Articles tagged with Cancer Cells
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Researchers found that metformin and syrosingopine combination blocks critical energy production step, driving cancer cells to death. The duo targets NAD+ regeneration, preventing lactate export and leading to cell demise.
Researchers at Osaka University have developed an AI-based system that can automatically differentiate between various types of cancer cells using microscopic images. The system achieved higher accuracy than human judgment, making it a potential game-changer in cancer diagnosis and treatment.
Scientists at DKFZ developed XRNAX to analyze interactions between all RNA classes with cellular proteins. The new method identifies hundreds of previously unknown protein-RNA bindings and sheds light on diseases including cancer, ALS, and viral infections.
Researchers at the Weizmann Institute of Science have created a new method to sequence individual cells from patient blood or bone marrow, capturing specific gene programs active in each cell. This allows for more precise diagnosis and treatment of multiple myeloma by identifying unique genetic blueprints for each patient.
Researchers have engineered sensors to monitor multiple signaling pathways driving tumor metastasis, enabling the prediction of a tumor cell's potential to spread. The development of Fluorescence Resonance Energy Transfer (FRET) biosensors has the potential to transform cancer cell biology and inform personalized treatment strategies.
Researchers at WashU Medicine have designed a 'flight data recorder' for developing cells, revealing the paths they take as they progress from one type to another. This tool has potential to boost regenerative medicine by guiding skin cells into new liver cells and may also be applied in cancer research.
A new method for detecting bladder cancer has been developed using atomic force microscopy (AFM), which can accurately identify cancerous cells in urine samples with high sensitivity. The test demonstrates over 90% sensitivity in detecting bladder cancer, compared to 20-80% for current non-invasive diagnostics.
A UCalgary research team analyzed publicly accessible health and genomics data to identify a gene signature that can help determine which cancer patients will benefit from immunotherapy. This discovery has the potential to improve treatment outcomes for these patients.
Researchers developed a new wound dressing that applies gentle electrical pulses using energy from body motions, significantly speeding up healing times in rodent tests.
Researchers from Princeton University developed new light-harnessing systems to probe membraneless organelle formation and its impact on cellular DNA. The discovery sheds light on the role of these organelles in diseases like cancer, Alzheimer's, and ALS.
Researchers at Max Delbrück Center develop strategy to selectively make cancer cells aggressive, making them vulnerable to anti-inflammatory substance. This approach aims to overcome chemotherapy resistance in certain types of cancer, such as non-small cell lung cancer.
A study found that restricting cancer cells' ability to metabolize sugar makes oncolytic viruses work better, multiplying faster and destroying cancer quicker. This approach may improve how potential cancer drugs are investigated in the lab.
Research unravels mechanism of defective ribosomes causing cellular damage, including DNA mutations and increased cancer protein levels. The discovery provides a solution to Dameshek's Riddle and turns ribosome defects into an attractive target in the fight against cancer.
Researchers at the University of Zurich identified a molecule that plays a key role in graft-versus-host responses, which can be fatal for leukemia patients. Blocking this molecule, GM-CSF, could significantly improve stem-cell transplant outcomes.
Researchers developed a mathematical model showing that two types of cellular asymmetry govern the shaping of cells into sheets and tubes. Altering one polarity can simulate diverse shapes, with initial cell arrangement and external boundaries influencing outcomes.
Scientists visualize immune system's action on tumor development, revealing its impact on cancer cell heterogeneity. The study highlights the potential for optimizing therapeutic combinations and sequences to improve immunotherapy outcomes.
Researchers fully described the mechanism of fungal luminescence, utilizing four key enzymes to produce light. They also created an entirely new molecular instrument for biotechnology by engineering a yeast strain that glows in the dark.
Researchers at Walter and Eliza Hall Institute identified a new component of the cell death machinery, protein VDAC2, which plays a crucial role in driving apoptosis in cancer cells. The study reveals that VDAC2 helps Bax drive apoptosis and may fine-tune cancer cells' response to anti-cancer agents.
A lab study funded by Cancer Research UK and Worldwide Cancer Research found that mannose can slow tumour growth and enhance the effects of chemotherapy in mice with multiple types of cancer. The researchers discovered a dosage of mannose that could block enough glucose to slow tumour growth in mice without affecting normal tissues.
Scientists at Lancaster University created a fluorescent biosensor to visualize cilia and cell division simultaneously, enabling the study of their interplay in development, regeneration, and disease. This new tool will help researchers understand how changes in cilia dynamics affect cell division speed and tissue development.
