Articles tagged with Cancer Cells
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Researchers discovered that a natural alkaloid extracted from Daffodils, called haemanthamine, blocks the production of proteins by ribosomes in cancer cells, leading to their elimination. The study provides a molecular explanation for the anti-tumoral activity of Daffodils used in folk medicine.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
Research by Prof. Dr. Prasad Shastri at the University of Freiburg found that cancer cell membrane stiffness affects nanoparticle internalization; increasing stiffness enhances polymer nanoparticle entry through pathways rich in cholesterol.
ILC2 cells play a crucial role in preventing or slowing metastasis in lung and prostate cancer by unleashing the killing power of T-cells. Researchers have concluded that ILC2 cells may be a potent weapon in stopping cancer from spreading, offering potential treatment for blood-borne and solid tumours.
A new regulator of the immune system has been identified by a Finnish research group, with potential implications for treating both cancer and immune-mediated diseases. HIC1 protein controls the expression of genes contributing to T cell function and regulates immune response.
Researchers have developed a new synthetic bioluminescence system that allows for imaging of cells from outside the body. The bioengineered light source enables tracking of cancer cells in mice and brain-cell activity in monkeys, with potential applications beyond lab research.
The discovery reveals that the enzyme RIPK1 decreases mitochondrial numbers, leading to oxidative stress and potential cell death. This finding could lead to a new strategy for eliminating ECM-detached cancer cells and improving patient survival.
Researchers at UC San Francisco have uncovered the architecture of the spindle pole body in yeast, shedding light on its function and potential connections to human centrosomes. The study reveals that the Spc110 protein plays a crucial role in the SPB's structure and may provide a binding surface for its architecture.
A new study published in the British Journal of Cancer found that self-sampling followed by HPV testing can identify twice as many women at risk of cervical cancer. This method also reaches women who have previously chosen not to participate, while reducing costs and increasing effectiveness.
The study identified specific 'metastatic variant enhancer loci' that drive cancer cell metastasis, and showed that inhibiting these enhancers can halt the spread of tumor cells. Blocking expression of individual genes regulated by these enhancers also diminished metastatic capacity.
A new machine learning algorithm, SWING, has been developed to uncover the underlying biological networks within cells by analyzing time-series data. This allows researchers to understand how cells make decisions and respond to stimuli, which can lead to strategies for intervening in diseases like cancer.
Researchers have discovered that naked mole rats are able to inhibit metabolic processes of senescent cells, making them less pathogenic. The rodents' cells also display increased resistance to DNA damage, which may be essential for their longevity and cancer resistance.
Cancer cells can lose multidrug resistance capabilities for days, creating a therapeutic window for chemotherapy. A breakthrough technique uses nanoparticles and near infrared laser treatment to cut off energy supply to efflux pumps, reducing resistance.
Researchers discover a two-step process to kill liver cancer cells by silencing an enzyme and adding metformin, potentially accelerating new treatments for this deadly disease. This approach has shown promise in treating liver cancer, where surgery is often not an option and available drugs are only moderately effective.
Researchers at Michigan Technological University developed a new cyanine dye that can work in water and exhibits fluorescence in acidic conditions. The dye has multiple benefits, including dual fluorescence under near-infrared and visible light, making it suitable for biomedical research.
Researchers investigated naked mole rats' cellular senescence mechanism, finding unique features that contribute to their cancer resistance and longevity. Despite exhibiting senescence similar to mice, naked mole rats display a more structured response to senescence, which may be beneficial for longevity.
Researchers have gained insight into the structure and regulation of Polycomb Repressive Complex 2 (PRC2), a gene regulator that controls cell differentiation and cancer development. The study's findings hold promise for developing new therapies for cancer by targeting PRC2 dysfunction.
Researchers identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells. The enzyme, GalNAc-T6, attaches sugar molecules to proteins, affecting cell-cell adhesion and leading to abnormal tissue formation. This discovery may lead to new therapies for colon cancer.
A new study reveals that starvation of sugar can trigger a unique signaling function in cancer cells, leading to cell death. By manipulating this property, researchers propose a potential combination therapy to target cancer metabolism and selectively kill cancer cells while leaving healthy cells intact.
Biologists from Konstanz, Ulm, and Karlsruhe decipher the biochemical mechanism of p53 and PARP-1 interaction, significant for tumour biology. The study reveals that the protein p53 is modified through interaction with the enzyme PARP-1, which has far-reaching implications for its regulation.
