Articles tagged with Cancer Cells
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A little-studied gene SLC13A5 may explain how liver cancer cells obtain energy to proliferate. Suppressing SLC13A5 in human hepatocellular carcinoma cell lines resulted in slower growth and division of cancer cells.
Researchers identified a 'killer peptide' released by therapy-sensitive cancer cells, which can kill therapy-resistant cells and inhibit metastasis. The peptide enters only cancer cells, preserving healthy tissue.
Researchers at the University of Bradford have discovered a new drug candidate, HXR9, that targets HOX genes to prevent cancer cell growth and induce apoptosis. Combining HXR9 with another drug shows enhanced results in reducing cancer growth.
Researchers at Purdue University have discovered a mechanism to deliver tumor-suppressing microRNAs without toxic delivery vehicles. They conjugated the microRNA to a folate molecule, which targets cancer cells while avoiding healthy cells.
Research funded by Cancer Research UK identified NOX4 as a common mechanism responsible for cancer-associated fibroblasts (CAFs) formation in tumours. Targeting this enzyme could lead to new treatments and improve existing therapies.
Researchers discovered that innate immune system's DNA-sensing mechanism controls cellular senescence, promoting the secretion of inflammation-mediating proteins. This process plays a role in various contexts of senescence, including oxidative stress, oncogene signaling, and irradiation.
Researchers discovered how DNA damage cues immune cells to arrive at cancer cells, leading to increased tumor response. Inhibiting cell division can prevent micronuclei formation and reduce immune responses to cancer cells.
A recent analysis of published studies found that higher alcohol intake increases the risk of basal cell carcinoma by 7% and cutaneous squamous cell carcinoma by 11% for every 10 gram increase per day. The study suggests that limiting alcohol consumption may help reduce skin cancer risk.
Researchers at Nagoya University have created a high-speed cell sorting method that can sort large cells with high viability, purity and success rates. The technique uses microfluidic chip-based dual on-chip pumps to control flow, enabling rapid sorting of both small and large cells.
Cancer cells use exosomes and semiochemicals to suppress the immune response, allowing them to multiply unopposed. Researchers have identified multiple new therapy approaches, including inhibiting PD-L1 receptors and blocking the recognition of Y RNA messages.
The study identified over 760 genes that cancer cells from multiple types strongly depend on for growth and survival. Many of these dependencies are specific to certain cancer types, while about 10% are common across multiple cancers, suggesting new therapeutic targets.
Researchers at Cold Spring Harbor Laboratory have discovered an epigenetic factor, FOXA1, that reprograms gene enhancers in cancer cells, allowing them to 'remember' an earlier developmental state and become metastatic. This mechanism is a major breakthrough in understanding the spread of pancreatic cancer.
Researchers at the Francis Crick Institute have worked out how major players in border formation between tissues keep cells in the right places. They found that ephrins and their Eph receptors trigger signalling inside both cells, stopping them from mixing, and that N-cadherin suppresses repulsion between like cells.
Scientists have identified a crucial mechanism by which cells detect and respond to DNA damage, shedding light on the body's natural surveillance systems. This discovery may help explain how the human body keeps disease in check and could lead to new therapeutic approaches for cancer prevention.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
Researchers have identified a new mechanism for silencing imprinted genes in cells, which could shed light on developmental disorders such as Angelman syndrome. The discovery also raises questions about the difficulty of cloning mammals, with potential implications for treating developmental failures.
A new CU Boulder study reveals that a protein called CPR-4 is responsible for the radiation-induced bystander effect, which can damage healthy cells. Researchers hope to develop a medication to inhibit this effect, allowing doctors to minimize side effects and enhance cancer cell killing.
Researchers at Penn have developed a new approach to targeting cancer cells using engineered macrophages, which distinguish between healthy and cancerous cells. The treatment shows promise in regressing human tumors without toxicity.
Researchers found that inhibiting the partnership between Tregs and dendritic cells might lead to effective immunotherapy for pancreatic cancer. Blocking this relationship may enable the immune system to target pancreatic tumor cells more effectively, potentially slowing tumor growth.
Researchers at the Francis Crick Institute have uncovered a pathway controlling autophagy, a process that eliminates diseased cell parts. This finding may help prevent diseases like Alzheimer's and Parkinson's by targeting the disposal system.
Researchers from Kyoto University developed a new method to transfer genes into cancer cells using gold nanorods coated with oleate and DOTAP. The nanorods are activated by near-infrared laser heat, inducing cell death in surrounding cancer cells.