Researchers have discovered a new compound, ancistrolikokine E3, from a Congolese rainforest vine that effectively targets and kills pancreatic cancer cells. The compound inhibits the Akt/mTOR pathway and autophagy pathway, leading to dramatic changes in cell morphology and preventing metastasis formation.
Ralph DeBerardinis' work has changed the understanding of how tumors reprogram metabolic pathways to maximize energy production and growth. His discoveries have opened new avenues for therapies and imaging techniques, targeting cancer cells' diverse metabolic preferences.
Researchers have identified a compound, ancistrolikokine E3, from the twigs of the Ancistrocladus likoko vine that kills pancreatic cancer cells when nutrients are scarce. The compound inhibits the Akt/mTOR pathway, which is responsible for the aggressive proliferation of these cancer cells.
A team of researchers developed new strategies to exploit CRISPR technology to target the mutant form of protein NPM1, which is associated with acute myeloid leukemia. By blocking the export of mutant NPM1 from the nucleus, they were able to inhibit leukemic cell growth and induce differentiation or death in cancerous cells.
New research reveals Gamma Delta T cells possess a two-pronged device to check cell health before killing cancer cells. The immune cells can act independently without relying on authorization from other signals.
A genetic test called ThyroSeq has been shown to reliably distinguish between benign and cancerous thyroid nodules using a small sample of cells. The test correctly identified cancerous nodules as positive 94% of the time and detected benign nodules as negative 82% of the time, preventing unnecessary diagnostic surgeries.
A team led by Dr. Sjoerd van Wijk is exploring M1-deubiquitinating enzymes and their interactions with death receptors to better comprehend programmed cell death regulation. This research may lead to insights into human diseases, such as cancer development and bacterial invasion.
A new analysis of E. coli cell data sheds light on the long-standing question of what triggers cell division, suggesting that both DNA replication and septum formation occur concurrently. This discovery challenges existing models and offers new perspectives on cellular growth and potential applications in understanding cancer.
A new 'lab on a chip' technology allows for individualized cancer treatments that target specific tumor cells with high specificity. This breakthrough reduces the cost and time required to develop effective treatments, potentially revolutionizing T cell therapy for cancer.
Scientists at Helmholtz Zentrum München have discovered new details about the UHRF1 protein, which regulates gene activity and is produced at elevated levels in cancer cells. The research reveals an unexpected function of the UBL domain in DNA methylation and defines a new role for this domain in regulating gene expression.
Researchers at Northwestern Medicine have successfully reprogrammed induced pluripotent stem cells into healthy uterine cells for potential treatment of endometriosis. The study marks a significant step towards treating the painful and persistent gynecological disease, which affects approximately 10% of women worldwide.
A new study has identified glycolytic enzymes as potential biomarkers for early detection and prevention of liver cancer. The research found that the shift to glycolysis in cirrhotic livers is associated with a higher risk of developing hepatocellular carcinoma, offering hope for improved early detection and treatment.
Researchers discovered a new compound that enhances the efficacy of proteasome inhibitors, commonly used to treat multiple myeloma. The compound targets protein disulfide isomerases, making it effective against drug-resistant cells. This breakthrough offers hope for patients with this cancer.
A new Northwestern Medicine study reveals a 'kill code' embedded in every cell that can trigger the self-destruction of cancerous cells. The toxic small RNA molecules can also be triggered by chemotherapy, offering a potential bulletproof treatment against cancer.
Researchers have used high-resolution electron microscopy to reveal how an anti-cancer virus interacts with tumor cells, increasing its potential. The Seneca Valley Virus selectively targets a receptor found in over 60% of human cancers, offering a promising approach for cancer treatment.
Researchers have discovered how cancer cells' cell replication is derailed, leading to rapid tumour expansion. The findings could help predict how cancer cells respond to chemotherapy and improve understanding of cancer evolution.
Biophysicists at Ruhr-University Bochum developed a Raman microscopy method to detect cancer drug resistance in tumour cells. The new approach shows effectiveness in non-mutated cells but remains ineffective in mutated cells, similar to clinical observations.
Researchers at University of Montreal discovered how metformin affects cell glucose uptake and metabolism, revealing a link to iron distribution. This finding may explain metformin's potential benefits beyond diabetes treatment, including prevention of chronic diseases like cancer.
Researchers at UCL have identified a new mechanism for neural crest cells to move from the back of the head to the front, crucial for forming facial features. This discovery could help understand how facial defects form and pave the way for developing new therapies.
