Articles tagged with Cancer Cells
Researchers at Baylor College of Medicine have identified a key regulator of a cellular pathway that selectively targets mutant p53-R175H proteins, which promote ovarian cancer growth. The study suggests designing drugs directed at this regulator might lead to better ways to control cancer growth.
A new study from Virginia Tech found that fluid shear stress causes cancerous cells to become more aggressive and benign cells to exhibit traits of cancer. This discovery could lead to the development of a predictor for ovarian cancer, enabling earlier diagnosis and potentially saving thousands of lives.
A study by Hiroshima University researchers found that a specific gene group controls DNA damage response in hypoxic cancer cells, weakening the effectiveness of anticancer therapies. Suppressing this gene, DEC2, made cancer cells more sensitive to radiation treatment.
Researchers discovered that asbestos exposure sends exosomes to distant cells, causing genetic changes and potentially leading to cancer or diseases. The findings suggest a new mechanism by which asbestos triggers deadly cancers.
Researchers at Saint Louis University have uncovered new answers about why cells rapidly age in children with a rare disease called Hutchinson-Gilford Progeria Syndrome. The team found that cellular replication stress and a mistaken innate immune response are culprits, and successfully blocked these processes with vitamin D.
A research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off. The technology could lead to the development of new cancer therapies and other drugs by activating non-toxic cancer prodrugs into their therapeutic forms.
Researchers at UCLA have created a new method for targeted gene delivery using 'nanospears,' which can enable safer, faster and more cost-effective gene therapies. The nanostructures are biodegradable and can be mass-produced inexpensively, delivering genetic information with minimal impact on cell viability and metabolism.
Researchers have created BN/Ag hybrid nanomaterials that demonstrate effectiveness as catalysts, antibacterial agents, and drug delivery systems for treating oncological diseases. The hybrids show high potential for cancer therapy and water disinfection, offering a new approach to combatting these threats.
Researchers discovered that inhibiting autophagy with the help of FOXO3a molecule can push cancer cells into apoptosis. The study found that combining autophagy inhibition with a drug called Nutlin increases PUMA production, leading to cell death.
Researchers at WashU Medicine used CRISPR to engineer human T cells that can attack human T cell cancers without succumbing to friendly fire. The new approach also allows for the use of therapeutic T cells from any healthy donor, eliminating the need for a matched donor or patient's own T cells.
Biochemists have made a discovery that sheds light on the molecular machinery that allows some cells to wiggle their way through tissues. The researchers identified two locations on Arp2/3 where an activator protein touches, promoting cell motility and potentially leading to new opportunities for cancer treatment.
The Scripps Research Institute has developed a new method for creating glycan arrays that can be used to study the interactions between glycans and proteins. The breakthrough, published in Nature Communications, uses enzymes naturally produced by cells to create branching glycans.
Researchers at Washington University in St. Louis have developed a method enabling effective insertion of large molecules into cells using acoustic shear poration and electrophoresis. The approach has achieved greater than 75 percent delivery efficiency of macromolecules, including DNA insertion, which is significantly more challenging.
Researchers discovered that a natural alkaloid extracted from Daffodils, called haemanthamine, blocks the production of proteins by ribosomes in cancer cells, leading to their elimination. The study provides a molecular explanation for the anti-tumoral activity of Daffodils used in folk medicine.
Researchers at Binghamton University have developed a new method of treating pancreatic cancer using dual thermal ablation, which combines heating and freezing to kill cancer cells. The study found that this approach achieves complete cell death in pancreatic cancer cells more effectively than heating or freezing alone.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
ILC2 cells play a crucial role in preventing or slowing metastasis in lung and prostate cancer by unleashing the killing power of T-cells. Researchers have concluded that ILC2 cells may be a potent weapon in stopping cancer from spreading, offering potential treatment for blood-borne and solid tumours.
Researchers have developed a new synthetic bioluminescence system that allows for imaging of cells from outside the body. The bioengineered light source enables tracking of cancer cells in mice and brain-cell activity in monkeys, with potential applications beyond lab research.
A new regulator of the immune system has been identified by a Finnish research group, with potential implications for treating both cancer and immune-mediated diseases. HIC1 protein controls the expression of genes contributing to T cell function and regulates immune response.
Research by Prof. Dr. Prasad Shastri at the University of Freiburg found that cancer cell membrane stiffness affects nanoparticle internalization; increasing stiffness enhances polymer nanoparticle entry through pathways rich in cholesterol.
