Articles tagged with Cancer Cells
Scientists at Virginia Tech Carilion Research Institute have identified a novel cellular mechanism that can lead to cancer metastasis. The researchers found that the formation of gap junction structures allowing cells to communicate was disrupted during epithelial mesenchymal transition (EMT), despite an abundance of connexin 43 proteins.
Breakthrough lab-on-a-chip technology allows scientists to isolate single cells, analyse them in real time and observe their complex signalling behaviour. This technology holds great promise for developing new treatments for diseases.
Researchers from EPFL have created an optofluidic device that allows them to observe cells in real-time without disrupting their environment. This technology enables the monitoring of chemical secretions and offers a powerful tool for studying individual cell behavior, which can inform new treatments for cancer and autoimmune diseases.
The study combines STED and SICM microscopy to link protein actin with cell membrane nanostructure, shedding light on the role of the cell membrane in migration processes. This technique offers novel insights into the biochemical organisation of cells and their surrounding membranes.
Researchers at the University of Córdoba have discovered that a selenium-enriched diet can partially repair cell damage caused by the pesticide DDT in mice. The study found that selenium stimulates antioxidant defenses in cells, preventing oxidative stress and damage similar to cancer cells.
Scientists found that non-diploid cells have unstable centrosomes and microtubules, leading to abnormalities in cell replication. This understanding could lead to new cancer treatment strategies.
A team of scientists led by University of Montana cell biologist Mark Grimes has identified networks in lung cancer cells that will help understand the disease and develop targeted treatments. The study used large-scale data analysis and mathematical approaches to define signaling pathways in lung cancer cells.
Scientists created self-contained spaces inside mammalian cells using bacterial proteins, allowing for controlled enzymatic reactions and iron biomineralization. This technology could aid in cell therapy, gene reporting, and sorting, opening new avenues for biomedical research.
Research by Swansea University and Indian team finds that tea leaf extract-based nanoparticles inhibit lung cancer cell growth, destroying up to 80%. Quantum dots produced from tea leaves also show promise in bioimaging and anticancer applications.
Recent studies suggest tRNAs and tRNA fragments are involved in cellular processes associated with diseases such as cancer, viral infections, and neurodegenerative disorders. Dr. Todd Lowe's lab is characterizing all 500 human tRNA genes to determine their roles in the cell.
Researchers found that combining erectile dysfunction drugs with the flu vaccine can reduce cancer spread by over 90% in a mouse model. The treatment works by blocking immune cells that suppress the immune system after surgery, allowing natural killer cells to fight cancer more effectively.
A team led by CSHL Professor Douglas Fearon found that dormant cancer cells are already in the liver before surgery, expressing MHC1 and CK19 markers. In a post-operative stress-induced state, these cells re-express markers and begin to divide, forming seeds of metastatic lesions.
Researchers at the University of Zurich have discovered the molecular structure of a cellular valve, which plays a crucial role in regulating cell volume. The study reveals potential approaches for treating conditions such as cerebral ischemia, stroke, and cancer by targeting this protein.
Early-stage colon cancers can be surgically removed but later stages require targeted treatments. Researchers discovered that colon cancers are composed of two different cell types with the ability to replace each other after one is killed.
Scientists have discovered two antioxidant enzymes that work together to prevent telomeric DNA oxidation, leading to telomere shortening and eventual cell death. Disrupting these enzymes in cancer cells has shown promising results in preventing the enzyme telomerase from extending telomeres.
Researchers identified metarrestin as a compound that stops tumor metastasis in animal models. The compound effectively blocks the spread of pancreatic and other cancers, with mice treated with metarrestin having fewer tumors and living longer.
Researchers have identified over 100 potential new targets for cancer treatment using state-of-the-art mass spectrometry technology, which could lead to the development of personalized medicine and targeted therapies.
A team of biophysicists from FAU presents a mathematically concise method for comparing different pricing models, predicting more accurately how parameters such as volatility change over time. This method enables researchers to identify triggering events in real-time and pinpoint invasive cancer cells.
A new study found that cells with abnormal centrosomes are present before they transform into cancer cells in patients with Barrett's esophagus. Centrosome amplification was found to be a hallmark of human tumors and may contribute to the initiation and progression of various cancers.
Scientists have identified a critical function of the PDK1 signaling pathway in cancer cells, which regulates the formation of a three-protein complex that facilitates purine production and thiamine synthesis. This discovery may lead to new insights into the causes of metastasis and potential ways to prevent it.
