Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
A new 'lab on a chip' technology allows for individualized cancer treatments that target specific tumor cells with high specificity. This breakthrough reduces the cost and time required to develop effective treatments, potentially revolutionizing T cell therapy for cancer.
Scientists at Helmholtz Zentrum München have discovered new details about the UHRF1 protein, which regulates gene activity and is produced at elevated levels in cancer cells. The research reveals an unexpected function of the UBL domain in DNA methylation and defines a new role for this domain in regulating gene expression.
Researchers at Northwestern Medicine have successfully reprogrammed induced pluripotent stem cells into healthy uterine cells for potential treatment of endometriosis. The study marks a significant step towards treating the painful and persistent gynecological disease, which affects approximately 10% of women worldwide.
A new study has identified glycolytic enzymes as potential biomarkers for early detection and prevention of liver cancer. The research found that the shift to glycolysis in cirrhotic livers is associated with a higher risk of developing hepatocellular carcinoma, offering hope for improved early detection and treatment.
Researchers discovered a new compound that enhances the efficacy of proteasome inhibitors, commonly used to treat multiple myeloma. The compound targets protein disulfide isomerases, making it effective against drug-resistant cells. This breakthrough offers hope for patients with this cancer.
Researchers have used high-resolution electron microscopy to reveal how an anti-cancer virus interacts with tumor cells, increasing its potential. The Seneca Valley Virus selectively targets a receptor found in over 60% of human cancers, offering a promising approach for cancer treatment.
A new Northwestern Medicine study reveals a 'kill code' embedded in every cell that can trigger the self-destruction of cancerous cells. The toxic small RNA molecules can also be triggered by chemotherapy, offering a potential bulletproof treatment against cancer.
Researchers have discovered how cancer cells' cell replication is derailed, leading to rapid tumour expansion. The findings could help predict how cancer cells respond to chemotherapy and improve understanding of cancer evolution.
Biophysicists at Ruhr-University Bochum developed a Raman microscopy method to detect cancer drug resistance in tumour cells. The new approach shows effectiveness in non-mutated cells but remains ineffective in mutated cells, similar to clinical observations.
Researchers at University of Montreal discovered how metformin affects cell glucose uptake and metabolism, revealing a link to iron distribution. This finding may explain metformin's potential benefits beyond diabetes treatment, including prevention of chronic diseases like cancer.
Researchers at UCL have identified a new mechanism for neural crest cells to move from the back of the head to the front, crucial for forming facial features. This discovery could help understand how facial defects form and pave the way for developing new therapies.
Researchers have released a massive dataset detailing molecular makeup of tumor cells from over 500 AML patients, enabling rapid advancement in clinical trials. The dataset includes how individual patients' cells responded to various drugs, providing insights into targeted therapies for specific subsets of AML cells.
Researchers discovered that loss of tumor protein p53 promotes cancer development by allowing cells to replicate despite growth stimuli deficiencies. This discovery provides insight into how cancer cells survive and multiply in adverse conditions.
A new study reveals that cells take an approach of 'purposeful inefficiency' in responding to diseases, offering new pathways for understanding and treating conditions like cancer and Parkinson's. The research team discovered surprising genetic responses to misfolded proteins, including increased protein production and wasteful processes.
A new cell-based immunotherapy using 'educated killer cells' has shown promise in eradicating pancreatic cancer, including cases where tumours have spread to multiple organs. The treatment could potentially be administered to human patients without toxic side effects.
Researchers found that cancer cells from the fallopian tube affect ovary's chemical signaling, leading to increased norepinephrine levels, which drive cancer cell migration. This study highlights the importance of understanding chemistry in ovarian cancer development and treatment protocols.
Researchers at Imperial College London have created a genetically engineered version of a cell called an invariant natural killer T-cell (iNKT) that shows potential as a new treatment for cancer. The CAR19-iNKT eliminated all cancer cells in 60% of mice and had 90% long-term survival rates.
A membrane transporter has been identified as crucial for the uptake of steroid hormones into cells, challenging decades-old assumptions about their biological effects. This breakthrough could lead to new treatments for diseases like cancer and immune disorders.
Researchers identified over 500 DNA sites requiring ATR enzyme to prevent breakage during replication. The findings suggest ATR inhibitors may enhance treatment efficacy for various cancers by targeting repetitive DNA sequences.
Researchers propose natural adaptive therapies to keep cancer in check by mimicking the immune system's approach. These therapies aim to stabilize tumor size and slow resistance evolution.