The discovery reveals that the enzyme RIPK1 decreases mitochondrial numbers, leading to oxidative stress and potential cell death. This finding could lead to a new strategy for eliminating ECM-detached cancer cells and improving patient survival.
Researchers at UC San Francisco have uncovered the architecture of the spindle pole body in yeast, shedding light on its function and potential connections to human centrosomes. The study reveals that the Spc110 protein plays a crucial role in the SPB's structure and may provide a binding surface for its architecture.
A new study published in the British Journal of Cancer found that self-sampling followed by HPV testing can identify twice as many women at risk of cervical cancer. This method also reaches women who have previously chosen not to participate, while reducing costs and increasing effectiveness.
A new machine learning algorithm, SWING, has been developed to uncover the underlying biological networks within cells by analyzing time-series data. This allows researchers to understand how cells make decisions and respond to stimuli, which can lead to strategies for intervening in diseases like cancer.
The study identified specific 'metastatic variant enhancer loci' that drive cancer cell metastasis, and showed that inhibiting these enhancers can halt the spread of tumor cells. Blocking expression of individual genes regulated by these enhancers also diminished metastatic capacity.
Researchers have discovered that naked mole rats are able to inhibit metabolic processes of senescent cells, making them less pathogenic. The rodents' cells also display increased resistance to DNA damage, which may be essential for their longevity and cancer resistance.
Cancer cells can lose multidrug resistance capabilities for days, creating a therapeutic window for chemotherapy. A breakthrough technique uses nanoparticles and near infrared laser treatment to cut off energy supply to efflux pumps, reducing resistance.
Researchers at Michigan Technological University developed a new cyanine dye that can work in water and exhibits fluorescence in acidic conditions. The dye has multiple benefits, including dual fluorescence under near-infrared and visible light, making it suitable for biomedical research.
Researchers discover a two-step process to kill liver cancer cells by silencing an enzyme and adding metformin, potentially accelerating new treatments for this deadly disease. This approach has shown promise in treating liver cancer, where surgery is often not an option and available drugs are only moderately effective.
Researchers investigated naked mole rats' cellular senescence mechanism, finding unique features that contribute to their cancer resistance and longevity. Despite exhibiting senescence similar to mice, naked mole rats display a more structured response to senescence, which may be beneficial for longevity.
Researchers have gained insight into the structure and regulation of Polycomb Repressive Complex 2 (PRC2), a gene regulator that controls cell differentiation and cancer development. The study's findings hold promise for developing new therapies for cancer by targeting PRC2 dysfunction.
Researchers identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells. The enzyme, GalNAc-T6, attaches sugar molecules to proteins, affecting cell-cell adhesion and leading to abnormal tissue formation. This discovery may lead to new therapies for colon cancer.
Biologists from Konstanz, Ulm, and Karlsruhe decipher the biochemical mechanism of p53 and PARP-1 interaction, significant for tumour biology. The study reveals that the protein p53 is modified through interaction with the enzyme PARP-1, which has far-reaching implications for its regulation.
A new study reveals that starvation of sugar can trigger a unique signaling function in cancer cells, leading to cell death. By manipulating this property, researchers propose a potential combination therapy to target cancer metabolism and selectively kill cancer cells while leaving healthy cells intact.
A comprehensive dataset of cancer cell metabolites has been compiled, showing consistent increases or decreases in certain metabolites across multiple tumor types. The study's findings offer insights into the metabolic programming between normal and cancer cells, with potential applications for novel therapies.
Scientists at Northwestern University discovered that mitochondria and lysosomes directly contact each other in cells to regulate their functions. This rare finding has important implications for understanding normal aging and diseases such as Parkinson's and cancer.
Researchers created a 3D model of telomerase, an enzyme that lengthens chromosome ends, in baker's yeast. The study provides new insights into how telomerase recruits itself to chromosome tips and sheds light on its role in cancer cell survival.
Cancer researchers have developed a new approach to target 'undruggable' cancer-causing genes by attacking the proteins they produce on the cell surface. The study reveals that antibodies against specific proteins can deliver cytotoxic or immunotherapeutic compounds to Ras-mutant cancer cells.
Researchers from Instituto de Medicina Molecular found that TERRA, a functional component of telomeres, must be constantly regulated to prevent telomeric and chromosomal instability. This study sheds light on the molecular basis of genome stability and may pave the way for new therapeutic approaches.
Researchers discovered that nuclei play a crucial role in cell movement, particularly in 3D environments. Cells lacking nuclei or disconnected from the cytoskeleton exhibit reduced mobility on soft surfaces and fail to move in three-dimensional matrices.
