Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Researchers discovered E. coli bacteria change behavior to navigate tiny obstacle courses, defying predictions of slowing progress. The study's findings have implications for biology, medicine, and robotic search-and-rescue tactics.
Researchers at Medical University of South Carolina identified a metabolic Achilles heel in cancer, exploiting glutamine addiction. A new combination treatment has shown promise in treating drug-resistant esophageal cancer cells.
Researchers at Dartmouth College and City University of Hong Kong developed a swimming robot with a light-controlled cellular engine that can perform highly-targeted drug delivery. The biohybrid device transforms its shape when exposed to skin-penetrating near-infrared light, allowing it to drive and brake through fluid environments.
A Yale study reveals how cediranib, a cancer drug of limited use, stops certain cancer cells from repairing their DNA to survive. The combination of cediranib with olaparib may deliver a lethal blow in cancers that rely on a specific DNA repair pathway.
Researchers found that targeting telomeres with oxidative stress can shorten them, leading to accelerated cellular aging and DNA instability. This could lead to potential cancer treatment strategies by stopping cancer cells from dividing.
Researchers developed cell membrane-coated nanocarriers to overcome immune clearance and biotoxicity issues. These biomimetic hybrids achieve improved biocompatibility, circulation time, and therapeutic efficiency.
A study published in ACS Central Science found that many DNA cage nanostructures are not taken up by cells, but rather degraded by enzymes outside the cell. The researchers' findings have significant implications for the use of DNA strands as a tool for delivering therapeutic agents into diseased cells.
Researchers at MD Anderson Cancer Center discovered a small molecule drug, IACS-10759, that targets metabolic reprogramming and inhibits OXPHOS, leading to marked growth inhibition in ibrutinib-resistant mantle cell lymphoma cells. The study provides hope for patients with this incurable B-cell lymphoma.
Researchers discovered that fibrinogen, a blood-clotting protein, plays a role in multiple sclerosis relapses. In a mouse model, injecting EVs containing fibrinogen activated CD8+ immune cells, leading to relapsing-remitting disease.
Researchers at Swansea University's Medical School have found that immune cells can re-programme their metabolic pathways to provide energy and building blocks when challenged. This discovery suggests that manipulating metabolism could lead to new therapies for infectious diseases and cancer.
Researchers have identified a key enzyme that helps cancer cells survive by eliminating junk RNA. Targeting this enzyme, ADAR, may lead to breakthroughs in treating various types of cancer.
Cells lacking CD13 protein can't move normally, hindering their ability to repair wounds and metastasize. Researchers discovered that CD13 acts as an organizer, gathering recycled integrin proteins at the cell membrane to enable movement.
Researchers found that cancer cells can capitalize on temporary gaps in endothelial cell layers caused by physical forces and mechanical stresses, allowing them to migrate through and colonize new organs. This opportunistic approach complements chemical signaling and enables cancer cells to spread more efficiently.
A study at UT MD Anderson Cancer Center identified a new therapeutic target in cancer cells, caseinolytic protease P (ClpP), which breaks down proteins within mitochondria. New anti-cancer agents called imipridones activate ClpP and cause cancer cell death via mitochondrial proteolysis.
Researchers have developed a computational approach to simulate the complex bioelectrical interaction at the tissue scale, enabling more accurate and capable virtual experiments of cell behavior. The technique has potential applications in treating cancer and accelerating combat wound healing.
Researchers found that MDM2 interacts with a mitochondrial protein to promote cancer cell death. Nutlin-3A enhances this interaction, helping kill cancer cells.
Researchers found that removing the ATDC gene from pancreatic cells prevented the development of pancreatic cancer in mice. The study identified ATDC as a key player in the reprogramming of adult cells into primitive, high-growth cell types, which can lead to cancer.
Researchers created SCOTfluors, a class of small fluorophores that can be attached to common metabolites and emit light in the visible to near-infrared range. This allows for the observation of metabolite trafficking in living cells without destroying them.
Researchers have engineered molecules that restrict access to heme, an oxygen-binding molecule, to slow the growth of lung cancer tumors in mice. By starving cancer cells of this essential molecule, the new approach may provide a potential new path forward in treating non-small cell lung cancer.
Researchers find a long-overlooked molecular machine in the cell nucleus, the spliceosome, that produces mutant gene/protein fueling cancerous cells. Targeting this protein with existing and developing drugs may offer new treatment options for aggressive leukemia.
