA damage. This could potentially be exploited by DNA-damaging chemotherapeutics.
Researchers developed a two-pronged approach to treat multiple blood cancers by targeting cancer cells directly and driving them out of the bone marrow environment. The new antibody PF-06747143 has been shown to eradicate more cancer cells compared to standard care in preclinical studies.
MIT biologists identified a mechanism for eliminating genetically imbalanced cells using natural killer cells. Aneuploidy, or uneven chromosome distribution, harms most cells but can help cancer cells grow uncontrollably.
Researchers discovered how dying cells alert neighbors to replace them, a process called compensatory proliferation signaling (CPS). Specialized vesicles containing the CrkI protein travel to neighboring cells and cause them to create new cells.
A team of engineers at the University of Pennsylvania has developed a new model that better simulates how cells interact with their environment and form focal adhesions. This understanding is crucial for diagnosing and combating cancer, as it reveals the importance of dynamic processes in cellular behavior.
Researchers discovered ZBTB48 regulates both telomeres and mitochondria, contributing to a better understanding of the human ageing process. The protein limits abnormal telomere lengthening in cells, while activating genes involved in mitochondrial function.
Researchers at UNIGE have discovered the essential role of Vps4 molecule in cell division, shedding light on the fight against cancer and HIV. The study reveals that Vps4 is necessary for abscission, a stage where cell membranes are severed, and its absence inhibits cell division and delays it significantly.
Research reveals a defective immune cell's sweet tooth predisposes people to shingles, exacerbating heart disease. The connection shows how the same mechanism disabling immune response to viral infections also affects heart conditions.
Researchers have developed a new surface molecule that makes immune cells more aggressive against cancer cells. The approach could enhance adoptive T-cell therapy, allowing for more effective treatments and personalized medicine.
Researchers at University of California San Diego School of Medicine found that cancer cells exploit the unfolded protein response (UPR) to activate Wnt signaling, promoting tumor survival and drug resistance. This mechanism enables cancer cells to cope with nutrient deprivation and therapies, contributing to intra-tumor heterogeneity.
Researchers discovered that cancer cells sense their environment's stiffness, slowing down movement with specific drug combinations. This finding has potential for regenerative medicine applications, such as improving adult stem cell therapy.
A new predictive model shows that radiation from cosmic rays can extend to healthy cells, doubling the cancer risk for astronauts on Mars missions. The study, published in Scientific Reports, highlights the need for additional research on cosmic ray exposures prior to long-term space missions.
A team of scientists has discovered a remarkable mechanism that enables cells to repair severely damaged chromosomes, preventing cell death and cancer. The 'Hail Mary' mechanism involves the creation of a DNA tether to keep the broken fragment connected to the chromosome.
Researchers found that squamous cell carcinoma is remarkably dependent on glucose as an energy source, with a protein called GLUT1 being highly active in the cancer. Elevated GLUT1 levels were also linked to other types of squamous cell cancers, including head and neck, esophageal, and cervical cancers.