Scientists in Japan develop a method to image cancer at the single-cell level, revealing cancerous colonies in detail. The technique allows researchers to track cancer cells as they multiply and metastasize, providing insight into metastatic pathways.
Researchers have developed a method to visualize cancer metastasis in whole organs at the single-cell level, enabling early detection of dormant or resistant cancer cells. This breakthrough uses transparent mice and advanced imaging techniques to create 3-D maps of cancer cells throughout the body and organs.
Researchers have developed a new method to detect genetic changes in cancer cells using Hi-C, which can identify major genome rearrangements and copy number variations with high accuracy. This approach has the potential to aid targeted treatments and enhance cancer diagnosis.
Research sheds light on how conserved mechanism regulates development and cancer; implications for new cancer therapies. TUTase enzymes interact with let-7, a small RNA molecule important in development and cancer.
Researchers at Ulsan National Institute of Science and Technology have developed a novel method to control cellular fate by introducing organelle-localized self-assembly of peptide amphiphiles. This approach enables targeted cancer chemotherapy by activating the intrinsic apoptotic pathway against cancer cells, reducing side effects.
Researchers at Kanazawa University have successfully imaged the dynamics of nuclear pores in colon cancer cells, revealing a new 'nano dying code' that could lead to novel treatments. The study uses high-speed Atomic Force Microscopy (HS-AFM) to visualize the structure and dynamics of nuclear membrane pores at the nanoscale.
Researchers discovered the role of TERRA in repairing critically short telomeres, which play a key role in determining cellular senescence. The study provides new insights into the regulation of cell senescence and survival in ageing and cancer.
A multimodal optical spectroscopy probe has been developed to detect brain, lung, colon, and skin cancer cells with nearly 100% sensitivity. The probe's high accuracy enables surgeons to minimize cancer cells during surgery, improving patient outcomes and reducing the risk of recurrence.
Researchers at Stanford University developed a new tool to efficiently slice cells in half, enabling faster and more standardized study of single-cell wound repair. The 'cellular guillotine' cuts Stentor cells up to 200 times faster than previous methods with similar survival rates.
Researchers at OIST have discovered a new photosensitizer that targets brain cancer cells with improved efficiency, using the naturally occurring amino acid taurine to enhance its effectiveness. The study shows promise for developing more effective brain cancer treatments through photodynamic therapy.
A study by the Stowers Institute for Medical Research found that cancer cells often lose copies of repetitive sequences known as ribosomal DNA, which may enable faster proliferation but also render them more sensitive to DNA damage. This could potentially be exploited by DNA-damaging chemotherapeutics.
Scientists have identified specific areas within cells where hormones can transmit information to exact locations. Targeted therapeutics could be more effective by activating enzymes in these regions. The study also highlights the importance of insulating signal effects to reduce side effects.
Researchers developed a two-pronged approach to treat multiple blood cancers by targeting cancer cells directly and driving them out of the bone marrow environment. The new antibody PF-06747143 has been shown to eradicate more cancer cells compared to standard care in preclinical studies.
Researchers discovered how dying cells alert neighbors to replace them, a process called compensatory proliferation signaling (CPS). Specialized vesicles containing the CrkI protein travel to neighboring cells and cause them to create new cells.
MIT biologists identified a mechanism for eliminating genetically imbalanced cells using natural killer cells. Aneuploidy, or uneven chromosome distribution, harms most cells but can help cancer cells grow uncontrollably.
A team of engineers at the University of Pennsylvania has developed a new model that better simulates how cells interact with their environment and form focal adhesions. This understanding is crucial for diagnosing and combating cancer, as it reveals the importance of dynamic processes in cellular behavior.
Researchers discovered ZBTB48 regulates both telomeres and mitochondria, contributing to a better understanding of the human ageing process. The protein limits abnormal telomere lengthening in cells, while activating genes involved in mitochondrial function.
Research reveals a defective immune cell's sweet tooth predisposes people to shingles, exacerbating heart disease. The connection shows how the same mechanism disabling immune response to viral infections also affects heart conditions.
Researchers at UNIGE have discovered the essential role of Vps4 molecule in cell division, shedding light on the fight against cancer and HIV. The study reveals that Vps4 is necessary for abscission, a stage where cell membranes are severed, and its absence inhibits cell division and delays it significantly.
Researchers have developed a new surface molecule that makes immune cells more aggressive against cancer cells. The approach could enhance adoptive T-cell therapy, allowing for more effective treatments and personalized medicine.