Researchers at IRB Barcelona and Vrije Universiteit Brussel have identified camelid nanobodies effective against EGF, a growth factor dysregulated in cancer cells. These nanobodies could provide a potential treatment for patients developing resistance to existing EGFR inhibitors.
Researchers at Penn discovered a new, rare mechanism that allows leukemia cells to relapse after CAR T cell therapy by masking the target protein CD19. This finding emphasizes the need for precise manufacturing processes to ensure the effectiveness of this treatment.
A new study suggests that organs affected by autoimmune disease can actively fight back by exhausting immune cells that cause damage. The research found that these cells exhibit characteristics similar to those used by cancer cells to evade the immune system.
Subtle changes in protein regulation can cause severe face and brain developmental abnormalities, highlighting the importance of striking a healthy balance between too little and too much cell death. The study suggests that excessive or inadequate cell death during embryonic development can lead to devastating birth defects or cancer.
Researchers found that for 85% of genes, noise magnitude is higher in the last step compared to the first. This discovery challenges the long-held assumption of a streamlined process and may impact disease treatment strategies.
Researchers developed a new cell culture platform to observe cancer cells' never-before-seen behaviors, revealing the mechanisms behind pancreatic cancer's clinical properties. The study shows that cancer cells can self-organize into micro-tumors and evade the immune system by releasing chemical markers on their surfaces.
Salk researchers discover that manipulating nuclear pores can increase their numbers in healthy cells, mimicking those found in cancer cells. This breakthrough could lead to a new way to fight cancer by targeting nuclear pores.
Researchers at UC San Diego School of Medicine discovered that ubiquitination influences GPCR function and promotes inflammation. Existing cancer drugs targeting enzymes involved in ubiquitination may be repurposed to treat vascular inflammation.
Researchers at the University of Oregon have created a new class of fluorescent dyes, called nanohoops, that can be used to track multiple biological activities in live cells. These circular structures emit colors based on their size and can be guided to specific sites within cells.
Researchers found that increased antioxidant enzyme expression and decreased NADPH-oxidase activity hinder treatment efficiency. This study reveals a redox-dependent mechanism of drug resistance development in ovarian cancer cells.
A study led by the University of Exeter Medical School found that disrupting genes and pathways regulating splicing factors can reverse signs of aging in cells. Disrupting ERK and AKT pathways reduced senescent cells, increasing splicing factors and leading to cellular rejuvenation.
Researchers developed a new framework combining three methods to find large DNA mutations in cancer cells. The approach reveals how these mutations contribute to cancer development and can help predict effective treatment plans.
Researchers developed a DNA-based test to predict which patients with acute myeloid leukemia (AML) are at risk of relapse. The test can identify treatment-resistant cancer cells three weeks after transplantation, allowing for earlier therapeutic intervention.
Researchers at NUST MISIS and University of Calgary create method to monitor virus spread and immune system response in real-time using intravital microscopy. This breakthrough enables visualization of virus behavior in tissues and organs of living animals.
A $2 million phase 2 grant will be used to further develop a compound that has shown efficacy in preclinical studies against treatment-resistant multiple myeloma. The goal is to create a one-two punch when administered with proteasome inhibitors, making it an effective treatment option for patients.
Researchers found liver cells do not need ORC1 to replicate DNA, a key component of cell division. This process, called an endocycle, allows cells to copy their DNA multiple times without dividing, resulting in larger cells with more DNA. Understanding this mechanism could help explain how cancer arises and how it spreads.
Researchers at UT Austin have developed a new approach to treating cancer using enzyme therapy, which boosts the immune system by degrading kynurenine, a metabolite that suppresses the immune system. The treatment could prove effective in treating various types of cancers and is expected to initiate clinical trials soon.
Scientists develop FliptR, a fluorescent molecule that measures cell membrane tension, revealing how cells adapt their surface to volume changes. The discovery paves the way for applications in cancer cell detection and membrane tension regulation.
Researchers developed an immunotherapy that induces antitumor immunity by provoking necroptosis in cancer cells, destroying tumors while protecting against secondary tumor formation. The treatment provides protection against disseminated tumors and stimulates the immune system to attack persistent surviving cancer cells.
Researchers at NUST MISIS have developed a system that improves cancer diagnosis accuracy and provides opportunities for targeted therapy. The magnetoferritin compound, introduced into the body before diagnosis, enhances contrast signals in imaging and targets tumor cells for destruction.