Researchers have shed light on how leukemia cells become resistant to drugs and describe a potential solution using two drugs in combination. The study identifies the genes responsible for resistance, revealing that cancer cells overcome the lack of asparagine by breaking down proteins.
Researchers found that the nutrient composition of interstitial fluid surrounding pancreatic tumors differs from blood and culture medium used to grow cancer cells. This discrepancy suggests growing cancer cells in a more similar environment could help predict how experimental drugs will affect cancer cells.
A new diagnostic method for pancreatic cancer has been developed by researchers at the University of Copenhagen, utilizing circular DNA to identify cancer cells in blood tests. The technology is expected to classify cancer cells in individual patients and implement personalized treatment regimens, leading to increased survival rates.
Cancer cells dependent on WRN enzyme to survive due to DNA repair system loss; MSI signature identified as effective biomarker for vulnerable tumors.
Scientists developed a new imaging technology to visualize what cells eat, such as glucose, which could aid in the diagnosis and treatment of diseases like cancer. The technique uses chemical probes that light up when they attach to specific molecules consumed by cells.
Researchers found that Chop expression is higher in T cells from ovarian cancer patients, and high nuclear levels of Chop are associated with poor clinical responses. Blocking Chop or ER stress may help improve T cell-based immunotherapy treatments.
A new study reveals blocking specific regions of UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells' ability to grow and spread. This protein is akin to a molecular Swiss army knife, with many different parts that each have a different job.
Researchers found that leukocytes select the path of least resistance by using their nucleus to measure pore sizes and guide movement. The nucleus acts as a mechanical gauge, pushing forward to insert into multiple pores to determine the largest size.
The study reveals the full structure of human ACLY at high resolution, paving the way for targeted drug development. ACLY inhibition could provide a better approach for treating cancer and metabolic disorders.
Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for various human cancers. The model provides insights into the structure and function of MEK1, which can help develop new classes of inhibitors for cancer therapeutics.
Researchers found that combining adavosertib with irinotecan, navitoclax or capecitabine increased its effectiveness against pancreatic cancer. The study aimed to identify new combinations of drugs to enhance adavosertib's effect.
Researchers have unraveled the inner workings of a process that allows T cells to tune out fake signals, providing an enormous leap forward in understanding immune system fine-tuning. The discovery sheds light on why immune system activity sometimes goes awry and may provide insights into curing cancer.
Researchers use laser technology to improve on existing methods for measuring metabolic activity in cancer cells. The new technique, single-cell metabolic photoacoustic microscopy, allows for the analysis of around 3,000 cells in about 15 minutes, enabling more accurate assessments of cancer cell characteristics.
Researchers discovered that a cellular protein acts as a 'gas pump attendant' controlling cancer cell growth, ensuring only necessary proteins are produced. This understanding may lead to new ways to inhibit cancer development.
Researchers identified a critical protein for tumor cell survival and found that targeting it could be a novel treatment strategy for MSI-H tumors. The study suggests that pharmacological inhibition of WRN function might serve as a targeted therapeutic approach.
Researchers identified two proteins, SIX1 and SIX2, that act as gatekeepers to regulate the immune response. The proteins were found to be involved in reducing inflammation by dampening the noncanonical NF-κB pathway.
Researchers discovered that adult tissues maintain a catalog of genes active in embryonic development, which can be accessed under certain conditions. This finding has major implications for regenerative medicine, as cells from patients may be coaxed into an earlier stage of development to replace diseased or failing organs.
Researchers found that cancer cells with fewer mitochondria are more likely to respond to certain drug treatments, offering a new avenue for targeted therapies. The study's findings suggest that enhancing understanding of the relationship between mitochondrial variability and drug response may lead to more effective cancer treatments.
Researchers at University of Alabama at Birmingham discovered androgen receptor imports into mitochondria, where it regulates multiple mitochondrial processes. This finding may lead to new treatment targets for castration-resistant prostate cancer.
Researchers at the University of Manchester have identified a new class of drugs that can stop ovarian cancer cells from growing. The PARG inhibitors target weaknesses in DNA replication, making them sensitive to these treatments.
Scientists have identified two coffee compounds, kahweol acetate and cafestol, which inhibit the growth of prostate cancer cells in cell culture and animal models. The study's findings suggest that these compounds may be used to treat drug-resistant prostate cancer, with further investigation needed.