Researchers discovered that cancer cells sense their environment's stiffness, slowing down movement with specific drug combinations. This finding has potential for regenerative medicine applications, such as improving adult stem cell therapy.
Researchers at University of California San Diego School of Medicine found that cancer cells exploit the unfolded protein response (UPR) to activate Wnt signaling, promoting tumor survival and drug resistance. This mechanism enables cancer cells to cope with nutrient deprivation and therapies, contributing to intra-tumor heterogeneity.
A team of scientists has discovered a remarkable mechanism that enables cells to repair severely damaged chromosomes, preventing cell death and cancer. The 'Hail Mary' mechanism involves the creation of a DNA tether to keep the broken fragment connected to the chromosome.
A new predictive model shows that radiation from cosmic rays can extend to healthy cells, doubling the cancer risk for astronauts on Mars missions. The study, published in Scientific Reports, highlights the need for additional research on cosmic ray exposures prior to long-term space missions.
Researchers found that squamous cell carcinoma is remarkably dependent on glucose as an energy source, with a protein called GLUT1 being highly active in the cancer. Elevated GLUT1 levels were also linked to other types of squamous cell cancers, including head and neck, esophageal, and cervical cancers.
Researchers have created artificial viruses that can specifically target and destroy cancer cells by stimulating the immune system. The unique combination of alarm signals and cancer cell proteins enables the creation of a powerful army of killer cells to identify and destroy cancer cells.
Researchers have identified a new way to potentially slow fast-growing cancer cells by targeting the Tudor-SN protein. The study, published in Science, found that eliminating this protein from cancer cells using CRISPR-Cas9 technology slowed their cell cycle and moved them more slowly towards division.
Researchers from the University of Michigan have discovered how polyomaviruses hijack cellular molecular motors to build a portal for itself, allowing it to reach the nucleus and cause problems. The findings could aid in the development of new treatments or preventive strategies against polyomavirus diseases such as Merkel cell carcinoma.
A CU Boulder study shows that some dividing human cells transmit low-level DNA damage to their daughters, causing them to enter a quiescent state previously thought to be random. The process is linked to the fate of daughter cells in subsequent cell cycles and has implications for cancer development and aging.
New study reveals that immune cells trained to recognize cancer can exit one tumor and move to another to attack cancerous cells. The research sheds light on how immune therapies for cancer might work and suggests new approaches to developing anti-cancer immune therapies.
Researchers discovered that normal cells recognize and attack transformed cells through metabolic changes, including mitochondrial dysfunction and elevated glucose uptake. These changes play a crucial role in eliminating early-stage cancer cells.
Researchers at Michigan Medicine discovered a protein called free C3d that stops cancer's ability to prevent the immune system from destroying cancer cells. The study showed an 80-90% decrease in cancerous tumors, and free C3d has potential as a cancer vaccine and treatment.
A study published in JAMA found that using a combination of docetaxel and selumetinib did not improve progression-free or overall survival for patients with KRAS-mutant non-small cell lung cancer. The treatment had more frequent grade 3 or higher adverse events compared to the placebo group.
A new cell separator developed by University of Surrey Biomedical Engineers uses dielectrophoresis to sort cells electrostatically, reducing costs and increasing efficiency. This innovation has significant promise for stem-cell therapy and cancer research, offering a more affordable and effective solution.
Researchers have identified a group of critical cells in the testes that play a key role in repairing damage to produce healthy sperm. These Miwi2-expressing cells are essential for regeneration and may help preserve fertility in pre-pubescent boys undergoing cancer treatment.
Researchers have discovered that excessive DNA replication can lead to cell malignancy but also offers a potential approach against cancer. By exploiting the cooperation of proteins CDC6 and CDT1, scientists aim to induce lethal DNA re-replication selectively in cancer cells.
Researchers at University of Warwick study brain tumor cells to investigate the cause of genetic defects in cancer cells. They aim to better understand how these problems occur and potentially develop drugs to stop cancer cells forming.
A new study by British American Tobacco found that commercially available e-cigarettes did not promote the development of cancer in laboratory cells. In contrast, smoke from a reference cigarette was positive for cancer-promoting activity at very low concentrations.
Researchers developed fCLIP-seq to analyze DROSHA's impact on miRNA fragments, revealing hundreds of new cleavage sites and alternative processing patterns. The study uncovers additional end modifications important for miRNA biogenesis, shedding light on its regulation in diseases like cancer.