Researchers at Uppsala University have discovered a new strategy to shut down specific enzymes that can help fight cancer. By studying the native structures and mechanisms of dehydroorotate dehydrogenase, they found that lipids play a crucial role in binding drugs to this enzyme.
Researchers have solved a longstanding puzzle of how cells compact DNA to enable healthy cell division. They found that single cells can compact DNA 10,000-fold by forming series of compacted loops and anchoring them to a central spiral axis.
Researchers have developed a biomaterials-based system that uses soft microfibers to activate and expand T cells, increasing their number by nearly an order of magnitude. This approach simplifies processing compared to existing systems and has the potential to bring new hope to cancer patients for T-cell therapy.
Conventional cancer therapy can create an inflammatory cascade in the body, leading to aggressive tumor progression and recurrence. However, resolvins have been shown to counteract these effects, enhancing the body's clearance of cell debris and reducing tumor growth.
Researchers used Cryo-EM to capture images of molecular machinery called RNA Polymerase III in unprecedented detail, revealing five key stages in which the complex reshapes itself to successfully transcribe the DNA code. This discovery could open up new approaches to cancer treatment by targeting the complex's activity.
A team of researchers has developed an innovative approach to remotely control genetic processes in live immune T cells, enabling them to recognize and kill cancer cells. The system uses mechanogenetics to convert mechanical signals into genetic control, with potential to increase precision and efficiency in CAR-T cell immunotherapy.
A team of cancer researchers has made a significant contribution to our understanding of cancer cell regulation, which could lead to improved cancer treatments. The study focuses on kinases, proteins that influence cancer cell growth and development, and identifies new strategies for killing cancer cells.
Researchers at the University of Warwick have developed a new line of attack against cancer using an organic-osmium compound, JPC11, which targets a metabolic process relied on by cancer cells. The treatment can be recycled and reused within cancer cells to attack them repeatedly.
Researchers at Cold Spring Harbor Laboratory have developed a method to selectively disable the MYB protein, which enables cancer cells to proliferate. In tests in mice, this approach resulted in an 80% reduction in size of aggressive leukemia without harming normal cells.
Researchers found combining blueberry extract with radiation increases treatment effectiveness for late-stage cervical cancer, reducing healthy cell damage by up to 70%. The study's lead author suggests blueberries as a potential radiosensitizer, a non-toxic chemical that enhances cancer cells' responsiveness to radiation therapy.
Researchers found a novel combination of PARP and BET inhibitors to be effective in treating ovarian cancers without BRCA1 and BRCA2 gene mutations. The combination resulted in enhanced sensitivity of cells to cell death, offering potential applications in broadening treatment options for various malignancies.
Researchers measured absolute cross sections for secondary electrons interacting with DNA molecules in a condensed-phase environment. This study provides insights into the damage and radiation dose delivered to patients in radiotherapy.
Researchers have measured and mapped the key molecular forces on platelets that trigger blood clotting. The findings suggest that platelets care about the direction of forces applied to them, requiring a lateral force signal to prevent unnecessary clotting.
Scientists at The Ottawa Hospital and University of Ottawa discover Maraba virus can eliminate latent HIV-infected cells. Laboratory tests show the virus targets cells with impaired interferon pathway, leaving healthy cells unharmed.
A KAIST research team developed technology to identify the optimal drug target for cancer cells based on molecular network dynamics. This approach uses systems biology to analyze genetic mutations and predict drug response, which could lead to more effective treatment strategies.
Researchers at the University of Copenhagen have discovered a new mechanism by which cancer-inhibiting proteins regulate signaling molecules. The study found that primary cilia, or cellular antennae, play a crucial role in balancing PDGFRα signaling, preventing excessive receptor activation that can lead to brain and gastrointestinal t...
Researchers at UNC School of Medicine discovered that the minichromosome maintenance (MCM) complex plays a crucial role in keeping stem cells in their immature state. The study suggests that rapid MCM loading rate is essential for maintaining stem cell identity.
A new study reveals that mutations in 'Ras' genes, which drive 25% of human cancers, can also suppress the immune system around tumors by increasing PD-L1 levels. This understanding will help offer patients more precise and effective treatments.
Researchers at iMM found that certain molecular signals allow cancer cells to survive chemotherapy by altering mitochondrial metabolism. Using VEGF-blocking drugs, they were able to render these cells vulnerable to chemotherapy.
A research team led by Professor Jens Nielsen has mapped out the complex metabolism of yeast cells, enabling the efficient production of protein therapies for diseases like cancer. The breakthrough could lead to significantly cheaper treatments, potentially reducing costs by 10%.