Articles tagged with Cancer Cells
Researchers at University of Alabama at Birmingham discovered androgen receptor imports into mitochondria, where it regulates multiple mitochondrial processes. This finding may lead to new treatment targets for castration-resistant prostate cancer.
Researchers at the University of Manchester have identified a new class of drugs that can stop ovarian cancer cells from growing. The PARG inhibitors target weaknesses in DNA replication, making them sensitive to these treatments.
Scientists have identified two coffee compounds, kahweol acetate and cafestol, which inhibit the growth of prostate cancer cells in cell culture and animal models. The study's findings suggest that these compounds may be used to treat drug-resistant prostate cancer, with further investigation needed.
Researchers created a nano-bot with magnetic 'tweezers' that can position a bead inside a human cell in three dimensions with unprecedented precision. The technology has been used to study cancer cells, showing the nucleus is not equally stiff in all directions and providing new insights for diagnosis.
A preclinical therapy attached to an antibody targeting the ALK protein shows effectiveness against most neuroblastoma cells, killing cancer cells with minimal harm to healthy tissues. This approach could lead to new treatment options for aggressive forms of neuroblastoma and other high-mortality childhood cancers.
Scientists have discovered that deleting the gene encoding ASCT2, a transporter enzyme responsible for bringing amino acids into cells, prolongs survival of mice with aggressive leukemia. The study found that ASCT2 is required for leukemia development and progression but dispensable for normal blood cell development.
Human cells can now travel more than five times faster than previously documented by slingshotting themselves forward, according to University of Michigan researchers. This new method of cell movement could be involved in the spread of cancer and potentially harnessed for tissue repair therapies.
A team of researchers led by James DeGregori will identify lung tissue characteristics that enable cancer cell growth, aiming to predict cancer risk and develop interventions. The study aims to modulate the lung environment to reduce cancer risk, rather than targeting cancer cells alone.
Researchers have developed a new tool called URSA(HD) that analyzes gene patterns to reveal molecular causes of diseases. The tool has already uncovered previously unknown contributions of four genes to a rare form of cancer primarily affecting babies and young children.
A new study reveals a specific mechanism in human cells that delay propagation of DNA damage, giving cells a chance to stop piling up mutations. The discovery relies on precise timing and control inside the cells and identifies key molecular proteins involved in repairing DNA lesions.
Researchers at Florida State University have found a critical missing step in proteasome assembly, which could be targeted to treat certain types of cancers. By manipulating this step, scientists may be able to regulate proteasome assembly and mitigate cancer-causing effects.
The study reveals that gene transcription is equally important to DNA damage response, with activated transcription facilitating DNA repair and limiting abnormal transcripts. Cells become hypersensitive to DNA damage-inducing agents when the RBM7-P-TEFb axis is interfered with.
New research shows that rapidly dividing cells fuse their mitochondria, increasing oxygen consumption and producing aspartate for cell replication. This process may have implications for cancer diagnosis and treatment.
Russian researchers created star-shaped nanoparticles with sharp spikes using laser irradiation for intracellular delivery. The method achieved efficiency rates of over 95% and minimal toxicity, making it a potential alternative to existing technologies.
A new technique developed at Purdue University could lead to faster and more accurate detection of cancer cells in patient blood samples. The method uses near-infrared spectroscopy to analyze proteins expressed on cancer cells, enabling early diagnosis and potentially improving outcomes.
Researchers develop a new assay to measure the eco-evolutionary interactions between sensitive and resistant tumor cells in non-small cell lung cancer. The study finds that by applying drug or eliminating fibroblasts, it is possible to 'treat the game', allowing for coopting of evolution to help patients
Researchers developed peptide-coated platinum nanoparticles that selectively target and kill liver cancer cells. The nanoparticles are oxidized inside the cell, triggering a cytotoxic effect, while sparing healthy tissue.
A study published in Genes & Development sheds light on the damage caused by senescence, a vital cell process that plays a key role in aging. The research reveals that manipulating tiny parts of cells can prevent certain forms of cellular damage.
Researchers discovered a rare tumor type that can't synthesize cholesterol, leading to its dependence on external nutrients. This vulnerability can be exploited with therapies blocking cholesterol uptake, offering a potential treatment for drug-resistant ALCL cells.
Researchers at Keck School of Medicine of USC develop a new laboratory tool, the Topanga assay, to improve cancer therapy effectiveness. The assay uses bioluminescent marine organisms' enzymes to measure chimeric antigen receptors on cancer-fighting white blood cells.