Researchers at Hebrew University of Jerusalem have developed a new biological drug that has shown a 50% cure rate in lab mice with acute leukemia. The single-molecule drug targets multiple leukemic proteins, making it difficult for cancer cells to evade therapy and reducing the need for multiple treatments.
University of Bristol researchers have discovered a way to exploit hypoxia to kill cancer cells without harming healthy tissue. The study found that a specific receptor, GPRC5A, can be targeted using genetic techniques to trigger cancer cell death.
Researchers found that nanoparticles and contaminants can be deadly to human cells, especially when combined. Exposure to silver nanoparticles alone was less toxic, but combining them with cadmium ions increased cell death by 60%. The study highlights the need for regulations on nanoparticle releases into the environment.
Scientists have introduced a microfluidic chip for manipulation and nucleic-acid analysis of individual cells. The technique uses dielectrophoresis to trap and analyze cells efficiently, overcoming conventional methods' limitations. This innovation paves the way for personalized medicine and improved diagnostics.
Research suggests an inverse relationship between fever and cancer incidence, potentially linked to enhanced gamma/delta T cell activity. This mechanistic hypothesis proposes that repeated exposure to fever boosts the ability of these T cells to detect cellular abnormalities and destroy malignant cells.
A study by researchers at the Instituto Gulbenkian de Ciencia found that the Spindle Assembly Checkpoint, a mechanism that regulates cell division, can sometimes be counterproductive. This checkpoint can increase genetic errors when cells have irreparable problems with chromosome cohesion.
Researchers at H. Lee Moffitt Cancer Center suggest that lowering pH inside cancer cells can slow down the growth and spread of the disease. By analyzing how variations in pH affect metabolic enzymes, they identified potential therapeutic targets for breast cancer treatment.
A new chemical compound has been developed and tested by scientists at the University of Huddersfield, which attracts vulnerable cancer cells while leaving healthy cells untouched. The compound contains ruthenium and is showing promising results in laboratory tests.
Researchers at Utah State University have developed a new flavonoid molecule that can release carbon monoxide in a controlled manner, triggering cancer cell death and reducing inflammation. The unique molecules are trackable, targetable, and triggerable using visible light.
Researchers have gained new understanding of how autophagosomes seal off waste material, with a key role identified for ESCRT complexes. This breakthrough could lead to new cancer treatments by inhibiting autophagy closure.
Researchers discovered an anti-cancer gene called LIF6 in elephants that helps destroy cells with damaged DNA, potentially preventing cancer. This gene emerged around 25-30 million years ago and may have played a key role in enabling the growth of modern elephants.
Scientists have created specialized delivery methods using nucleic acid-based nanostructures to target cancer cells while leaving normal cells intact. The new approach utilizes aptamers to bind to specific receptors on cancer cells, allowing for the targeted delivery of chemotherapeutic drugs.
Researchers at University of Illinois Chicago discovered that a mutation in the NPM1 gene helps improve sensitivity to chemotherapy in patients. The study found that patients with this mutation tend to respond better to chemotherapy and have higher rates of remission.
Researchers identified specific gene activity in each cell, revealing that Wilms' tumour cells have the same characteristics as normal developing kidney cells. Adult renal carcinoma cells were found to be a version of rare healthy adult kidney cells called PT1.
Researchers identify MUC5AC gene as a key player in KRAS-mutant non-small cell lung cancers, which are resistant to current treatments. Inhibiting this gene may lead to new therapeutic strategies against KRAS-driven lung cancer.
Researchers developed a new sensor that detects hydrogen peroxide levels in human cells to identify effective chemotherapy drugs. The sensor can be used to screen existing drugs and predict success in individual patients' tumors. This breakthrough could lead to more targeted and effective cancer treatments.
Researchers identify a new mechanism used by Henipaviruses to hijack the DNA-damage response machinery, allowing them to prosper in cells. This discovery may lead to the development of new anti-viral therapies.
Researchers investigate how a group of cells breaks off from a colony, leading to large-scale metastasis. Mechanical engineer Amit Pathak aims to understand the mechanisms behind disease pathways and fundamental cell behavior.
Rice University's Luay Nakhleh has received $1.5 million in grants from the NSF to develop algorithms that can infer evolutionary histories of tumor cells, helping researchers understand why some cancer cells spread and mutate differently.
A computational study has shown that cancer cells proliferate less and are more vulnerable to acidic conditions than initially thought. The researchers have identified potential therapeutic targets by analyzing how variations in pH affect metabolic enzyme activity, providing opportunities for new treatments.