Researchers have released a massive dataset detailing molecular makeup of tumor cells from over 500 AML patients, enabling rapid advancement in clinical trials. The dataset includes how individual patients' cells responded to various drugs, providing insights into targeted therapies for specific subsets of AML cells.
Researchers discovered that loss of tumor protein p53 promotes cancer development by allowing cells to replicate despite growth stimuli deficiencies. This discovery provides insight into how cancer cells survive and multiply in adverse conditions.
A new study reveals that cells take an approach of 'purposeful inefficiency' in responding to diseases, offering new pathways for understanding and treating conditions like cancer and Parkinson's. The research team discovered surprising genetic responses to misfolded proteins, including increased protein production and wasteful processes.
A new cell-based immunotherapy using 'educated killer cells' has shown promise in eradicating pancreatic cancer, including cases where tumours have spread to multiple organs. The treatment could potentially be administered to human patients without toxic side effects.
Researchers found that cancer cells from the fallopian tube affect ovary's chemical signaling, leading to increased norepinephrine levels, which drive cancer cell migration. This study highlights the importance of understanding chemistry in ovarian cancer development and treatment protocols.
Researchers at Imperial College London have created a genetically engineered version of a cell called an invariant natural killer T-cell (iNKT) that shows potential as a new treatment for cancer. The CAR19-iNKT eliminated all cancer cells in 60% of mice and had 90% long-term survival rates.
A membrane transporter has been identified as crucial for the uptake of steroid hormones into cells, challenging decades-old assumptions about their biological effects. This breakthrough could lead to new treatments for diseases like cancer and immune disorders.
Researchers identified over 500 DNA sites requiring ATR enzyme to prevent breakage during replication. The findings suggest ATR inhibitors may enhance treatment efficacy for various cancers by targeting repetitive DNA sequences.
Researchers at IRB Barcelona and Vrije Universiteit Brussel have identified camelid nanobodies effective against EGF, a growth factor dysregulated in cancer cells. These nanobodies could provide a potential treatment for patients developing resistance to existing EGFR inhibitors.
Researchers propose natural adaptive therapies to keep cancer in check by mimicking the immune system's approach. These therapies aim to stabilize tumor size and slow resistance evolution.
Researchers at Penn discovered a new, rare mechanism that allows leukemia cells to relapse after CAR T cell therapy by masking the target protein CD19. This finding emphasizes the need for precise manufacturing processes to ensure the effectiveness of this treatment.
A new study suggests that organs affected by autoimmune disease can actively fight back by exhausting immune cells that cause damage. The research found that these cells exhibit characteristics similar to those used by cancer cells to evade the immune system.
Subtle changes in protein regulation can cause severe face and brain developmental abnormalities, highlighting the importance of striking a healthy balance between too little and too much cell death. The study suggests that excessive or inadequate cell death during embryonic development can lead to devastating birth defects or cancer.
Researchers developed a new cell culture platform to observe cancer cells' never-before-seen behaviors, revealing the mechanisms behind pancreatic cancer's clinical properties. The study shows that cancer cells can self-organize into micro-tumors and evade the immune system by releasing chemical markers on their surfaces.
Researchers found that for 85% of genes, noise magnitude is higher in the last step compared to the first. This discovery challenges the long-held assumption of a streamlined process and may impact disease treatment strategies.
Salk researchers discover that manipulating nuclear pores can increase their numbers in healthy cells, mimicking those found in cancer cells. This breakthrough could lead to a new way to fight cancer by targeting nuclear pores.
Researchers at UC San Diego School of Medicine discovered that ubiquitination influences GPCR function and promotes inflammation. Existing cancer drugs targeting enzymes involved in ubiquitination may be repurposed to treat vascular inflammation.
Researchers at the University of Oregon have created a new class of fluorescent dyes, called nanohoops, that can be used to track multiple biological activities in live cells. These circular structures emit colors based on their size and can be guided to specific sites within cells.
Researchers found that increased antioxidant enzyme expression and decreased NADPH-oxidase activity hinder treatment efficiency. This study reveals a redox-dependent mechanism of drug resistance development in ovarian cancer cells.
A study led by the University of Exeter Medical School found that disrupting genes and pathways regulating splicing factors can reverse signs of aging in cells. Disrupting ERK and AKT pathways reduced senescent cells, increasing splicing factors and leading to cellular rejuvenation.
Researchers developed a DNA-based test to predict which patients with acute myeloid leukemia (AML) are at risk of relapse. The test can identify treatment-resistant cancer cells three weeks after transplantation, allowing for earlier therapeutic intervention.