Researchers at Hollings Cancer Center have discovered a new sub-cellular complex called ceramidosomes, which form in the cell membrane and induce cancer cell death. The complexes are made up of lipid molecules called ceramide and two protein components, and their formation is integral to drug-induced cancer cell death.
Researchers found blood cells retain intrinsic age nearly two decades after transplant, using epigenetic patterns to calculate cellular age. The study suggests blood cells could be the master clock of human aging, with implications for understanding age-associated diseases and developing new therapies.
Pembrolizumab, a new immunotherapy drug, shows lasting tumor control and improved overall survival in advanced Merkel cell carcinoma patients. The study reports generally manageable side effects and supports the use of immunotherapy as an effective treatment option for this aggressive form of skin cancer.
New DNA-based nanomachines can selectively target malignant cells, breaking down vital genes and inducing apoptotic death. The design allows for better interaction with folded RNA molecules, but further experiments are needed to improve specificity.
Researchers discovered a novel metabolic pathway in cancer cells that produces an unusual fatty acid, sapienate, allowing them to bypass fatty acid metabolism inhibition. This finding can explain the resistance of certain cancer types to therapy and opens new avenues for targeted treatment.
Researchers at Penn State College of Medicine identified 10 synthetic cannabinoid compounds that effectively inhibited the growth of seven types of human colon cancer cells. These compounds work through alternative mechanisms, not relying on traditional marijuana receptors, and hold promise for developing drugs to treat cancer.
Scientists have discovered how DNA topoisomerase II and CKII enzymes in fission yeast interact to promote cell growth, a mechanism that may be similar in human cancer cells. Inhibiting these enzymes could lead to new cancer treatments.
A new study led by Grant Brown suggests that at times of stress, DNA replication errors are far more frequent than previously appreciated. This could lead to increased mutations in human cells, potentially contributing to cancer and other diseases.
Researchers at the University of Seville have characterized the normal electrical activity in PC-3 prostate cancer cells, showing a low-frequency pattern between 0.1 and 10 Hz. This study aims to explore the relationship between electrical patterns and cell proliferation, with potential applications for medicine delivery.
A new compound based on Iridium, a rare metal, can penetrate into cancerous cells and deliver iridium, killing them when exposed to light. The discovery could lead to effective treatment against resistant cancers with reduced side effects.
Scientists have discovered proteins that regulate mucin production in the body, which could lead to new treatments for diseases such as asthma and colorectal cancer. The study also found a calcium sensor protein that controls the thickness of the mucus layer in the colon.
New research shows cancer cells cause premature ageing in healthy bone marrow cells, leading to faster disease progression. The study identifies NOX2 enzyme as key player in this process, highlighting potential for new treatments.
Researchers engineered a virus that selectively targets and kills cancer cells, surpassing another viral treatment currently in use. The modified adenovirus, dl355, replicates more efficiently in cancer cells than normal cells, resulting in higher cancer cell kill rates.
Scientists have isolated a gene, miR-I35B, linked to both inflammation and gastric cancer. The study suggests that miR-135B plays a role in the development of gastric abnormalities and may help develop diagnostic tools for early detection.
A study published in Life Science Alliance found that the enzyme D-amino acid oxidase (DAO) promotes cellular senescence and aging by producing reactive oxygen species. By inducing DNA double-strand breaks, researchers found increased expression of DAO is dependent on p53, a cancer-suppressing protein.
A study by Salk researchers found that autophagy, a process thought to be a survival mechanism, actually promotes cell death and prevents cancer initiation. This discovery reveals autophagy as a novel tumor-suppressing pathway and challenges the conventional understanding of cancer development.
Researchers have discovered a promising new drug that targets the biological clock of cancer cells, slowing their growth and halting their spread. By disrupting the circadian rhythm of cancer cells, this drug may provide an effective new treatment option for various types of cancer.
Researchers at the University of Pennsylvania School of Medicine have identified a method to fuel macrophages with energy needed to attack and eat cancer cells. By rewiring macrophage metabolism, macrophages can overcome signals that prevent them from attacking tumors, leading to tumor shrinkage and prolonged survival in mice.
Scientists have discovered two methods to mend DNA-protein crosslinks and established how DNA replication triggers these repair processes. The researchers hope their findings can be used to develop more efficient combination treatments for cancer cells.
Researchers at Ural Federal University have synthesized multi-purpose fluorophores that can track the absorption of medications in the body, helping diagnose cancer. The technology has far-reaching implications for pharmaceuticals and environmental analysis, offering a low-cost and sustainable alternative to traditional methods.