Researchers created a nano-bot with magnetic 'tweezers' that can position a bead inside a human cell in three dimensions with unprecedented precision. The technology has been used to study cancer cells, showing the nucleus is not equally stiff in all directions and providing new insights for diagnosis.
A preclinical therapy attached to an antibody targeting the ALK protein shows effectiveness against most neuroblastoma cells, killing cancer cells with minimal harm to healthy tissues. This approach could lead to new treatment options for aggressive forms of neuroblastoma and other high-mortality childhood cancers.
Scientists have discovered that deleting the gene encoding ASCT2, a transporter enzyme responsible for bringing amino acids into cells, prolongs survival of mice with aggressive leukemia. The study found that ASCT2 is required for leukemia development and progression but dispensable for normal blood cell development.
Human cells can now travel more than five times faster than previously documented by slingshotting themselves forward, according to University of Michigan researchers. This new method of cell movement could be involved in the spread of cancer and potentially harnessed for tissue repair therapies.
A team of researchers led by James DeGregori will identify lung tissue characteristics that enable cancer cell growth, aiming to predict cancer risk and develop interventions. The study aims to modulate the lung environment to reduce cancer risk, rather than targeting cancer cells alone.
Researchers have developed a new tool called URSA(HD) that analyzes gene patterns to reveal molecular causes of diseases. The tool has already uncovered previously unknown contributions of four genes to a rare form of cancer primarily affecting babies and young children.
A new study reveals a specific mechanism in human cells that delay propagation of DNA damage, giving cells a chance to stop piling up mutations. The discovery relies on precise timing and control inside the cells and identifies key molecular proteins involved in repairing DNA lesions.
Researchers at Florida State University have found a critical missing step in proteasome assembly, which could be targeted to treat certain types of cancers. By manipulating this step, scientists may be able to regulate proteasome assembly and mitigate cancer-causing effects.
The study reveals that gene transcription is equally important to DNA damage response, with activated transcription facilitating DNA repair and limiting abnormal transcripts. Cells become hypersensitive to DNA damage-inducing agents when the RBM7-P-TEFb axis is interfered with.
New research shows that rapidly dividing cells fuse their mitochondria, increasing oxygen consumption and producing aspartate for cell replication. This process may have implications for cancer diagnosis and treatment.
Russian researchers created star-shaped nanoparticles with sharp spikes using laser irradiation for intracellular delivery. The method achieved efficiency rates of over 95% and minimal toxicity, making it a potential alternative to existing technologies.
A new technique developed at Purdue University could lead to faster and more accurate detection of cancer cells in patient blood samples. The method uses near-infrared spectroscopy to analyze proteins expressed on cancer cells, enabling early diagnosis and potentially improving outcomes.
Researchers develop a new assay to measure the eco-evolutionary interactions between sensitive and resistant tumor cells in non-small cell lung cancer. The study finds that by applying drug or eliminating fibroblasts, it is possible to 'treat the game', allowing for coopting of evolution to help patients
Researchers developed peptide-coated platinum nanoparticles that selectively target and kill liver cancer cells. The nanoparticles are oxidized inside the cell, triggering a cytotoxic effect, while sparing healthy tissue.
A study published in Genes & Development sheds light on the damage caused by senescence, a vital cell process that plays a key role in aging. The research reveals that manipulating tiny parts of cells can prevent certain forms of cellular damage.
Researchers discovered a rare tumor type that can't synthesize cholesterol, leading to its dependence on external nutrients. This vulnerability can be exploited with therapies blocking cholesterol uptake, offering a potential treatment for drug-resistant ALCL cells.
Researchers at Keck School of Medicine of USC develop a new laboratory tool, the Topanga assay, to improve cancer therapy effectiveness. The assay uses bioluminescent marine organisms' enzymes to measure chimeric antigen receptors on cancer-fighting white blood cells.
Researchers at Hollings Cancer Center have discovered a new sub-cellular complex called ceramidosomes, which form in the cell membrane and induce cancer cell death. The complexes are made up of lipid molecules called ceramide and two protein components, and their formation is integral to drug-induced cancer cell death.
Researchers found blood cells retain intrinsic age nearly two decades after transplant, using epigenetic patterns to calculate cellular age. The study suggests blood cells could be the master clock of human aging, with implications for understanding age-associated diseases and developing new therapies.