Researchers discover a new protein called ZUFSP that plays a key role in maintaining genetic stability, which is crucial for preventing cancer and other diseases. The study highlights the potential of ZUFSP as a target for drug development, particularly in treating cancer.
Researchers have developed a new way to introduce molecules and therapeutic genes into human cells using ultrafast compression, which can improve cell transfection efficiency. The technique involves compressing cells in microfluidic devices, causing them to take up surrounding fluid and macromolecules.
Early intervention after completed clinical staging leads to increased survival rates in non-small cell lung cancer patients. Surgery within eight weeks from diagnosis significantly improves overall survival.
Researchers found that metastatic cancer cells reprogram their metabolism to capitalize on fructose levels in the liver, leading to unchecked growth and proliferation. This discovery could lead to new therapies targeting metastatic cells and provide insight into how cancers adapt to new environments.
Researchers have developed a refined CAR-T therapy called SUPRA-CART that addresses the three major flaws of traditional CAR-T: target specificity, response strength, and adaptive capability. This new system allows for continuous alteration to target different types of cancer cells and can be deactivated in case of severe side effects.
Researchers have identified key molecular events and genomic profiles in clear-cell renal carcinoma, a type of kidney cancer. The study's findings could lead to the prediction of metastasis patterns and potentially inform new treatment strategies.
Researchers at Umeå University have discovered that adenovirus binds to polysialic acid, a carbohydrate receptor overexpressed on certain types of cancer cells. This finding opens new possibilities for using adenovirus as a treatment for corresponding types of cancer.
Scientists have developed a new microscope that can capture unprecedented 3-D detail of cells in their natural state, overcoming previous limitations. The technology combines adaptive optics and lattice light sheet microscopy to create high-resolution images of cellular dynamics.
A simple handgrip strength test is a good indicator of short- and long-term survival in early-stage non-small cell lung cancer patients. Patients with weak handgrips were 1.5 times more likely to die within five years, compared to those with strong handgrips.
Chronic lymphocytic leukemia (CLL) originates from blood-forming cells and spreads to organs through the bloodstream, suppressing immune response to survive. Researchers propose an immunotherapeutic strategy with two immune checkpoint inhibitors that block disease development in preclinical tests.
Pancreatic cancer cells rely on autophagy for fuel, a process that can be blocked with an ERK inhibitor. Researchers at UNC Lineberger Comprehensive Cancer Center report a synergistic effect when combining the ERK inhibitor with a compound that blocks autophagy to starve cells completely.
Scientists identified critical genetic changes that can lead to kidney cancer, with the first mutation occurring in childhood or adolescence. The findings suggest that early detection and intervention may be possible, particularly for high-risk groups.
Researchers at University of Sydney establish method to identify individual extracellular vesicles (EVs) using resonance-enhanced atomic force microscope infrared spectroscopy. This allows for biomarkers for diverse diseases such as cancers, cardiovascular, kidney and liver disease, dementia, and multiple sclerosis.
Two common iron compounds, ferric citrate and ferric EDTA, have been shown to increase the formation of a known biomarker for cancer, amphiregulin. This is the case even at low doses. The study suggests that these iron supplements may be carcinogenic.
Researchers at Gladstone Institutes have uncovered the role of MYC and LIN41 in reprogramming cells. They found that MYC helps cells overcome a roadblock, while LIN41 blocks another protein that causes the roadblock, allowing adult cells to successfully convert into induced pluripotent stem cells.
Scientists at Oregon Health & Science University have developed a new method to quickly and efficiently recognize the subtypes of cells within the body. This technology, led by Andrew Adey, allows for profiling thousands of cells simultaneously, improving our understanding of disease at the molecular level.
Researchers found that tungsten oxide nanoparticles selectively target cancer cells while being harmless to healthy cells, opening up new therapeutic possibilities. The particles also exhibit strong antibacterial properties, making them a potential solution for wastewater purification.
Researchers have developed an imaging method for live cells that suppresses photobleaching, allowing observation of individual molecules for up to 400 seconds. This enables study of protein movements and interactions in the cell membrane, shedding light on cellular behavior and potential targets for cancer treatment.
Researchers found that cell shapes play a key role in jamming and unjamming, driving biological events like embryonic development and wound healing. This insight could lead to potential treatments for conditions like asthma and cancer.
Researchers developed a process to observe lipid-flipping enzymes' activity in conjunction with membrane deformation. They found that ATP10A enzyme flips phosphatidylcholine lipids, causing curvature changes that trigger tubule formation, enhancing endocytosis and membrane dynamics.