Researchers created a 3D model of telomerase, an enzyme that lengthens chromosome ends, in baker's yeast. The study provides new insights into how telomerase recruits itself to chromosome tips and sheds light on its role in cancer cell survival.
Scientists at Northwestern University discovered that mitochondria and lysosomes directly contact each other in cells to regulate their functions. This rare finding has important implications for understanding normal aging and diseases such as Parkinson's and cancer.
A comprehensive dataset of cancer cell metabolites has been compiled, showing consistent increases or decreases in certain metabolites across multiple tumor types. The study's findings offer insights into the metabolic programming between normal and cancer cells, with potential applications for novel therapies.
Cancer researchers have developed a new approach to target 'undruggable' cancer-causing genes by attacking the proteins they produce on the cell surface. The study reveals that antibodies against specific proteins can deliver cytotoxic or immunotherapeutic compounds to Ras-mutant cancer cells.
Researchers from Instituto de Medicina Molecular found that TERRA, a functional component of telomeres, must be constantly regulated to prevent telomeric and chromosomal instability. This study sheds light on the molecular basis of genome stability and may pave the way for new therapeutic approaches.
Researchers discovered that nuclei play a crucial role in cell movement, particularly in 3D environments. Cells lacking nuclei or disconnected from the cytoskeleton exhibit reduced mobility on soft surfaces and fail to move in three-dimensional matrices.
Researchers have solved a longstanding puzzle of how cells compact DNA to enable healthy cell division. They found that single cells can compact DNA 10,000-fold by forming series of compacted loops and anchoring them to a central spiral axis.
Researchers at Uppsala University have discovered a new strategy to shut down specific enzymes that can help fight cancer. By studying the native structures and mechanisms of dehydroorotate dehydrogenase, they found that lipids play a crucial role in binding drugs to this enzyme.
Researchers used Cryo-EM to capture images of molecular machinery called RNA Polymerase III in unprecedented detail, revealing five key stages in which the complex reshapes itself to successfully transcribe the DNA code. This discovery could open up new approaches to cancer treatment by targeting the complex's activity.
Conventional cancer therapy can create an inflammatory cascade in the body, leading to aggressive tumor progression and recurrence. However, resolvins have been shown to counteract these effects, enhancing the body's clearance of cell debris and reducing tumor growth.
Researchers have developed a biomaterials-based system that uses soft microfibers to activate and expand T cells, increasing their number by nearly an order of magnitude. This approach simplifies processing compared to existing systems and has the potential to bring new hope to cancer patients for T-cell therapy.
A team of researchers has developed an innovative approach to remotely control genetic processes in live immune T cells, enabling them to recognize and kill cancer cells. The system uses mechanogenetics to convert mechanical signals into genetic control, with potential to increase precision and efficiency in CAR-T cell immunotherapy.
A team of cancer researchers has made a significant contribution to our understanding of cancer cell regulation, which could lead to improved cancer treatments. The study focuses on kinases, proteins that influence cancer cell growth and development, and identifies new strategies for killing cancer cells.
Researchers at the University of Warwick have developed a new line of attack against cancer using an organic-osmium compound, JPC11, which targets a metabolic process relied on by cancer cells. The treatment can be recycled and reused within cancer cells to attack them repeatedly.
Researchers at Cold Spring Harbor Laboratory have developed a method to selectively disable the MYB protein, which enables cancer cells to proliferate. In tests in mice, this approach resulted in an 80% reduction in size of aggressive leukemia without harming normal cells.
Researchers found combining blueberry extract with radiation increases treatment effectiveness for late-stage cervical cancer, reducing healthy cell damage by up to 70%. The study's lead author suggests blueberries as a potential radiosensitizer, a non-toxic chemical that enhances cancer cells' responsiveness to radiation therapy.
Researchers measured absolute cross sections for secondary electrons interacting with DNA molecules in a condensed-phase environment. This study provides insights into the damage and radiation dose delivered to patients in radiotherapy.
Researchers found a novel combination of PARP and BET inhibitors to be effective in treating ovarian cancers without BRCA1 and BRCA2 gene mutations. The combination resulted in enhanced sensitivity of cells to cell death, offering potential applications in broadening treatment options for various malignancies.
Researchers have measured and mapped the key molecular forces on platelets that trigger blood clotting. The findings suggest that platelets care about the direction of forces applied to them, requiring a lateral force signal to prevent unnecessary clotting.