A team of scientists has successfully developed a hybrid molecule that uses light therapy to stop tumor growth in mice, with a remarkable 70% success rate. The innovative approach combines photodynamic therapy with targeted drug delivery, allowing for precise elimination of malignant cells and reduced toxicity.
Researchers at the University of Sussex have identified a protein partner that promotes β-catenin's movement into the nucleus of myeloid leukaemia cells, driving cancer development. This finding could lead to the development of targeted therapies to treat acute myeloid leukaemia (AML), with potential benefits for up to 80% of cases.
Researchers studied HeLa cells and found that cancer cells accumulate harmful mutations, but about 13% of cells remain mutation-free. This allows them to survive despite reducing their growth rate and chromosome numbers. The study suggests that high rates of deleterious mutations are necessary for the population to die out.
Researchers have discovered molecular mechanisms that enable the transmission of a deadly facial tumor among Tasmanian devils. The study found that ERBB receptors and STAT3 proteins play a key role in the transmissibility of the disease, which has killed 90% of the wild population.
Researchers created Cas9-CPs and ProCas9s, which simplify genome editing and epigenetic modifications. These variants enable molecular sensing, tissue-specific genome editing, and potential application as a pathogen-sensing system.
Researchers have designed a new Cas9 enzyme, ProCas9, that can be controlled by specific enzymes present in cells or viruses. This allows for more accurate and precise gene editing with added security. The technology has potential applications in treating diseases and improving crop resistance to viral pathogens.
Researchers at Osaka University have identified Semaphorin 7a as a protein involved in treatment resistance in lung cancer cells with common EGFR mutations. High levels of Semaphorin 7a inhibit apoptosis, making it harder for cancerous cells to be eradicated.
Researchers at Emory University have developed a high-throughput screening platform to identify small molecules that can enhance the ability of human immune cells to kill cancer cells. The platform, called HTiP, has identified compounds such as birinapant, which has shown strong evidence for its relevance as an immune enhancer.
Researchers have discovered a new population of immune cells that respond to immunotherapy treatment, as well as a critical molecular factor required for the therapy's success. The study highlights the importance of early-stage T cells and the need for further understanding of how checkpoint blockade therapies work.
Yeast cells produce ethanol as a 'safety valve' when their metabolic operation reaches a critical level. This discovery also explains the Warburg effect in cancer cells, where energy is wasted by producing lactate.
Cells utilize membrane tension to regulate endocytosis and maintain homeostasis. A protein called vinculin senses changes in force and regulates the CLIC/GEEC pathway to control endocytic processes.
Researchers at São Paulo State University synthesized a compound called GA-Hecate that effectively inhibits the replication of hepatitis C virus (HCV) in multiple stages. The compound also displays activity against bacteria, fungi, and cancer cells, and is being tested against Zika and yellow fever viruses.
A specific transcription factor called JunB helps control the activity of effector regulatory T cells, which suppress immune activity. Without JunB regulation, mice develop severe inflammation in their lungs and colons, suggesting JunB prevents autoimmunity in specific organs.
Researchers found that metformin and syrosingopine combination blocks critical energy production step, driving cancer cells to death. The duo targets NAD+ regeneration, preventing lactate export and leading to cell demise.
Scientists have developed a new technique using light to detect signaling molecule secretion from individual cells, allowing for the simultaneous analysis of cell behavior over time. This enables early detection of diseases such as cancer and blood clots, which is critical for improving survival rates.
Researchers at Osaka University have developed an AI-based system that can automatically differentiate between various types of cancer cells using microscopic images. The system achieved higher accuracy than human judgment, making it a potential game-changer in cancer diagnosis and treatment.
Researchers at the Weizmann Institute of Science have created a new method to sequence individual cells from patient blood or bone marrow, capturing specific gene programs active in each cell. This allows for more precise diagnosis and treatment of multiple myeloma by identifying unique genetic blueprints for each patient.
Scientists at DKFZ developed XRNAX to analyze interactions between all RNA classes with cellular proteins. The new method identifies hundreds of previously unknown protein-RNA bindings and sheds light on diseases including cancer, ALS, and viral infections.
Researchers have engineered sensors to monitor multiple signaling pathways driving tumor metastasis, enabling the prediction of a tumor cell's potential to spread. The development of Fluorescence Resonance Energy Transfer (FRET) biosensors has the potential to transform cancer cell biology and inform personalized treatment strategies.
Researchers at WashU Medicine have designed a 'flight data recorder' for developing cells, revealing the paths they take as they progress from one type to another. This tool has potential to boost regenerative medicine by guiding skin cells into new liver cells and may also be applied in cancer research.