Researchers at Baylor College of Medicine have identified a key regulator of a cellular pathway that selectively targets mutant p53-R175H proteins, which promote ovarian cancer growth. The study suggests designing drugs directed at this regulator might lead to better ways to control cancer growth.
A new study from Virginia Tech found that fluid shear stress causes cancerous cells to become more aggressive and benign cells to exhibit traits of cancer. This discovery could lead to the development of a predictor for ovarian cancer, enabling earlier diagnosis and potentially saving thousands of lives.
A study by Hiroshima University researchers found that a specific gene group controls DNA damage response in hypoxic cancer cells, weakening the effectiveness of anticancer therapies. Suppressing this gene, DEC2, made cancer cells more sensitive to radiation treatment.
Researchers discovered that asbestos exposure sends exosomes to distant cells, causing genetic changes and potentially leading to cancer or diseases. The findings suggest a new mechanism by which asbestos triggers deadly cancers.
Researchers at Saint Louis University have uncovered new answers about why cells rapidly age in children with a rare disease called Hutchinson-Gilford Progeria Syndrome. The team found that cellular replication stress and a mistaken innate immune response are culprits, and successfully blocked these processes with vitamin D.
A research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off. The technology could lead to the development of new cancer therapies and other drugs by activating non-toxic cancer prodrugs into their therapeutic forms.
Researchers at UCLA have created a new method for targeted gene delivery using 'nanospears,' which can enable safer, faster and more cost-effective gene therapies. The nanostructures are biodegradable and can be mass-produced inexpensively, delivering genetic information with minimal impact on cell viability and metabolism.
Researchers have created BN/Ag hybrid nanomaterials that demonstrate effectiveness as catalysts, antibacterial agents, and drug delivery systems for treating oncological diseases. The hybrids show high potential for cancer therapy and water disinfection, offering a new approach to combatting these threats.
Researchers discovered that inhibiting autophagy with the help of FOXO3a molecule can push cancer cells into apoptosis. The study found that combining autophagy inhibition with a drug called Nutlin increases PUMA production, leading to cell death.
Researchers at WashU Medicine used CRISPR to engineer human T cells that can attack human T cell cancers without succumbing to friendly fire. The new approach also allows for the use of therapeutic T cells from any healthy donor, eliminating the need for a matched donor or patient's own T cells.
Biochemists have made a discovery that sheds light on the molecular machinery that allows some cells to wiggle their way through tissues. The researchers identified two locations on Arp2/3 where an activator protein touches, promoting cell motility and potentially leading to new opportunities for cancer treatment.
The Scripps Research Institute has developed a new method for creating glycan arrays that can be used to study the interactions between glycans and proteins. The breakthrough, published in Nature Communications, uses enzymes naturally produced by cells to create branching glycans.
Researchers at Washington University in St. Louis have developed a method enabling effective insertion of large molecules into cells using acoustic shear poration and electrophoresis. The approach has achieved greater than 75 percent delivery efficiency of macromolecules, including DNA insertion, which is significantly more challenging.
Researchers discovered that a natural alkaloid extracted from Daffodils, called haemanthamine, blocks the production of proteins by ribosomes in cancer cells, leading to their elimination. The study provides a molecular explanation for the anti-tumoral activity of Daffodils used in folk medicine.
Researchers at Binghamton University have developed a new method of treating pancreatic cancer using dual thermal ablation, which combines heating and freezing to kill cancer cells. The study found that this approach achieves complete cell death in pancreatic cancer cells more effectively than heating or freezing alone.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
ILC2 cells play a crucial role in preventing or slowing metastasis in lung and prostate cancer by unleashing the killing power of T-cells. Researchers have concluded that ILC2 cells may be a potent weapon in stopping cancer from spreading, offering potential treatment for blood-borne and solid tumours.
Researchers have developed a new synthetic bioluminescence system that allows for imaging of cells from outside the body. The bioengineered light source enables tracking of cancer cells in mice and brain-cell activity in monkeys, with potential applications beyond lab research.
A new regulator of the immune system has been identified by a Finnish research group, with potential implications for treating both cancer and immune-mediated diseases. HIC1 protein controls the expression of genes contributing to T cell function and regulates immune response.
Research by Prof. Dr. Prasad Shastri at the University of Freiburg found that cancer cell membrane stiffness affects nanoparticle internalization; increasing stiffness enhances polymer nanoparticle entry through pathways rich in cholesterol.