Scientists at The Ottawa Hospital and University of Ottawa discover Maraba virus can eliminate latent HIV-infected cells. Laboratory tests show the virus targets cells with impaired interferon pathway, leaving healthy cells unharmed.
A KAIST research team developed technology to identify the optimal drug target for cancer cells based on molecular network dynamics. This approach uses systems biology to analyze genetic mutations and predict drug response, which could lead to more effective treatment strategies.
Researchers at the University of Copenhagen have discovered a new mechanism by which cancer-inhibiting proteins regulate signaling molecules. The study found that primary cilia, or cellular antennae, play a crucial role in balancing PDGFRα signaling, preventing excessive receptor activation that can lead to brain and gastrointestinal t...
Researchers at UNC School of Medicine discovered that the minichromosome maintenance (MCM) complex plays a crucial role in keeping stem cells in their immature state. The study suggests that rapid MCM loading rate is essential for maintaining stem cell identity.
Researchers at iMM found that certain molecular signals allow cancer cells to survive chemotherapy by altering mitochondrial metabolism. Using VEGF-blocking drugs, they were able to render these cells vulnerable to chemotherapy.
A new study reveals that mutations in 'Ras' genes, which drive 25% of human cancers, can also suppress the immune system around tumors by increasing PD-L1 levels. This understanding will help offer patients more precise and effective treatments.
A research team led by Professor Jens Nielsen has mapped out the complex metabolism of yeast cells, enabling the efficient production of protein therapies for diseases like cancer. The breakthrough could lead to significantly cheaper treatments, potentially reducing costs by 10%.
Researchers at German Cancer Research Center prove grid cells measure distances and enable path integration in mice, aiding spatial orientation. This innate behavior helps animals find the most direct route from A to C without learning or visual cues.
A Phase 1 trial of the targeted agent BLU-285 demonstrated rapid and durable responses with minimal adverse effects in patients with advanced systemic mastocytosis. The study found that 72% of evaluable patients achieved an overall response, with 100% having disease control.
A landmark clinical trial has shown impressive results for a CAR-T cancer treatment in refractory large B-cell lymphoma patients, achieving complete remission in 42% of cases. However, severe side effects including cytokine release syndrome and neurologic problems were also observed, affecting up to 95% of patients.
Researchers found that leftover cancer cell debris can stimulate tumor growth, but resolvins can block this response. The study suggests a new approach to enhance cancer therapy and prevent recurrence.
Researchers found that ERK activity propagates as a wave, guiding cells to migrate in the opposite direction. This mechanism may be used to suppress cancer cell infiltration.
Researchers found that SIRT1 stabilizes a mechanism preventing immune cell toxic effects, but its loss accelerates glycolysis and cytokine production. This understanding led to potential new drug targets to strengthen or weaken SIRT1, potentially countering age-related diseases.
Researchers identify a fleeting, yet key structure that allows cells to break through tissues and spread to other parts of the body. A single protrusion bulges out from the cell surface, wedges a hole through the protective layer, and swells until the breach is wide enough for the entire cell to squeeze through.
Researchers at Cardiff University have developed a new method of engineering T-cells to attack cancer using CRISPR genome editing. This breakthrough enhances the T-cells' ability to recognize specific cancer cells and destroy them, offering new hope in the fight against various types of cancers.
Researchers discovered that tumor metabolism damages naïve T-cells, affecting cancer immunity and immunotherapy. The study suggests targeting lactate pathway to improve immunotherapy effectiveness.
Scientists at NIST have discovered a way to make tiny colonies of cells grow in three-dimensional structures inside petri dishes, paving the way for more realistic biological environments for testing pharmaceuticals. The method could help bridge the gap between lab and living creature testing, speeding up drug development.
Researchers at the University of Bergen find that NTZ deactivates activated Beta-catenin in prostate and colon cancer cells, stopping their growth. The discovery could lead to faster development of new treatments for these cancers.
Researchers have created an artificial protein that inhibits G protein activators, leading to the potential blockage of malignant properties in cancer cells and correction of birth defects. The findings may pave the way for identifying new molecular targets for therapeutic intervention.
Researchers have developed a molecular sensor that can detect and eliminate cells with mutated TP53 genes, which are responsible for 50% of all human tumors. The sensor initiates cell death if the gene is non-functional, preventing tumor formation at an early stage.
Researchers discovered that T cells can thrive in oxygen-depleted environments when equipped with growth factor VEGF-A. This adaptation allows them to kill cancer cells more effectively, contrary to previous assumptions.